MX370658B - Proceso en dos etapas para preparar fenilalquilaminas sustituidas en la posición 3. - Google Patents

Proceso en dos etapas para preparar fenilalquilaminas sustituidas en la posición 3.

Info

Publication number
MX370658B
MX370658B MX2017016624A MX2017016624A MX370658B MX 370658 B MX370658 B MX 370658B MX 2017016624 A MX2017016624 A MX 2017016624A MX 2017016624 A MX2017016624 A MX 2017016624A MX 370658 B MX370658 B MX 370658B
Authority
MX
Mexico
Prior art keywords
preparing
step process
substituted phenylalkylamines
phenylalkylamines
substituted
Prior art date
Application number
MX2017016624A
Other languages
English (en)
Other versions
MX2017016624A (es
Inventor
Liao Subo
Teramura Doug
Original Assignee
SpecGx LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by SpecGx LLC filed Critical SpecGx LLC
Publication of MX2017016624A publication Critical patent/MX2017016624A/es
Publication of MX370658B publication Critical patent/MX370658B/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C213/00—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton
    • C07C213/02—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton by reactions involving the formation of amino groups from compounds containing hydroxy groups or etherified or esterified hydroxy groups
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A61P29/02—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID] without antiinflammatory effect
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
    • C07C45/67—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton
    • C07C45/68—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms
    • C07C45/69—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms by addition to carbon-to-carbon double or triple bonds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/07—Optical isomers

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pain & Pain Management (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Rheumatology (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Catalysts (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

Procesos para preparar fenilalquilaminas sustituidas en la posición 3 que comprenden hacer reaccionar a un compuesto fenilborónico con un compuesto que contiene carbonilo a-ß insaturado a través de una reacción de adición 1,4 asimétrica, seguida por alquilación reductora. Los procesos pueden ser útiles en la síntesis de tapentadol.
MX2017016624A 2015-07-10 2016-07-06 Proceso en dos etapas para preparar fenilalquilaminas sustituidas en la posición 3. MX370658B (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201562190975P 2015-07-10 2015-07-10
PCT/US2016/041027 WO2017011231A1 (en) 2015-07-10 2016-07-06 A two-step process for preparing 3-substituted phenylalkylamines

Publications (2)

Publication Number Publication Date
MX2017016624A MX2017016624A (es) 2018-11-09
MX370658B true MX370658B (es) 2019-12-19

Family

ID=57730262

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2017016624A MX370658B (es) 2015-07-10 2016-07-06 Proceso en dos etapas para preparar fenilalquilaminas sustituidas en la posición 3.

Country Status (13)

Country Link
US (1) US9914695B2 (es)
EP (2) EP3319941B1 (es)
JP (1) JP6463854B2 (es)
AU (1) AU2016292797B2 (es)
BR (1) BR112018000036B1 (es)
CA (1) CA2991421C (es)
DK (1) DK3319941T3 (es)
ES (1) ES2908442T3 (es)
HU (1) HUE058824T2 (es)
MX (1) MX370658B (es)
PL (1) PL3319941T3 (es)
PT (1) PT3319941T (es)
WO (1) WO2017011231A1 (es)

Family Cites Families (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2340812C2 (de) 1973-08-11 1982-05-27 Basf Ag, 6700 Ludwigshafen Phenylpropanale sowie ein Verfahren zu deren Herstellung
DE4426245A1 (de) 1994-07-23 1996-02-22 Gruenenthal Gmbh 1-Phenyl-3-dimethylamino-propanverbindungen mit pharmakologischer Wirkung
CA2285578A1 (en) 1999-10-07 2001-04-07 Innovations Foundation Rhodium-catalyzed addition of alkenyl- and aryltrifluoroborates to aldehydes and enones
US7399858B2 (en) 2002-11-11 2008-07-15 Mallinckrodt Inc. Method for the catalytic production of hydrocodone, hydromorphone, and derivatives thereof
US7323565B2 (en) 2002-11-11 2008-01-29 Mallinckrodt Inc. Method for the catalytic production of hydrocodone and hydromorphone
US7321038B2 (en) 2002-11-11 2008-01-22 Mallinckrodt Inc. Method for the catalytic production of hydrocodone and hydromorphone
DE10326097A1 (de) 2003-06-06 2005-01-05 Grünenthal GmbH Verfahren zur Herstellung von Dimethyl-(3-aryl-butyl)-aminverbindungen
DE10328316A1 (de) 2003-06-23 2005-01-20 Grünenthal GmbH Verfahren zur Herstellung von Dimethyl-(3-aryl-buthyl)-aminverbindungen als pharmazeutische Wirkstoffe
CA2656696C (en) 2006-07-24 2013-06-11 Janssen Pharmaceutica N.V. Preparation of (2r,3r)-3-(3-methoxyphenyl)-n,n,2-trimethylpentanamine
TWI401237B (zh) 2006-07-24 2013-07-11 ３-〔（１ｒ，２ｒ）-３-（二甲基氨基）-１-乙基-２-甲基丙基〕酚之製備
US7399859B1 (en) 2007-02-06 2008-07-15 Cody Laboratories Inc. Method for catalytic preparation of hydromorphone and hydrocodone
CN102002065B (zh) 2009-09-02 2014-09-10 上海特化医药科技有限公司 他喷他多的制备方法及其中间体
CN102711461A (zh) 2009-12-29 2012-10-03 Mapi医药公司 用于制备他喷他多及相关化合物的中间体化合物和方法
WO2011092719A2 (en) * 2010-02-01 2011-08-04 Ind-Swift Laboratories Limited Process for the preparation of l-phenyl-3-dimethylaminopropane derivatives
CA2790519A1 (en) 2010-03-05 2011-09-09 Actavis Group Ptc Ehf Improved resolution methods for isolating desired enantiomers of tapentadol intermediates and use thereof for the preparation of tapentadol
EP2792668B1 (en) * 2010-06-15 2017-05-31 Grünenthal GmbH Process for the preparation of substituted 3-(1-amino-2-methyl-pentane-3-yl)phenyl compounds
US8853456B2 (en) 2010-08-16 2014-10-07 Indoco Remedies Limited Process for the preparation of tapentadol
WO2012038974A1 (en) 2010-09-20 2012-03-29 Ind-Swift Laboratories Limited Process for preparing l-phenyl-3-dimethylaminopropane derivative
US20130296608A1 (en) 2011-01-27 2013-11-07 Symed Labs Limited Novel stereospecific synthesis of (-) (2s, 3s)-1-dimethylamino-3-(3-methoxyphenyl)-2-methyl pentan-3-ol
US20130150622A1 (en) 2011-12-12 2013-06-13 Boehringer Ingelheim International Gmbh Stereoselective synthesis of tapentadol and its salts
JP6502397B2 (ja) * 2014-07-10 2019-04-17 スペックジーエックス エルエルシー 置換フェニルアルカンの製造方法

Also Published As

Publication number Publication date
WO2017011231A1 (en) 2017-01-19
ES2908442T3 (es) 2022-04-29
US20170008832A1 (en) 2017-01-12
EP3319941B1 (en) 2021-12-29
MX2017016624A (es) 2018-11-09
CA2991421A1 (en) 2017-01-19
PL3319941T3 (pl) 2022-05-02
CA2991421C (en) 2019-04-30
AU2016292797A1 (en) 2018-01-25
HUE058824T2 (hu) 2022-09-28
EP3319941A4 (en) 2019-03-20
PT3319941T (pt) 2022-03-18
EP3319941A1 (en) 2018-05-16
US9914695B2 (en) 2018-03-13
AU2016292797B2 (en) 2018-05-31
BR112018000036A2 (pt) 2018-09-04
EP3995492B1 (en) 2024-05-29
EP3995492A1 (en) 2022-05-11
JP2018524322A (ja) 2018-08-30
BR112018000036B1 (pt) 2023-12-12
JP6463854B2 (ja) 2019-02-06
DK3319941T3 (da) 2022-03-14

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FG Grant or registration