DK1173431T4 - Fremgangsmåde til fremstilling af citalopram - Google Patents

Fremgangsmåde til fremstilling af citalopram

Info

Publication number
DK1173431T4
DK1173431T4 DK99913120T DK99913120T DK1173431T4 DK 1173431 T4 DK1173431 T4 DK 1173431T4 DK 99913120 T DK99913120 T DK 99913120T DK 99913120 T DK99913120 T DK 99913120T DK 1173431 T4 DK1173431 T4 DK 1173431T4
Authority
DK
Denmark
Prior art keywords
citalopram
preparation
Prior art date
Application number
DK99913120T
Other languages
English (en)
Other versions
DK1173431T3 (da
Inventor
Hans Petersen
Original Assignee
Lundbeck & Co As H
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=8156954&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DK1173431(T4) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Lundbeck & Co As H filed Critical Lundbeck & Co As H
Publication of DK1173431T3 publication Critical patent/DK1173431T3/da
Application granted granted Critical
Publication of DK1173431T4 publication Critical patent/DK1173431T4/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/87—Benzo [c] furans; Hydrogenated benzo [c] furans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
    • A61K31/343—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide condensed with a carbocyclic ring, e.g. coumaran, bufuralol, befunolol, clobenfurol, amiodarone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
    • C07D263/08—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D263/16—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D263/18—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
DK99913120T 1999-04-14 1999-04-14 Fremgangsmåde til fremstilling af citalopram DK1173431T4 (da)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/DK1999/000210 WO1999030548A2 (en) 1999-04-14 1999-04-14 Method for the preparation of citalopram

Publications (2)

Publication Number Publication Date
DK1173431T3 DK1173431T3 (da) 2003-08-04
DK1173431T4 true DK1173431T4 (da) 2010-01-04

Family

ID=8156954

Family Applications (1)

Application Number Title Priority Date Filing Date
DK99913120T DK1173431T4 (da) 1999-04-14 1999-04-14 Fremgangsmåde til fremstilling af citalopram

Country Status (29)

Country Link
US (2) US6849749B2 (da)
EP (1) EP1173431B2 (da)
JP (1) JP3798940B2 (da)
KR (1) KR100604156B1 (da)
CN (1) CN1142926C (da)
AR (1) AR018204A1 (da)
AT (1) ATE237604T1 (da)
AU (1) AU759716B2 (da)
BR (1) BR9917346A (da)
CA (1) CA2291129C (da)
CZ (1) CZ296537B6 (da)
DE (1) DE69907037T3 (da)
DK (1) DK1173431T4 (da)
EA (1) EA004033B1 (da)
ES (1) ES2195554T5 (da)
HK (1) HK1048122B (da)
HU (1) HU227473B1 (da)
IL (1) IL145615A0 (da)
IS (1) IS2697B (da)
IT (1) ITMI991580A1 (da)
MX (1) MXPA01010134A (da)
NO (1) NO327719B1 (da)
NZ (1) NZ514671A (da)
PL (1) PL198024B1 (da)
PT (1) PT1173431E (da)
SI (1) SI1173431T2 (da)
SK (1) SK285604B6 (da)
TR (1) TR200102957T2 (da)
WO (1) WO1999030548A2 (da)

Families Citing this family (45)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000023431A1 (en) 1998-10-20 2000-04-27 H. Lundbeck A/S Method for the preparation of citalopram
ES2195644T3 (es) 1998-12-23 2003-12-01 Lundbeck & Co As H Metodo para la preparacion de 5-cianoftalida.
AR022329A1 (es) 1999-01-29 2002-09-04 Lundbeck & Co As H Metodo para la preparacion de 5-cianoftalida
ES2195554T5 (es) 1999-04-14 2010-02-02 H. Lundbeck A/S Metodo para la preparacion de citalopram.
ITMI991581A1 (it) * 1999-06-25 2001-01-15 Lundbeck & Co As H Metodo per la preparazione di citalopram
ITMI991579A1 (it) 1999-06-25 2001-01-15 Lundbeck & Co As H Metodo per la preparazione di citalopram
AR021155A1 (es) * 1999-07-08 2002-06-12 Lundbeck & Co As H Tratamiento de desordenes neuroticos
AU742554B2 (en) 1999-10-25 2002-01-03 H. Lundbeck A/S Method for the preparation of citalopram
DE69935355T2 (de) * 1999-10-25 2007-11-08 H. Lundbeck A/S, Valby Verfahren zur Herstellung von Citalopram
US6310222B1 (en) 1999-11-01 2001-10-30 Sumika Fine Chemicals Co., Ltd. Production method of 5-phthalancarbonitrile compound, intermediate therefor and production method of the intermediate
AR026063A1 (es) 1999-11-01 2002-12-26 Lundbeck & Co As H Metodo para la preparacion de 5-carboxiftalida.
MXPA02006503A (es) 1999-12-28 2002-12-09 Lundbeck & Co As H Metodo para la preparacion de citalopram.
EA004055B1 (ru) 1999-12-30 2003-12-25 Х.Лундбекк А/С Способ получения циталопрама
ATE252570T1 (de) 2000-01-14 2003-11-15 Lundbeck & Co As H Verfahren zur herstellung von 5-cyanophthalid
US6433196B1 (en) 2000-02-17 2002-08-13 Sumika Fine Chemicals Co., Ltd. Production method of citalopram, intermediate therefor and production method of the intermediate
NL1017415C1 (nl) 2000-02-24 2001-05-18 Lundbeck & Co As H Werkwijze voor de bereiding van Citalopram.
IES20010143A2 (en) * 2000-02-24 2001-07-25 Lundbeck & Co As H Method for the preparation of citalopram
IES20010157A2 (en) 2000-03-03 2002-03-06 Lundbeck & Co As H Method for the preparation of citalopram
GB0005477D0 (en) 2000-03-07 2000-04-26 Resolution Chemicals Limited Process for the preparation of citalopram
GB2357762B (en) 2000-03-13 2002-01-30 Lundbeck & Co As H Crystalline base of citalopram
AU2001242298A1 (en) 2000-03-13 2001-09-24 H Lunbeck A/S Method for the preparation of citalopram
NL1017500C1 (nl) 2000-03-13 2001-04-26 Lundbeck & Co As H Werkwijze voor de bereiding van Citalopram.
WO2001068629A1 (en) * 2000-03-13 2001-09-20 H. Lundbeck A/S Stepwise alkylation of 5-substituted 1-(4-fluorophenyl)-1,3-dihydroisobenzofurans
MXPA02008653A (es) 2000-03-14 2003-02-24 Lundbeck & Co As H Metodo para la preparacion de citalopram.
CN1418206A (zh) * 2000-03-16 2003-05-14 H·隆德贝克有限公司 5－氰基－1－(4－氟苯基)－1,3－二氢异苯并呋喃的制备方法
AR032455A1 (es) 2000-05-12 2003-11-12 Lundbeck & Co As H Metodo para la preparacion de citalopram, un intermediario empleado en el metodo, un metodo para la preparacion del intermediario empleado en el metodo y composicion farmaceutica antidepresiva
FI20011622A (fi) 2000-08-18 2002-02-19 Lundbeck & Co As H Menetelmä sitalopraamin valmistamiseksi
IT1319686B1 (it) * 2000-12-12 2003-10-23 C D Farmasint S R L Procedimento di preparazione di citalopram.
SI1181713T1 (en) 2000-12-22 2005-02-28 H. Lundbeck A/S Method for the preparation of pure citalopram
TR200200018T1 (tr) 2000-12-28 2002-06-21 H. Lundbeck A/S Saf sitalopram hazırlanması için yöntem.
EP1355897A1 (en) 2001-01-30 2003-10-29 Orion Corporation Fermion Process for the preparation of 1-(3-dimethylaminopropyl)-1-(4-fluorophenyl)-1,3-dihydroisobenzofuran-5-carbonitrile
GB0105627D0 (en) * 2001-03-07 2001-04-25 Cipla Ltd Preparation of phthalanes
KR20040030609A (ko) * 2001-05-01 2004-04-09 하. 룬트벡 아크티에 셀스카브 경상이성체성 순수 에스시탈로프람의 용도
PL366995A1 (en) 2001-07-31 2005-02-07 H.Lundbeck A/S Crystalline composition containing escitalopram
ATE286037T1 (de) * 2001-08-02 2005-01-15 Infosint Sa Verfahren zur herstellung von 5-substituierten isobenzofuranen
IS7239A (is) * 2001-12-14 2004-04-29 H. Lundbeck A/S Aðferð til framleiðslu á essítalóprami
US7148364B2 (en) 2002-01-07 2006-12-12 Sun Pharmaceutical Industries Process for the preparation of 1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3-dihydro-5-isobenzofuran carbonitrile
TWI306846B (en) * 2002-08-12 2009-03-01 Lundbeck & Co As H Method for the separation of intermediates which may be used for the preparation of escitalopram
GB2385051B (en) * 2002-08-29 2003-12-24 Max India Ltd Improved process for the preparation of 5-substituted-1 (4-fluorophenyl)-1,3-dihydro isobenzofurans
US6812355B2 (en) 2002-10-22 2004-11-02 Sekhsaria Chemicals Limited Process for the manufacture of citalopram hydrobromide from 5-bromophthalide
WO2004085416A1 (en) * 2003-03-24 2004-10-07 Hetero Drugs Limited Novel crystalline forms of (s)-citalopram oxalate
EP1486492A3 (en) 2003-06-10 2005-02-23 Sun Pharmaceuticals Industries Ltd. A process for hydrogenolysis of [1-(3-dimethylamino)propyl)]-1-(4-fluorophenyl)-1,3-dihydro-5-halo-isobenzofuran.
WO2006021971A2 (en) 2004-08-23 2006-03-02 Sun Pharmaceutical Industries Limited 'process for preparation of citalopram and enantiomers'
CN111533662B (zh) * 2020-04-07 2022-08-23 福建海西新药创制有限公司 一种西酞普兰中间体的合成方法
CN114763343A (zh) * 2021-01-14 2022-07-19 浙江华海药业股份有限公司 一种西酞普兰或s-西酞普兰的纯化方法

Family Cites Families (43)

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Publication number Priority date Publication date Assignee Title
GB1143702A (da) * 1965-03-18
GB1526331A (en) * 1976-01-14 1978-09-27 Kefalas As Phthalanes
GB8419963D0 (en) 1984-08-06 1984-09-12 Lundbeck & Co As H Intermediate compound and method
GB8814057D0 (en) * 1988-06-14 1988-07-20 Lundbeck & Co As H New enantiomers & their isolation
DK213290D0 (da) 1990-09-06 1990-09-06 Lundbeck & Co As H Treatment of cerebrovascular disorders
DE19626659A1 (de) * 1996-07-03 1998-01-08 Basf Ag Verfahren zur Herstellung von Phthaliden
DE19627697A1 (de) * 1996-07-10 1998-01-15 Basf Ag Verfahren zur Herstellung von Phthaliden
ZA9711376B (en) 1996-12-20 1998-07-21 Lundbeck & Co As H Indole or dihydroindole derivatives
DE19706648A1 (de) 1997-02-20 1998-08-27 Bayer Ag Verfahren zur Herstellung von aromatischen Nitrilen
ATE205824T1 (de) * 1997-07-08 2001-10-15 Lundbeck & Co As H Verfahren zur herstellung von citalopram
UA62985C2 (en) * 1997-11-10 2004-01-15 Lunnbeck As H A method for the preparation of citalopram
TR200001341T2 (tr) 1997-11-11 2000-11-21 H. Lundbeck A/S Sitalopramın hazırlandığı metot
WO2000023431A1 (en) 1998-10-20 2000-04-27 H. Lundbeck A/S Method for the preparation of citalopram
ES2195644T3 (es) 1998-12-23 2003-12-01 Lundbeck & Co As H Metodo para la preparacion de 5-cianoftalida.
AR022329A1 (es) * 1999-01-29 2002-09-04 Lundbeck & Co As H Metodo para la preparacion de 5-cianoftalida
US6331628B1 (en) 1999-03-29 2001-12-18 Nissan Chemical Industries, Ltd. Process for the preparation of benzonitrile compounds
ES2195554T5 (es) 1999-04-14 2010-02-02 H. Lundbeck A/S Metodo para la preparacion de citalopram.
ITMI991581A1 (it) 1999-06-25 2001-01-15 Lundbeck & Co As H Metodo per la preparazione di citalopram
ITMI991579A1 (it) 1999-06-25 2001-01-15 Lundbeck & Co As H Metodo per la preparazione di citalopram
ITMI991486A1 (it) 1999-07-06 2001-01-06 Vis Farmaceutici S P A Processo per la sintesi di citalopram
AU742554B2 (en) 1999-10-25 2002-01-03 H. Lundbeck A/S Method for the preparation of citalopram
BR0014995A (pt) 1999-10-29 2002-06-18 Exxon Res And Egineering Compa Processo de oxidação parcial catalìtica
AR026063A1 (es) 1999-11-01 2002-12-26 Lundbeck & Co As H Metodo para la preparacion de 5-carboxiftalida.
US6310222B1 (en) 1999-11-01 2001-10-30 Sumika Fine Chemicals Co., Ltd. Production method of 5-phthalancarbonitrile compound, intermediate therefor and production method of the intermediate
MXPA02006503A (es) 1999-12-28 2002-12-09 Lundbeck & Co As H Metodo para la preparacion de citalopram.
EA004055B1 (ru) 1999-12-30 2003-12-25 Х.Лундбекк А/С Способ получения циталопрама
ATE252570T1 (de) 2000-01-14 2003-11-15 Lundbeck & Co As H Verfahren zur herstellung von 5-cyanophthalid
US6433196B1 (en) 2000-02-17 2002-08-13 Sumika Fine Chemicals Co., Ltd. Production method of citalopram, intermediate therefor and production method of the intermediate
IES20010143A2 (en) * 2000-02-24 2001-07-25 Lundbeck & Co As H Method for the preparation of citalopram
NL1017415C1 (nl) * 2000-02-24 2001-05-18 Lundbeck & Co As H Werkwijze voor de bereiding van Citalopram.
IES20010157A2 (en) 2000-03-03 2002-03-06 Lundbeck & Co As H Method for the preparation of citalopram
GB2357762B (en) 2000-03-13 2002-01-30 Lundbeck & Co As H Crystalline base of citalopram
AU2001242298A1 (en) 2000-03-13 2001-09-24 H Lunbeck A/S Method for the preparation of citalopram
WO2001068629A1 (en) 2000-03-13 2001-09-20 H. Lundbeck A/S Stepwise alkylation of 5-substituted 1-(4-fluorophenyl)-1,3-dihydroisobenzofurans
NL1017500C1 (nl) 2000-03-13 2001-04-26 Lundbeck & Co As H Werkwijze voor de bereiding van Citalopram.
MXPA02008653A (es) 2000-03-14 2003-02-24 Lundbeck & Co As H Metodo para la preparacion de citalopram.
CN1418206A (zh) 2000-03-16 2003-05-14 H·隆德贝克有限公司 5－氰基－1－(4－氟苯基)－1,3－二氢异苯并呋喃的制备方法
AR032455A1 (es) 2000-05-12 2003-11-12 Lundbeck & Co As H Metodo para la preparacion de citalopram, un intermediario empleado en el metodo, un metodo para la preparacion del intermediario empleado en el metodo y composicion farmaceutica antidepresiva
AU2001272368A1 (en) 2000-07-06 2002-01-21 H. Lundbeck, A/S Method for the preparation of citalopram
FI20011622A (fi) 2000-08-18 2002-02-19 Lundbeck & Co As H Menetelmä sitalopraamin valmistamiseksi
SI1181713T1 (en) 2000-12-22 2005-02-28 H. Lundbeck A/S Method for the preparation of pure citalopram
TR200200018T1 (tr) 2000-12-28 2002-06-21 H. Lundbeck A/S Saf sitalopram hazırlanması için yöntem.
PL366995A1 (en) 2001-07-31 2005-02-07 H.Lundbeck A/S Crystalline composition containing escitalopram

Also Published As

Publication number Publication date
ATE237604T1 (de) 2003-05-15
WO1999030548A2 (en) 1999-06-24
WO1999030548A3 (en) 2000-02-10
NZ514671A (en) 2003-10-31
BR9917346A (pt) 2002-02-26
WO1999030548B1 (en) 2000-03-16
US20050124817A1 (en) 2005-06-09
IL145615A0 (en) 2002-06-30
EP1173431B2 (en) 2009-08-26
DK1173431T3 (da) 2003-08-04
CA2291129A1 (en) 1999-06-24
AU759716B2 (en) 2003-04-17
HK1048122A1 (en) 2003-03-21
IS2697B (is) 2010-11-15
US7030252B2 (en) 2006-04-18
KR100604156B1 (ko) 2006-07-25
KR20010112421A (ko) 2001-12-20
AU3137899A (en) 1999-07-05
IS6091A (is) 2001-09-28
SI1173431T2 (sl) 2009-12-31
NO20015017D0 (no) 2001-10-15
ES2195554T3 (es) 2003-12-01
AR018204A1 (es) 2001-10-31
JP3798940B2 (ja) 2006-07-19
CA2291129C (en) 2002-10-22
CN1142926C (zh) 2004-03-24
SK14402001A3 (sk) 2002-04-04
US20020040153A1 (en) 2002-04-04
NO327719B1 (no) 2009-09-14
PT1173431E (pt) 2003-09-30
DE69907037T2 (de) 2004-01-29
DE69907037T3 (de) 2010-02-18
DE69907037D1 (de) 2003-05-22
CZ296537B6 (cs) 2006-04-12
SK285604B6 (sk) 2007-04-05
PL198024B1 (pl) 2008-05-30
US6849749B2 (en) 2005-02-01
HK1048122B (zh) 2005-01-14
HUP0200678A2 (hu) 2002-07-29
TR200102957T2 (tr) 2004-12-21
MXPA01010134A (es) 2002-04-15
JP2002509864A (ja) 2002-04-02
EP1173431A2 (en) 2002-01-23
SI1173431T1 (en) 2003-08-31
ITMI991580A0 (it) 1999-07-15
CN1359382A (zh) 2002-07-17
ES2195554T5 (es) 2010-02-02
ITMI991580A1 (it) 2001-01-15
EP1173431B1 (en) 2003-04-16
EA004033B1 (ru) 2003-12-25
NO20015017L (no) 2001-10-15
HUP0200678A3 (en) 2002-09-30
HU227473B1 (en) 2011-07-28
CZ20013693A3 (cs) 2002-02-13
EA200101081A1 (ru) 2002-04-25
PL350803A1 (en) 2003-02-10

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