YU8496A - Postupak za dobijanje aza cikloheksapeptida - Google Patents

Postupak za dobijanje aza cikloheksapeptida

Info

Publication number
YU8496A
YU8496A YU8496A YU8496A YU8496A YU 8496 A YU8496 A YU 8496A YU 8496 A YU8496 A YU 8496A YU 8496 A YU8496 A YU 8496A YU 8496 A YU8496 A YU 8496A
Authority
YU
Yugoslavia
Prior art keywords
preparation
amine
azacyclohexapeptides
compound
formula
Prior art date
Application number
YU8496A
Other languages
English (en)
Other versions
YU49459B (sh
Inventor
Kevin Belyk
Dean R. Bender
Regina M. Black
David L. Hughes
William Leonard
Original Assignee
Merck & Co.Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck & Co.Inc. filed Critical Merck & Co.Inc.
Publication of YU8496A publication Critical patent/YU8496A/sh
Publication of YU49459B publication Critical patent/YU49459B/sh

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/50—Cyclic peptides containing at least one abnormal peptide link
    • C07K7/54—Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring
    • C07K7/56—Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring the cyclisation not occurring through 2,4-diamino-butanoic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/04—Surgical instruments, devices or methods, e.g. tourniquets for suturing wounds; Holders or packages for needles or suture materials
    • A61B17/06—Needles ; Sutures; Needle-suture combinations; Holders or packages for needles or suture materials
    • A61B17/06114—Packages or dispensers for needles or sutures
    • A61B17/06133—Packages or dispensers for needles or sutures of parallelepipedal shape, e.g. made of rectangular or slightly oval panels
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/04—Surgical instruments, devices or methods, e.g. tourniquets for suturing wounds; Holders or packages for needles or suture materials
    • A61B17/06—Needles ; Sutures; Needle-suture combinations; Holders or packages for needles or suture materials
    • A61B17/06114—Packages or dispensers for needles or sutures
    • A61B2017/06142—Packages or dispensers for needles or sutures having needle- or suture- retaining members, e.g. holding tabs or needle parks
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S930/00—Peptide or protein sequence
    • Y10S930/01—Peptide or protein sequence
    • Y10S930/27—Cyclic peptide or cyclic protein

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Surgery (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medical Informatics (AREA)
  • Dentistry (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Communicable Diseases (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Oncology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Biomedical Technology (AREA)
  • Virology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Opisan je nov postupak za dobijanje aza cikloheksapeptida formule: gde su sve promenljive veličine definisane u opisu. Ovaj postupak obuhvata stupnjeve: a) redukciju amida boran kompleksom do amina b) reakciju amina sa tiofenolom u acetonitrilu i sa trifluorsirćetnom kiselinom do fenilsulfida c) stereoselektivno konvertovanje ovog jedinjenja dislociranjem feniltio grupe do jedinjenja formule I.
YU8496A 1995-02-10 1996-02-09 Postupak za dobijanje azacikloheksapeptida YU49459B (sh)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US08/386,618 US5552521A (en) 1995-02-10 1995-02-10 Process for preparing certain aza cyclohexapeptides

Publications (2)

Publication Number Publication Date
YU8496A true YU8496A (sh) 1999-06-15
YU49459B YU49459B (sh) 2006-03-03

Family

ID=23526350

Family Applications (1)

Application Number Title Priority Date Filing Date
YU8496A YU49459B (sh) 1995-02-10 1996-02-09 Postupak za dobijanje azacikloheksapeptida

Country Status (21)

Country Link
US (1) US5552521A (sh)
EP (1) EP0808330B1 (sh)
CN (1) CN1127515C (sh)
AR (2) AR001081A1 (sh)
AT (1) ATE309266T1 (sh)
AU (1) AU692071B2 (sh)
BR (1) BR9607721A (sh)
CA (1) CA2211314C (sh)
CZ (2) CZ286683B6 (sh)
DE (1) DE69635405T2 (sh)
EA (1) EA000564B1 (sh)
ES (1) ES2249778T3 (sh)
FI (1) FI120693B (sh)
HK (1) HK1004676A1 (sh)
HR (1) HRP960054B1 (sh)
HU (1) HU229780B1 (sh)
NZ (1) NZ302967A (sh)
SK (1) SK283115B6 (sh)
TW (1) TW515805B (sh)
WO (1) WO1996024613A1 (sh)
YU (1) YU49459B (sh)

Families Citing this family (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU692043B2 (en) * 1994-08-23 1998-05-28 Merck & Co., Inc. An improved process for preparing side chain derivatives of cyclohexapeptidyl lipopeptides
JP3657989B2 (ja) * 1994-09-16 2005-06-08 メルク エンド カンパニー インコーポレーテッド アザシクロヘキサペプチド化合物
US5952300A (en) * 1996-04-19 1999-09-14 Merck & Co., Inc. Antifungal compositions
HRP970318B1 (en) * 1996-06-14 2002-06-30 Merck & Co Inc A process for preparing certain aza cyclohexapeptides
US6069126A (en) * 1996-09-12 2000-05-30 Merck & Co., Inc. Antifungal combination therapy
US5936062A (en) * 1997-06-12 1999-08-10 Merck & Co., Inc. Process for preparing certain aza cyclohexapeptides
AU1517900A (en) * 1998-10-28 2000-05-15 Eli Lilly And Company Photochemical process for making 1-deoxy-2-keto derivatives
AR035808A1 (es) * 2001-04-12 2004-07-14 Merck & Co Inc Proceso de deshidratacion capaz de minimizar la epimerizacion de un grupo hidroxilo por ciertas equinocandinas
US7214768B2 (en) * 2002-04-08 2007-05-08 Merck & Co., Inc. Echinocandin process
EP1785432A1 (en) * 2005-11-15 2007-05-16 Sandoz AG Process and intermediates for the synthesis of caspofungin.
EP2340846A1 (en) 2006-07-26 2011-07-06 Sandoz Ag Caspofungin formulations
US20100137197A1 (en) * 2007-06-26 2010-06-03 Sachin Mittal Lyophilized anti-fungal composition
US20090075870A1 (en) * 2007-09-17 2009-03-19 Protia, Llc Deuterium-enriched caspofungin
US20090291996A1 (en) * 2008-05-21 2009-11-26 Ferenc Korodi Caspofungin free of caspofungin Co
US8048853B2 (en) * 2008-06-13 2011-11-01 Xellia Pharmaceuticals Aps Process for preparing pharmaceutical compound and intermediates thereof
US20100256074A1 (en) * 2008-06-25 2010-10-07 Chaim Eidelman Processes for preparing high purity aza cyclohexapeptides
EP2183271A1 (en) * 2008-06-25 2010-05-12 TEVA Gyógyszergyár Zártkörüen Müködö Részvénytársaság Caspofungin free of caspofungin impurity a
WO2010064219A1 (en) 2008-12-04 2010-06-10 Ranbaxy Laboratories Limited Process for the preparation of a novel intermediate for caspofungin
WO2011014990A1 (zh) * 2009-08-06 2011-02-10 上海天伟生物制药有限公司 一种氮杂环己肽或其药学上可接受的盐及其制备方法和用途
CN101792486A (zh) * 2010-04-12 2010-08-04 浙江海正药业股份有限公司 一种合成醋酸卡泊芬净的方法
CN102219832B (zh) 2010-04-15 2013-08-21 上海天伟生物制药有限公司 一种氮杂环六肽或其盐的纯化方法
US9056897B2 (en) * 2010-09-28 2015-06-16 DSM Sinochem Pharmaceuticals Method for isolating a cyclohexapeptide
CA2813330A1 (en) * 2010-09-29 2012-04-05 Shanghai Techwell Biopharmaceutical Co., Ltd. Process for purifying cyclolipopeptide compounds or the salts thereof
CN102367267B (zh) 2010-11-10 2013-09-04 上海天伟生物制药有限公司 一种卡泊芬净的制备方法
CN102367268B (zh) 2010-11-10 2013-11-06 上海天伟生物制药有限公司 一种卡泊芬净类似物及其用途
CN102367269B (zh) * 2010-11-10 2013-11-06 上海天伟生物制药有限公司 一种卡泊芬净类似物及其制备方法和用途
KR101331984B1 (ko) 2010-12-09 2013-11-25 종근당바이오 주식회사 카스포펀진 제조방법 및 그의 신규 중간체
CN102219833A (zh) * 2011-04-18 2011-10-19 深圳市健元医药科技有限公司 一种更加安全的棘白菌类抗真菌药的制备方法
CN102746384B (zh) * 2011-04-22 2016-01-20 上海天伟生物制药有限公司 一种高纯度的卡泊芬净或其盐及其制备方法和用途
CA2833206A1 (en) * 2011-04-28 2012-11-01 Unitris Biopharma Co., Ltd. Intermediate for synthesizing caspofungin and preparation method therefor
CN103483426A (zh) * 2012-06-14 2014-01-01 博瑞生物医药技术(苏州)有限公司 一种氮杂环己肽的制备方法
PL2922530T3 (pl) 2012-11-20 2017-04-28 Fresenius Kabi Usa, Llc Formulacje octanu kaspofunginy
EP3620462A1 (en) 2018-09-04 2020-03-11 Xellia Pharmaceuticals ApS Process for the preparation of caspofungin

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2704030A1 (de) * 1976-02-12 1977-08-18 Sandoz Ag Neue organische verbindungen, ihre herstellung und verwendung
IE910892A1 (en) * 1990-03-19 1991-09-25 Merck & Co Inc Lipopeptide compounds
US5939384A (en) * 1991-10-01 1999-08-17 Merck & Co., Inc. Cyclohexapeptidyl propanolamine compounds
US5378804A (en) * 1993-03-16 1995-01-03 Merck & Co., Inc. Aza cyclohexapeptide compounds
US6268338B1 (en) * 1993-04-30 2001-07-31 Merck & Co., Inc. Cyclohexapeptidyl amine compounds
AU692043B2 (en) * 1994-08-23 1998-05-28 Merck & Co., Inc. An improved process for preparing side chain derivatives of cyclohexapeptidyl lipopeptides
JP3657989B2 (ja) * 1994-09-16 2005-06-08 メルク エンド カンパニー インコーポレーテッド アザシクロヘキサペプチド化合物

Also Published As

Publication number Publication date
WO1996024613A1 (en) 1996-08-15
EP0808330B1 (en) 2005-11-09
CZ252597A3 (cs) 1998-01-14
YU49459B (sh) 2006-03-03
AR005462A1 (es) 1999-06-23
AU4914796A (en) 1996-08-27
ATE309266T1 (de) 2005-11-15
CA2211314A1 (en) 1996-08-15
DE69635405D1 (de) 2005-12-15
AR001081A1 (es) 1997-09-24
CZ286767B6 (cs) 2000-06-14
EA199700170A1 (ru) 1997-12-30
ES2249778T3 (es) 2006-04-01
HRP960054B1 (en) 2008-07-31
CN1127515C (zh) 2003-11-12
HU229780B1 (en) 2014-07-28
US5552521A (en) 1996-09-03
CA2211314C (en) 2007-04-17
CZ286683B6 (en) 2000-06-14
BR9607721A (pt) 1998-07-14
EP0808330A1 (en) 1997-11-26
HUP9901085A2 (hu) 1999-09-28
DE69635405T2 (de) 2006-07-27
FI973281A0 (fi) 1997-08-08
HRP960054A2 (en) 1997-10-31
EA000564B1 (ru) 1999-12-29
AU692071B2 (en) 1998-05-28
HK1004676A1 (en) 1998-12-04
FI120693B (fi) 2010-01-29
MX9706101A (es) 1997-10-31
FI973281A (fi) 1997-08-08
NZ302967A (en) 1998-11-25
HUP9901085A3 (en) 2000-11-28
CN1173875A (zh) 1998-02-18
SK107997A3 (en) 1998-02-04
TW515805B (en) 2003-01-01
SK283115B6 (sk) 2003-02-04

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