AR016175A1 - Compuestos derivados del acido dihidroxihexanoico, su uso para la preparacion de medicamentos y composiciones de los mismos. - Google Patents
Compuestos derivados del acido dihidroxihexanoico, su uso para la preparacion de medicamentos y composiciones de los mismos.Info
- Publication number
- AR016175A1 AR016175A1 ARP990100443A ARP990100443A AR016175A1 AR 016175 A1 AR016175 A1 AR 016175A1 AR P990100443 A ARP990100443 A AR P990100443A AR P990100443 A ARP990100443 A AR P990100443A AR 016175 A1 AR016175 A1 AR 016175A1
- Authority
- AR
- Argentina
- Prior art keywords
- octyl
- amide
- methyl
- carboxylic acid
- dihydroxy
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
- C07D241/36—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings condensed with carbocyclic rings or ring systems
- C07D241/50—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings condensed with carbocyclic rings or ring systems with hetero atoms directly attached to ring nitrogen atoms
- C07D241/52—Oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C231/00—Preparation of carboxylic acid amides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- A61P31/06—Antibacterial agents for tuberculosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- A61P31/08—Antibacterial agents for leprosy
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
- C07D215/54—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
- C07D241/36—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings condensed with carbocyclic rings or ring systems
- C07D241/38—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings condensed with carbocyclic rings or ring systems with only hydrogen or carbon atoms directly attached to the ring nitrogen atoms
- C07D241/40—Benzopyrazines
- C07D241/44—Benzopyrazines with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Virology (AREA)
- Pulmonology (AREA)
- Rheumatology (AREA)
- Pain & Pain Management (AREA)
- Tropical Medicine & Parasitology (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Molecular Biology (AREA)
- AIDS & HIV (AREA)
- Transplantation (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Quinoline Compounds (AREA)
Abstract
Un compuesto de la formula I en la que dicho compuesto es:4(R)-carbamoil-1(S)-(3-cloro-bencil)-2(S),7-dihidroxi-7-metil-octil]-amida del ácido quinoxalina-2-carboxílico; (1S)-bencil-4(R)-carbamoil-2(S), 7--dihidroxi-7-metil octil)-amida del ácido 7,8-difluoro-quinolina-3-carboxílico; (1(S)-bencil-4(R)-carbamoil-2(S), 7-dihidroxi-7-metil-octil)-amida del ácido 6, 7, 8-trifluoro-quinolina-3-carboxílico; [4(R)-carbamoil-1(S)-(3-fluoro-bencil)-2(S), 7-dihidroxi-7 metil-octil]-amida del ácido quinoxalina-2-carboxílico;(1(S)-bencil-2(S), 7-dihidroxi-4(R)-hidroxicarbamoil-7-metil-octil)-amida del ácido quinoxalina-2-carboxílico;[1(S)-(2-fluoro-bencil)-2(S), 7-dihidroxi-4(R)-hidroxicarbamoil-7-metil-octil]-amida del ácido quinoxalina-2-carboxílico;[4(R)-carbamoil-1(S)-(2-fluoro-bencil)-2(S), 7-dihidroxi-7-metil-octil]-amida del ácido quinoxalina-2-carboxílico; [1(S)-(3,4-difluoro-bencil)-2(S), 7-dihidroxi-4(R)-hidroxicarbamoil-7-metil-octil]-amida del ácido quinoxalina-2-carboxílico; [4(R)-carbamoil-1(S)-(3,4-difluoro-bencil)-2(S), 7dihidroxi-7-metil-octil]-amida del ácido quinoxalina-2-carboxílico; o (4(R)-carbamoil-2(S), 7-dihidroxi-7-metil-1(S)-naftalen-1-ilmetil-octil)-amida del ácidoquinoxalina-2-carboxílico. También se describen elusode dicho compuesto para preparar composiciones así como las composiciones obtenidas.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US7380198P | 1998-02-05 | 1998-02-05 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR016175A1 true AR016175A1 (es) | 2001-06-20 |
Family
ID=22115885
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP990100443A AR016175A1 (es) | 1998-02-05 | 1999-02-03 | Compuestos derivados del acido dihidroxihexanoico, su uso para la preparacion de medicamentos y composiciones de los mismos. |
Country Status (37)
| Country | Link |
|---|---|
| EP (1) | EP1051405B1 (es) |
| JP (1) | JP3693916B2 (es) |
| KR (1) | KR100385529B1 (es) |
| CN (1) | CN1177834C (es) |
| AP (1) | AP992A (es) |
| AR (1) | AR016175A1 (es) |
| AT (1) | ATE337307T1 (es) |
| AU (1) | AU752407B2 (es) |
| BG (1) | BG104726A (es) |
| BR (1) | BR9907655A (es) |
| CA (1) | CA2320388C (es) |
| DE (1) | DE69932920T2 (es) |
| DZ (1) | DZ2717A1 (es) |
| EA (1) | EA003137B1 (es) |
| ES (1) | ES2268847T3 (es) |
| GT (1) | GT199900011A (es) |
| HK (1) | HK1034969A1 (es) |
| HR (1) | HRP20000529B1 (es) |
| HU (1) | HUP0100832A3 (es) |
| IL (1) | IL137330A0 (es) |
| IS (1) | IS5562A (es) |
| MA (1) | MA26603A1 (es) |
| MY (1) | MY133125A (es) |
| NO (1) | NO20003965D0 (es) |
| NZ (1) | NZ505724A (es) |
| OA (1) | OA11448A (es) |
| PA (1) | PA8467301A1 (es) |
| PE (1) | PE20000243A1 (es) |
| PL (1) | PL342817A1 (es) |
| SK (1) | SK11262000A3 (es) |
| TN (1) | TNSN99013A1 (es) |
| TR (1) | TR200002248T2 (es) |
| TW (1) | TW470744B (es) |
| UA (1) | UA57824C2 (es) |
| WO (1) | WO1999040061A2 (es) |
| YU (1) | YU47100A (es) |
| ZA (1) | ZA99873B (es) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2862300A (en) * | 1999-01-29 | 2000-08-18 | Millennium Pharmaceuticals, Inc. | Methods for preventing graft rejection and ischemia-reperfusion injury |
| TR200200409T2 (tr) * | 1999-08-20 | 2003-03-21 | Dow Agrosciences Llc | Mantar öldürücü heterosiklik aromatik amitler ve bileşimleri, bunları kullanma ve hazırlama yöntemleri. |
| UA72789C2 (en) | 2000-02-04 | 2005-04-15 | Pfizer Prod Inc | Heterocyclic amide derivatives |
| EP1498417A1 (en) * | 2000-02-04 | 2005-01-19 | Pfizer Products Inc. | Heterocyclic amide derivatives |
| US6740636B2 (en) * | 2000-07-31 | 2004-05-25 | Schering Aktiengesellschaft | Non-peptide CCR1 receptor antagonists in combination with cyclosporin A for the treatment of heart transplant rejection |
| US6746856B2 (en) | 2000-08-09 | 2004-06-08 | Pfizer Inc. | Microbial conversion of bicyclic heteroaromatic compounds |
| EA006777B1 (ru) | 2001-06-22 | 2006-04-28 | Пфайзер Продактс Инк. | Фармацевтические композиции адсорбатов аморфного лекарственного средства |
| EP1269994A3 (en) * | 2001-06-22 | 2003-02-12 | Pfizer Products Inc. | Pharmaceutical compositions comprising drug and concentration-enhancing polymers |
| EP1404300B1 (en) | 2001-06-22 | 2009-09-30 | Pfizer Products Inc. | Pharmaceutical compositions of dispersions of drugs and neutral polymers |
| DE10152351B4 (de) * | 2001-10-18 | 2005-09-22 | Schering Ag | Feste Arzneimittelformulierung für ein Piperazinharnstoffderivat |
| ATE395044T1 (de) | 2002-02-01 | 2008-05-15 | Pfizer Prod Inc | Pharmazeutische zusammensetzungen amorpher dispersionen von wirkstoffen und lipophiler mikrophasenbildender materialien |
| WO2003095439A1 (en) * | 2002-05-14 | 2003-11-20 | Pfizer Products Inc. | Methods for manufacture of dihydro-furan-2-one derivatives |
| RU2004133530A (ru) * | 2002-05-14 | 2005-06-10 | Пфайзер Продактс Инк. (Us) | Производные дигидроксигексановой кислоты, их промежуточные соединения и способы получения |
| OA12894A (en) * | 2002-08-12 | 2006-10-13 | Pfizer Prod Inc | Crystal forms of quinoxaline-2-carboxylic acid [4-carbamoy 1-1-(3-fluorobenzyl)-2,7-dihydroxy-7-met hyl-octyl]-amide. |
| ATE442130T1 (de) | 2002-08-12 | 2009-09-15 | Bend Res Inc | Arzneizubereitungen bestehend aus arzneimitteln in halb-geordneter form und polymeren |
| US20040097554A1 (en) * | 2002-10-30 | 2004-05-20 | Pfizer Inc | Heteroaryl-hexanoic acid amide derivatives as immonomodulatory agents |
| US20040087571A1 (en) * | 2002-10-30 | 2004-05-06 | Pfizer Inc | Methods of using CCR1 antagonists as immunomodulatory agents |
| JP2007501218A (ja) | 2003-08-04 | 2007-01-25 | ファイザー・プロダクツ・インク | 非晶質薬物の吸着物および親油性ミクロ相形成物質の医薬組成物 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4923864A (en) * | 1987-12-15 | 1990-05-08 | Pfizer Inc. | Certain heterocyclic-hexanamides useful for treating hypertension |
| ATE220661T1 (de) * | 1994-10-19 | 2002-08-15 | Novartis Erfind Verwalt Gmbh | Antivirale ether von aspartat-protease-substrat- isosteren |
| DE19708106A1 (de) * | 1997-02-28 | 1998-09-03 | Bosch Gmbh Robert | Einrichtung und Verfahren zur Information über Verkehrsstörungen |
-
1999
- 1999-01-18 IL IL13733099A patent/IL137330A0/xx unknown
- 1999-01-18 UA UA2000074534A patent/UA57824C2/uk unknown
- 1999-01-18 DE DE69932920T patent/DE69932920T2/de not_active Expired - Lifetime
- 1999-01-18 AT AT99900098T patent/ATE337307T1/de not_active IP Right Cessation
- 1999-01-18 TR TR2000/02248T patent/TR200002248T2/xx unknown
- 1999-01-18 ES ES99900098T patent/ES2268847T3/es not_active Expired - Lifetime
- 1999-01-18 EA EA200000741A patent/EA003137B1/ru not_active IP Right Cessation
- 1999-01-18 PL PL99342817A patent/PL342817A1/xx not_active Application Discontinuation
- 1999-01-18 NZ NZ505724A patent/NZ505724A/xx unknown
- 1999-01-18 JP JP2000530493A patent/JP3693916B2/ja not_active Expired - Lifetime
- 1999-01-18 SK SK1126-2000A patent/SK11262000A3/sk unknown
- 1999-01-18 KR KR10-2000-7008561A patent/KR100385529B1/ko not_active IP Right Cessation
- 1999-01-18 CN CNB998027138A patent/CN1177834C/zh not_active Expired - Fee Related
- 1999-01-18 YU YU47100A patent/YU47100A/sh unknown
- 1999-01-18 CA CA002320388A patent/CA2320388C/en not_active Expired - Fee Related
- 1999-01-18 WO PCT/IB1999/000067 patent/WO1999040061A2/en active IP Right Grant
- 1999-01-18 PA PA19998467301A patent/PA8467301A1/es unknown
- 1999-01-18 HU HU0100832A patent/HUP0100832A3/hu unknown
- 1999-01-18 EP EP99900098A patent/EP1051405B1/en not_active Expired - Lifetime
- 1999-01-18 AU AU17789/99A patent/AU752407B2/en not_active Ceased
- 1999-01-18 BR BR9907655-1A patent/BR9907655A/pt not_active Application Discontinuation
- 1999-01-27 GT GT199900011A patent/GT199900011A/es unknown
- 1999-02-01 PE PE1999000071A patent/PE20000243A1/es not_active Application Discontinuation
- 1999-02-01 TW TW088101505A patent/TW470744B/zh not_active IP Right Cessation
- 1999-02-03 MY MYPI99000363A patent/MY133125A/en unknown
- 1999-02-03 DZ DZ990018A patent/DZ2717A1/xx active
- 1999-02-03 MA MA25448A patent/MA26603A1/fr unknown
- 1999-02-03 AR ARP990100443A patent/AR016175A1/es unknown
- 1999-02-03 TN TNTNSN99013A patent/TNSN99013A1/fr unknown
- 1999-02-04 AP APAP/P/1999/001457A patent/AP992A/en active
- 1999-02-04 ZA ZA9900873A patent/ZA99873B/xx unknown
-
2000
- 2000-07-14 IS IS5562A patent/IS5562A/is unknown
- 2000-07-28 OA OA1200000214A patent/OA11448A/en unknown
- 2000-08-04 HR HR20000529 patent/HRP20000529B1/xx not_active IP Right Cessation
- 2000-08-04 NO NO20003965A patent/NO20003965D0/no not_active Application Discontinuation
- 2000-08-29 BG BG104726A patent/BG104726A/xx unknown
-
2001
- 2001-08-15 HK HK01105717A patent/HK1034969A1/xx not_active IP Right Cessation
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