ES2230719T3 - Compuestos basados en azabencimidazol para modular una funcion de proteina-quinasa de serina/treonina. - Google Patents

Compuestos basados en azabencimidazol para modular una funcion de proteina-quinasa de serina/treonina.

Info

Publication number
ES2230719T3
ES2230719T3 ES98949464T ES98949464T ES2230719T3 ES 2230719 T3 ES2230719 T3 ES 2230719T3 ES 98949464 T ES98949464 T ES 98949464T ES 98949464 T ES98949464 T ES 98949464T ES 2230719 T3 ES2230719 T3 ES 2230719T3
Authority
ES
Spain
Prior art keywords
group
alkyl
formula
independently selected
hydrogen
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES98949464T
Other languages
English (en)
Inventor
Gerald Mcmahon
Heinz Weinberger
Bernhard Kutscher
Harald App
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Aeterna Zentaris GmbH
Original Assignee
Zentaris AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Zentaris AG filed Critical Zentaris AG
Application granted granted Critical
Publication of ES2230719T3 publication Critical patent/ES2230719T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

Un compuesto de azabencimidazol que tiene una estructura expuesta en la fórmula I, II o III: **(Fórmulas)** en las que (a) R1, R2, R3 y R4 se seleccionan independientemente entre el grupo constituido por: (i) hidrógeno; (ii) alquilo saturado o insaturado; (iii) NX2X3, en donde X2 y X3 se seleccionan independientemente entre el grupo constituido por hidrógeno, alquilo saturado o insaturado y restos de anillos homocíclicos o heterocíclicos; (iv) halógeno o trihalometilo; (v) una cetona de fórmula -CO-X4, en la que X4 se selecciona entre el grupo constituido por hidrógeno, alquilo y restos de anillos homocíclicos o heterocíclicos; (vii) un alcohol de fórmula (X8)n-OH o un resto alcoxi de fórmula -(X8)n-O-X9, en las que X8 y X9 se seleccionan independientemente entre el grupo constituido por hidrógeno, alquilo saturado o insaturado y restos de anillos homocíclicos o heterocíclicos, en las que dicho anillo está opcionalmente sustituido con uno o más sustituyentes seleccionados independientementeentre el grupo constituido por alquilo, alcoxi, halógeno, trihalometilo, carboxilato, nitro y éster, y en las que n es 0 ó 1; (ix) -SO2NX11X12, en donde X11 y X12 se seleccionan entre el grupo constituido por hidrógeno, alquilo y restos de anillos homocíclicos o heterocíclicos; (vi) un ácido carboxílico de fórmula -(X5)n-COOH o un éster de fórmula -(X6)n-COO-X7, en las que X5, X6 y X7 se seleccionan independientemente entre el grupo constituido por alquilo y restos de anillos homocíclicos o heterocíclicos, y en las que n es 0 ó 1; (viii) una amida de fórmula -NHCOX10, en la que X10 se selecciona entre el grupo constituido por alquilo, hidroxilo y restos de anillos homocíclicos o heterocíclicos, en los que dicho anillo está opcionalmente sustituido con uno o más sustituyentes seleccionados independientemente entre el grupo constituido por alquilo, alcoxi, halógeno, trihalometilo, carboxilato, nitro y éster.
ES98949464T 1997-09-26 1998-09-23 Compuestos basados en azabencimidazol para modular una funcion de proteina-quinasa de serina/treonina. Expired - Lifetime ES2230719T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US6014597P 1997-09-26 1997-09-26

Publications (1)

Publication Number Publication Date
ES2230719T3 true ES2230719T3 (es) 2005-05-01

Family

ID=22027657

Family Applications (1)

Application Number Title Priority Date Filing Date
ES98949464T Expired - Lifetime ES2230719T3 (es) 1997-09-26 1998-09-23 Compuestos basados en azabencimidazol para modular una funcion de proteina-quinasa de serina/treonina.

Country Status (28)

Country Link
US (2) US6093728A (es)
EP (1) EP1017384B1 (es)
JP (1) JP2001517699A (es)
KR (1) KR100547929B1 (es)
CN (1) CN1167420C (es)
AR (1) AR017266A1 (es)
AT (1) ATE281834T1 (es)
AU (1) AU748849B2 (es)
BG (1) BG64784B1 (es)
BR (1) BR9812682A (es)
CA (1) CA2305370C (es)
DE (1) DE69827516T2 (es)
DK (1) DK1017384T3 (es)
ES (1) ES2230719T3 (es)
HK (1) HK1032206A1 (es)
HU (1) HUP0004024A3 (es)
IL (4) IL135109A0 (es)
NO (1) NO325663B1 (es)
NZ (2) NZ503432A (es)
PL (1) PL191618B1 (es)
PT (1) PT1017384E (es)
RU (1) RU2230553C2 (es)
SK (1) SK285357B6 (es)
TR (1) TR200001546T2 (es)
TW (1) TW581815B (es)
UA (1) UA72448C2 (es)
WO (1) WO1999016438A1 (es)
ZA (1) ZA988797B (es)

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Also Published As

Publication number Publication date
KR100547929B1 (ko) 2006-02-02
CA2305370A1 (en) 1999-04-08
HK1032206A1 (en) 2001-07-13
JP2001517699A (ja) 2001-10-09
US6093728A (en) 2000-07-25
CA2305370C (en) 2006-11-28
NZ503432A (en) 2002-11-26
PL339744A1 (en) 2001-01-02
SK4152000A3 (en) 2002-02-05
ATE281834T1 (de) 2004-11-15
UA72448C2 (en) 2005-03-15
NO325663B1 (no) 2008-07-07
WO1999016438A1 (en) 1999-04-08
HUP0004024A2 (hu) 2001-04-28
DE69827516D1 (de) 2004-12-16
IL158649A0 (en) 2004-05-12
AU748849B2 (en) 2002-06-13
NZ517808A (en) 2003-07-25
IL135109A (en) 2007-07-04
ZA988797B (en) 1999-12-02
CN1278172A (zh) 2000-12-27
EP1017384B1 (en) 2004-11-10
SK285357B6 (sk) 2006-11-03
AU9578198A (en) 1999-04-23
NO20001555L (no) 2000-03-24
BR9812682A (pt) 2000-08-22
DE69827516T2 (de) 2005-12-01
KR20010015623A (ko) 2001-02-26
CN1167420C (zh) 2004-09-22
BG104356A (en) 2000-12-29
BG64784B1 (bg) 2006-04-28
US6855723B2 (en) 2005-02-15
TW581815B (en) 2004-04-01
EP1017384A1 (en) 2000-07-12
AR017266A1 (es) 2001-09-05
DK1017384T3 (da) 2005-01-31
RU2230553C2 (ru) 2004-06-20
PT1017384E (pt) 2005-03-31
HUP0004024A3 (en) 2001-10-29
NO20001555D0 (no) 2000-03-24
PL191618B1 (pl) 2006-06-30
US20030181480A1 (en) 2003-09-25
IL135109A0 (en) 2001-05-20
IL158649A (en) 2006-12-10
TR200001546T2 (tr) 2000-10-23

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