ES2199086B1 - Nuevos derivados de cicloalcanodionas, procedimiento para su preparacion y sus aplicaciones farmacologicas. - Google Patents

Nuevos derivados de cicloalcanodionas, procedimiento para su preparacion y sus aplicaciones farmacologicas.

Info

Publication number
ES2199086B1
ES2199086B1 ES200201811A ES200201811A ES2199086B1 ES 2199086 B1 ES2199086 B1 ES 2199086B1 ES 200201811 A ES200201811 A ES 200201811A ES 200201811 A ES200201811 A ES 200201811A ES 2199086 B1 ES2199086 B1 ES 2199086B1
Authority
ES
Spain
Prior art keywords
new derivatives
procedure
preparation
cycllocanodionas
pharmacological applications
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
ES200201811A
Other languages
English (en)
Other versions
ES2199086A1 (es
Inventor
Joaquin Del Rio Zambrana
Diana Frechilla Manso
M. Luz Lopez Rodriguez
Bellinda Benhamu Salama
Jose Angel Fuentes Cubero
Mercedes Delgado Wallace
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Schwarz Pharma SL
Original Assignee
Cepa Schwarz Pharma SL
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to ES200201811A priority Critical patent/ES2199086B1/es
Application filed by Cepa Schwarz Pharma SL filed Critical Cepa Schwarz Pharma SL
Priority to CA002492837A priority patent/CA2492837A1/en
Priority to CNB038183390A priority patent/CN100422185C/zh
Priority to PCT/ES2003/000394 priority patent/WO2004014915A1/es
Priority to US10/522,697 priority patent/US7351732B2/en
Priority to KR1020057001543A priority patent/KR20050042471A/ko
Priority to PL03373644A priority patent/PL373644A1/xx
Priority to SI200330451T priority patent/SI1544201T1/sl
Priority to AU2003254512A priority patent/AU2003254512A1/en
Priority to RU2005102821/04A priority patent/RU2322445C2/ru
Priority to PT03784210T priority patent/PT1544201E/pt
Priority to AT03784210T priority patent/ATE331717T1/de
Priority to DE60306534T priority patent/DE60306534T2/de
Priority to DK03784210T priority patent/DK1544201T3/da
Priority to UAA200500843A priority patent/UA79801C2/uk
Priority to JP2004526925A priority patent/JP2005539017A/ja
Priority to ES03784210T priority patent/ES2271673T3/es
Priority to EP03784210A priority patent/EP1544201B1/en
Priority to CNA2007101694908A priority patent/CN101172977A/zh
Priority to NZ538489A priority patent/NZ538489A/en
Priority to MXPA05001245A priority patent/MXPA05001245A/es
Priority to BR0313375-3A priority patent/BR0313375A/pt
Publication of ES2199086A1 publication Critical patent/ES2199086A1/es
Priority to IL16646905A priority patent/IL166469A0/xx
Priority to ZA200500784A priority patent/ZA200500784B/xx
Priority to NO20051068A priority patent/NO20051068L/no
Application granted granted Critical
Publication of ES2199086B1 publication Critical patent/ES2199086B1/es
Priority to CY20061101376T priority patent/CY1106170T1/el
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
    • A61K31/381—Heterocyclic compounds having sulfur as a ring hetero atom having five-membered rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4188—1,3-Diazoles condensed with other heterocyclic ring systems, e.g. biotin, sorbinil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/04—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/34—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Vascular Medicine (AREA)
  • Neurosurgery (AREA)
  • Urology & Nephrology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

Nuevos derivados de cicloalcanodionas, procedimiento para su preparación y sus aplicaciones farmacológicas Nuevos derivados de cicloalcanodionas que son agonistas del subtipo de receptor de serotonina (5-hidroxitriptamina, 5-HT) 5-HTIA y que, consiguientemente, son útiles en el tratamiento de estados patológicos para los que está indicado un agonista de estos receptores. Particularmente, son útiles como agentes neuroprotectores, de especial interés en el tratamiento y profilaxis del daño cerebral producido por el ictus isquémico o traumático. De forma general, dichos derivados de cicloalcanodiona corresponden a la **fórmula**.
ES200201811A 2002-07-31 2002-07-31 Nuevos derivados de cicloalcanodionas, procedimiento para su preparacion y sus aplicaciones farmacologicas. Expired - Fee Related ES2199086B1 (es)

Priority Applications (26)

Application Number Priority Date Filing Date Title
ES200201811A ES2199086B1 (es) 2002-07-31 2002-07-31 Nuevos derivados de cicloalcanodionas, procedimiento para su preparacion y sus aplicaciones farmacologicas.
JP2004526925A JP2005539017A (ja) 2002-07-31 2003-07-29 新規シクロアルカンジオン誘導体、それらの製造方法、及びそれらの医薬適用
PCT/ES2003/000394 WO2004014915A1 (es) 2002-07-31 2003-07-29 Nuevos derivados de cicloalcanodionas procedimiento para su preparación y sus aplicaciones farmacológicas
US10/522,697 US7351732B2 (en) 2002-07-31 2003-07-29 Cycloalkanedione derivatives, method for the production thereof and their pharmacological applications
KR1020057001543A KR20050042471A (ko) 2002-07-31 2003-07-29 신규한 사이클로알카노디온 유도체, 그의 제조방법 및그의 약리학적 적용
PL03373644A PL373644A1 (en) 2002-07-31 2003-07-29 Novel derivatives of cycloalcanodiones, method for the production thereof and their pharmacological applications
SI200330451T SI1544201T1 (sl) 2002-07-31 2003-07-29 Novi derivati cikloalkanodionov, postopek za proizvodnjo le-teh in njihove farmacevtske aplikacije
AU2003254512A AU2003254512A1 (en) 2002-07-31 2003-07-29 Novel derivatives of cycloalcanodiones, method for the production thereof and their pharmacological applications
RU2005102821/04A RU2322445C2 (ru) 2002-07-31 2003-07-29 Новые производные циклоалкандиона, способ их получения и их применение в фармацевтике
PT03784210T PT1544201E (pt) 2002-07-31 2003-07-29 Novos derivados de cicloalcanodionas, métodos para a sua preparação e suas aplicações farmacológicas
AT03784210T ATE331717T1 (de) 2002-07-31 2003-07-29 Neue derivate von cycloalkanodionen, verfahren zu deren herstellung und deren pharmakologische anwendungen
DE60306534T DE60306534T2 (de) 2002-07-31 2003-07-29 Neue derivate von cycloalkanodionen, verfahren zu deren herstellung und deren pharmakologische anwendungen
DK03784210T DK1544201T3 (da) 2002-07-31 2003-07-29 Nye cycloalkanedionderivater, fremgangsmåde til fremstilling deraf og deres farmakologiske anvendelser
UAA200500843A UA79801C2 (en) 2002-07-31 2003-07-29 Novel derivatives of cycloalcanodiones, method for the production thereof and their pharmacological applications
CA002492837A CA2492837A1 (en) 2002-07-31 2003-07-29 Novel derivatives of cycloalcanodiones, method for the production thereof and their pharmacological applications
BR0313375-3A BR0313375A (pt) 2002-07-31 2003-07-29 Composto de cicloalcanodioanas, método para prepará-lo, composição farmacêutica compreendendo-o e seu uso
ES03784210T ES2271673T3 (es) 2002-07-31 2003-07-29 Nuevos derivados de cicloalcanodionas, procedimiento para su preparacion y sus aplicaciones farmacologicas.
CNA2007101694908A CN101172977A (zh) 2002-07-31 2003-07-29 新的环烷二酮衍生物、它们的制备方法和它们的药物应用
NZ538489A NZ538489A (en) 2002-07-31 2003-07-29 Novel derivatives of cycloalkanodiones, method for the production thereof and their pharmacological applications
MXPA05001245A MXPA05001245A (es) 2002-07-31 2003-07-29 Nuevos derivados de cicloalcanodionas, procedimiento para su preparacion y sus aplicaciones farmacologicas.
CNB038183390A CN100422185C (zh) 2002-07-31 2003-07-29 新的环烷二酮衍生物、它们的制备方法和它们的药物应用
EP03784210A EP1544201B1 (en) 2002-07-31 2003-07-29 Novel derivatives of cycloalcanodiones, method for the production thereof and their pharmacological applications
IL16646905A IL166469A0 (en) 2002-07-31 2005-01-24 Novel derivatives of cycloalcanodiones method for the production thereof and their pharmacological applications
ZA200500784A ZA200500784B (en) 2002-07-31 2005-01-25 Novel derivatives of cycloalcanodiones, method for the production thereof and their pharmacological applications
NO20051068A NO20051068L (no) 2002-07-31 2005-02-25 Nye derivater av sykloalkandioner, fremgangsmate for fremstilling derav og deres farmakologiske applikasjoner
CY20061101376T CY1106170T1 (el) 2002-07-31 2006-09-26 Νεα παραγωγα κυκλοαλκανοδιονων,μεθοδος για την παρασκευη τους και οι φαρμακολογικες τους εφαρμογες

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ES200201811A ES2199086B1 (es) 2002-07-31 2002-07-31 Nuevos derivados de cicloalcanodionas, procedimiento para su preparacion y sus aplicaciones farmacologicas.

Publications (2)

Publication Number Publication Date
ES2199086A1 ES2199086A1 (es) 2004-02-01
ES2199086B1 true ES2199086B1 (es) 2005-06-01

Family

ID=31198114

Family Applications (2)

Application Number Title Priority Date Filing Date
ES200201811A Expired - Fee Related ES2199086B1 (es) 2002-07-31 2002-07-31 Nuevos derivados de cicloalcanodionas, procedimiento para su preparacion y sus aplicaciones farmacologicas.
ES03784210T Expired - Lifetime ES2271673T3 (es) 2002-07-31 2003-07-29 Nuevos derivados de cicloalcanodionas, procedimiento para su preparacion y sus aplicaciones farmacologicas.

Family Applications After (1)

Application Number Title Priority Date Filing Date
ES03784210T Expired - Lifetime ES2271673T3 (es) 2002-07-31 2003-07-29 Nuevos derivados de cicloalcanodionas, procedimiento para su preparacion y sus aplicaciones farmacologicas.

Country Status (23)

Country Link
US (1) US7351732B2 (es)
EP (1) EP1544201B1 (es)
JP (1) JP2005539017A (es)
KR (1) KR20050042471A (es)
CN (2) CN100422185C (es)
AT (1) ATE331717T1 (es)
AU (1) AU2003254512A1 (es)
BR (1) BR0313375A (es)
CA (1) CA2492837A1 (es)
CY (1) CY1106170T1 (es)
DE (1) DE60306534T2 (es)
DK (1) DK1544201T3 (es)
ES (2) ES2199086B1 (es)
IL (1) IL166469A0 (es)
MX (1) MXPA05001245A (es)
NO (1) NO20051068L (es)
NZ (1) NZ538489A (es)
PL (1) PL373644A1 (es)
PT (1) PT1544201E (es)
RU (1) RU2322445C2 (es)
UA (1) UA79801C2 (es)
WO (1) WO2004014915A1 (es)
ZA (1) ZA200500784B (es)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2199086B1 (es) 2002-07-31 2005-06-01 Cepa Schwarz Pharma Sl Nuevos derivados de cicloalcanodionas, procedimiento para su preparacion y sus aplicaciones farmacologicas.
ES2238015B1 (es) * 2004-01-30 2006-11-01 Cepa Schwarz Pharma, S.L. Derivados de cicloalcanodionas con actividad neuroprotectora.
WO2008015538A2 (en) * 2006-07-31 2008-02-07 Schwarz Pharma S.L. Use of diaza- and thiaza-cycloalkanediones for preventing and/or treating pain and /or migraine
EP2338873A1 (en) 2009-12-22 2011-06-29 Gmeiner, Peter New aminotetraline derivatives

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4055410A (en) * 1976-03-15 1977-10-25 E. I. Du Pont De Nemours And Company Substituted bromo- or chloroacetamide herbicides
DE2862059D1 (en) * 1977-12-29 1982-11-11 Synthelabo Thiazolidinedione-2,4 derivatives, their preparation and pharmaceutical applications
DE3901814A1 (de) 1988-07-28 1990-02-01 Bayer Ag Substituierte aminomethylzetraline sowie ihre heterocyclischen analoga
CA2067031C (en) * 1991-04-26 2003-02-18 Shigekazu Nagata Dna coding for human cell surface antigen
TW288010B (es) * 1992-03-05 1996-10-11 Pfizer
AP486A (en) * 1993-04-27 1996-04-16 Pfizer Indole derivatives.
ES2082727B1 (es) 1994-09-01 1996-10-16 Univ Madrid Complutense Nuevos derivados de arilpiperazinas.
WO1996006846A1 (es) 1994-09-01 1996-03-07 Universidad Complutense De Madrid Nuevos derivados de arilpiperazinas
ES2094690B1 (es) 1994-11-22 1997-08-01 Univ Madrid Complutense Nuevos derivados de imida-piperazinas.
ES2109190B1 (es) 1996-03-22 1998-07-01 Univ Madrid Complutense Nuevos derivados de bencimidazol con afinidad por los receptores serotoninergicos 5-ht /5-ht
ES2129370B1 (es) 1997-09-23 2000-03-01 Univ Madrid Complutense Procedimiento para la obtencion del 2-(4-(4-(m-etilsulfonamidofenil)p iperazin-1-il(butil)-1,3-dioxoperhidropirrolo)1,2-c(imidazol
US6133277A (en) 1997-12-05 2000-10-17 Janssen Pharmaceutica N.V. (Benzodioxan, benzofuran or benzopyran) derivatives having fundic relaxation properties
ES2154605B1 (es) 1999-09-14 2001-11-16 Univ Madrid Complutense Nuevos derivados mixtos de bencimidazol-arilpiperazina con afinidad por los receptores serotoninergicos 5-ht1a y 5-ht3
DE10148425A1 (de) 2001-10-01 2003-04-17 Bayer Ag Chromane
ES2199086B1 (es) 2002-07-31 2005-06-01 Cepa Schwarz Pharma Sl Nuevos derivados de cicloalcanodionas, procedimiento para su preparacion y sus aplicaciones farmacologicas.
ES2238015B1 (es) 2004-01-30 2006-11-01 Cepa Schwarz Pharma, S.L. Derivados de cicloalcanodionas con actividad neuroprotectora.
EP1674103A1 (en) 2004-12-27 2006-06-28 Cepa Schwarz Pharma s.l. Arylpiperazine derivatives and use thereof as 5-HT1A receptor ligands

Also Published As

Publication number Publication date
EP1544201A1 (en) 2005-06-22
EP1544201B1 (en) 2006-06-28
JP2005539017A (ja) 2005-12-22
US20050250777A1 (en) 2005-11-10
ES2271673T3 (es) 2007-04-16
CN1671708A (zh) 2005-09-21
BR0313375A (pt) 2005-06-21
DE60306534D1 (de) 2006-08-10
KR20050042471A (ko) 2005-05-09
CA2492837A1 (en) 2004-02-19
ES2199086A1 (es) 2004-02-01
CN100422185C (zh) 2008-10-01
NO20051068L (no) 2005-02-25
AU2003254512A1 (en) 2004-02-25
MXPA05001245A (es) 2005-09-12
CY1106170T1 (el) 2011-06-08
US7351732B2 (en) 2008-04-01
DE60306534T2 (de) 2007-04-19
WO2004014915A1 (es) 2004-02-19
RU2322445C2 (ru) 2008-04-20
RU2005102821A (ru) 2005-10-10
ZA200500784B (en) 2006-08-30
ATE331717T1 (de) 2006-07-15
UA79801C2 (en) 2007-07-25
IL166469A0 (en) 2006-01-15
CN101172977A (zh) 2008-05-07
NZ538489A (en) 2006-09-29
DK1544201T3 (da) 2006-10-30
PT1544201E (pt) 2006-11-30
PL373644A1 (en) 2005-09-05

Similar Documents

Publication Publication Date Title
PE20061298A1 (es) Compuestos derivados de dihidrobenzofurano como agonistas del receptor de serotonina 5-ht2c
GT200600166A (es) Derivados de cromano y cromeno y usos de los mismos
ECSP109957A (es) Derivados de pirimidinil-piridazinona.
CL2011001464A1 (es) Compuestos derivados de purina, agonistas del receptor cb2; composicion farmaceutica que los comprende; y uso del compuesto para tratar el dolor osteoartritico.
CR9098A (es) 3-phenyl-pyrazole derivatives as modulators of the 5-ht2a serotonin receptor useful for the treatment of disorders related thereto
ECSP066520A (es) Derivados de dihidrobenzofuranilo alcanamina y métodos para su uso
HRP20120129T1 (hr) Hidroksimetil pirolidini kao agonisti beta 3 adrenergičkog receptora
ECSP11011348A (es) 2-mercaptoquinolin-3-carboxamidas sustituidas como moduladores de kcnq2/3
ECSP088585A (es) Derivados de cinnolina sustituidos como moduladores del receptor del gabaa y método para su síntesis
AR064165A1 (es) Un procedimiento para la preparacion de capecitabina e intermediarios utilizables en dicho procedimiento
AR051904A1 (es) Peptidos con actividad agonista del receptor del neuropeptido-2 (y2r)
CL2009000404A1 (es) Compuestos derivados de piperidin-indol-sustituidos, moduladores de receptores nociceptina/orl1; proceso de preparacion de dichos compuestos; composicion farmaceutica que los comprende; y su uso en el tratamiento de enfermedades del snc, cardiovasculares, metabolicas, entre otras.
ECSP088584A (es) Nuevos derivados de benzimidazol como inhibidores del receptor vanilloide 1 (vrl)
PE20060937A1 (es) Derivados de sulfonilbencimidazol como agonistas del receptor cannabinoide 2 (cb2)
EA200701588A1 (ru) Способы получения замещённых фенилпиразолмочевин
AR054786A1 (es) (6-fluor-benzol(1,3) dioxolil)-morfolin-4-il-metanomas, moduladoras del receptor cb1
NI200900179A (es) Pirimidinil - piperazinas útiles como ligandos receptores de dopamina d3/d2.
CR20190379A (es) Moduladores del receptor de estrógeno
CO6410291A2 (es) 3-amino-2-mercaptoquinolina sustituidacomo modulador de kcnq2/3
ECSP11011345A (es) 2-mercapto-3-aminopiridina sustituida como moduladores de kcnq2/3
EA200801001A1 (ru) Соединения, которые обладают активностью по отношению к рецепторам м, и их применения в медицине
ES2199086B1 (es) Nuevos derivados de cicloalcanodionas, procedimiento para su preparacion y sus aplicaciones farmacologicas.
CR11860A (es) Derivados de dibenzotiazepina y sus usos - 424
MX2019006270A (es) Compuestos de morfinano.
AR069009A1 (es) Arilindenopirimidinas y su uso como antagonistas del receptor a₂a de adenosina

Legal Events

Date Code Title Description
EC2A Search report published

Date of ref document: 20040201

Kind code of ref document: A1

FG2A Definitive protection

Ref document number: 2199086B1

Country of ref document: ES

PC2A Transfer of patent
FD2A Announcement of lapse in spain

Effective date: 20180808