AR016675A1 - Metodo para la preparacion de citalopram y composiciones farmaceuticas antidepresivas que comprenden el citalopram preparado. - Google Patents
Metodo para la preparacion de citalopram y composiciones farmaceuticas antidepresivas que comprenden el citalopram preparado.Info
- Publication number
- AR016675A1 AR016675A1 ARP980105658A ARP980105658A AR016675A1 AR 016675 A1 AR016675 A1 AR 016675A1 AR P980105658 A ARP980105658 A AR P980105658A AR P980105658 A ARP980105658 A AR P980105658A AR 016675 A1 AR016675 A1 AR 016675A1
- Authority
- AR
- Argentina
- Prior art keywords
- citalopram
- compound
- preparation
- pharmaceutical compositions
- antidepressive
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D307/87—Benzo [c] furans; Hydrogenated benzo [c] furans
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
- A61K31/343—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide condensed with a carbocyclic ring, e.g. coumaran, bufuralol, befunolol, clobenfurol, amiodarone
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
- C07C235/42—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C255/00—Carboxylic acid nitriles
- C07C255/49—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
- C07C255/53—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton containing cyano groups and hydroxy groups bound to the carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
- C07C69/76—Esters of carboxylic acids having a carboxyl group bound to a carbon atom of a six-membered aromatic ring
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
Se describe un método para la preparacion de citalopram que comprende la reduccion del grupo oxo de un compuesto de formula IV donde R1 es CN oalquiloxicarbonilo C1-6 o alquilaminocarbonilo C1-6, efectuando el cierre de anillos del compuesto hidroxiresultante, por el cual se obtiene elcorrespondiente 1(4-fluorfenil)1,3-dihidroisobenzofurano, entonces si R1 es ciano, usándolo directamente en el paso siguiente y si R1 es alquiloxicarboniloC1-6 o alquilaminocarbonilo C1-6, la conversion del compuesto en el compuesto correspondiente donde R1 es ciano, y la alquilacion del compuesto 5-ciano resultanto con haluro de 3-dimetil-aminopropilo en condiciones básicas por el cual se obtiene citalopram; y composiciones farmacéuticas antidepresivas quecomprendencitalopram fabricado mediante el método.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
PCT/DK1997/000511 WO1998019511A2 (en) | 1997-11-10 | 1997-11-10 | Method for the preparation of citalopram |
Publications (1)
Publication Number | Publication Date |
---|---|
AR016675A1 true AR016675A1 (es) | 2001-07-25 |
Family
ID=45606213
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ARP980105658A AR016675A1 (es) | 1997-11-10 | 1998-11-09 | Metodo para la preparacion de citalopram y composiciones farmaceuticas antidepresivas que comprenden el citalopram preparado. |
Country Status (2)
Country | Link |
---|---|
KR (1) | KR100466463B1 (es) |
AR (1) | AR016675A1 (es) |
-
1997
- 1997-11-10 KR KR10-2000-7004961A patent/KR100466463B1/ko not_active IP Right Cessation
-
1998
- 1998-11-09 AR ARP980105658A patent/AR016675A1/es unknown
Also Published As
Publication number | Publication date |
---|---|
KR20010031877A (ko) | 2001-04-16 |
KR100466463B1 (ko) | 2005-01-13 |
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Legal Events
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