TR200001546T2 - Serin/treonin protein kinaz fonksiyonunu modüle etmek için azabenzimidazol esaslı bileşikler. - Google Patents
Serin/treonin protein kinaz fonksiyonunu modüle etmek için azabenzimidazol esaslı bileşikler.Info
- Publication number
- TR200001546T2 TR200001546T2 TR2000/01546T TR200001546T TR200001546T2 TR 200001546 T2 TR200001546 T2 TR 200001546T2 TR 2000/01546 T TR2000/01546 T TR 2000/01546T TR 200001546 T TR200001546 T TR 200001546T TR 200001546 T2 TR200001546 T2 TR 200001546T2
- Authority
- TR
- Turkey
- Prior art keywords
- threonine protein
- protein kinase
- serine
- azabenzimidazole
- based compounds
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/415—1,2-Diazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Epidemiology (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Abstract
Bu bulus kismen , serin/treonin protein kinazlarin islevini, azabenzimidazol esasli bilesikler ile modüle etmeye mahsus yöntemlere yöneltilmistir. Bu yöntemler, RAF gibi bir serin/treonin protein kinazin ekspresyonunu yapan hücreleri içine alir. Bu bulus ayrica organizmalardaki, serin/ treonin protein kinaz ile baglantili anormal durumlari, bu bulus tarafindan teshis edilmis bir bilesik ile önlemek ve tedavi etmek için yöntemler de tarif eder. Bu bulus bunlardan baska, ezabenzimidazol bilesikleri ve bu bilesikleri ihtiva eden farmasötik terkiplerle de ilgilidir.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US6014597P | 1997-09-26 | 1997-09-26 |
Publications (1)
Publication Number | Publication Date |
---|---|
TR200001546T2 true TR200001546T2 (tr) | 2000-10-23 |
Family
ID=22027657
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
TR2000/01546T TR200001546T2 (tr) | 1997-09-26 | 1998-09-23 | Serin/treonin protein kinaz fonksiyonunu modüle etmek için azabenzimidazol esaslı bileşikler. |
Country Status (28)
Country | Link |
---|---|
US (2) | US6093728A (tr) |
EP (1) | EP1017384B1 (tr) |
JP (1) | JP2001517699A (tr) |
KR (1) | KR100547929B1 (tr) |
CN (1) | CN1167420C (tr) |
AR (1) | AR017266A1 (tr) |
AT (1) | ATE281834T1 (tr) |
AU (1) | AU748849B2 (tr) |
BG (1) | BG64784B1 (tr) |
BR (1) | BR9812682A (tr) |
CA (1) | CA2305370C (tr) |
DE (1) | DE69827516T2 (tr) |
DK (1) | DK1017384T3 (tr) |
ES (1) | ES2230719T3 (tr) |
HK (1) | HK1032206A1 (tr) |
HU (1) | HUP0004024A3 (tr) |
IL (4) | IL135109A0 (tr) |
NO (1) | NO325663B1 (tr) |
NZ (2) | NZ503432A (tr) |
PL (1) | PL191618B1 (tr) |
PT (1) | PT1017384E (tr) |
RU (1) | RU2230553C2 (tr) |
SK (1) | SK285357B6 (tr) |
TR (1) | TR200001546T2 (tr) |
TW (1) | TW581815B (tr) |
UA (1) | UA72448C2 (tr) |
WO (1) | WO1999016438A1 (tr) |
ZA (1) | ZA988797B (tr) |
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US6384049B1 (en) * | 2000-05-25 | 2002-05-07 | The Procter & Gamble Company | Cancer treatment |
BR0208010A (pt) * | 2001-03-12 | 2004-12-21 | Avanir Pharmaceuticals | Composto de benzimidazol para modulação de ige e inibição de proliferação celular |
TW200304820A (en) * | 2002-03-25 | 2003-10-16 | Avanir Pharmaceuticals | Use of benzimidazole analogs in the treatment of cell proliferation |
AU2003270426A1 (en) | 2002-09-12 | 2004-04-30 | Avanir Pharmaceuticals | PHENYL-INDOLE COMPOUNDS FOR MODULATING IgE AND INHIBITING CELLULAR PROLIFERATION |
TWI276631B (en) * | 2002-09-12 | 2007-03-21 | Avanir Pharmaceuticals | Phenyl-aza-benzimidazole compounds for modulating IgE and inhibiting cellular proliferation |
WO2005013950A2 (en) * | 2003-08-08 | 2005-02-17 | Avanir Pharmaceuticals | Selective pharmacologic inhibition of protein trafficking and related methods of treating human diseases |
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WO2007062222A2 (en) * | 2005-11-22 | 2007-05-31 | University Of South Florida | Inhibition of cell proliferation |
US7951819B2 (en) | 2006-04-26 | 2011-05-31 | Cancer Research Technology Limited | Imidazo[4, 5-B]pyridin-2-one and oxazolo[4, 5-B] pyridin-2-one compounds and analogs thereof as cancer therapeutic compounds |
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BRPI0821227A2 (pt) | 2007-12-19 | 2015-06-16 | Cancer Rec Tech Ltd | Composto, composição farmacêutica, método para preparar a mesma, uso de um composto, método para tratar uma doença ou distúrbio, para inibir função de raf e para inibir proliferação celular, inibir progressão do ciclo celular, promover apoptose, ou uma combinação de um ou mais dos mesmos |
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US20100184851A1 (en) * | 2008-08-29 | 2010-07-22 | University Of South Florida | Inhibition of cell proliferation |
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JO3101B1 (ar) | 2008-12-02 | 2017-09-20 | Takeda Pharmaceuticals Co | مشتقات بنزوثيازول كعوامل مضادة للسرطان |
JP2012197231A (ja) * | 2009-08-06 | 2012-10-18 | Oncotherapy Science Ltd | Ttk阻害作用を有するピリジンおよびピリミジン誘導体 |
EP3091021B1 (en) | 2009-10-26 | 2019-08-28 | Signal Pharmaceuticals, LLC | Methods of synthesis and purification of heteroaryl compounds |
DK2531502T3 (da) | 2010-02-01 | 2014-05-19 | Cancer Rec Tech Ltd | 1-(5-tert-butyl-2-phenyl-2h-pyrazol-3-yl)-3-[2-fluoro-4-(1-methyl-2-oxo-2,3-dihydro-1h-imidazo[4,5-b]pyridin-7-yloxy)-phenyl]-urea og associerede forbindelser og ders anvendelse i terapi |
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-
1998
- 1998-09-23 PT PT98949464T patent/PT1017384E/pt unknown
- 1998-09-23 US US09/160,212 patent/US6093728A/en not_active Expired - Fee Related
- 1998-09-23 DE DE69827516T patent/DE69827516T2/de not_active Expired - Fee Related
- 1998-09-23 UA UA2000042349A patent/UA72448C2/uk unknown
- 1998-09-23 AT AT98949464T patent/ATE281834T1/de not_active IP Right Cessation
- 1998-09-23 DK DK98949464T patent/DK1017384T3/da active
- 1998-09-23 HU HU0004024A patent/HUP0004024A3/hu unknown
- 1998-09-23 EP EP98949464A patent/EP1017384B1/en not_active Expired - Lifetime
- 1998-09-23 NZ NZ503432A patent/NZ503432A/xx unknown
- 1998-09-23 ES ES98949464T patent/ES2230719T3/es not_active Expired - Lifetime
- 1998-09-23 CN CNB988107538A patent/CN1167420C/zh not_active Expired - Fee Related
- 1998-09-23 CA CA002305370A patent/CA2305370C/en not_active Expired - Fee Related
- 1998-09-23 TR TR2000/01546T patent/TR200001546T2/tr unknown
- 1998-09-23 KR KR1020007003192A patent/KR100547929B1/ko not_active IP Right Cessation
- 1998-09-23 WO PCT/US1998/019973 patent/WO1999016438A1/en active IP Right Grant
- 1998-09-23 RU RU2000110736/15A patent/RU2230553C2/ru not_active IP Right Cessation
- 1998-09-23 PL PL339744A patent/PL191618B1/pl not_active IP Right Cessation
- 1998-09-23 IL IL13510998A patent/IL135109A0/xx not_active IP Right Cessation
- 1998-09-23 IL IL15864998A patent/IL158649A0/xx not_active IP Right Cessation
- 1998-09-23 AU AU95781/98A patent/AU748849B2/en not_active Ceased
- 1998-09-23 JP JP2000513574A patent/JP2001517699A/ja not_active Withdrawn
- 1998-09-23 SK SK415-2000A patent/SK285357B6/sk unknown
- 1998-09-23 BR BR9812682-2A patent/BR9812682A/pt not_active Application Discontinuation
- 1998-09-25 ZA ZA9808797A patent/ZA988797B/xx unknown
- 1998-09-25 AR ARP980104793A patent/AR017266A1/es unknown
- 1998-09-25 TW TW087115979A patent/TW581815B/zh not_active IP Right Cessation
-
2000
- 2000-03-15 IL IL135109A patent/IL135109A/en unknown
- 2000-03-24 NO NO20001555A patent/NO325663B1/no unknown
- 2000-04-19 BG BG104356A patent/BG64784B1/bg unknown
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2001
- 2001-04-23 HK HK01102854A patent/HK1032206A1/xx not_active IP Right Cessation
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2002
- 2002-03-15 NZ NZ517808A patent/NZ517808A/en unknown
- 2002-11-15 US US10/294,802 patent/US6855723B2/en not_active Expired - Fee Related
-
2003
- 2003-10-29 IL IL158649A patent/IL158649A/en unknown
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