WO2011061609A3 - Processes for the preparation of cilastatin - Google Patents

Processes for the preparation of cilastatin Download PDF

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Publication number
WO2011061609A3
WO2011061609A3 PCT/IB2010/002962 IB2010002962W WO2011061609A3 WO 2011061609 A3 WO2011061609 A3 WO 2011061609A3 IB 2010002962 W IB2010002962 W IB 2010002962W WO 2011061609 A3 WO2011061609 A3 WO 2011061609A3
Authority
WO
WIPO (PCT)
Prior art keywords
cilastatin
processes
preparation
pharmaceutically acceptable
acceptable salts
Prior art date
Application number
PCT/IB2010/002962
Other languages
French (fr)
Other versions
WO2011061609A2 (en
Inventor
Suresh Babu Jayachandra
Ruchika Yogesh
Raghuram Morampudi
Chandra Has Khanduri
Original Assignee
Ranbaxy Laboratories Limited
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ranbaxy Laboratories Limited filed Critical Ranbaxy Laboratories Limited
Publication of WO2011061609A2 publication Critical patent/WO2011061609A2/en
Publication of WO2011061609A3 publication Critical patent/WO2011061609A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/50—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton
    • C07C323/51—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C323/57—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being further substituted by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C323/58—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being further substituted by nitrogen atoms, not being part of nitro or nitroso groups with amino groups bound to the carbon skeleton
    • C07C323/59—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being further substituted by nitrogen atoms, not being part of nitro or nitroso groups with amino groups bound to the carbon skeleton with acylated amino groups bound to the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C231/00—Preparation of carboxylic acid amides
    • C07C231/12—Preparation of carboxylic acid amides by reactions not involving the formation of carboxamide groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C319/00—Preparation of thiols, sulfides, hydropolysulfides or polysulfides
    • C07C319/14—Preparation of thiols, sulfides, hydropolysulfides or polysulfides of sulfides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/02—Systems containing only non-condensed rings with a three-membered ring

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

The present invention provides improved process for preparing substantially pure cilastatin and pharmaceutically acceptable salts thereof.
PCT/IB2010/002962 2009-11-19 2010-11-19 Processes for the preparation of cilastatin WO2011061609A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IN2387/DEL/2009 2009-11-19
IN2387DE2009 2009-11-19

Publications (2)

Publication Number Publication Date
WO2011061609A2 WO2011061609A2 (en) 2011-05-26
WO2011061609A3 true WO2011061609A3 (en) 2012-07-26

Family

ID=43928116

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IB2010/002962 WO2011061609A2 (en) 2009-11-19 2010-11-19 Processes for the preparation of cilastatin

Country Status (1)

Country Link
WO (1) WO2011061609A2 (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102875433A (en) * 2012-10-29 2013-01-16 江西金顿香料有限公司 Preparation method of cilastatin acid
CN103709035B (en) * 2013-03-15 2015-09-02 衡水衡林生物科技有限公司 A kind of preparation method of 7-chloro-2-oxoheptanoate
CN104649948B (en) * 2013-11-19 2017-05-24 江苏迪赛诺制药有限公司 Cilastatin calcium crystal, preparation method and application thereof

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5147868A (en) * 1978-07-24 1992-09-15 Merck & Co., Inc. Thienamycin renal peptidase inhibitors
WO2007054771A2 (en) * 2005-11-09 2007-05-18 Orchid Chemicals & Pharmaceuticals Limited An improved process for the preparation of cilastatin and sodium salt
US7371897B1 (en) * 2006-12-11 2008-05-13 Wischem Co., Ltd. Preparation method for (Z)-7-chloro-((S)-2,2-dimethylcyclopropanecarboxamido)-2-heptenoic acid

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5147868A (en) * 1978-07-24 1992-09-15 Merck & Co., Inc. Thienamycin renal peptidase inhibitors
WO2007054771A2 (en) * 2005-11-09 2007-05-18 Orchid Chemicals & Pharmaceuticals Limited An improved process for the preparation of cilastatin and sodium salt
US7371897B1 (en) * 2006-12-11 2008-05-13 Wischem Co., Ltd. Preparation method for (Z)-7-chloro-((S)-2,2-dimethylcyclopropanecarboxamido)-2-heptenoic acid

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
GRAHAM D W ET AL: "INHIBITION OF THE MAMMALIAN BETA-LACTAMASE RENAL DIPEPTIDASE (DEHYDROPEPTIDASE-I) BY (Z)-2-(ACYLAMINO)-3-SUBSTITUTED-PROPENOIC ACIDS", JOURNAL OF MEDICINAL CHEMISTRY, AMERICAN CHEMICAL SOCIETY, US, vol. 30, 1 January 1987 (1987-01-01), pages 1074 - 1090, XP001064529, ISSN: 0022-2623, DOI: 10.1021/JM00389A018 *
VINOGRADOV M G ET AL: "Chemistry of natural compounds and bioorganic chemistry, a new approach to the synthesis of cilastatin, and inhibitor of renal dipeptidase", RUSSIAN CHEMICAL BULLETIN, SPRINGER NEW YORK LLC, US; RU, vol. 44, no. 1, 1 January 1995 (1995-01-01), pages 167 - 171, XP002636765, ISSN: 1066-5285, DOI: 10.1007/BF00696982 *

Also Published As

Publication number Publication date
WO2011061609A2 (en) 2011-05-26

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