ATE19066T1 - 1,3-dihydro 4-(1-hydroxy-2-aminoethyl)2-h-indol-2-on-deriva e, ihre saelze, verfahren zu ihrer herstellung, verwendung als heilmittel und zusammenstellungen die sie enthalten. - Google Patents

1,3-dihydro 4-(1-hydroxy-2-aminoethyl)2-h-indol-2-on-deriva e, ihre saelze, verfahren zu ihrer herstellung, verwendung als heilmittel und zusammenstellungen die sie enthalten.

Info

Publication number
ATE19066T1
ATE19066T1 AT83401104T AT83401104T ATE19066T1 AT E19066 T1 ATE19066 T1 AT E19066T1 AT 83401104 T AT83401104 T AT 83401104T AT 83401104 T AT83401104 T AT 83401104T AT E19066 T1 ATE19066 T1 AT E19066T1
Authority
AT
Austria
Prior art keywords
carbon atoms
radical containing
hydroxy
phenyl
halogen
Prior art date
Application number
AT83401104T
Other languages
English (en)
Inventor
Jacques Guillaume
Lucien Nedelec
Neil Leslie Brown
Guy Plassard
Original Assignee
Roussel Uclaf
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Roussel Uclaf filed Critical Roussel Uclaf
Application granted granted Critical
Publication of ATE19066T1 publication Critical patent/ATE19066T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/08—Indoles; Hydrogenated indoles with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to carbon atoms of the hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/32—Oxygen atoms
    • C07D209/34—Oxygen atoms in position 2

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Cardiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
AT83401104T 1982-06-03 1983-06-01 1,3-dihydro 4-(1-hydroxy-2-aminoethyl)2-h-indol-2-on-deriva e, ihre saelze, verfahren zu ihrer herstellung, verwendung als heilmittel und zusammenstellungen die sie enthalten. ATE19066T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR8209655A FR2528043A1 (fr) 1982-06-03 1982-06-03 Nouveaux derives de la 1,3-dihydro 4-/1-hydroxy-2-amino-ethyl/2h-indol-2-one, leurs sels, procede de preparation, application a titre de medicaments et compositions les renfermant
EP83401104A EP0099766B1 (de) 1982-06-03 1983-06-01 1,3-Dihydro 4-(1-hydroxy-2-aminoethyl)2-H-indol-2-on-Derivate, ihre Sälze, Verfahren zu ihrer Herstellung, Verwendung als Heilmittel und Zusammenstellungen die sie enthalten

Publications (1)

Publication Number Publication Date
ATE19066T1 true ATE19066T1 (de) 1986-04-15

Family

ID=9274590

Family Applications (1)

Application Number Title Priority Date Filing Date
AT83401104T ATE19066T1 (de) 1982-06-03 1983-06-01 1,3-dihydro 4-(1-hydroxy-2-aminoethyl)2-h-indol-2-on-deriva e, ihre saelze, verfahren zu ihrer herstellung, verwendung als heilmittel und zusammenstellungen die sie enthalten.

Country Status (6)

Country Link
EP (1) EP0099766B1 (de)
JP (1) JPS58219161A (de)
AT (1) ATE19066T1 (de)
CA (1) CA1204445A (de)
DE (1) DE3362894D1 (de)
FR (1) FR2528043A1 (de)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2558158B1 (fr) * 1984-01-13 1986-05-16 Roussel Uclaf Derives de l'indole ethenyl phenol, leurs sels, procede de preparation, application a titre de medicaments, compositions les renfermant et intermediaires
US4853408A (en) * 1985-04-23 1989-08-01 Roussel Uclaf 4-phenylpropyl-indoles having antiarythmic activity
FR2580638B1 (fr) * 1985-04-23 1987-06-12 Roussel Uclaf Nouveaux derives du 4-phenylpropyl indole, leurs sels, procede de preparation, application a titre de medicaments et compositions les renfermant
FR2593176B2 (fr) * 1986-01-21 1990-10-12 Roussel Uclaf Nouveaux derives du 4-phenylpropyl indole, leurs sels, procede de preparation, application a titre de medicaments et compositions les renfermant.
FR2583047B1 (fr) * 1985-06-05 1988-01-08 Roussel Uclaf Procede de preparation de derives du 4-phenylpropyl indole, et intermediaires
FR2584070B1 (fr) * 1985-06-27 1987-08-28 Roussel Uclaf Nouveaux derives de l'hydroxy alkoxy 4-phenyl propyl indole, leurs sels, procede et intermediaires de preparation, application a titre de medicaments et compositions les renfermant.
FR2608601B2 (fr) * 1985-07-11 1989-04-14 Roussel Uclaf Nouveaux derives de l'indole carboxamide, leurs sels, procede et intermediaires de preparation, application a titre de medicaments et compositions les renfermant
FR2584713B1 (fr) * 1985-07-11 1988-09-09 Roussel Uclaf Nouveaux derives de l'indole carboxamide, leurs sels, procede et intermediaires de preparation, application a titre de medicaments et compositions les renfermant
DE3788207T2 (de) * 1986-12-19 1994-03-31 Roussel Uclaf Indol-Carboxamid-Derivate und ihre Salze, Verfahren und Zwischenprodukte zur Herstellung, Anwendung als Heilmittel und Zusammenstellungen, die sie enthalten.
FR2640266B2 (fr) * 1988-07-12 1992-07-10 Synthelabo Derives de (hydroxy-1 piperidinyl-2 alkyl) indolones-2, quinoleinones-2, benzo(b)azepinones-2 et benzimidazolones-2, leur preparation et leur application en therapeutique
FR2634206B1 (fr) * 1988-07-12 1992-05-15 Synthelabo Derives de (hydroxy-1 piperidinyl-2 alkyl) indolones-2 et quinoleinones-2, leur preparation et leur application en therapeutique
FR2688504B1 (fr) * 1992-03-13 1995-05-05 Synthelabo Derives de 2-(piperidin-1-yl)ethanol, leur preparation et leur application en therapeutique.
US5776983A (en) * 1993-12-21 1998-07-07 Bristol-Myers Squibb Company Catecholamine surrogates useful as β3 agonists
US5770615A (en) * 1996-04-04 1998-06-23 Bristol-Myers Squibb Company Catecholamine surrogates useful as β3 agonists
FR2792313A1 (fr) * 1999-04-13 2000-10-20 Synthelabo Derives de 2-aminoethyl-indole, leur preparation et leur application en therapeutique
CN114340740A (zh) * 2019-07-01 2022-04-12 库拉森疗法公司 β肾上腺素能激动剂及其使用方法

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR1532210A (fr) * 1963-06-21 1968-07-12 Ici Ltd Composés hétérocycliques et leur procédé de préparation
FR2370472A2 (fr) * 1976-11-10 1978-06-09 Continental Pharma Amino-alcool heterocyclique, son sel et son procede de preparation
JPS5919537B2 (ja) * 1976-08-02 1984-05-07 大塚製薬株式会社 オキシインド−ル誘導体

Also Published As

Publication number Publication date
DE3362894D1 (en) 1986-05-15
FR2528043A1 (fr) 1983-12-09
CA1204445A (fr) 1986-05-13
JPS58219161A (ja) 1983-12-20
JPH0344068B2 (de) 1991-07-04
EP0099766A1 (de) 1984-02-01
EP0099766B1 (de) 1986-04-09
FR2528043B1 (de) 1984-12-28

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