AR064165A1 - Un procedimiento para la preparacion de capecitabina e intermediarios utilizables en dicho procedimiento - Google Patents

Un procedimiento para la preparacion de capecitabina e intermediarios utilizables en dicho procedimiento

Info

Publication number
AR064165A1
AR064165A1 ARP070105460A AR064165A1 AR 064165 A1 AR064165 A1 AR 064165A1 AR P070105460 A ARP070105460 A AR P070105460A AR 064165 A1 AR064165 A1 AR 064165A1
Authority
AR
Argentina
Prior art keywords
procedure
preparation
capecitabin
intermediaries used
disclosed
Prior art date
Application number
Other languages
English (en)
Inventor
Esteban Ravaschino
Eleonora Elhalem
Juan Bautista Rodriguez
Original Assignee
Richmond Sa Com Ind Y Financie
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Richmond Sa Com Ind Y Financie filed Critical Richmond Sa Com Ind Y Financie
Priority to ARP070105460 priority Critical patent/AR064165A1/es
Priority to EP08857450A priority patent/EP2241556A1/en
Priority to PCT/ES2008/000766 priority patent/WO2009071726A1/es
Publication of AR064165A1 publication Critical patent/AR064165A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • C07H19/067—Pyrimidine radicals with ribosyl as the saccharide radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/47—One nitrogen atom and one oxygen or sulfur atom, e.g. cytosine

Abstract

Se revela un procedimiento para la obtencion del compuesto capecitabina y sus derivados farmacéuticamente aceptables. Asimismo, se revelan intermediarios utilizables en la preparacion del compuesto capecitabina y sus derivados farmacéuticamente aceptables. El procedimiento comprende la etapa de hacer reaccionar N4-(n-pentiloxicarbonil))-5-fluorocitosina con (1,2,3-tri-O-acetil-5-desoxi-alfa,beta-D-ribofuranosa.
ARP070105460 2007-12-06 2007-12-06 Un procedimiento para la preparacion de capecitabina e intermediarios utilizables en dicho procedimiento AR064165A1 (es)

Priority Applications (3)

Application Number Priority Date Filing Date Title
ARP070105460 AR064165A1 (es) 2007-12-06 2007-12-06 Un procedimiento para la preparacion de capecitabina e intermediarios utilizables en dicho procedimiento
EP08857450A EP2241556A1 (en) 2007-12-06 2008-12-05 Method for the preparation of capecitabine and intermediates used in said method
PCT/ES2008/000766 WO2009071726A1 (es) 2007-12-06 2008-12-05 Un procedimiento para la preparación de capecitabina e intermediarios utilizables en dicho procedimiento

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ARP070105460 AR064165A1 (es) 2007-12-06 2007-12-06 Un procedimiento para la preparacion de capecitabina e intermediarios utilizables en dicho procedimiento

Publications (1)

Publication Number Publication Date
AR064165A1 true AR064165A1 (es) 2009-03-18

Family

ID=40521307

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP070105460 AR064165A1 (es) 2007-12-06 2007-12-06 Un procedimiento para la preparacion de capecitabina e intermediarios utilizables en dicho procedimiento

Country Status (3)

Country Link
EP (1) EP2241556A1 (es)
AR (1) AR064165A1 (es)
WO (1) WO2009071726A1 (es)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN114236008A (zh) * 2021-12-17 2022-03-25 山东铂源药业有限公司 一种卡培他滨中间体中d-核糖及5-脱氧-d-呋喃核糖含量的检测方法

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2010047866A2 (en) 2008-08-01 2010-04-29 Dow Agrosciences Llc Use of 5-fluorocytosine as a fungicide
CN101987857A (zh) * 2009-08-07 2011-03-23 合肥华方医药科技有限公司 一种抗肿瘤药物卡培他滨及其中间体的合成方法
CN101845070B (zh) * 2010-05-25 2012-05-16 郑州大学 抗肿瘤药物卡培他滨的合成方法
CN102199180B (zh) * 2011-04-12 2014-07-09 连云港杰瑞药业有限公司 一种卡培他滨的制备方法
CN102344469A (zh) * 2011-07-26 2012-02-08 江西科技师范学院 固体酸SO42-/γ-AL2O3催化合成1, 2, 3-O-三乙酰基-5-脱氧-D-呋喃核糖的方法
CN103897005B (zh) * 2012-12-27 2017-07-28 鲁南制药集团股份有限公司 一种连续操作合成卡培他滨的方法
CN104650160A (zh) * 2015-01-13 2015-05-27 济南大学 卡培他滨关键中间体1,2,3-o-三乙酰基-5-脱氧-d-核糖的合成新方法
CN104744537B (zh) * 2015-04-09 2018-06-08 山东诺德生物科技有限公司 一种卡培他滨的合成方法
JP2016198075A (ja) * 2015-04-14 2016-12-01 プラズミア バイオテック，エス．エル． シトシンヌクレオシドアナログの酵素産生
US20160312261A1 (en) * 2015-04-24 2016-10-27 Plasmia Biotech, S.L. Enzymatic production of cytosinic nucleoside analogues
CN104926901B (zh) * 2015-06-15 2018-04-20 广安凯特制药有限公司 一种卡培他滨关键中间体的合成方法
CN105566419A (zh) * 2015-12-28 2016-05-11 上海金和生物技术有限公司 卡培他滨的制备方法
CN107365333A (zh) * 2017-07-31 2017-11-21 上海创诺医药集团有限公司 一种卡培他滨中间体的合成方法
CN109336827A (zh) * 2018-12-21 2019-02-15 山东铂源药业有限公司 卡培他滨杂质(5-氟-2-氧代-1,2-二氢嘧啶-4-基)氨基甲酸戊酯的制备方法

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1135258A (en) 1979-06-15 1982-11-09 Richard D'souza Process for the preparation of 5'deoxy-5-fluorouridine
AU671491B2 (en) 1992-12-18 1996-08-29 F. Hoffmann-La Roche Ag N-oxycarbonyl substituted 5'-deoxy-5-fluorcytidines
TW254946B (es) * 1992-12-18 1995-08-21 Hoffmann La Roche
US5476932A (en) 1994-08-26 1995-12-19 Hoffmann-La Roche Inc. Process for producing N4-acyl-5'-deoxy-5-fluorocytidine derivatives
EP2335706B1 (en) 1998-07-23 2013-10-23 Southern Research Institute Preparation of thioarabinofuranosyl compounds
CN100383128C (zh) * 2004-02-23 2008-04-23 上海迪赛诺医药发展有限公司 N4－氧羰基胞嘧啶衍生物及制备方法与应用
US20100130734A1 (en) * 2007-04-20 2010-05-27 Dr. Reddy's Laboratories Ltd. Process for preparing capecitabine
CN101239998A (zh) * 2008-02-03 2008-08-13 王效山 一种1,2,3-三乙酰基-5-脱氧-d-核糖合成方法

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN114236008A (zh) * 2021-12-17 2022-03-25 山东铂源药业有限公司 一种卡培他滨中间体中d-核糖及5-脱氧-d-呋喃核糖含量的检测方法
CN114236008B (zh) * 2021-12-17 2023-11-28 山东铂源药业股份有限公司 一种卡培他滨中间体中d-核糖及5-脱氧-d-呋喃核糖含量的检测方法

Also Published As

Publication number Publication date
WO2009071726A1 (es) 2009-06-11
EP2241556A1 (en) 2010-10-20

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