BR0016547A - Composição para a modulação e inibição da permeabilidade vascular (vp) - Google Patents
Composição para a modulação e inibição da permeabilidade vascular (vp)Info
- Publication number
- BR0016547A BR0016547A BR0016547-6A BR0016547A BR0016547A BR 0016547 A BR0016547 A BR 0016547A BR 0016547 A BR0016547 A BR 0016547A BR 0016547 A BR0016547 A BR 0016547A
- Authority
- BR
- Brazil
- Prior art keywords
- protein
- src
- yes
- modified
- vascular permeability
- Prior art date
Links
- 239000000203 mixture Substances 0.000 title abstract 5
- 230000018103 negative regulation of vascular permeability Effects 0.000 title 1
- 230000008728 vascular permeability Effects 0.000 abstract 5
- 102000004169 proteins and genes Human genes 0.000 abstract 4
- 108090000623 proteins and genes Proteins 0.000 abstract 4
- 102000039446 nucleic acids Human genes 0.000 abstract 3
- 108020004707 nucleic acids Proteins 0.000 abstract 3
- 150000007523 nucleic acids Chemical class 0.000 abstract 3
- 238000000034 method Methods 0.000 abstract 2
- 239000005483 tyrosine kinase inhibitor Substances 0.000 abstract 2
- JRZJKWGQFNTSRN-UHFFFAOYSA-N Geldanamycin Natural products C1C(C)CC(OC)C(O)C(C)C=C(C)C(OC(N)=O)C(OC)CCC=C(C)C(=O)NC2=CC(=O)C(OC)=C1C2=O JRZJKWGQFNTSRN-UHFFFAOYSA-N 0.000 abstract 1
- 239000013000 chemical inhibitor Substances 0.000 abstract 1
- QTQAWLPCGQOSGP-GBTDJJJQSA-N geldanamycin Chemical compound N1C(=O)\C(C)=C/C=C\[C@@H](OC)[C@H](OC(N)=O)\C(C)=C/[C@@H](C)[C@@H](O)[C@H](OC)C[C@@H](C)CC2=C(OC)C(=O)C=C1C2=O QTQAWLPCGQOSGP-GBTDJJJQSA-N 0.000 abstract 1
- 230000002401 inhibitory effect Effects 0.000 abstract 1
- 230000005764 inhibitory process Effects 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- WYZWZEOGROVVHK-GTMNPGAYSA-N radicicol Chemical compound C/1=C/C=C/C(=O)CC2=C(Cl)C(O)=CC(O)=C2C(=O)O[C@H](C)C[C@H]2O[C@@H]2\1 WYZWZEOGROVVHK-GTMNPGAYSA-N 0.000 abstract 1
- 108010087686 src-Family Kinases Proteins 0.000 abstract 1
- 102000009076 src-Family Kinases Human genes 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
- A61K38/45—Transferases (2)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
- A01K67/027—New or modified breeds of vertebrates
- A01K67/0271—Chimeric vertebrates, e.g. comprising exogenous cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Immunology (AREA)
- Heart & Thoracic Surgery (AREA)
- Rheumatology (AREA)
- Epidemiology (AREA)
- Cardiology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Gastroenterology & Hepatology (AREA)
- Environmental Sciences (AREA)
- Ophthalmology & Optometry (AREA)
- Urology & Nephrology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Dermatology (AREA)
- Cell Biology (AREA)
- Zoology (AREA)
- Animal Husbandry (AREA)
- Biodiversity & Conservation Biology (AREA)
- Pain & Pain Management (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Vascular Medicine (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Abstract
"COMPOSIçãO PARA A MODULAçãO E INIBIçãO PERMEABILIDADE VASCULAR (VP)". A presente invenção descreve métodos para a modulação da permeabilidade vascular (VP) em tecidos usando proteína Src ou Src modificada, proteína Yes ou Yes modificada, inibidores da proteína tirosina quinase da família Src, e ácidos nucléicos capazes de expressão de proteína Src ou Src modificada, proteína Yes ou Yes modificada, inibidores da proteína tirosina quinase da família Src, ou misturas destas. A invenção também descreve métodos para a inibição da VP usando uma proteína Src ou Yes inativa ou uma mistura destas, ou proteína CSK ou proteína CSK modificada, ou ácidos nucléicos que as codifiquem, ou pelo uso de inibidores químicos da tirosina quinase da família Src tais como PP1, PP2, PD173955, AGL1872, PD162531, Radicicol R2146, e Geldanamicina, ou para a potencialização da VP usando uma proteína Src ou Yes ativa, ou uma mistura destas, ou ácidos nucléicos que as codifiquem. Com posições e artigos de manufatura relacionados também são revelados.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US09/470,881 US6685938B1 (en) | 1998-05-29 | 1999-12-22 | Methods and compositions useful for modulation of angiogenesis and vascular permeability using SRC or Yes tyrosine kinases |
US53824800A | 2000-03-29 | 2000-03-29 | |
PCT/US2000/035396 WO2001045751A1 (en) | 1999-12-22 | 2000-12-22 | Angiogenesis and vascular permeability modulators and inhibitors |
Publications (1)
Publication Number | Publication Date |
---|---|
BR0016547A true BR0016547A (pt) | 2002-10-29 |
Family
ID=27043259
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR0016547-6A BR0016547A (pt) | 1999-12-22 | 2000-12-22 | Composição para a modulação e inibição da permeabilidade vascular (vp) |
Country Status (19)
Country | Link |
---|---|
EP (2) | EP1905457B1 (pt) |
JP (1) | JP2003518077A (pt) |
KR (1) | KR100813818B1 (pt) |
CN (1) | CN1434727A (pt) |
AT (2) | ATE392215T1 (pt) |
AU (1) | AU781444B2 (pt) |
BR (1) | BR0016547A (pt) |
CA (1) | CA2395136A1 (pt) |
CZ (1) | CZ304320B6 (pt) |
DE (1) | DE60038631T2 (pt) |
DK (2) | DK1905457T3 (pt) |
ES (2) | ES2303514T3 (pt) |
HU (1) | HU229628B1 (pt) |
NO (1) | NO20023036L (pt) |
PL (1) | PL356815A1 (pt) |
PT (2) | PT1250155E (pt) |
RU (1) | RU2271216C2 (pt) |
SK (1) | SK287575B6 (pt) |
WO (1) | WO2001045751A1 (pt) |
Families Citing this family (18)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20030130209A1 (en) * | 1999-12-22 | 2003-07-10 | Cheresh David A. | Method of treatment of myocardial infarction |
DE60120427D1 (de) | 2000-08-25 | 2006-07-20 | Sloan Kettering Inst Cancer | Radicicol und monocillin und ihre analogen und ihre anwendungen |
US20030207856A1 (en) * | 2002-03-18 | 2003-11-06 | Patrice Tremble | Medical devices and compositions for delivering anti-proliferatives to anatomical sites at risk for restenosis |
WO2004006947A1 (en) * | 2002-07-12 | 2004-01-22 | Yihai Cao | A method for inhibiting vascular permeability and tissue edema |
EP1413887A1 (en) * | 2002-10-22 | 2004-04-28 | Aventis Pharma S.A. | Inhibitors of Src kinase for use in Alzheimer's disease |
WO2004056386A2 (en) * | 2002-12-19 | 2004-07-08 | To-Bbb Holding B.V. | Nucleic acids involved in blood-brain barrier control |
GB0307333D0 (en) * | 2003-03-29 | 2003-05-07 | Astrazeneca Ab | Therapeutic agent |
CA2554201C (en) | 2004-01-21 | 2015-04-14 | Emory University | Compositions and use of tyrosine kinase inhibitors to treat pathogenic infection |
US20060094682A1 (en) | 2004-10-29 | 2006-05-04 | Odyssey Thera, Inc. | Kinase inhibitors for the treatment of diabetes and obesity |
EP1965762A1 (en) * | 2005-12-23 | 2008-09-10 | Alcon, Inc. | Pharmaceutical formulation for delivery of receptor tyrosine kinase inhibiting (rtki) compounds to the eye |
BRPI0711901A2 (pt) * | 2006-05-22 | 2012-03-06 | The Regents Of The University Of California | Composições e métodos para a liberação de oxigênio |
ES2318616T3 (es) * | 2006-06-01 | 2009-05-01 | Cellzome Ag | Metodos para la identificacion de moleculas que interactuan con zap-70 y para la purificacion de zap-70. |
DE102007037008B4 (de) * | 2007-08-06 | 2015-09-10 | Siemens Aktiengesellschaft | Diagnosesubstanz zur Anwendung in einem Verfahren zur Bestimmung der Aggressivität eines Prostatatumors |
WO2011053048A2 (ko) * | 2009-10-29 | 2011-05-05 | 연세대학교 산학협력단 | 신규 혈관누출 차단제 |
US8557513B2 (en) * | 2011-06-27 | 2013-10-15 | Biocrine Ab | Methods for treating and/or limiting development of diabetes |
WO2014152122A2 (en) * | 2013-03-15 | 2014-09-25 | Children's Medical Center Corporation | Methods of altering vascular permeability and uses thereof |
CN105288654B (zh) * | 2015-01-23 | 2018-11-30 | 中国人民解放军第二军医大学 | 蛋白酪氨酸激酶fyn癌基因在防治肠道病毒71型感染中的应用 |
CN105311645B (zh) * | 2015-01-23 | 2018-11-30 | 中国人民解放军第二军医大学 | 胚胎fyn相关底物efs在防治肠道病毒71型感染中的应用 |
Family Cites Families (18)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4356167A (en) | 1978-01-27 | 1982-10-26 | Sandoz, Inc. | Liposome drug delivery systems |
US5092885A (en) | 1987-02-12 | 1992-03-03 | The Government Of The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Peptides with laminin activity |
US5112946A (en) | 1989-07-06 | 1992-05-12 | Repligen Corporation | Modified pf4 compositions and methods of use |
US5542935A (en) | 1989-12-22 | 1996-08-06 | Imarx Pharmaceutical Corp. | Therapeutic delivery systems related applications |
US5580575A (en) | 1989-12-22 | 1996-12-03 | Imarx Pharmaceutical Corp. | Therapeutic drug delivery systems |
US5192744A (en) | 1990-01-12 | 1993-03-09 | Northwestern University | Method of inhibiting angiogenesis of tumors |
DE69108716T2 (de) * | 1990-01-26 | 1995-08-17 | Washington Research Foundation, Seattle, Wash. | Immunreaktivität gegenüber exprimierten aktivierten oncogenen zur diagnose und behandlung von bösartigen geschwülsten. |
EP0470569B1 (en) | 1990-08-08 | 1995-11-22 | Takeda Chemical Industries, Ltd. | Intravascular embolizing agent containing angiogenesis inhibiting substance |
US5753230A (en) | 1994-03-18 | 1998-05-19 | The Scripps Research Institute | Methods and compositions useful for inhibition of angiogenesis |
US5643599A (en) | 1995-06-07 | 1997-07-01 | President And Fellows Of Harvard College | Intracellular delivery of macromolecules |
US5922697A (en) * | 1996-10-02 | 1999-07-13 | Warner-Lambert Company | Compounds, compositions and methods for inhibiting the binding of proteins containing an SH2 domain to cognate phosphorylated proteins |
US6093740A (en) * | 1997-04-30 | 2000-07-25 | Eli Lilly And Company | Therapeutic treatment for skin disorders |
WO1998050356A1 (en) * | 1997-05-07 | 1998-11-12 | Sugen, Inc. | 2-indolinone derivatives as modulators of protein kinase activity |
US6723694B1 (en) * | 1997-05-21 | 2004-04-20 | The Children's Medical Center Corp. | Short peptides which selectively modulate intracellular signalling |
US6420338B1 (en) * | 1997-06-13 | 2002-07-16 | New York University Medical Center | Inhibition of the Src kinase family pathway as a method of treating HBV infection and hepatocellular carcinoma |
WO1999017770A1 (en) * | 1997-10-06 | 1999-04-15 | Basf Aktiengesellschaft | Indeno[1,2-c]pyrazole derivatives for inhibiting tyrosine kinase activity |
DE69943374D1 (de) * | 1998-05-29 | 2011-06-01 | Us Government | Verfahren zur modulation der angiogenese mittels der tyrosin kinase src |
AU1908000A (en) * | 1998-11-06 | 2000-05-29 | Basf Aktiengesellschaft | Inhibition of the formation of vascular hyperpermeability |
-
2000
- 2000-12-22 SK SK849-2002A patent/SK287575B6/sk not_active IP Right Cessation
- 2000-12-22 AU AU27400/01A patent/AU781444B2/en not_active Ceased
- 2000-12-22 JP JP2001546690A patent/JP2003518077A/ja active Pending
- 2000-12-22 WO PCT/US2000/035396 patent/WO2001045751A1/en active Application Filing
- 2000-12-22 ES ES00990365T patent/ES2303514T3/es not_active Expired - Lifetime
- 2000-12-22 CZ CZ2002-2156A patent/CZ304320B6/cs not_active IP Right Cessation
- 2000-12-22 HU HU0203957A patent/HU229628B1/hu not_active IP Right Cessation
- 2000-12-22 AT AT00990365T patent/ATE392215T1/de active
- 2000-12-22 DE DE60038631T patent/DE60038631T2/de not_active Expired - Lifetime
- 2000-12-22 EP EP07020078A patent/EP1905457B1/en not_active Expired - Lifetime
- 2000-12-22 CN CN00819151A patent/CN1434727A/zh active Pending
- 2000-12-22 AT AT07020078T patent/ATE553782T1/de active
- 2000-12-22 KR KR1020027008102A patent/KR100813818B1/ko not_active IP Right Cessation
- 2000-12-22 ES ES07020078T patent/ES2383763T3/es not_active Expired - Lifetime
- 2000-12-22 BR BR0016547-6A patent/BR0016547A/pt not_active Application Discontinuation
- 2000-12-22 PT PT00990365T patent/PT1250155E/pt unknown
- 2000-12-22 PT PT07020078T patent/PT1905457E/pt unknown
- 2000-12-22 EP EP00990365A patent/EP1250155B1/en not_active Expired - Lifetime
- 2000-12-22 CA CA002395136A patent/CA2395136A1/en not_active Abandoned
- 2000-12-22 PL PL00356815A patent/PL356815A1/xx not_active Application Discontinuation
- 2000-12-22 RU RU2002119399/15A patent/RU2271216C2/ru not_active IP Right Cessation
- 2000-12-22 DK DK07020078.7T patent/DK1905457T3/da active
- 2000-12-22 DK DK00990365T patent/DK1250155T3/da active
-
2002
- 2002-06-21 NO NO20023036A patent/NO20023036L/no not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
EP1250155B1 (en) | 2008-04-16 |
HUP0203957A3 (en) | 2005-07-28 |
DK1250155T3 (da) | 2008-08-25 |
KR100813818B1 (ko) | 2008-03-17 |
AU2740001A (en) | 2001-07-03 |
CZ304320B6 (cs) | 2014-03-05 |
CA2395136A1 (en) | 2001-06-28 |
NO20023036L (no) | 2002-07-22 |
ATE553782T1 (de) | 2012-05-15 |
CN1434727A (zh) | 2003-08-06 |
DE60038631T2 (de) | 2009-06-10 |
EP1250155A4 (en) | 2003-08-20 |
HU229628B1 (en) | 2014-03-28 |
HUP0203957A2 (hu) | 2003-03-28 |
PL356815A1 (en) | 2004-07-12 |
JP2003518077A (ja) | 2003-06-03 |
ATE392215T1 (de) | 2008-05-15 |
ES2383763T3 (es) | 2012-06-26 |
RU2271216C2 (ru) | 2006-03-10 |
SK287575B6 (sk) | 2011-03-04 |
PT1905457E (pt) | 2012-05-25 |
EP1905457B1 (en) | 2012-04-18 |
ES2303514T3 (es) | 2008-08-16 |
EP1250155A1 (en) | 2002-10-23 |
DK1905457T3 (da) | 2012-05-29 |
WO2001045751A1 (en) | 2001-06-28 |
RU2002119399A (ru) | 2004-02-27 |
EP1905457A1 (en) | 2008-04-02 |
DE60038631D1 (de) | 2008-05-29 |
SK8492002A3 (en) | 2002-11-06 |
KR20020063259A (ko) | 2002-08-01 |
NO20023036D0 (no) | 2002-06-21 |
PT1250155E (pt) | 2008-06-06 |
AU781444B2 (en) | 2005-05-26 |
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Legal Events
Date | Code | Title | Description |
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B06F | Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette] | ||
B07A | Application suspended after technical examination (opinion) [chapter 7.1 patent gazette] | ||
B09B | Patent application refused [chapter 9.2 patent gazette] |
Free format text: INDEFIRO O PEDIDO DE ACORDO COM O(S) ARTIGO(S) 8O, 11, 13 E 24 DA LPI. |
|
B09B | Patent application refused [chapter 9.2 patent gazette] |
Free format text: MANTIDO O INDEFERIMENTO UMA VEZ QUE NAO FOI APRESENTADO RECURSO DENTRO DO PRAZO LEGAL. |