HRP20090333T1 - Postupak za proizvodnju supstituiranih spojeva 3-aril-butil-amina - Google Patents

Postupak za proizvodnju supstituiranih spojeva 3-aril-butil-amina

Info

Publication number
HRP20090333T1
HRP20090333T1 HR20090333T HRP20090333T HRP20090333T1 HR P20090333 T1 HRP20090333 T1 HR P20090333T1 HR 20090333 T HR20090333 T HR 20090333T HR P20090333 T HRP20090333 T HR P20090333T HR P20090333 T1 HRP20090333 T1 HR P20090333T1
Authority
HR
Croatia
Prior art keywords
alkyl
polysubstituted
mono
unsubstituted
saturated
Prior art date
Application number
HR20090333T
Other languages
English (en)
Inventor
Hell Wolfgang
Kegel Markus
Akteries Bernhard
Buschmann Helmut
Holenz Jrg
L�bermann Hartmut
Heller D.
Drexler H.J.
Gladow Stefan
Original Assignee
Grnenthal Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=33494923&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=HRP20090333(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Grnenthal Gmbh filed Critical Grnenthal Gmbh
Publication of HRP20090333T1 publication Critical patent/HRP20090333T1/hr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C217/00—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
    • C07C217/54—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
    • C07C217/64—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by carbon chains further substituted by singly-bound oxygen atoms
    • C07C217/66—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by carbon chains further substituted by singly-bound oxygen atoms with singly-bound oxygen atoms and six-membered aromatic rings bound to the same carbon atom of the carbon chain
    • C07C217/72—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by carbon chains further substituted by singly-bound oxygen atoms with singly-bound oxygen atoms and six-membered aromatic rings bound to the same carbon atom of the carbon chain linked by carbon chains having at least three carbon atoms between the amino groups and the six-membered aromatic ring or the condensed ring system containing that ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C209/00—Preparation of compounds containing amino groups bound to a carbon skeleton
    • C07C209/68—Preparation of compounds containing amino groups bound to a carbon skeleton from amines, by reactions not involving amino groups, e.g. reduction of unsaturated amines, aromatisation, or substitution of the carbon skeleton
    • C07C209/70—Preparation of compounds containing amino groups bound to a carbon skeleton from amines, by reactions not involving amino groups, e.g. reduction of unsaturated amines, aromatisation, or substitution of the carbon skeleton by reduction of unsaturated amines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C211/00—Compounds containing amino groups bound to a carbon skeleton
    • C07C211/01—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms
    • C07C211/26—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms of an unsaturated carbon skeleton containing at least one six-membered aromatic ring
    • C07C211/27—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms of an unsaturated carbon skeleton containing at least one six-membered aromatic ring having amino groups linked to the six-membered aromatic ring by saturated carbon chains
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C211/00—Compounds containing amino groups bound to a carbon skeleton
    • C07C211/01—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms
    • C07C211/26—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms of an unsaturated carbon skeleton containing at least one six-membered aromatic ring
    • C07C211/28—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms of an unsaturated carbon skeleton containing at least one six-membered aromatic ring having amino groups linked to the six-membered aromatic ring by unsaturated carbon chains
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C213/00—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton
    • C07C213/08—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton by reactions not involving the formation of amino groups, hydroxy groups or etherified or esterified hydroxy groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C215/00—Compounds containing amino and hydroxy groups bound to the same carbon skeleton
    • C07C215/46—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
    • C07C215/56—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by carbon chains further substituted by hydroxy groups
    • C07C215/58—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by carbon chains further substituted by hydroxy groups with hydroxy groups and the six-membered aromatic ring, or the condensed ring system containing that ring, bound to the same carbon atom of the carbon chain
    • C07C215/62—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by carbon chains further substituted by hydroxy groups with hydroxy groups and the six-membered aromatic ring, or the condensed ring system containing that ring, bound to the same carbon atom of the carbon chain the chain having at least three carbon atoms between the amino groups and the six-membered aromatic ring or the condensed ring system containing that ring

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

Postupak za pripravljanje supstituiranog spoja 3-aril-butil-amina opće formule Igdje R1 je odabran od H, C1-3-alkila, razgrananog ili nerazgrananog, zasićenog ili nezasićenog, nesupstituiranog ili jednostruko ili višestruko supstituiranog, R2 i R3 su uvijek neovisno jedan o drugome odabrani od H ili C1-4-alkila, razgrananog ili nerazgrananog, zasićenog ili nezasićenog, nesupstituiranog ili jednostruko ili višestruko supstituiranog, iliR2 i R3 zajedno tvore zasićeni C4-7-cikloalkilni ostatak, nesupstituiran ili jednostruko ili višestruko supstituiran, R4 je odabran od H, C1-3-alkila, razgrananog ili nerazgrananog, zasićenog ili nezasićenog, nesupstituiranog ili jednostruko ili višestruko supstituiranog, aR7 i R8 su uvijek neovisno jedan o drugome odabrani od H ili C1-3-alkila, razgrananog ili nerazgrananog, zasićenog ili nezasićenog, nesupstituiranog ili jednostruko ili višestruko supstituiranog, R9 do R13 su uvijek neovisno jedan o drugome odabrani od H, F, Cl, Br, I, CH2F, CHF2, CF3, OH, SH, OR14, OCF3, SR14, NR17R18, SOCH3, SOCF3; SO2CH3, SO2CF3, CN, COOR14, NO2, CONR17R18; C1-6-alkila, razgrananog ili nerazgrananog, zasićenog ili nezasićenog, nesupstituiranog ili jednostruko ili višestruko supstituiranog; fenila, nesupstituiranog ili jednostruko ili višestruko supstituiranog; gdje je R14 odabran od C1-6-alkila; piridila, tienila, tiazolila, fenila, benzila ili fenetila, uvijek nesupstituiranog ili jednostruko ili višestruko supstituiranog; PO(O-C1-4-alkila)2, CO(OC1-5-alkila), CONH-C6H4-(C1-3-alkila), CO(C1-5-alkila), CO-CHR17-NHR18, CO-C6H4-R15, gdje R15 je orto-OCOC1-3-alkil ili meta- ili para-CH2N(R16)2, gdje R16 je C1-4-alkil ili 4-morfolino, kod čega u ostacima R14, R15 i R16 alkilne skupine mogu biti razgranane ili nerazgranane, zasićene ili nezasićene, nesupstituirane ili jednostruko ili višestruko supstituirane; gdje su R17 i R18 uvijek neovisno jedan o drugome odabrani od H; C1-6-alkila, razgrananog ili nerazgrananog, zasićenog ili nezasićenog, nesupstituiranog ili jednostruko ili višestruko supstituiranog; fenila, benzila ili fenetila, uvijek nesupstituiranog ili jednostruko ili višestruko supstituiranog, iliR9 i R10 ili R10 i R11 zajedno tvore OCH2O, OCH2CH2O, OCH=CH, CH=CHO, CH=C(CH3)O, OC(CH3)=CH, (CH2)4 ili OCH=CHO prsten, uvijek u obliku jednog od njegovih čistih stereoizomera, osobito enantiomera ili dijastereomera, njihovih racemata ili u obliku smjese stereoizomera, osobito enentiomera ili dijastereomera, u bilo kojem proizvoljnom odnosu miješanja, ili uvijek u obliku fiziološki prihvatljive soli, ili uvijek u obliku solvata, naznačen time da je u prvom koraku a) primijenjen spoj 1-amino-3-aril-butan-3-ol opće formule IIgdje R1, R2, R3, R4, R7, R8, R9, R10, R11, R12 i R13 imaju prethodno navedeno značenje, uvijek po potrebi u obliku jednog od njegovih čistih stereoizomera, osobito enantiomera ili dijastereomera, njegovih racemata ili u obliku smjese stereoizomera, osobito enantiomera ili dijastereomera, u bilo kojem proizvolj
HR20090333T 2003-06-06 2009-06-08 Postupak za proizvodnju supstituiranih spojeva 3-aril-butil-amina HRP20090333T1 (hr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE10326097A DE10326097A1 (de) 2003-06-06 2003-06-06 Verfahren zur Herstellung von Dimethyl-(3-aryl-butyl)-aminverbindungen
PCT/EP2004/006027 WO2004108658A1 (de) 2003-06-06 2004-06-04 Verfahren zur herstellung substituierter 3-aryl-butyl-aminverbindungen

Publications (1)

Publication Number Publication Date
HRP20090333T1 true HRP20090333T1 (hr) 2009-07-31

Family

ID=33494923

Family Applications (1)

Application Number Title Priority Date Filing Date
HR20090333T HRP20090333T1 (hr) 2003-06-06 2009-06-08 Postupak za proizvodnju supstituiranih spojeva 3-aril-butil-amina

Country Status (26)

Country Link
US (1) US7417170B2 (hr)
EP (1) EP1633697B1 (hr)
JP (1) JP4848268B2 (hr)
KR (1) KR101146205B1 (hr)
CN (1) CN1829681B (hr)
AT (1) ATE425136T1 (hr)
AU (1) AU2004245223C1 (hr)
BR (1) BRPI0411268C8 (hr)
CA (1) CA2528087C (hr)
CY (1) CY1109088T1 (hr)
DE (2) DE10326097A1 (hr)
DK (1) DK1633697T3 (hr)
EC (1) ECSP056218A (hr)
ES (1) ES2323870T3 (hr)
HK (1) HK1088597A1 (hr)
HR (1) HRP20090333T1 (hr)
IL (1) IL172357A (hr)
MX (1) MXPA05013193A (hr)
NO (1) NO335587B1 (hr)
NZ (1) NZ544231A (hr)
PL (1) PL1633697T3 (hr)
PT (1) PT1633697E (hr)
RU (1) RU2380355C2 (hr)
SI (1) SI1633697T1 (hr)
WO (1) WO2004108658A1 (hr)
ZA (1) ZA200600109B (hr)

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DE10328316A1 (de) 2003-06-23 2005-01-20 Grünenthal GmbH Verfahren zur Herstellung von Dimethyl-(3-aryl-buthyl)-aminverbindungen als pharmazeutische Wirkstoffe
DE102005052588A1 (de) * 2005-11-02 2007-05-10 Grünenthal GmbH Verfahren zur Herstellung substituierter Dimethyl-(3-aryl-butyl)-amin-Verbindungen mittels homogener Katalyse
PT2046726E (pt) * 2006-07-24 2010-04-15 Janssen Pharmaceutica Nv Preparação da (2r,3r)-3-(3-metoxifenil)-n,n,2- trimetilpentanamina
TWI401237B (zh) 2006-07-24 2013-07-11 ３-〔（１ｒ，２ｒ）-３-（二甲基氨基）-１-乙基-２-甲基丙基〕酚之製備
TWI448447B (zh) * 2006-07-24 2014-08-11 Gruenenthal Chemie 製備（１ｒ，２ｒ）-３-（３-二甲胺基-１-乙基-２-甲基-丙基）-酚之方法
DK2240431T3 (en) * 2007-12-07 2017-04-10 Gruenenthal Gmbh CRYSTALLIC MODIFICATION OF (1R, 2R) -3- (3-DIMETHYLAMINO-1-ETHYL-2-METHYL-PROPYL) -PHENOL
WO2010100477A2 (en) * 2009-03-03 2010-09-10 Shire Llc Amino acid and peptide carbamate prodrugs of tapentadol and uses thereof
CN102002065B (zh) * 2009-09-02 2014-09-10 上海特化医药科技有限公司 他喷他多的制备方法及其中间体
US8288592B2 (en) 2009-09-22 2012-10-16 Actavis Group Ptc Ehf Solid state forms of tapentadol salts
IT1397189B1 (it) 2009-12-01 2013-01-04 Archimica Srl Nuovo processo per la preparazione di tapentadol e suoi intermedi.
MX2012007759A (es) * 2009-12-29 2012-08-01 Mapi Pharma Ltd Compuestos intermedios y procesos para la preparacion de tapentadol y compuestos relacionados.
WO2011092719A2 (en) * 2010-02-01 2011-08-04 Ind-Swift Laboratories Limited Process for the preparation of l-phenyl-3-dimethylaminopropane derivatives
CA2790519A1 (en) 2010-03-05 2011-09-09 Actavis Group Ptc Ehf Improved resolution methods for isolating desired enantiomers of tapentadol intermediates and use thereof for the preparation of tapentadol
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ITMI20100924A1 (it) * 2010-05-21 2011-11-22 Fidia Farmaceutici Nuovo metodo di sintesi delle due forme enantiomeriche del tapentadol
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CN102477016B (zh) * 2010-11-26 2014-12-17 中国医学科学院药物研究所 他喷他多的中间体的合成与应用
HUP1300623A2 (en) * 2010-12-30 2014-03-28 Zentiva Ks O-substituted (2r,3r)-3-(3-hidroxiphenil)-2-metyil-4-pentenoic acids and a method of obtaining the same
CZ302993B6 (cs) * 2010-12-30 2012-02-08 Zentiva, K.S. Zpusob výroby (2R,3R)-N,N-dimethyl-3-(3-hydroxyfenyl)-2-methylpentylaminu (tapentadolu)
CZ2010997A3 (cs) * 2010-12-30 2012-02-08 Zentiva, K.S. Zpusob výroby (2R,3R)-N,N-dimethyl-3-(3-hydroxyfenyl)-2-methylpentylaminu (tapentadolu)
WO2012146978A2 (en) 2011-04-28 2012-11-01 Actavis Group Ptc Ehf A novel process for the preparation of tapentadol or a pharmaceutically acceptable salt thereof
EP2530072A1 (en) 2011-06-03 2012-12-05 Lacer, S.A. New compounds, synthesis and use thereof in the treatment of pain
EP2617706B1 (en) 2011-07-29 2017-09-06 Anhui New Star Pharmaceutical Development Co., Ltd Novel intermediate used for preparing tapentadol or analogues thereof
WO2013105109A1 (en) 2011-11-09 2013-07-18 Indoco Remedies Limited Process for the preparation of tapentadol
US20130150622A1 (en) 2011-12-12 2013-06-13 Boehringer Ingelheim International Gmbh Stereoselective synthesis of tapentadol and its salts
WO2013120466A1 (en) 2012-02-17 2013-08-22 Zentiva, K.S. A new solid form of tapentadol and a method of its preparation
EP2674414A1 (en) 2012-06-15 2013-12-18 Siegfried AG Method for the preparation of 1-aryl-1-alkyl-3-dialkylaminopropane compounds
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Also Published As

Publication number Publication date
BRPI0411268B1 (pt) 2020-11-03
IL172357A (en) 2014-09-30
BRPI0411268A (pt) 2006-08-01
PT1633697E (pt) 2009-06-04
NZ544231A (en) 2009-06-26
DE10326097A1 (de) 2005-01-05
AU2004245223C1 (en) 2010-06-10
WO2004108658A1 (de) 2004-12-16
RU2005141518A (ru) 2007-07-20
CN1829681A (zh) 2006-09-06
BRPI0411268C8 (pt) 2021-11-16
CN1829681B (zh) 2013-02-06
EP1633697B1 (de) 2009-03-11
NO20060044L (no) 2006-01-04
CY1109088T1 (el) 2014-07-02
AU2004245223A1 (en) 2004-12-16
EP1633697A1 (de) 2006-03-15
JP2006527178A (ja) 2006-11-30
KR20060036923A (ko) 2006-05-02
DE502004009142D1 (de) 2009-04-23
ES2323870T3 (es) 2009-07-27
RU2380355C2 (ru) 2010-01-27
MXPA05013193A (es) 2006-03-09
JP4848268B2 (ja) 2011-12-28
KR101146205B1 (ko) 2012-05-25
DK1633697T3 (da) 2009-06-02
IL172357A0 (en) 2009-02-11
HK1088597A1 (en) 2006-11-10
ECSP056218A (es) 2006-04-19
CA2528087C (en) 2012-05-01
US7417170B2 (en) 2008-08-26
BRPI0411268B8 (pt) 2021-01-19
CA2528087A1 (en) 2004-12-16
BRPI0411268C1 (pt) 2021-05-25
NO335587B1 (no) 2015-01-05
ZA200600109B (en) 2007-01-31
SI1633697T1 (sl) 2009-08-31
PL1633697T3 (pl) 2009-08-31
US20060194988A1 (en) 2006-08-31
AU2004245223B2 (en) 2010-01-28
ATE425136T1 (de) 2009-03-15

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