CO4950554A1 - Derivados de 1,3-dihidro o 3,4-dihidroisoquinolin-benzamida - Google Patents
Derivados de 1,3-dihidro o 3,4-dihidroisoquinolin-benzamidaInfo
- Publication number
- CO4950554A1 CO4950554A1 CO98014463A CO98014463A CO4950554A1 CO 4950554 A1 CO4950554 A1 CO 4950554A1 CO 98014463 A CO98014463 A CO 98014463A CO 98014463 A CO98014463 A CO 98014463A CO 4950554 A1 CO4950554 A1 CO 4950554A1
- Authority
- CO
- Colombia
- Prior art keywords
- 4alkyl
- hydrogen
- groups
- 6alkyl
- cycloalkyl
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/02—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines
- C07D217/04—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines with hydrocarbon or substituted hydrocarbon radicals attached to the ring nitrogen atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pain & Pain Management (AREA)
- Psychiatry (AREA)
- Psychology (AREA)
- Hospice & Palliative Care (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Addiction (AREA)
- Anesthesiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
Un compuesto de la fórmula (I) o una sal farmacéuticamenteaceptable del mismo.donde: R1 es hidrógeno, alquilo C1-6 (sustituido opcionalmente por hidroxi o alcoxi C1-4 ), alqueniloC1-6 , alquiniloC1-6 , alquilCO-C1-6 , formilo, CF3 CO- o alquilSO2 -C1-6 ,R2 es hidrógeno o hasta tres sustituyentes seleccionados de halógeno, NO2 , CN, N3 , CF3 O, CF3 S-, CF3 CO-, triflurometildiazinirilo, alquiloC1-6 , alqueniloC1-6 , alquiniloC1-6 , perfluoroalquilo C1-6 , cicloalquiloC3-6 , cicloalquilo C3-6 - alquiloC1-4 , alquilO-C1-6 , alquilCO-C1-6 , cicloalquilO-C3-6 , cicloalquilCO- C3-6 , cicloalquil C3-6 alquilO-C1-4 , cicloalquilo-C3-6 -alquilCO-C1-4 , fenilo, fenoxi, benzoniloxi, benzoilo, fenil-alquilC1-4 , alquilS-C1-6 , alquilSO2 -C1-2 , (alquilC1-4 )2 NSO2 -, (alquilC1-4 )NHSO2 , (alquil C1-4 )NCO-, (alquilC1-4 )NHCO- o CONH2 ;o NR5 R6 , donde R5 es hidrógeno o alquilC1-4 , yR6 es hidrógeno, alquilC1-4 , formil, alquil-CO2 C1-4 o alquil -COC1-4 ; o dos grupos R2 juntos forman un anillo carbocíclico saturado o insaturado y sustituido o no sustituido por -OH o =O; ylos dos grupos R3 y los grupos R4 son cada uno independiente hidrógeno o alquilC1-6 o los dos grupos R3 y/o los grupos R4 juntos forman un grupo espiroalquilC3-6 siempre y cuando que al menos un grupo R3 y R4 no sea hidrógeno.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB9705620.4A GB9705620D0 (en) | 1997-03-18 | 1997-03-18 | Novel compounds |
| GBGB9726660.5A GB9726660D0 (en) | 1997-12-17 | 1997-12-17 | Novel compounds |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CO4950554A1 true CO4950554A1 (es) | 2000-09-01 |
Family
ID=26311216
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CO98014463A CO4950554A1 (es) | 1997-03-18 | 1998-03-16 | Derivados de 1,3-dihidro o 3,4-dihidroisoquinolin-benzamida |
Country Status (26)
| Country | Link |
|---|---|
| US (1) | US6277861B1 (es) |
| EP (1) | EP0971897A1 (es) |
| JP (1) | JP2001516357A (es) |
| KR (1) | KR20000076343A (es) |
| CN (1) | CN1255917A (es) |
| AP (1) | AP9901635A0 (es) |
| AR (1) | AR012078A1 (es) |
| AU (1) | AU732162B2 (es) |
| BG (1) | BG103807A (es) |
| BR (1) | BR9809048A (es) |
| CA (1) | CA2283682A1 (es) |
| CO (1) | CO4950554A1 (es) |
| DZ (1) | DZ2446A1 (es) |
| EA (1) | EA199900836A1 (es) |
| ID (1) | ID22730A (es) |
| IL (1) | IL131958A0 (es) |
| MA (1) | MA24499A1 (es) |
| NO (1) | NO313753B1 (es) |
| NZ (1) | NZ337579A (es) |
| OA (1) | OA11390A (es) |
| PE (1) | PE62199A1 (es) |
| PL (1) | PL335675A1 (es) |
| SK (1) | SK126799A3 (es) |
| TR (1) | TR199902282T2 (es) |
| TW (1) | TW509679B (es) |
| WO (1) | WO1998041507A1 (es) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1023269A4 (en) * | 1997-09-30 | 2001-06-27 | Molecular Design Int | BETA3-ADRENORECEPTOR AGONISTS, AGONIST COMPOSITIONS AND METHODS OF USE |
| GB9817424D0 (en) | 1998-08-11 | 1998-10-07 | Smithkline Beecham Plc | Novel compounds |
| GB9915589D0 (en) * | 1999-07-02 | 1999-09-01 | Smithkline Beecham Plc | Novel compounds |
| US6593341B2 (en) | 2001-03-29 | 2003-07-15 | Molecular Design International, Inc. | β3-adrenoreceptor agonists, agonist compositions and methods of making and using the same |
| US6596734B1 (en) | 2002-10-11 | 2003-07-22 | Molecular Design International, Inc. | Tetrahydroisoquinoline compounds for use as β3-adrenoreceptor agonists |
| CN109608325A (zh) * | 2018-12-27 | 2019-04-12 | 先尼科化工（上海）有限公司 | 一种卤代苯甲酸衍生物的工业化合成方法 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4022900A (en) * | 1970-09-09 | 1977-05-10 | Marion Laboratories, Inc. | Compositions containing 1,2,3,4-tetrahydroisoquinolines used as hypotensive agents |
| EP0266949B1 (en) * | 1986-10-28 | 1990-11-28 | Smith Kline & French Laboratories Limited | Tetrahydroisoquinolin-2-yl derivatives of carboxylic acids as thromboxane a2 antagonists |
| GB8807922D0 (en) * | 1988-04-05 | 1988-05-05 | Fujisawa Pharmaceutical Co | Isoquinoline compound & process for preparation thereof |
| US4883593A (en) * | 1988-10-27 | 1989-11-28 | Bend Research, Inc. | Ultrathin-skinned asymmetric membranes by immiscible solvents treatment |
| GB9112721D0 (en) * | 1991-06-13 | 1991-07-31 | Smithkline Beecham Plc | Novel treatment |
| BR9709906A (pt) * | 1996-06-17 | 1999-08-10 | Smithkline Beecham Plc | Derivados de benzamida substituídos e o uso dos mesmos como anticonvulsivantes |
-
1998
- 1998-03-07 DZ DZ980056A patent/DZ2446A1/xx active
- 1998-03-16 AR ARP980101173A patent/AR012078A1/es not_active Application Discontinuation
- 1998-03-16 MA MA25000A patent/MA24499A1/fr unknown
- 1998-03-16 PL PL98335675A patent/PL335675A1/xx unknown
- 1998-03-16 IL IL13195898A patent/IL131958A0/xx unknown
- 1998-03-16 EA EA199900836A patent/EA199900836A1/ru unknown
- 1998-03-16 BR BR9809048-8A patent/BR9809048A/pt not_active IP Right Cessation
- 1998-03-16 AU AU64127/98A patent/AU732162B2/en not_active Ceased
- 1998-03-16 ID IDW991041D patent/ID22730A/id unknown
- 1998-03-16 NZ NZ337579A patent/NZ337579A/en unknown
- 1998-03-16 TR TR1999/02282T patent/TR199902282T2/xx unknown
- 1998-03-16 WO PCT/GB1998/000781 patent/WO1998041507A1/en not_active Application Discontinuation
- 1998-03-16 AP APAP/P/1999/001635A patent/AP9901635A0/en unknown
- 1998-03-16 CO CO98014463A patent/CO4950554A1/es unknown
- 1998-03-16 EP EP98909646A patent/EP0971897A1/en not_active Withdrawn
- 1998-03-16 JP JP54024798A patent/JP2001516357A/ja not_active Withdrawn
- 1998-03-16 CN CN98805128A patent/CN1255917A/zh active Pending
- 1998-03-16 SK SK1267-99A patent/SK126799A3/sk unknown
- 1998-03-16 US US09/381,369 patent/US6277861B1/en not_active Expired - Fee Related
- 1998-03-16 KR KR1019997008444A patent/KR20000076343A/ko not_active Application Discontinuation
- 1998-03-16 CA CA002283682A patent/CA2283682A1/en not_active Abandoned
- 1998-03-17 PE PE1998000190A patent/PE62199A1/es not_active Application Discontinuation
- 1998-03-20 TW TW087104134A patent/TW509679B/zh not_active IP Right Cessation
-
1999
- 1999-09-17 NO NO19994504A patent/NO313753B1/no not_active IP Right Cessation
- 1999-09-17 OA OA9900210A patent/OA11390A/en unknown
- 1999-10-13 BG BG103807A patent/BG103807A/bg unknown
Also Published As
| Publication number | Publication date |
|---|---|
| PE62199A1 (es) | 1999-09-10 |
| NO994504D0 (no) | 1999-09-17 |
| DZ2446A1 (fr) | 2003-01-11 |
| MA24499A1 (fr) | 1998-10-01 |
| SK126799A3 (en) | 2000-05-16 |
| NZ337579A (en) | 2001-04-27 |
| EP0971897A1 (en) | 2000-01-19 |
| PL335675A1 (en) | 2000-05-08 |
| ID22730A (id) | 1999-12-09 |
| AR012078A1 (es) | 2000-09-27 |
| AU732162B2 (en) | 2001-04-12 |
| BG103807A (bg) | 2001-05-31 |
| EA199900836A1 (ru) | 2000-04-24 |
| JP2001516357A (ja) | 2001-09-25 |
| TR199902282T2 (en) | 2000-07-21 |
| BR9809048A (pt) | 2000-08-01 |
| CN1255917A (zh) | 2000-06-07 |
| OA11390A (en) | 2004-04-14 |
| TW509679B (en) | 2002-11-11 |
| NO313753B1 (no) | 2002-11-25 |
| AP9901635A0 (en) | 1999-09-30 |
| KR20000076343A (ko) | 2000-12-26 |
| CA2283682A1 (en) | 1998-09-24 |
| WO1998041507A1 (en) | 1998-09-24 |
| US6277861B1 (en) | 2001-08-21 |
| IL131958A0 (en) | 2001-03-19 |
| NO994504L (no) | 1999-09-17 |
| AU6412798A (en) | 1998-10-12 |
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