PE62199A1 - Derivado de tetrahidro isoquinolinil-benzamida - Google Patents
Derivado de tetrahidro isoquinolinil-benzamidaInfo
- Publication number
- PE62199A1 PE62199A1 PE1998000190A PE00019098A PE62199A1 PE 62199 A1 PE62199 A1 PE 62199A1 PE 1998000190 A PE1998000190 A PE 1998000190A PE 00019098 A PE00019098 A PE 00019098A PE 62199 A1 PE62199 A1 PE 62199A1
- Authority
- PE
- Peru
- Prior art keywords
- compound
- formula
- alkyl
- halogen
- refers
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/02—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines
- C07D217/04—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines with hydrocarbon or substituted hydrocarbon radicals attached to the ring nitrogen atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Pain & Pain Management (AREA)
- Psychiatry (AREA)
- Psychology (AREA)
- Anesthesiology (AREA)
- Hospice & Palliative Care (AREA)
- Addiction (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
SE REFIERE A UN COMPUESTO DE FORMULA (I) DONDE R1 ES H, ALQUILO C1-C6 OPCIONALMENTE SUSTITUIDO CON OH, ALCOXI C1-C4, ALQUENILO C1-C6, ENTRE OTROS; R2 ES H, HALOGENO, NO2, CN, ENTRE OTROS; R3 Y R4 SON H O ALQUILO C1-C6, LOS GRUPOS R3 Y/O R4 FORMAN JUNTOS UN ESPIROALQUILO C3-C6, CUANDO UNO DE R3 Y R4 NO ES H. TAMBIEN SE REFIERE A UN COMPUESTO DE FORMULA (IA), R22 ES ALQUIL(C1-C6)-O, CICLOALQUIL(C3-C6)-O o CICLOALQUIL(C3-C6)-ALQUIL(C1-C4)-O; R23 ES H, HALOGENO, CN, N3, ENTRE OTROS; R24 ES H, HALOGENO, NO2, CN, NR5R6, ENTRE OTROS; R5 ES H o ALQUILO C1-C4; R6 ES H, ALQUILO C1-C4, FORMILO, ENTRE OTROS; o R23 Y R24 FORMAN JUNTOS UN ANILLO CARBOCICLICO INSATURADO O SATURADO OPCIONALMENTE SUSTITUIDO CON CARBONILO O HIDROXILO. TAMBIEN SE REFIERE A UN COMPUESTO DE FORMULA (IB). UN COMPUESTO PREFERIDO ES (+/-)-N-(1-METIL-1,2,3,4-TETRAHIDROISOQUINOLIN-5-IL)-5-CLORO-4-ETOXI-2-METOXIBENZAMIDA. EL COMPUESTO DE FORMULA (I) SE UTILIZA PARA EL TRATAMIENTO, PROFILAXIS DE ANSIEDAD, MANIA, DEPRESION, TRASTORNOS DE PANICO, AGRESION
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB9705620.4A GB9705620D0 (en) | 1997-03-18 | 1997-03-18 | Novel compounds |
| GBGB9726660.5A GB9726660D0 (en) | 1997-12-17 | 1997-12-17 | Novel compounds |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PE62199A1 true PE62199A1 (es) | 1999-09-10 |
Family
ID=26311216
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PE1998000190A PE62199A1 (es) | 1997-03-18 | 1998-03-17 | Derivado de tetrahidro isoquinolinil-benzamida |
Country Status (26)
| Country | Link |
|---|---|
| US (1) | US6277861B1 (es) |
| EP (1) | EP0971897A1 (es) |
| JP (1) | JP2001516357A (es) |
| KR (1) | KR20000076343A (es) |
| CN (1) | CN1255917A (es) |
| AP (1) | AP9901635A0 (es) |
| AR (1) | AR012078A1 (es) |
| AU (1) | AU732162B2 (es) |
| BG (1) | BG103807A (es) |
| BR (1) | BR9809048A (es) |
| CA (1) | CA2283682A1 (es) |
| CO (1) | CO4950554A1 (es) |
| DZ (1) | DZ2446A1 (es) |
| EA (1) | EA199900836A1 (es) |
| ID (1) | ID22730A (es) |
| IL (1) | IL131958A0 (es) |
| MA (1) | MA24499A1 (es) |
| NO (1) | NO313753B1 (es) |
| NZ (1) | NZ337579A (es) |
| OA (1) | OA11390A (es) |
| PE (1) | PE62199A1 (es) |
| PL (1) | PL335675A1 (es) |
| SK (1) | SK126799A3 (es) |
| TR (1) | TR199902282T2 (es) |
| TW (1) | TW509679B (es) |
| WO (1) | WO1998041507A1 (es) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1023269A4 (en) * | 1997-09-30 | 2001-06-27 | Molecular Design Int | BETA3-ADRENORECEPTOR AGONISTS, AGONIST COMPOSITIONS AND METHODS OF USE |
| GB9817424D0 (en) | 1998-08-11 | 1998-10-07 | Smithkline Beecham Plc | Novel compounds |
| GB9915589D0 (en) | 1999-07-02 | 1999-09-01 | Smithkline Beecham Plc | Novel compounds |
| US6593341B2 (en) | 2001-03-29 | 2003-07-15 | Molecular Design International, Inc. | β3-adrenoreceptor agonists, agonist compositions and methods of making and using the same |
| US6596734B1 (en) | 2002-10-11 | 2003-07-22 | Molecular Design International, Inc. | Tetrahydroisoquinoline compounds for use as β3-adrenoreceptor agonists |
| CN109608325A (zh) * | 2018-12-27 | 2019-04-12 | 先尼科化工（上海）有限公司 | 一种卤代苯甲酸衍生物的工业化合成方法 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4022900A (en) * | 1970-09-09 | 1977-05-10 | Marion Laboratories, Inc. | Compositions containing 1,2,3,4-tetrahydroisoquinolines used as hypotensive agents |
| EP0266949B1 (en) * | 1986-10-28 | 1990-11-28 | Smith Kline & French Laboratories Limited | Tetrahydroisoquinolin-2-yl derivatives of carboxylic acids as thromboxane a2 antagonists |
| GB8807922D0 (en) * | 1988-04-05 | 1988-05-05 | Fujisawa Pharmaceutical Co | Isoquinoline compound & process for preparation thereof |
| US4883593A (en) * | 1988-10-27 | 1989-11-28 | Bend Research, Inc. | Ultrathin-skinned asymmetric membranes by immiscible solvents treatment |
| GB9112721D0 (en) * | 1991-06-13 | 1991-07-31 | Smithkline Beecham Plc | Novel treatment |
| TR199802745T2 (xx) * | 1996-06-17 | 1999-04-21 | Smithkline Beecham Plc | �kameli benzamid t�revleri ve bunlar�n ihtiya�lar� durdurucu veya engelleyici maddeler olarak kullan�lmas�. |
-
1998
- 1998-03-07 DZ DZ980056A patent/DZ2446A1/xx active
- 1998-03-16 AP APAP/P/1999/001635A patent/AP9901635A0/en unknown
- 1998-03-16 JP JP54024798A patent/JP2001516357A/ja not_active Withdrawn
- 1998-03-16 IL IL13195898A patent/IL131958A0/xx unknown
- 1998-03-16 NZ NZ337579A patent/NZ337579A/en unknown
- 1998-03-16 CO CO98014463A patent/CO4950554A1/es unknown
- 1998-03-16 MA MA25000A patent/MA24499A1/fr unknown
- 1998-03-16 SK SK1267-99A patent/SK126799A3/sk unknown
- 1998-03-16 ID IDW991041D patent/ID22730A/id unknown
- 1998-03-16 AR ARP980101173A patent/AR012078A1/es not_active Application Discontinuation
- 1998-03-16 US US09/381,369 patent/US6277861B1/en not_active Expired - Fee Related
- 1998-03-16 BR BR9809048-8A patent/BR9809048A/pt not_active IP Right Cessation
- 1998-03-16 AU AU64127/98A patent/AU732162B2/en not_active Ceased
- 1998-03-16 EP EP98909646A patent/EP0971897A1/en not_active Withdrawn
- 1998-03-16 TR TR1999/02282T patent/TR199902282T2/xx unknown
- 1998-03-16 WO PCT/GB1998/000781 patent/WO1998041507A1/en not_active Application Discontinuation
- 1998-03-16 CN CN98805128A patent/CN1255917A/zh active Pending
- 1998-03-16 KR KR1019997008444A patent/KR20000076343A/ko not_active Application Discontinuation
- 1998-03-16 EA EA199900836A patent/EA199900836A1/ru unknown
- 1998-03-16 PL PL98335675A patent/PL335675A1/xx unknown
- 1998-03-16 CA CA002283682A patent/CA2283682A1/en not_active Abandoned
- 1998-03-17 PE PE1998000190A patent/PE62199A1/es not_active Application Discontinuation
- 1998-03-20 TW TW087104134A patent/TW509679B/zh not_active IP Right Cessation
-
1999
- 1999-09-17 OA OA9900210A patent/OA11390A/en unknown
- 1999-09-17 NO NO19994504A patent/NO313753B1/no not_active IP Right Cessation
- 1999-10-13 BG BG103807A patent/BG103807A/bg unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CO4950554A1 (es) | 2000-09-01 |
| AR012078A1 (es) | 2000-09-27 |
| WO1998041507A1 (en) | 1998-09-24 |
| NO994504D0 (no) | 1999-09-17 |
| BR9809048A (pt) | 2000-08-01 |
| EP0971897A1 (en) | 2000-01-19 |
| TW509679B (en) | 2002-11-11 |
| AU6412798A (en) | 1998-10-12 |
| US6277861B1 (en) | 2001-08-21 |
| DZ2446A1 (fr) | 2003-01-11 |
| JP2001516357A (ja) | 2001-09-25 |
| KR20000076343A (ko) | 2000-12-26 |
| MA24499A1 (fr) | 1998-10-01 |
| AP9901635A0 (en) | 1999-09-30 |
| BG103807A (bg) | 2001-05-31 |
| NZ337579A (en) | 2001-04-27 |
| SK126799A3 (en) | 2000-05-16 |
| EA199900836A1 (ru) | 2000-04-24 |
| NO313753B1 (no) | 2002-11-25 |
| TR199902282T2 (en) | 2000-07-21 |
| CN1255917A (zh) | 2000-06-07 |
| AU732162B2 (en) | 2001-04-12 |
| ID22730A (id) | 1999-12-09 |
| CA2283682A1 (en) | 1998-09-24 |
| OA11390A (en) | 2004-04-14 |
| PL335675A1 (en) | 2000-05-08 |
| IL131958A0 (en) | 2001-03-19 |
| NO994504L (no) | 1999-09-17 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG | Grant, registration | ||
| FD | Application declared void or lapsed |