MX2012007759A - Compuestos intermedios y procesos para la preparacion de tapentadol y compuestos relacionados. - Google Patents

Compuestos intermedios y procesos para la preparacion de tapentadol y compuestos relacionados.

Info

Publication number
MX2012007759A
MX2012007759A MX2012007759A MX2012007759A MX2012007759A MX 2012007759 A MX2012007759 A MX 2012007759A MX 2012007759 A MX2012007759 A MX 2012007759A MX 2012007759 A MX2012007759 A MX 2012007759A MX 2012007759 A MX2012007759 A MX 2012007759A
Authority
MX
Mexico
Prior art keywords
tapentadol
preparation
compounds
processes
related compounds
Prior art date
Application number
MX2012007759A
Other languages
English (en)
Inventor
Ehud Marom
Michael Mizhiritskii
Original Assignee
Mapi Pharma Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Mapi Pharma Ltd filed Critical Mapi Pharma Ltd
Publication of MX2012007759A publication Critical patent/MX2012007759A/es

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C231/00—Preparation of carboxylic acid amides
    • C07C231/02—Preparation of carboxylic acid amides from carboxylic acids or from esters, anhydrides, or halides thereof by reaction with ammonia or amines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C213/00—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton
    • C07C213/02—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton by reactions involving the formation of amino groups from compounds containing hydroxy groups or etherified or esterified hydroxy groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C213/00—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton
    • C07C213/08—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton by reactions not involving the formation of amino groups, hydroxy groups or etherified or esterified hydroxy groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C231/00—Preparation of carboxylic acid amides
    • C07C231/16—Preparation of optical isomers
    • C07C231/18—Preparation of optical isomers by stereospecific synthesis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
    • C07C235/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton
    • C07C235/32—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton containing six-membered aromatic rings
    • C07C235/34—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton containing six-membered aromatic rings having the nitrogen atoms of the carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C67/00—Preparation of carboxylic acid esters
    • C07C67/30—Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group
    • C07C67/303—Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group by hydrogenation of unsaturated carbon-to-carbon bonds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C67/00—Preparation of carboxylic acid esters
    • C07C67/30—Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group
    • C07C67/333—Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group by isomerisation; by change of size of the carbon skeleton
    • C07C67/343—Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
    • C07F9/40—Esters thereof
    • C07F9/4003—Esters thereof the acid moiety containing a substituent or a structure which is considered as characteristic
    • C07F9/4006—Esters of acyclic acids which can have further substituents on alkyl
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/07—Optical isomers

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

La presente invención describe procesos para la preparación de 3-[(1R, 2R)-3-(dimetil-amino)-1-etil-2-metil-propil] fenol (Tapentadol), sus sales y compuestos relacionados de fórmula (A), incluyendo estereoisómeros y sales farmacéuticamente aceptables de los mismos, y a ciertos intermedios en dicho proceso.
MX2012007759A 2009-12-29 2010-12-26 Compuestos intermedios y procesos para la preparacion de tapentadol y compuestos relacionados. MX2012007759A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US29053209P 2009-12-29 2009-12-29
PCT/IL2010/001085 WO2011080736A1 (en) 2009-12-29 2010-12-26 Intermediate compounds and processes for the preparation of tapentadol and related compounds

Publications (1)

Publication Number Publication Date
MX2012007759A true MX2012007759A (es) 2012-08-01

Family

ID=44226219

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2012007759A MX2012007759A (es) 2009-12-29 2010-12-26 Compuestos intermedios y procesos para la preparacion de tapentadol y compuestos relacionados.

Country Status (11)

Country Link
US (1) US8410176B2 (es)
EP (1) EP2519100B1 (es)
JP (1) JP2013515761A (es)
CN (1) CN102711461A (es)
AU (1) AU2010337825A1 (es)
BR (1) BR112012016059A2 (es)
CA (1) CA2785035A1 (es)
ES (1) ES2627682T3 (es)
MX (1) MX2012007759A (es)
PL (1) PL2519100T3 (es)
WO (1) WO2011080736A1 (es)

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EP2792668B1 (en) * 2010-06-15 2017-05-31 Grünenthal GmbH Process for the preparation of substituted 3-(1-amino-2-methyl-pentane-3-yl)phenyl compounds
CN102477016B (zh) * 2010-11-26 2014-12-17 中国医学科学院药物研究所 他喷他多的中间体的合成与应用
CN102617501A (zh) * 2011-01-31 2012-08-01 中国科学院上海药物研究所 取代正戊酰胺类化合物、其制备方法及用途
WO2012146978A2 (en) * 2011-04-28 2012-11-01 Actavis Group Ptc Ehf A novel process for the preparation of tapentadol or a pharmaceutically acceptable salt thereof
US8853393B2 (en) * 2011-07-29 2014-10-07 Anhui New Star Pharmaceutical Development Co., Ltd. Intermediate for preparing tapentadol or analogues thereof
EP2674414A1 (en) 2012-06-15 2013-12-18 Siegfried AG Method for the preparation of 1-aryl-1-alkyl-3-dialkylaminopropane compounds
CZ304576B6 (cs) * 2012-07-24 2014-07-16 Zentiva, K.S. Oxalát TAPENTADOLU a způsob jeho přípravy
CN102936205B (zh) * 2012-11-12 2014-06-18 合肥市新星医药化工有限公司 一种他喷他多的合成方法
US9090539B2 (en) * 2013-05-24 2015-07-28 Ampac Fine Chemicals Llc Compounds and methods for preparing substituted 3-(1-amino-2-methylpentane-3-yl)phenyl compounds
CN103553940A (zh) * 2013-11-07 2014-02-05 南京艾德凯腾生物医药有限责任公司 一种新晶型盐酸他喷他多的制备方法
WO2015075678A1 (en) 2013-11-21 2015-05-28 Unimark Remedies Ltd. A novel process for the preparation of 1-phenyl-3-aminopropane derivatives
CZ307492B6 (cs) 2014-02-04 2018-10-17 Zentiva, K.S. Pevná forma maleátu tapentadolu a způsob její přípravy
JP6502397B2 (ja) * 2014-07-10 2019-04-17 スペックジーエックス エルエルシー 置換フェニルアルカンの製造方法
CN106573873A (zh) * 2014-08-11 2017-04-19 桑多斯股份公司 3‑[（1r，2r）‑3‑（二甲氨基）‑1‑乙基‑2‑甲基丙基]‑苯酚的制备方法
US9914695B2 (en) 2015-07-10 2018-03-13 Mallinckrodt Llc Two-step process for preparing 3-substituted phenylalkylamines
CN110743622B (zh) * 2019-11-07 2022-07-12 西安石油大学 一种蒙脱土固载手性化合物及其制备方法
CN113101975B (zh) * 2020-01-13 2022-04-22 万华化学集团股份有限公司 一种多膦配体催化剂体系及其在乙烯齐聚反应的应用
CN116102586B (zh) * 2023-01-18 2024-05-28 四川大学 一种合成二芳基硅基甲烷的方法

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Also Published As

Publication number Publication date
WO2011080736A1 (en) 2011-07-07
US8410176B2 (en) 2013-04-02
CN102711461A (zh) 2012-10-03
AU2010337825A1 (en) 2012-07-05
BR112012016059A2 (pt) 2015-09-01
PL2519100T3 (pl) 2017-09-29
EP2519100A4 (en) 2013-06-26
US20120283463A1 (en) 2012-11-08
EP2519100A1 (en) 2012-11-07
EP2519100B1 (en) 2017-03-15
JP2013515761A (ja) 2013-05-09
ES2627682T3 (es) 2017-07-31
CA2785035A1 (en) 2011-07-07

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