EA201000496A1 - Замещенное соединение миноциклина, способ получения замещенных соединений миноциклина (варианты) - Google Patents

Замещенное соединение миноциклина, способ получения замещенных соединений миноциклина (варианты)

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Publication number
EA201000496A1
EA201000496A1 EA201000496A EA201000496A EA201000496A1 EA 201000496 A1 EA201000496 A1 EA 201000496A1 EA 201000496 A EA201000496 A EA 201000496A EA 201000496 A EA201000496 A EA 201000496A EA 201000496 A1 EA201000496 A1 EA 201000496A1
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EA
Eurasian Patent Office
Prior art keywords
substituted minocycline
options
compounds
obtaining
substituted
Prior art date
Application number
EA201000496A
Other languages
English (en)
Inventor
Тодд Баузер
Бина Бхатиа
Атул Верма
Питер Виски
Джимми Дьюморней
Мохамед Измаил
Дэррелл Коуза
Гуй Лю
Лора Макинтайр
Марк Л. Нельсон
Глен Ренни
Карен Стэплетон
Тэд Уорчол
Роджер Фречетт
Пол Хокинс
Пол Шихэн
Original Assignee
Трастис Оф Тафтс Коллидж
Пэрэтек Фамэсьютикэлс, Инк.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Application filed by Трастис Оф Тафтс Коллидж, Пэрэтек Фамэсьютикэлс, Инк. filed Critical Трастис Оф Тафтс Коллидж
Publication of EA201000496A1 publication Critical patent/EA201000496A1/ru

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • C07C237/26—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a ring other than a six-membered aromatic ring of the carbon skeleton of a ring being part of a condensed ring system formed by at least four rings, e.g. tetracycline
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    • C07C255/59—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton containing cyano groups and singly-bound nitrogen atoms, not being further bound to other hetero atoms, bound to the carbon skeleton the carbon skeleton being further substituted by singly-bound oxygen atoms
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    • C07C271/30—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atom of at least one of the carbamate groups bound to a carbon atom of a six-membered aromatic ring to a carbon atom of a six-membered aromatic ring being part of a condensed ring system
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Abstract

Настоящее изобретение относится, по крайней мере частично, к новым 9-замещенным соединениям миноциклина, а также к способам их получения. В частности, настоящее изобретение относится к способам получения 9-аризамещенных и 9-аминометилзамещенных соединений миноциклина.
EA201000496A 2000-07-07 2001-06-29 Замещенное соединение миноциклина, способ получения замещенных соединений миноциклина (варианты) EA201000496A1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US21665900P 2000-07-07 2000-07-07
US27562101P 2001-03-13 2001-03-13

Publications (1)

Publication Number Publication Date
EA201000496A1 true EA201000496A1 (ru) 2010-10-29

Family

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Family Applications (3)

Application Number Title Priority Date Filing Date
EA200401579A EA013908B1 (ru) 2000-07-07 2001-06-29 Замещенные соединения миноциклина (варианты), фармацевтическая композиция и способ лечения чувствительного к тетрациклину состояния млекопитающего
EA201000496A EA201000496A1 (ru) 2000-07-07 2001-06-29 Замещенное соединение миноциклина, способ получения замещенных соединений миноциклина (варианты)
EA200300135A EA009175B1 (ru) 2000-07-07 2001-06-29 Замещенные соединения миноциклина, фармацевтическая композиция и способ лечения чувствительного к тетрациклину состояния млекопитающего

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EA200401579A EA013908B1 (ru) 2000-07-07 2001-06-29 Замещенные соединения миноциклина (варианты), фармацевтическая композиция и способ лечения чувствительного к тетрациклину состояния млекопитающего

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Country Status (24)

Country Link
US (5) US6846939B2 (ru)
EP (4) EP1301467B1 (ru)
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EP2308832B8 (en) 2019-04-24
ES2701599T3 (es) 2019-02-25
HUP0301169A3 (en) 2009-08-28
EP1301467B1 (en) 2006-08-16
EP1679305B1 (en) 2012-02-08
CZ303702B6 (cs) 2013-03-20
AU2009201857B9 (en) 2012-05-10
TWI299038B (en) 2008-07-21
US20030125348A1 (en) 2003-07-03
KR100674047B1 (ko) 2007-01-25
CZ2003344A3 (cs) 2003-05-14
DE60122341D1 (de) 2006-09-28
JP2004502752A (ja) 2004-01-29
HU229577B1 (en) 2014-02-28
CA2415178A1 (en) 2002-01-17
IL177854A (en) 2013-02-28
IL177854A0 (en) 2006-12-31
JP2012107045A (ja) 2012-06-07
KR20030017610A (ko) 2003-03-03
AU2005201623A1 (en) 2005-05-05
US9090541B2 (en) 2015-07-28
CN1690047A (zh) 2005-11-02
EA200300135A1 (ru) 2003-06-26
ES2271070T3 (es) 2007-04-16
AU2009201857B2 (en) 2011-12-22
ATE336481T1 (de) 2006-09-15
DK1679305T3 (da) 2012-05-29
US20150265635A1 (en) 2015-09-24
EA009175B1 (ru) 2007-12-28
EP1679305A1 (en) 2006-07-12
BRPI0112269B8 (pt) 2021-05-25
DE60122341T2 (de) 2007-08-09
ZA200300749B (en) 2005-08-31
WO2002004406A3 (en) 2002-06-06
JP5037436B2 (ja) 2012-09-26
EA200401579A1 (ru) 2005-06-30
IL153639A0 (en) 2003-07-06
AU2009201857A8 (en) 2011-01-06
US6846939B2 (en) 2005-01-25
JP4925549B2 (ja) 2012-04-25
EP3461808A1 (en) 2019-04-03
TWI305528B (en) 2009-01-21
MXPA03000055A (es) 2003-07-14
KR100699390B1 (ko) 2007-03-28
US20040214801A1 (en) 2004-10-28
CN1690047B (zh) 2010-10-06
EP2308832B1 (en) 2018-09-12
JP2009029785A (ja) 2009-02-12
CN100473644C (zh) 2009-04-01
CY1107524T1 (el) 2013-03-13
US8048867B2 (en) 2011-11-01
TW200519070A (en) 2005-06-16
BRPI0112269B1 (pt) 2016-07-05
CA2415178C (en) 2010-05-25
AU8638801A (en) 2002-01-21
HRP20030091B1 (en) 2011-10-31
HUP0301169A2 (hu) 2003-08-28
HRP20030091A2 (en) 2005-02-28
PT1301467E (pt) 2006-12-29
EP2308832A1 (en) 2011-04-13
AU2005201623B2 (en) 2009-02-12
BR0112269A (pt) 2003-07-01
DK1301467T3 (da) 2006-12-27
CN1471509A (zh) 2004-01-28
EA013908B1 (ru) 2010-08-30
KR20060014446A (ko) 2006-02-15
AU2005201623B8 (en) 2009-03-12
SI1301467T1 (sl) 2007-02-28
US20120283201A1 (en) 2012-11-08
AU2001286388B2 (en) 2005-07-14
AU2009201857A1 (en) 2009-06-04
EP1301467A2 (en) 2003-04-16
WO2002004406A2 (en) 2002-01-17
ATE544745T1 (de) 2012-02-15
US8258120B2 (en) 2012-09-04

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