ES476408A1 - Un procedimiento de preparacion de derivados de 2,4-tiazoli-dindiona. - Google Patents
Un procedimiento de preparacion de derivados de 2,4-tiazoli-dindiona.Info
- Publication number
- ES476408A1 ES476408A1 ES476408A ES476408A ES476408A1 ES 476408 A1 ES476408 A1 ES 476408A1 ES 476408 A ES476408 A ES 476408A ES 476408 A ES476408 A ES 476408A ES 476408 A1 ES476408 A1 ES 476408A1
- Authority
- ES
- Spain
- Prior art keywords
- alkyl
- derivatives
- thiazolidinedione
- preparation
- pharmaceutical applications
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/26—Psychostimulants, e.g. nicotine, cocaine
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D277/34—Oxygen atoms
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Neurology (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Neurosurgery (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pain & Pain Management (AREA)
- Psychiatry (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Thiazole And Isothizaole Compounds (AREA)
Abstract
Un procedimiento de preparación de derivados de 2, 4-tiazolidindiona, en forma de racematos o de isómeros ópticamente activos, que responden a la fórmula (I) **fórmula** en la que no es 2 ó 3; R1 es un átomo de hidrógeno, un radical alcohilo de 1 a 4 átomos de carbono, el radical benzoílo, el radical acetilo o el radical bencilo, pudiendo o no llevar un substituyente escogido entre los radicales metilo o metoxi y los átomos de halógeno, R2 es un átomo de hidrógeno o un radical alcohilo de 1 a 4 átomos de carbono; R3 es o bien un radical fenilo que puede llevar o no uno o varios substituyentes escogidos entre el grupo constituido por los átomos de halógeno, los radicales alcohilo y alcoxi de 1 a 4 átomos de carbono, los radicales NO2, CF3 y CF3S, o bien un radical naftilo ; R4 es un átomo de hidrógeno, un radical alcohilo de 1 a 4 átomos de carbono, el radical fenilo, el radical bencilo o el radical alilo, con excepción de los compuestos para los que R3 es C6H5 y R4 es H cuando R1 y R2 son CH3 y n es 2 ó 3, así como sus sales de adición son ácidos farmaceúticamente aceptables, caracterizado porque se hace reaccionar un compuesto de fórmula (II) **fórmula**^en la que m es 1 ó 2, con ácido bromado de fórmula (III) **fórmula** y después se hidroliza el compuesto obtenido, de fórmula (IV) **fórmula** y si se desea, se alcohila el compuesto (I) obtenido en el que R1 y R2 son H, teniendo los símbolos los significados dados anteriormente.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR7739559A FR2413381A1 (fr) | 1977-12-29 | 1977-12-29 | Derives de thiazolidinedione et leur application en therapeutique |
FR7833244A FR2442232A2 (fr) | 1978-11-24 | 1978-11-24 | Derives de thiazolidinedione-2,4 et leur application en therapeutique |
Publications (1)
Publication Number | Publication Date |
---|---|
ES476408A1 true ES476408A1 (es) | 1979-04-01 |
Family
ID=26220372
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES476408A Expired ES476408A1 (es) | 1977-12-29 | 1978-12-28 | Un procedimiento de preparacion de derivados de 2,4-tiazoli-dindiona. |
Country Status (17)
Country | Link |
---|---|
US (1) | US4349683A (es) |
EP (1) | EP0002978B1 (es) |
JP (1) | JPS6011908B2 (es) |
AR (1) | AR223160A1 (es) |
AT (1) | AT370098B (es) |
AU (1) | AU517221B2 (es) |
CA (1) | CA1107740A (es) |
DE (1) | DE2862059D1 (es) |
DK (1) | DK149429C (es) |
ES (1) | ES476408A1 (es) |
FI (1) | FI68819C (es) |
GR (1) | GR65312B (es) |
IE (1) | IE47902B1 (es) |
IL (1) | IL56304A (es) |
NO (1) | NO148454C (es) |
NZ (1) | NZ189300A (es) |
PT (1) | PT68991A (es) |
Families Citing this family (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU6610081A (en) * | 1980-01-24 | 1981-07-30 | Senju Pharmaceutical Co., Ltd. | Thiazolidine derivatives |
JPH0750560B2 (ja) * | 1981-05-09 | 1995-05-31 | ヤマハ株式会社 | ディジタル集積回路装置 |
US4456756A (en) * | 1981-08-03 | 1984-06-26 | Mead Johnson & Company | Spirothiazolidinyl piperazine derivatives |
US4367335A (en) * | 1981-08-03 | 1983-01-04 | Mead Johnson & Company | Thiazolidinylalkylene piperazine derivatives |
EP0715853A1 (en) * | 1991-01-10 | 1996-06-12 | Transcend Therapeutics, Inc. | Use of glutathione esters for the treatment of pulmonary diseases |
US5747459A (en) * | 1991-02-04 | 1998-05-05 | Nestec, Ltd. | Method for insuring adequate intracellular glutathione in tissue |
US5430045A (en) * | 1992-04-23 | 1995-07-04 | Free Radical Sciences, Inc. | Method of reducing or preventing bone marrow hypoplasia |
US5447712A (en) * | 1993-12-09 | 1995-09-05 | Free Radical Sciences | Method of reducing cyclophosphamide induced hemorrhagic cystitis |
ES2199086B1 (es) * | 2002-07-31 | 2005-06-01 | Cepa Schwarz Pharma Sl | Nuevos derivados de cicloalcanodionas, procedimiento para su preparacion y sus aplicaciones farmacologicas. |
KR20150068829A (ko) * | 2013-12-12 | 2015-06-22 | 삼성전자주식회사 | 알킬 암모늄염 화합물을 포함하는 유도 용질 |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR1435004A (fr) * | 1965-02-04 | 1966-04-15 | Sobio Lab | Dérivés de thiazolidine-dione-2, 4- et procédé de préparation |
-
1978
- 1978-12-13 DE DE7878400236T patent/DE2862059D1/de not_active Expired
- 1978-12-13 EP EP78400236A patent/EP0002978B1/fr not_active Expired
- 1978-12-26 IL IL56304A patent/IL56304A/xx unknown
- 1978-12-27 CA CA318,655A patent/CA1107740A/en not_active Expired
- 1978-12-27 NO NO784382A patent/NO148454C/no unknown
- 1978-12-27 DK DK582578A patent/DK149429C/da not_active IP Right Cessation
- 1978-12-27 FI FI783995A patent/FI68819C/fi not_active IP Right Cessation
- 1978-12-28 ES ES476408A patent/ES476408A1/es not_active Expired
- 1978-12-28 AU AU42961/78A patent/AU517221B2/en not_active Expired
- 1978-12-28 PT PT68991A patent/PT68991A/pt unknown
- 1978-12-28 IE IE2561/78A patent/IE47902B1/en unknown
- 1978-12-28 JP JP53164429A patent/JPS6011908B2/ja not_active Expired
- 1978-12-28 GR GR57988A patent/GR65312B/el unknown
- 1978-12-28 AR AR274998A patent/AR223160A1/es active
- 1978-12-29 AT AT0936678A patent/AT370098B/de not_active IP Right Cessation
-
1979
- 1979-01-04 NZ NZ189300A patent/NZ189300A/xx unknown
-
1980
- 1980-08-26 US US06/181,475 patent/US4349683A/en not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
JPS6011908B2 (ja) | 1985-03-28 |
PT68991A (fr) | 1979-01-01 |
IL56304A (en) | 1982-02-28 |
IE782561L (en) | 1979-06-29 |
AU517221B2 (en) | 1981-07-16 |
NO784382L (no) | 1979-07-02 |
EP0002978A3 (en) | 1979-07-25 |
NO148454C (no) | 1983-10-12 |
DK582578A (da) | 1979-06-30 |
FI68819B (fi) | 1985-07-31 |
NO148454B (no) | 1983-07-04 |
DE2862059D1 (en) | 1982-11-11 |
FI68819C (fi) | 1985-11-11 |
FI783995A (fi) | 1979-06-30 |
DK149429B (da) | 1986-06-09 |
EP0002978A2 (fr) | 1979-07-11 |
AT370098B (de) | 1983-02-25 |
ATA936678A (de) | 1982-07-15 |
US4349683A (en) | 1982-09-14 |
GR65312B (en) | 1980-08-02 |
JPS5498758A (en) | 1979-08-03 |
DK149429C (da) | 1987-03-09 |
IE47902B1 (en) | 1984-07-25 |
IL56304A0 (en) | 1979-03-12 |
AR223160A1 (es) | 1981-07-31 |
EP0002978B1 (fr) | 1982-10-06 |
AU4296178A (en) | 1979-07-05 |
CA1107740A (en) | 1981-08-25 |
NZ189300A (en) | 1980-05-27 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FD1A | Patent lapsed |
Effective date: 19971201 |