BR112012016059A2 - "compostos intermediários e processos para a preparação de tapentadol e compostos relacionados". - Google Patents

"compostos intermediários e processos para a preparação de tapentadol e compostos relacionados".

Info

Publication number
BR112012016059A2
BR112012016059A2 BRBR112012016059-1A BR112012016059A BR112012016059A2 BR 112012016059 A2 BR112012016059 A2 BR 112012016059A2 BR 112012016059 A BR112012016059 A BR 112012016059A BR 112012016059 A2 BR112012016059 A2 BR 112012016059A2
Authority
BR
Brazil
Prior art keywords
processes
tapentadol
preparation
compounds
related compounds
Prior art date
Application number
BRBR112012016059-1A
Other languages
English (en)
Inventor
Ehud Marom
Michael Mizhiritskii
Original Assignee
Mapi Pharma Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Mapi Pharma Ltd filed Critical Mapi Pharma Ltd
Publication of BR112012016059A2 publication Critical patent/BR112012016059A2/pt

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C231/00Preparation of carboxylic acid amides
    • C07C231/02Preparation of carboxylic acid amides from carboxylic acids or from esters, anhydrides, or halides thereof by reaction with ammonia or amines
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C213/00Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton
    • C07C213/02Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton by reactions involving the formation of amino groups from compounds containing hydroxy groups or etherified or esterified hydroxy groups
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C213/00Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton
    • C07C213/08Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton by reactions not involving the formation of amino groups, hydroxy groups or etherified or esterified hydroxy groups
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C231/00Preparation of carboxylic acid amides
    • C07C231/16Preparation of optical isomers
    • C07C231/18Preparation of optical isomers by stereospecific synthesis
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C235/00Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
    • C07C235/02Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton
    • C07C235/32Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton containing six-membered aromatic rings
    • C07C235/34Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton containing six-membered aromatic rings having the nitrogen atoms of the carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C67/00Preparation of carboxylic acid esters
    • C07C67/30Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group
    • C07C67/303Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group by hydrogenation of unsaturated carbon-to-carbon bonds
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C67/00Preparation of carboxylic acid esters
    • C07C67/30Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group
    • C07C67/333Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group by isomerisation; by change of size of the carbon skeleton
    • C07C67/343Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02Phosphorus compounds
    • C07F9/28Phosphorus compounds with one or more P—C bonds
    • C07F9/38Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
    • C07F9/40Esters thereof
    • C07F9/4003Esters thereof the acid moiety containing a substituent or a structure which is considered as characteristic
    • C07F9/4006Esters of acyclic acids which can have further substituents on alkyl
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07BGENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00Indexing scheme relating to specific properties of organic compounds
    • C07B2200/07Optical isomers

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

"compostos intermediários e processos para a preparação de tapentadol e compostos relacionados". A presente invenção revela processos para a preparação de 3-[(1r,2r)-3-(dimetil - amino)-1-etil-2-metilpropil]fenol (tapentadol), seus sais e compostos relacionados da fórmula (a), incluindo estereosômeros e seus sais farmaceuticamente aceitáveis, e para certos intermediários utilizados em tais processos.
BRBR112012016059-1A 2009-12-29 2010-12-26 "compostos intermediários e processos para a preparação de tapentadol e compostos relacionados". BR112012016059A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US29053209P 2009-12-29 2009-12-29
PCT/IL2010/001085 WO2011080736A1 (en) 2009-12-29 2010-12-26 Intermediate compounds and processes for the preparation of tapentadol and related compounds

Publications (1)

Publication Number Publication Date
BR112012016059A2 true BR112012016059A2 (pt) 2015-09-01

Family

ID=44226219

Family Applications (1)

Application Number Title Priority Date Filing Date
BRBR112012016059-1A BR112012016059A2 (pt) 2009-12-29 2010-12-26 "compostos intermediários e processos para a preparação de tapentadol e compostos relacionados".

Country Status (11)

Country Link
US (1) US8410176B2 (pt)
EP (1) EP2519100B1 (pt)
JP (1) JP2013515761A (pt)
CN (1) CN102711461A (pt)
AU (1) AU2010337825A1 (pt)
BR (1) BR112012016059A2 (pt)
CA (1) CA2785035A1 (pt)
ES (1) ES2627682T3 (pt)
MX (1) MX2012007759A (pt)
PL (1) PL2519100T3 (pt)
WO (1) WO2011080736A1 (pt)

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EP2582659B1 (en) 2010-06-15 2015-03-11 Grünenthal GmbH Process for the preparation of substituted 3-(1-amino-2-methylpentane-3-yl)phenyl compounds
CN102477016B (zh) * 2010-11-26 2014-12-17 中国医学科学院药物研究所 他喷他多的中间体的合成与应用
CN102617501A (zh) 2011-01-31 2012-08-01 中国科学院上海药物研究所 取代正戊酰胺类化合物、其制备方法及用途
WO2012146978A2 (en) * 2011-04-28 2012-11-01 Actavis Group Ptc Ehf A novel process for the preparation of tapentadol or a pharmaceutically acceptable salt thereof
WO2013016840A1 (zh) * 2011-07-29 2013-02-07 安徽省新星药物开发有限责任公司 用于合成他喷他多或其类似物的新中间体
EP2674414A1 (en) 2012-06-15 2013-12-18 Siegfried AG Method for the preparation of 1-aryl-1-alkyl-3-dialkylaminopropane compounds
CZ304576B6 (cs) * 2012-07-24 2014-07-16 Zentiva, K.S. Oxalát TAPENTADOLU a způsob jeho přípravy
CN102936205B (zh) * 2012-11-12 2014-06-18 合肥市新星医药化工有限公司 一种他喷他多的合成方法
US9090539B2 (en) * 2013-05-24 2015-07-28 Ampac Fine Chemicals Llc Compounds and methods for preparing substituted 3-(1-amino-2-methylpentane-3-yl)phenyl compounds
CN103553940A (zh) * 2013-11-07 2014-02-05 南京艾德凯腾生物医药有限责任公司 一种新晶型盐酸他喷他多的制备方法
WO2015075678A1 (en) 2013-11-21 2015-05-28 Unimark Remedies Ltd. A novel process for the preparation of 1-phenyl-3-aminopropane derivatives
CZ307492B6 (cs) 2014-02-04 2018-10-17 Zentiva, K.S. Pevná forma maleátu tapentadolu a způsob její přípravy
DK3166923T3 (da) 2014-07-10 2023-04-11 SpecGx LLC Fremgangsmåde til fremstilling af substituerede phenylalkaner
WO2016023913A1 (en) * 2014-08-11 2016-02-18 Sandoz Ag Process for the preparation of 3-[(1r,2r)-3-(dimethylamino)-1-ethyl-2-methylpropyl]-phenol
CA2991421C (en) 2015-07-10 2019-04-30 Mallinckrodt Llc A two-step process for preparing 3-substituted phenylalkylamines
CN110743622B (zh) * 2019-11-07 2022-07-12 西安石油大学 一种蒙脱土固载手性化合物及其制备方法
CN113101975B (zh) * 2020-01-13 2022-04-22 万华化学集团股份有限公司 一种多膦配体催化剂体系及其在乙烯齐聚反应的应用
CN116102586B (zh) * 2023-01-18 2024-05-28 四川大学 一种合成二芳基硅基甲烷的方法

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Also Published As

Publication number Publication date
ES2627682T3 (es) 2017-07-31
CA2785035A1 (en) 2011-07-07
EP2519100B1 (en) 2017-03-15
MX2012007759A (es) 2012-08-01
US8410176B2 (en) 2013-04-02
PL2519100T3 (pl) 2017-09-29
EP2519100A1 (en) 2012-11-07
JP2013515761A (ja) 2013-05-09
EP2519100A4 (en) 2013-06-26
WO2011080736A1 (en) 2011-07-07
AU2010337825A1 (en) 2012-07-05
CN102711461A (zh) 2012-10-03
US20120283463A1 (en) 2012-11-08

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B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE AS 4A E 5A ANUIDADES.

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: EM VIRTUDE DO ARQUIVAMENTO PUBLICADO NA RPI 2343 DE 01-12-2015 E CONSIDERANDO AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS, INFORMO QUE CABE SER MANTIDO O ARQUIVAMENTO DO PEDIDO DE PATENTE, CONFORME O DISPOSTO NO ARTIGO 12, DA RESOLUCAO 113/2013.