ECSP056218A - Metodo para la produccion de compuestos de 3-aryl-butil-amina substituidos. - Google Patents

Metodo para la produccion de compuestos de 3-aryl-butil-amina substituidos.

Info

Publication number
ECSP056218A
ECSP056218A EC2005006218A ECSP056218A ECSP056218A EC SP056218 A ECSP056218 A EC SP056218A EC 2005006218 A EC2005006218 A EC 2005006218A EC SP056218 A ECSP056218 A EC SP056218A EC SP056218 A ECSP056218 A EC SP056218A
Authority
EC
Ecuador
Prior art keywords
aryl
substituted
compound
compounds
butil
Prior art date
Application number
EC2005006218A
Other languages
English (en)
Inventor
Wolfgang Hell
Marcus Kegel
Bernhard Akteries
Helmut Buschmann
Joerg Holenz
Hartmut Lobermann
Detlef Detlef Heller
Hans-Joachim Drexler
Stefan Gladow
Original Assignee
Gruenenthal Chemie
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=33494923&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ECSP056218(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Gruenenthal Chemie filed Critical Gruenenthal Chemie
Publication of ECSP056218A publication Critical patent/ECSP056218A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C217/00—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
    • C07C217/54—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
    • C07C217/64—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by carbon chains further substituted by singly-bound oxygen atoms
    • C07C217/66—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by carbon chains further substituted by singly-bound oxygen atoms with singly-bound oxygen atoms and six-membered aromatic rings bound to the same carbon atom of the carbon chain
    • C07C217/72—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by carbon chains further substituted by singly-bound oxygen atoms with singly-bound oxygen atoms and six-membered aromatic rings bound to the same carbon atom of the carbon chain linked by carbon chains having at least three carbon atoms between the amino groups and the six-membered aromatic ring or the condensed ring system containing that ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C209/00—Preparation of compounds containing amino groups bound to a carbon skeleton
    • C07C209/68—Preparation of compounds containing amino groups bound to a carbon skeleton from amines, by reactions not involving amino groups, e.g. reduction of unsaturated amines, aromatisation, or substitution of the carbon skeleton
    • C07C209/70—Preparation of compounds containing amino groups bound to a carbon skeleton from amines, by reactions not involving amino groups, e.g. reduction of unsaturated amines, aromatisation, or substitution of the carbon skeleton by reduction of unsaturated amines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C211/00—Compounds containing amino groups bound to a carbon skeleton
    • C07C211/01—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms
    • C07C211/26—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms of an unsaturated carbon skeleton containing at least one six-membered aromatic ring
    • C07C211/27—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms of an unsaturated carbon skeleton containing at least one six-membered aromatic ring having amino groups linked to the six-membered aromatic ring by saturated carbon chains
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C211/00—Compounds containing amino groups bound to a carbon skeleton
    • C07C211/01—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms
    • C07C211/26—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms of an unsaturated carbon skeleton containing at least one six-membered aromatic ring
    • C07C211/28—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms of an unsaturated carbon skeleton containing at least one six-membered aromatic ring having amino groups linked to the six-membered aromatic ring by unsaturated carbon chains
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C213/00—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton
    • C07C213/08—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton by reactions not involving the formation of amino groups, hydroxy groups or etherified or esterified hydroxy groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C215/00—Compounds containing amino and hydroxy groups bound to the same carbon skeleton
    • C07C215/46—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
    • C07C215/56—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by carbon chains further substituted by hydroxy groups
    • C07C215/58—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by carbon chains further substituted by hydroxy groups with hydroxy groups and the six-membered aromatic ring, or the condensed ring system containing that ring, bound to the same carbon atom of the carbon chain
    • C07C215/62—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by carbon chains further substituted by hydroxy groups with hydroxy groups and the six-membered aromatic ring, or the condensed ring system containing that ring, bound to the same carbon atom of the carbon chain the chain having at least three carbon atoms between the amino groups and the six-membered aromatic ring or the condensed ring system containing that ring

Abstract

La presente invención se refiere a un procedimiento para la deshidratación de compuestos 1-amino-3-aril-butan-3-ol substituidos para preparar compuestos 3-aril-butil-amina substituidos.El procedimiento se utiliza en una primera etapa (s) un comuesto 1-amino-3-aril-butan-3-ol de la fórmula general II, opcionalmente en la forma de uno de sus estereoisómeros puros, en particular enantiómeros o diastereómeros, sus racematos o en la forma de mezcla de estereoisómeros, una sal farmacéuticamente aceptable o como un solvato, efectuándose la eliminación bajo la acción de un ácido para entregar un compuesto substituido de la fórmula general III y luego, en una segunda etapa (b) se hidrogena el mencionado compuesto de la fórmula III en presencia de un catalizador metálico, preferentemente paladio sobre carbón vegetal activado, para entregar el compuesto requerido.
EC2005006218A 2003-06-06 2005-12-13 Metodo para la produccion de compuestos de 3-aryl-butil-amina substituidos. ECSP056218A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE10326097A DE10326097A1 (de) 2003-06-06 2003-06-06 Verfahren zur Herstellung von Dimethyl-(3-aryl-butyl)-aminverbindungen

Publications (1)

Publication Number Publication Date
ECSP056218A true ECSP056218A (es) 2006-04-19

Family

ID=33494923

Family Applications (1)

Application Number Title Priority Date Filing Date
EC2005006218A ECSP056218A (es) 2003-06-06 2005-12-13 Metodo para la produccion de compuestos de 3-aryl-butil-amina substituidos.

Country Status (26)

Country Link
US (1) US7417170B2 (es)
EP (1) EP1633697B1 (es)
JP (1) JP4848268B2 (es)
KR (1) KR101146205B1 (es)
CN (1) CN1829681B (es)
AT (1) ATE425136T1 (es)
AU (1) AU2004245223C1 (es)
BR (1) BRPI0411268C8 (es)
CA (1) CA2528087C (es)
CY (1) CY1109088T1 (es)
DE (2) DE10326097A1 (es)
DK (1) DK1633697T3 (es)
EC (1) ECSP056218A (es)
ES (1) ES2323870T3 (es)
HK (1) HK1088597A1 (es)
HR (1) HRP20090333T1 (es)
IL (1) IL172357A (es)
MX (1) MXPA05013193A (es)
NO (1) NO335587B1 (es)
NZ (1) NZ544231A (es)
PL (1) PL1633697T3 (es)
PT (1) PT1633697E (es)
RU (1) RU2380355C2 (es)
SI (1) SI1633697T1 (es)
WO (1) WO2004108658A1 (es)
ZA (1) ZA200600109B (es)

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DE10328316A1 (de) 2003-06-23 2005-01-20 Grünenthal GmbH Verfahren zur Herstellung von Dimethyl-(3-aryl-buthyl)-aminverbindungen als pharmazeutische Wirkstoffe
DE102005052588A1 (de) 2005-11-02 2007-05-10 Grünenthal GmbH Verfahren zur Herstellung substituierter Dimethyl-(3-aryl-butyl)-amin-Verbindungen mittels homogener Katalyse
TWI401237B (zh) 2006-07-24 2013-07-11 ３-〔（１ｒ，２ｒ）-３-（二甲基氨基）-１-乙基-２-甲基丙基〕酚之製備
TWI496762B (zh) 2006-07-24 2015-08-21 製備（１ｒ，２ｒ）-３-（３-二甲胺基-１-乙基-２-甲基-丙基）-酚之方法
ES2339403T3 (es) 2006-07-24 2010-05-19 Janssen Pharmaceutica Nv Preparacion de (2r,3r)-3-(3-metoxifenil)-n,n,2-trimetilpentanamina.
PL2240431T3 (pl) * 2007-12-07 2017-07-31 Grünenthal GmbH Krystaliczne modyfikacje (1R,2R)-3-(3-dimetyloamino-1-etylo-2-metyIopropylo)fenoIu
US20100227921A1 (en) * 2009-03-03 2010-09-09 Shire Llc Amino acid and peptide carbamate prodrugs of tapentadol and uses thereof
CN102002065B (zh) * 2009-09-02 2014-09-10 上海特化医药科技有限公司 他喷他多的制备方法及其中间体
US8288592B2 (en) 2009-09-22 2012-10-16 Actavis Group Ptc Ehf Solid state forms of tapentadol salts
IT1397189B1 (it) * 2009-12-01 2013-01-04 Archimica Srl Nuovo processo per la preparazione di tapentadol e suoi intermedi.
BR112012016059A2 (pt) 2009-12-29 2015-09-01 Mapi Pharma Ltd "compostos intermediários e processos para a preparação de tapentadol e compostos relacionados".
WO2011092719A2 (en) * 2010-02-01 2011-08-04 Ind-Swift Laboratories Limited Process for the preparation of l-phenyl-3-dimethylaminopropane derivatives
US20130096346A1 (en) 2010-03-05 2013-04-18 Actavis Group Ptc Ehf Resolution methods for isolating desired enantiomers of tapentadol intermediates and use thereof for the preparation of tapentadol
WO2011128784A2 (en) 2010-04-05 2011-10-20 Actavis Group Ptc Ehf Novel process for preparing highly pure tapentadol or a pharmaceutically acceptable salt thereof
ITMI20100924A1 (it) * 2010-05-21 2011-11-22 Fidia Farmaceutici Nuovo metodo di sintesi delle due forme enantiomeriche del tapentadol
CN104725245A (zh) * 2010-06-15 2015-06-24 格吕伦塔尔有限公司 用于制备取代的3-(1-氨基-2-甲基戊烷-3-基)苯基化合物的方法
IT1401109B1 (it) 2010-07-02 2013-07-12 Archimica Srl Nuovo processo per la preparazione di tapentadol e suoi intermedi.
PT3650439T (pt) * 2010-07-23 2021-03-03 Gruenenthal Gmbh Sais ou cocristais de 3-(3-dimetilamino-1-etil-2-metilpropil)fenol
WO2012023147A1 (en) 2010-08-16 2012-02-23 Indoco Remedies Limited Process for the preparation of tapentadol
WO2012038974A1 (en) * 2010-09-20 2012-03-29 Ind-Swift Laboratories Limited Process for preparing l-phenyl-3-dimethylaminopropane derivative
CN102477016B (zh) * 2010-11-26 2014-12-17 中国医学科学院药物研究所 他喷他多的中间体的合成与应用
WO2012089181A1 (en) * 2010-12-30 2012-07-05 Zentiva, K.S. O-substituted (2r,3r)-3-(3-hydroxyphenyl)-2-methyl-4-pentenoic acids and a method of obtaining the same
CZ2010998A3 (cs) * 2010-12-30 2012-02-08 Zentiva, K.S. Zpusob výroby (2R,3R)-N,N-dimethyl-3-(3-hydroxyfenyl)-2-methylpentylaminu (tapentadolu)
CZ2010997A3 (cs) * 2010-12-30 2012-02-08 Zentiva, K.S. Zpusob výroby (2R,3R)-N,N-dimethyl-3-(3-hydroxyfenyl)-2-methylpentylaminu (tapentadolu)
WO2012146978A2 (en) 2011-04-28 2012-11-01 Actavis Group Ptc Ehf A novel process for the preparation of tapentadol or a pharmaceutically acceptable salt thereof
EP2530072A1 (en) 2011-06-03 2012-12-05 Lacer, S.A. New compounds, synthesis and use thereof in the treatment of pain
US8853393B2 (en) 2011-07-29 2014-10-07 Anhui New Star Pharmaceutical Development Co., Ltd. Intermediate for preparing tapentadol or analogues thereof
WO2013105109A1 (en) 2011-11-09 2013-07-18 Indoco Remedies Limited Process for the preparation of tapentadol
WO2013090161A1 (en) 2011-12-12 2013-06-20 Boehringer Ingelheim International Gmbh Stereoselective synthesis of tapentadol and its salts
WO2013120466A1 (en) 2012-02-17 2013-08-22 Zentiva, K.S. A new solid form of tapentadol and a method of its preparation
EP2674414A1 (en) 2012-06-15 2013-12-18 Siegfried AG Method for the preparation of 1-aryl-1-alkyl-3-dialkylaminopropane compounds
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Also Published As

Publication number Publication date
CA2528087C (en) 2012-05-01
WO2004108658A1 (de) 2004-12-16
MXPA05013193A (es) 2006-03-09
EP1633697A1 (de) 2006-03-15
AU2004245223B2 (en) 2010-01-28
NO20060044L (no) 2006-01-04
US20060194988A1 (en) 2006-08-31
ATE425136T1 (de) 2009-03-15
CA2528087A1 (en) 2004-12-16
BRPI0411268A (pt) 2006-08-01
IL172357A0 (en) 2009-02-11
BRPI0411268B8 (pt) 2021-01-19
CN1829681A (zh) 2006-09-06
ZA200600109B (en) 2007-01-31
BRPI0411268C1 (pt) 2021-05-25
EP1633697B1 (de) 2009-03-11
JP2006527178A (ja) 2006-11-30
PL1633697T3 (pl) 2009-08-31
AU2004245223A1 (en) 2004-12-16
NO335587B1 (no) 2015-01-05
CN1829681B (zh) 2013-02-06
SI1633697T1 (sl) 2009-08-31
BRPI0411268C8 (pt) 2021-11-16
RU2005141518A (ru) 2007-07-20
CY1109088T1 (el) 2014-07-02
JP4848268B2 (ja) 2011-12-28
BRPI0411268B1 (pt) 2020-11-03
DE502004009142D1 (de) 2009-04-23
RU2380355C2 (ru) 2010-01-27
KR101146205B1 (ko) 2012-05-25
ES2323870T3 (es) 2009-07-27
AU2004245223C1 (en) 2010-06-10
HRP20090333T1 (en) 2009-07-31
DE10326097A1 (de) 2005-01-05
NZ544231A (en) 2009-06-26
PT1633697E (pt) 2009-06-04
DK1633697T3 (da) 2009-06-02
US7417170B2 (en) 2008-08-26
KR20060036923A (ko) 2006-05-02
HK1088597A1 (en) 2006-11-10
IL172357A (en) 2014-09-30

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