EA199900836A1 - Противосудорожные производные изохинолилбензамида - Google Patents
Противосудорожные производные изохинолилбензамидаInfo
- Publication number
- EA199900836A1 EA199900836A1 EA199900836A EA199900836A EA199900836A1 EA 199900836 A1 EA199900836 A1 EA 199900836A1 EA 199900836 A EA199900836 A EA 199900836A EA 199900836 A EA199900836 A EA 199900836A EA 199900836 A1 EA199900836 A1 EA 199900836A1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- alkyl
- groups
- hydrogen
- 6alko
- cfco
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/02—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines
- C07D217/04—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines with hydrocarbon or substituted hydrocarbon radicals attached to the ring nitrogen atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Psychology (AREA)
- Anesthesiology (AREA)
- Addiction (AREA)
- Hospice & Palliative Care (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
Соединения формулы (I) и их фармацевтически приемлемые солигде Rпредставляет водород, Cалкил (необязательно замещенный группой гидрокси или Cалкокси), Cалкенил, Cалкинил, C-алкилCO-, формил, CFCO- или CалкилSO-; Rпредставляет водород или до трех заместителей, выбранных из групп галоген, NO, CN, N, CFO-, CFS-, CFCO-, трифторметилдиазиринил, Cалкил, Cалкенил, Cалкинил, Cперфторалкил, Cциклоалкил, C-циалоалкил-Cалкил-, CалкилO-, CалкилCO-, Cцикло-алкилO-, CциклоалкилCO-, Cциклоалкил-CалкилO-, Cциклоалкил-CалкилCO-, фенил, фенокси, бензилокси, бензоил, фенил-Cалкил-, CалкилS-, CалкилSO-, (Cалкил)NSO-, (C-алкил)NHSO-, (Cалкил)HCO-, (Cалкил)NHCO- или CONH; или группу -NRR, где R- водород или Cалкил, а R- водород, Cалкил, формил, -COCалкил или -COCалкил; или две группы Rвместе образуют карбоциклическое кольцо, насыщенное или ненасыщенное и незамещенное или замещенное группой -OH или =O; и две группы Rи две группы R, каждая независимо, представляют собой водород или Cалкил, либо две группы Rи/или две группы Rвместе образуют Cспироалкильную группу при условии, что, по меньшей мере, одна из групп Rи Rне представляет собой водород, могут быть использованы для лечения и профилактики эпилепсии и других расстройств.Международная заявка была опубликована вместе с отчетом о международном поиске.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GBGB9705620.4A GB9705620D0 (en) | 1997-03-18 | 1997-03-18 | Novel compounds |
GBGB9726660.5A GB9726660D0 (en) | 1997-12-17 | 1997-12-17 | Novel compounds |
PCT/GB1998/000781 WO1998041507A1 (en) | 1997-03-18 | 1998-03-16 | Anti-convulsant isoquinolyl-benzamide derivatives |
Publications (1)
Publication Number | Publication Date |
---|---|
EA199900836A1 true EA199900836A1 (ru) | 2000-04-24 |
Family
ID=26311216
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EA199900836A EA199900836A1 (ru) | 1997-03-18 | 1998-03-16 | Противосудорожные производные изохинолилбензамида |
Country Status (26)
Country | Link |
---|---|
US (1) | US6277861B1 (ru) |
EP (1) | EP0971897A1 (ru) |
JP (1) | JP2001516357A (ru) |
KR (1) | KR20000076343A (ru) |
CN (1) | CN1255917A (ru) |
AP (1) | AP9901635A0 (ru) |
AR (1) | AR012078A1 (ru) |
AU (1) | AU732162B2 (ru) |
BG (1) | BG103807A (ru) |
BR (1) | BR9809048A (ru) |
CA (1) | CA2283682A1 (ru) |
CO (1) | CO4950554A1 (ru) |
DZ (1) | DZ2446A1 (ru) |
EA (1) | EA199900836A1 (ru) |
ID (1) | ID22730A (ru) |
IL (1) | IL131958A0 (ru) |
MA (1) | MA24499A1 (ru) |
NO (1) | NO313753B1 (ru) |
NZ (1) | NZ337579A (ru) |
OA (1) | OA11390A (ru) |
PE (1) | PE62199A1 (ru) |
PL (1) | PL335675A1 (ru) |
SK (1) | SK126799A3 (ru) |
TR (1) | TR199902282T2 (ru) |
TW (1) | TW509679B (ru) |
WO (1) | WO1998041507A1 (ru) |
Families Citing this family (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU9512298A (en) * | 1997-09-30 | 1999-04-23 | Molecular Design International, Inc. | Beta3-adrenoreceptor agonists, agonist compositions and methods of using |
GB9817424D0 (en) * | 1998-08-11 | 1998-10-07 | Smithkline Beecham Plc | Novel compounds |
GB9915589D0 (en) | 1999-07-02 | 1999-09-01 | Smithkline Beecham Plc | Novel compounds |
US6593341B2 (en) | 2001-03-29 | 2003-07-15 | Molecular Design International, Inc. | β3-adrenoreceptor agonists, agonist compositions and methods of making and using the same |
US6596734B1 (en) | 2002-10-11 | 2003-07-22 | Molecular Design International, Inc. | Tetrahydroisoquinoline compounds for use as β3-adrenoreceptor agonists |
CN109608325A (zh) * | 2018-12-27 | 2019-04-12 | 先尼科化工(上海)有限公司 | 一种卤代苯甲酸衍生物的工业化合成方法 |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4022900A (en) * | 1970-09-09 | 1977-05-10 | Marion Laboratories, Inc. | Compositions containing 1,2,3,4-tetrahydroisoquinolines used as hypotensive agents |
WO1988003137A1 (en) * | 1986-10-28 | 1988-05-05 | Smith Kline & French Laboratories Limited | Tetrahydroisoquinolin-2-yl derivatives of carboxylic acids as thromboxane a2 antagonists |
GB8807922D0 (en) * | 1988-04-05 | 1988-05-05 | Fujisawa Pharmaceutical Co | Isoquinoline compound & process for preparation thereof |
US4883593A (en) * | 1988-10-27 | 1989-11-28 | Bend Research, Inc. | Ultrathin-skinned asymmetric membranes by immiscible solvents treatment |
GB9112721D0 (en) * | 1991-06-13 | 1991-07-31 | Smithkline Beecham Plc | Novel treatment |
WO1997048683A1 (en) * | 1996-06-17 | 1997-12-24 | Smithkline Beecham Plc | Substituted benzamide derivatives and their use as anticonvulsants |
-
1998
- 1998-03-07 DZ DZ980056A patent/DZ2446A1/xx active
- 1998-03-16 BR BR9809048-8A patent/BR9809048A/pt not_active IP Right Cessation
- 1998-03-16 ID IDW991041D patent/ID22730A/id unknown
- 1998-03-16 AU AU64127/98A patent/AU732162B2/en not_active Ceased
- 1998-03-16 PL PL98335675A patent/PL335675A1/xx unknown
- 1998-03-16 CO CO98014463A patent/CO4950554A1/es unknown
- 1998-03-16 SK SK1267-99A patent/SK126799A3/sk unknown
- 1998-03-16 AP APAP/P/1999/001635A patent/AP9901635A0/en unknown
- 1998-03-16 CA CA002283682A patent/CA2283682A1/en not_active Abandoned
- 1998-03-16 TR TR1999/02282T patent/TR199902282T2/xx unknown
- 1998-03-16 KR KR1019997008444A patent/KR20000076343A/ko not_active Application Discontinuation
- 1998-03-16 IL IL13195898A patent/IL131958A0/xx unknown
- 1998-03-16 US US09/381,369 patent/US6277861B1/en not_active Expired - Fee Related
- 1998-03-16 EA EA199900836A patent/EA199900836A1/ru unknown
- 1998-03-16 JP JP54024798A patent/JP2001516357A/ja not_active Withdrawn
- 1998-03-16 CN CN98805128A patent/CN1255917A/zh active Pending
- 1998-03-16 MA MA25000A patent/MA24499A1/fr unknown
- 1998-03-16 WO PCT/GB1998/000781 patent/WO1998041507A1/en not_active Application Discontinuation
- 1998-03-16 AR ARP980101173A patent/AR012078A1/es not_active Application Discontinuation
- 1998-03-16 NZ NZ337579A patent/NZ337579A/en unknown
- 1998-03-16 EP EP98909646A patent/EP0971897A1/en not_active Withdrawn
- 1998-03-17 PE PE1998000190A patent/PE62199A1/es not_active Application Discontinuation
- 1998-03-20 TW TW087104134A patent/TW509679B/zh not_active IP Right Cessation
-
1999
- 1999-09-17 NO NO19994504A patent/NO313753B1/no not_active IP Right Cessation
- 1999-09-17 OA OA9900210A patent/OA11390A/en unknown
- 1999-10-13 BG BG103807A patent/BG103807A/bg unknown
Also Published As
Publication number | Publication date |
---|---|
CN1255917A (zh) | 2000-06-07 |
IL131958A0 (en) | 2001-03-19 |
PL335675A1 (en) | 2000-05-08 |
BR9809048A (pt) | 2000-08-01 |
SK126799A3 (en) | 2000-05-16 |
AU6412798A (en) | 1998-10-12 |
CA2283682A1 (en) | 1998-09-24 |
WO1998041507A1 (en) | 1998-09-24 |
OA11390A (en) | 2004-04-14 |
TW509679B (en) | 2002-11-11 |
PE62199A1 (es) | 1999-09-10 |
AU732162B2 (en) | 2001-04-12 |
MA24499A1 (fr) | 1998-10-01 |
DZ2446A1 (fr) | 2003-01-11 |
TR199902282T2 (en) | 2000-07-21 |
AR012078A1 (es) | 2000-09-27 |
EP0971897A1 (en) | 2000-01-19 |
CO4950554A1 (es) | 2000-09-01 |
NO994504D0 (no) | 1999-09-17 |
BG103807A (bg) | 2001-05-31 |
JP2001516357A (ja) | 2001-09-25 |
ID22730A (id) | 1999-12-09 |
NO994504L (no) | 1999-09-17 |
NZ337579A (en) | 2001-04-27 |
NO313753B1 (no) | 2002-11-25 |
US6277861B1 (en) | 2001-08-21 |
AP9901635A0 (en) | 1999-09-30 |
KR20000076343A (ko) | 2000-12-26 |
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