ES467170A1 - Procedimiento para preparar tetrahidro-1,3,5-triazina-2,6- dionas - Google Patents
Procedimiento para preparar tetrahidro-1,3,5-triazina-2,6- dionasInfo
- Publication number
- ES467170A1 ES467170A1 ES467170A ES467170A ES467170A1 ES 467170 A1 ES467170 A1 ES 467170A1 ES 467170 A ES467170 A ES 467170A ES 467170 A ES467170 A ES 467170A ES 467170 A1 ES467170 A1 ES 467170A1
- Authority
- ES
- Spain
- Prior art keywords
- pharmaceutical compositions
- alkanoyl
- analgesic
- dione
- tetrahydro
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D251/00—Heterocyclic compounds containing 1,3,5-triazine rings
- C07D251/02—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings
- C07D251/12—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
- C07D251/26—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with only hetero atoms directly attached to ring carbon atoms
- C07D251/40—Nitrogen atoms
- C07D251/42—One nitrogen atom
- C07D251/46—One nitrogen atom with oxygen or sulfur atoms attached to the two other ring carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Pain & Pain Management (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Rheumatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Procedimiento para preparar tetrahidro-1,3,5-triazina-2,6- dionas, de fórmula: **(Fórmula 01)** donde R1 es un radical alquila C1-6; y R2 es un radical alquilo C1-4 portando un radical alcoxi C1-4, un radical cicloalquilo C3-8 o alquenilo C3-6, o un radical alquilo C5-10 en donde el átomo de carbono de enlace alfa es secundario, un radical bencilo o 1-(fenil)etilo, ó un radical fenilo portando opcionalmente un sustituyente aromático seleccionado entre átomos de halógeno, radicales alquilo C1-4 y alcoxi C1-4; o en donde R1 es un radical n-propilo o etilo, y R2 es un radical n-propilo; o en donde R1 es un radical isopropilo y R2 es un radical 3,3-dimetilbutilo; o una sal farmacéuticamente aceptable de los mismos; pero excluyendo aquellos compuestos de fórmula I en donde R1 es un radical isopropilo o n-propilo y R2 es un radical pent-2-ilo, pent-3-ilo, hex-3-ilo o ciclohexilo; caracterizado porque comprende acetilar un compuesto de fórmula: **(Fórmula 02)** en la que R1 y R2 se definen como anteriormente, por reacción con un agente acetilante elegido entre cloruro de acetilo, bromuro de acetilo y anhídrido acético; tras lo cual cuando se requiere una sal de adición de base farmacéuticamente aceptable, se hace reaccionar el compuesto de fórmula I con una base adecuada.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB7183/77A GB1599518A (en) | 1977-02-21 | 1977-02-21 | 1,3,5-triazine-2,6-diones and pharmaceutical compositions thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES467170A1 true ES467170A1 (es) | 1979-08-16 |
Family
ID=9828208
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES467170A Expired ES467170A1 (es) | 1977-02-21 | 1978-02-21 | Procedimiento para preparar tetrahidro-1,3,5-triazina-2,6- dionas |
| ES476428A Expired ES476428A1 (es) | 1977-02-21 | 1978-12-28 | Procedimiento para preparar tetrahidro-1,3,5-triazina-2,6- dionas. |
| ES476427A Expired ES476427A1 (es) | 1977-02-21 | 1978-12-28 | Procedimiento para preparar tetrahidro-1,3,5-triazina-2,6- dionas. |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES476428A Expired ES476428A1 (es) | 1977-02-21 | 1978-12-28 | Procedimiento para preparar tetrahidro-1,3,5-triazina-2,6- dionas. |
| ES476427A Expired ES476427A1 (es) | 1977-02-21 | 1978-12-28 | Procedimiento para preparar tetrahidro-1,3,5-triazina-2,6- dionas. |
Country Status (32)
| Country | Link |
|---|---|
| US (1) | US4156002A (es) |
| JP (1) | JPS53105487A (es) |
| AR (1) | AR220120A1 (es) |
| AT (1) | AT358592B (es) |
| AU (1) | AU519803B2 (es) |
| BE (1) | BE864124A (es) |
| CA (1) | CA1117867A (es) |
| CH (1) | CH637646A5 (es) |
| CS (2) | CS208463B2 (es) |
| DD (1) | DD134091A5 (es) |
| DE (1) | DE2807381A1 (es) |
| DK (1) | DK67978A (es) |
| ES (3) | ES467170A1 (es) |
| FI (1) | FI64152C (es) |
| FR (1) | FR2381034A1 (es) |
| GB (1) | GB1599518A (es) |
| GR (1) | GR62157B (es) |
| HU (2) | HU182653B (es) |
| IE (1) | IE46650B1 (es) |
| IL (1) | IL54026A (es) |
| IT (1) | IT1158652B (es) |
| LU (1) | LU79092A1 (es) |
| MW (1) | MW478A1 (es) |
| NL (1) | NL7801921A (es) |
| NO (1) | NO780576L (es) |
| NZ (1) | NZ186406A (es) |
| PL (2) | PL109995B1 (es) |
| PT (1) | PT67668B (es) |
| SE (1) | SE440775B (es) |
| SU (2) | SU890976A3 (es) |
| ZA (1) | ZA78671B (es) |
| ZM (1) | ZM1878A1 (es) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0005911B1 (en) * | 1978-05-26 | 1982-02-17 | Imperial Chemical Industries Plc | Analgesic 6-acylaminotetrahydro-1,3,5-triazine-2,4-dione derivatives, pharmaceutical compositions thereof, and process for their manufacture |
| GB8629567D0 (en) * | 1986-12-10 | 1987-01-21 | Boots Co Plc | Therapeutic agents |
| US6348216B1 (en) * | 1996-06-10 | 2002-02-19 | Knoll Pharmaceutical Company | Ibuprofen and narcotic analgesic compositions |
| US6361794B1 (en) | 1996-06-12 | 2002-03-26 | Basf Corporation | Method of making ibuprofen and narcotic analgesic composition |
| CA2752269C (en) * | 2009-02-13 | 2016-08-30 | Hiroyuki Kai | Novel triazine derivative and pharmaceutical composition comprising the same |
| JP6075621B2 (ja) | 2010-08-10 | 2017-02-08 | 塩野義製薬株式会社 | 新規複素環誘導体およびそれらを含有する医薬組成物 |
| WO2012020749A1 (ja) | 2010-08-10 | 2012-02-16 | 塩野義製薬株式会社 | トリアジン誘導体およびそれを含有する鎮痛作用を有する医薬組成物 |
| WO2013118855A1 (ja) | 2012-02-09 | 2013-08-15 | 塩野義製薬株式会社 | 複素環および炭素環誘導体 |
| TWI637949B (zh) | 2013-06-14 | 2018-10-11 | 塩野義製藥股份有限公司 | 胺基三衍生物及含有其等之醫藥組合物 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK117230B (da) * | 1965-07-21 | 1970-03-31 | Takeda Chemical Industries Ltd | Analogifremgangsmåde til fremstilling af 1-phenyl- eller -cyclohexyl-5-(γ-carboxypropyl-, γ-hydroxy-n-butyl-, β-acetylethyl- eller γ-hydroxy-n-butyl)-barbitursyrer eller salte deraf. |
| GB1543037A (en) * | 1975-02-05 | 1979-03-28 | Ici Ltd | Selective herbicidal triazine-diones |
| US4035365A (en) * | 1973-11-01 | 1977-07-12 | Imperial Chemical Industries Limited | Triazinediones |
| JPS5623425B2 (es) * | 1973-11-09 | 1981-05-30 |
-
1977
- 1977-02-21 GB GB7183/77A patent/GB1599518A/en not_active Expired
-
1978
- 1978-02-02 IE IE217/78A patent/IE46650B1/en unknown
- 1978-02-03 ZA ZA00780671A patent/ZA78671B/xx unknown
- 1978-02-07 NZ NZ186406A patent/NZ186406A/en unknown
- 1978-02-07 CA CA000296415A patent/CA1117867A/en not_active Expired
- 1978-02-08 AU AU33112/78A patent/AU519803B2/en not_active Expired
- 1978-02-09 ZM ZM18/78A patent/ZM1878A1/xx unknown
- 1978-02-12 IL IL54026A patent/IL54026A/xx unknown
- 1978-02-13 US US05/877,391 patent/US4156002A/en not_active Expired - Lifetime
- 1978-02-15 PL PL1978211162A patent/PL109995B1/pl unknown
- 1978-02-15 PL PL1978204641A patent/PL107871B1/pl unknown
- 1978-02-15 HU HU78IE836A patent/HU182653B/hu unknown
- 1978-02-15 DK DK67978A patent/DK67978A/da not_active Application Discontinuation
- 1978-02-15 HU HU78IE826A patent/HU176980B/hu unknown
- 1978-02-16 GR GR55469A patent/GR62157B/el unknown
- 1978-02-16 PT PT67668A patent/PT67668B/pt unknown
- 1978-02-17 CS CS781045A patent/CS208463B2/cs unknown
- 1978-02-17 FI FI780529A patent/FI64152C/fi not_active IP Right Cessation
- 1978-02-20 NO NO780576A patent/NO780576L/no unknown
- 1978-02-20 LU LU79092A patent/LU79092A1/xx unknown
- 1978-02-20 BE BE185309A patent/BE864124A/xx not_active IP Right Cessation
- 1978-02-20 SU SU782587045A patent/SU890976A3/ru active
- 1978-02-20 FR FR7804760A patent/FR2381034A1/fr active Granted
- 1978-02-20 SE SE7801930A patent/SE440775B/sv not_active IP Right Cessation
- 1978-02-21 DE DE19782807381 patent/DE2807381A1/de not_active Ceased
- 1978-02-21 NL NL7801921A patent/NL7801921A/xx not_active Application Discontinuation
- 1978-02-21 MW MW4/78A patent/MW478A1/xx unknown
- 1978-02-21 CH CH186378A patent/CH637646A5/de not_active IP Right Cessation
- 1978-02-21 AT AT127178A patent/AT358592B/de not_active IP Right Cessation
- 1978-02-21 JP JP1898978A patent/JPS53105487A/ja active Pending
- 1978-02-21 AR AR271164A patent/AR220120A1/es active
- 1978-02-21 DD DD78203776A patent/DD134091A5/xx unknown
- 1978-02-21 IT IT20500/78A patent/IT1158652B/it active
- 1978-02-21 ES ES467170A patent/ES467170A1/es not_active Expired
- 1978-12-28 ES ES476428A patent/ES476428A1/es not_active Expired
- 1978-12-28 ES ES476427A patent/ES476427A1/es not_active Expired
-
1979
- 1979-02-13 SU SU792723300A patent/SU867303A3/ru active
-
1980
- 1980-05-22 CS CS803610A patent/CS208464B2/cs unknown
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FD1A | Patent lapsed |
Effective date: 20000301 |