NZ504192A - Method for the preparation of citalopram - Google Patents

Method for the preparation of citalopram

Info

Publication number
NZ504192A
NZ504192A NZ504192A NZ50419297A NZ504192A NZ 504192 A NZ504192 A NZ 504192A NZ 504192 A NZ504192 A NZ 504192A NZ 50419297 A NZ50419297 A NZ 50419297A NZ 504192 A NZ504192 A NZ 504192A
Authority
NZ
New Zealand
Prior art keywords
formula
compound
citalopram
cyano
preparation
Prior art date
Application number
NZ504192A
Inventor
Hans Petersen
Klaus Peter Bogeso
Sommer Michael Beck
Original Assignee
H
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by H filed Critical H
Priority to NZ504192A priority Critical patent/NZ504192A/en
Priority claimed from PCT/DK1997/000511 external-priority patent/WO1998019511A2/en
Publication of NZ504192A publication Critical patent/NZ504192A/en

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Abstract

Described is a method for the preparation of citalopram, shown as formula (I), comprising the steps of: (a) reduction of a compound of formula (IV), wherein R1 is CN, C1-6alkyloxycarbonyl or C1 6alkylaminocarbonyl, (b) effecting ring closure of the resulting compound of formula (V), wherein R1 is as defined above, thereby obtaining a compound of formula (VI), wherein R1 is as defined above, (c) then if R1 is cyano, using the compound of formula (VI) directly in the next step and if R1 is C1-6alkyloxycarbonyl or C1-6alkylaminocarbonyl, converting the compound of formula (VI) to the corresponding compound wherein R1 is cyano, (d) alkylating the resulting 5-cyano compound of formula (VI) (R1=CN) with 3 dimethylaminopropylhalogenide in basic conditions, thereby obtaining citalopram.
NZ504192A 1997-11-10 1997-11-10 Method for the preparation of citalopram NZ504192A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
NZ504192A NZ504192A (en) 1997-11-10 1997-11-10 Method for the preparation of citalopram

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
NZ504192A NZ504192A (en) 1997-11-10 1997-11-10 Method for the preparation of citalopram
PCT/DK1997/000511 WO1998019511A2 (en) 1997-11-10 1997-11-10 Method for the preparation of citalopram

Publications (1)

Publication Number Publication Date
NZ504192A true NZ504192A (en) 2002-12-20

Family

ID=19927853

Family Applications (1)

Application Number Title Priority Date Filing Date
NZ504192A NZ504192A (en) 1997-11-10 1997-11-10 Method for the preparation of citalopram

Country Status (1)

Country Link
NZ (1) NZ504192A (en)

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