AR001081A1 - Un proceso para preparar ciertos aza ciclohexapeptidos y compuestos preparados mediante dicho proceso - Google Patents

Un proceso para preparar ciertos aza ciclohexapeptidos y compuestos preparados mediante dicho proceso

Info

Publication number
AR001081A1
AR001081A1 AR33533596A AR33533596A AR001081A1 AR 001081 A1 AR001081 A1 AR 001081A1 AR 33533596 A AR33533596 A AR 33533596A AR 33533596 A AR33533596 A AR 33533596A AR 001081 A1 AR001081 A1 AR 001081A1
Authority
AR
Argentina
Prior art keywords
compounds prepared
compound
prepare certain
formula
cyclohexapeptides
Prior art date
Application number
AR33533596A
Other languages
English (en)
Original Assignee
Merck & Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck & Co Inc filed Critical Merck & Co Inc
Publication of AR001081A1 publication Critical patent/AR001081A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/50—Cyclic peptides containing at least one abnormal peptide link
    • C07K7/54—Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring
    • C07K7/56—Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring the cyclisation not occurring through 2,4-diamino-butanoic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods
    • A61B17/04—Surgical instruments, devices or methods for suturing wounds; Holders or packages for needles or suture materials
    • A61B17/06—Needles ; Sutures; Needle-suture combinations; Holders or packages for needles or suture materials
    • A61B17/06114—Packages or dispensers for needles or sutures
    • A61B17/06133—Packages or dispensers for needles or sutures of parallelepipedal shape, e.g. made of rectangular or slightly oval panels
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods
    • A61B17/04—Surgical instruments, devices or methods for suturing wounds; Holders or packages for needles or suture materials
    • A61B17/06—Needles ; Sutures; Needle-suture combinations; Holders or packages for needles or suture materials
    • A61B17/06114—Packages or dispensers for needles or sutures
    • A61B2017/06142—Packages or dispensers for needles or sutures having needle- or suture- retaining members, e.g. holding tabs or needle parks
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S930/00—Peptide or protein sequence
    • Y10S930/01—Peptide or protein sequence
    • Y10S930/27—Cyclic peptide or cyclic protein

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Surgery (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medical Informatics (AREA)
  • Dentistry (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Communicable Diseases (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Oncology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Biomedical Technology (AREA)
  • Virology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Un proceso para preparar aza ciclohexapéptidos de fórmula (I), reduciendo un compuesto de la fórmula (II) a un compuesto de la fórmula (III),convirtiendo el compuesto (III) al compuesto de fórmula (IV) y reemplazando el grupo feniltio para llegaral compuesto (I). La invención también incluyecompuestos obtenidos mediante el mencionado proceso.
AR33533596A 1995-02-10 1996-02-07 Un proceso para preparar ciertos aza ciclohexapeptidos y compuestos preparados mediante dicho proceso AR001081A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US08/386,618 US5552521A (en) 1995-02-10 1995-02-10 Process for preparing certain aza cyclohexapeptides

Publications (1)

Publication Number Publication Date
AR001081A1 true AR001081A1 (es) 1997-09-24

Family

ID=23526350

Family Applications (2)

Application Number Title Priority Date Filing Date
AR33533596A AR001081A1 (es) 1995-02-10 1996-02-07 Un proceso para preparar ciertos aza ciclohexapeptidos y compuestos preparados mediante dicho proceso
ARP970100139A AR005462A1 (es) 1995-02-10 1997-01-14 Un proceso para preparar ciertos ciclohexapeptidos y compuestos obtenidos mediante dicho procedimiento.

Family Applications After (1)

Application Number Title Priority Date Filing Date
ARP970100139A AR005462A1 (es) 1995-02-10 1997-01-14 Un proceso para preparar ciertos ciclohexapeptidos y compuestos obtenidos mediante dicho procedimiento.

Country Status (20)

Country Link
US (1) US5552521A (es)
EP (1) EP0808330B1 (es)
CN (1) CN1127515C (es)
AR (2) AR001081A1 (es)
AT (1) ATE309266T1 (es)
AU (1) AU692071B2 (es)
BR (1) BR9607721A (es)
CA (1) CA2211314C (es)
CZ (2) CZ286683B6 (es)
DE (1) DE69635405T2 (es)
EA (1) EA000564B1 (es)
ES (1) ES2249778T3 (es)
FI (1) FI120693B (es)
HR (1) HRP960054B1 (es)
HU (1) HU229780B1 (es)
NZ (1) NZ302967A (es)
SK (1) SK283115B6 (es)
TW (1) TW515805B (es)
WO (1) WO1996024613A1 (es)
YU (1) YU49459B (es)

Families Citing this family (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE69513408T2 (de) * 1994-08-23 2000-06-08 Merck & Co., Inc. Ein verbessertes verfahren für die herstellung von seitenketten-derivaten von cyclohexapeptidyl-lipopeptiden
EP0781141B1 (en) * 1994-09-16 2002-09-04 Merck & Co. Inc. Aza cyclohexapeptide compounds
US5952300A (en) * 1996-04-19 1999-09-14 Merck & Co., Inc. Antifungal compositions
HRP970318B1 (en) * 1996-06-14 2002-06-30 Merck & Co Inc A process for preparing certain aza cyclohexapeptides
US6069126A (en) * 1996-09-12 2000-05-30 Merck & Co., Inc. Antifungal combination therapy
US5936062A (en) * 1997-06-12 1999-08-10 Merck & Co., Inc. Process for preparing certain aza cyclohexapeptides
WO2000024694A1 (en) * 1998-10-28 2000-05-04 Eli Lilly And Company Photochemical process for making 1-deoxy-2-keto derivatives
AR035808A1 (es) * 2001-04-12 2004-07-14 Merck & Co Inc Proceso de deshidratacion capaz de minimizar la epimerizacion de un grupo hidroxilo por ciertas equinocandinas
US7214768B2 (en) * 2002-04-08 2007-05-08 Merck & Co., Inc. Echinocandin process
EP1785432A1 (en) * 2005-11-15 2007-05-16 Sandoz AG Process and intermediates for the synthesis of caspofungin.
JP5373606B2 (ja) 2006-07-26 2013-12-18 サンド・アクチエンゲゼルシヤフト カスポファンギン製剤
EP2170362B1 (en) 2007-06-26 2015-11-04 Merck Sharp & Dohme Corp. Lyophilized anti-fungal composition
US20090075870A1 (en) * 2007-09-17 2009-03-19 Protia, Llc Deuterium-enriched caspofungin
WO2009142761A1 (en) * 2008-05-21 2009-11-26 Teva Gyogyszergyar Zartkoruen Mukodo Reszvenytarsasag Caspofungin bo free of caspofungin co
US8048853B2 (en) 2008-06-13 2011-11-01 Xellia Pharmaceuticals Aps Process for preparing pharmaceutical compound and intermediates thereof
US20100256074A1 (en) * 2008-06-25 2010-10-07 Chaim Eidelman Processes for preparing high purity aza cyclohexapeptides
WO2009158034A1 (en) * 2008-06-25 2009-12-30 Teva Gyogyszergyar Zartkoruen Mukodo Reszvenytarsasag Caspofungin free of caspofungin impurity a
WO2010064219A1 (en) 2008-12-04 2010-06-10 Ranbaxy Laboratories Limited Process for the preparation of a novel intermediate for caspofungin
EP2463293A4 (en) * 2009-08-06 2013-06-05 Shanghai Techwell Biopharm Co AZACYCLOHEXAPEPTIDE BZW. ITS PHARMACEUTICAL ACCEPTABLE SALT, MANUFACTURING PROCESS AND USE
CN101792486A (zh) * 2010-04-12 2010-08-04 浙江海正药业股份有限公司 一种合成醋酸卡泊芬净的方法
CN102219832B (zh) 2010-04-15 2013-08-21 上海天伟生物制药有限公司 一种氮杂环六肽或其盐的纯化方法
CN103180336B (zh) * 2010-09-28 2016-06-15 中化帝斯曼制药有限公司荷兰公司 用于分离环六肽的方法
US8927690B2 (en) * 2010-09-29 2015-01-06 Shanghai Techwell Biopharmaceutical Co., Ltd. Process for purifying cyclolipopeptide compounds or the salts thereof
CN102367267B (zh) * 2010-11-10 2013-09-04 上海天伟生物制药有限公司 一种卡泊芬净的制备方法
CN102367268B (zh) 2010-11-10 2013-11-06 上海天伟生物制药有限公司 一种卡泊芬净类似物及其用途
CN102367269B (zh) 2010-11-10 2013-11-06 上海天伟生物制药有限公司 一种卡泊芬净类似物及其制备方法和用途
KR101331984B1 (ko) 2010-12-09 2013-11-25 종근당바이오 주식회사 카스포펀진 제조방법 및 그의 신규 중간체
CN102219833A (zh) * 2011-04-18 2011-10-19 深圳市健元医药科技有限公司 一种更加安全的棘白菌类抗真菌药的制备方法
CN102746384B (zh) 2011-04-22 2016-01-20 上海天伟生物制药有限公司 一种高纯度的卡泊芬净或其盐及其制备方法和用途
WO2012146099A1 (zh) 2011-04-28 2012-11-01 上海源力生物技术有限公司 用于合成卡帕芬净的中间体及其制备方法
CN103483426A (zh) * 2012-06-14 2014-01-01 博瑞生物医药技术(苏州)有限公司 一种氮杂环己肽的制备方法
PL2922530T3 (pl) 2012-11-20 2017-04-28 Fresenius Kabi Usa, Llc Formulacje octanu kaspofunginy
EP3620462A1 (en) 2018-09-04 2020-03-11 Xellia Pharmaceuticals ApS Process for the preparation of caspofungin

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2704030A1 (de) * 1976-02-12 1977-08-18 Sandoz Ag Neue organische verbindungen, ihre herstellung und verwendung
IE910892A1 (en) * 1990-03-19 1991-09-25 Merck & Co Inc Lipopeptide compounds
US5939384A (en) * 1991-10-01 1999-08-17 Merck & Co., Inc. Cyclohexapeptidyl propanolamine compounds
US5378804A (en) * 1993-03-16 1995-01-03 Merck & Co., Inc. Aza cyclohexapeptide compounds
US6268338B1 (en) * 1993-04-30 2001-07-31 Merck & Co., Inc. Cyclohexapeptidyl amine compounds
DE69513408T2 (de) * 1994-08-23 2000-06-08 Merck & Co., Inc. Ein verbessertes verfahren für die herstellung von seitenketten-derivaten von cyclohexapeptidyl-lipopeptiden
EP0781141B1 (en) * 1994-09-16 2002-09-04 Merck & Co. Inc. Aza cyclohexapeptide compounds

Also Published As

Publication number Publication date
DE69635405T2 (de) 2006-07-27
BR9607721A (pt) 1998-07-14
YU49459B (sh) 2006-03-03
CZ286767B6 (cs) 2000-06-14
FI973281A0 (fi) 1997-08-08
AU692071B2 (en) 1998-05-28
WO1996024613A1 (en) 1996-08-15
DE69635405D1 (de) 2005-12-15
EA199700170A1 (ru) 1997-12-30
CN1173875A (zh) 1998-02-18
YU8496A (sh) 1999-06-15
HK1004676A1 (en) 1998-12-04
FI120693B (fi) 2010-01-29
ATE309266T1 (de) 2005-11-15
CN1127515C (zh) 2003-11-12
HUP9901085A3 (en) 2000-11-28
ES2249778T3 (es) 2006-04-01
HRP960054A2 (en) 1997-10-31
HU229780B1 (en) 2014-07-28
FI973281L (fi) 1997-08-08
CA2211314C (en) 2007-04-17
AR005462A1 (es) 1999-06-23
AU4914796A (en) 1996-08-27
HRP960054B1 (en) 2008-07-31
EP0808330B1 (en) 2005-11-09
CZ286683B6 (en) 2000-06-14
CZ252597A3 (cs) 1998-01-14
TW515805B (en) 2003-01-01
MX9706101A (es) 1997-10-31
EA000564B1 (ru) 1999-12-29
HUP9901085A2 (hu) 1999-09-28
NZ302967A (en) 1998-11-25
CA2211314A1 (en) 1996-08-15
SK283115B6 (sk) 2003-02-04
US5552521A (en) 1996-09-03
SK107997A3 (en) 1998-02-04
EP0808330A1 (en) 1997-11-26

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