WO2011025932A3 - Preparation of sitagliptin and salts thereof - Google Patents

Preparation of sitagliptin and salts thereof Download PDF

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Publication number
WO2011025932A3
WO2011025932A3 PCT/US2010/046938 US2010046938W WO2011025932A3 WO 2011025932 A3 WO2011025932 A3 WO 2011025932A3 US 2010046938 W US2010046938 W US 2010046938W WO 2011025932 A3 WO2011025932 A3 WO 2011025932A3
Authority
WO
WIPO (PCT)
Prior art keywords
sitagliptin
salts
preparation
processes
pharmaceutically acceptable
Prior art date
Application number
PCT/US2010/046938
Other languages
French (fr)
Other versions
WO2011025932A2 (en
Inventor
Rakeshwar Bandichhor
Nagaraju Gudimalla
Namrata Dwivedi
Kiran Kumar Chetluru
Srinivas Reddy Gade
Venkateswarlu Muvva
Bindu Srivastava
Original Assignee
Dr. Reddy's Laboratories Ltd.
Dr. Reddy's Laboratories, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dr. Reddy's Laboratories Ltd., Dr. Reddy's Laboratories, Inc. filed Critical Dr. Reddy's Laboratories Ltd.
Priority to EP10812650.9A priority Critical patent/EP2470542A4/en
Publication of WO2011025932A2 publication Critical patent/WO2011025932A2/en
Publication of WO2011025932A3 publication Critical patent/WO2011025932A3/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Diabetes (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Endocrinology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Emergency Medicine (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Processes for preparing sitagliptin and its pharmaceutically acceptable salts, and process intermediates.
PCT/US2010/046938 2009-08-28 2010-08-27 Preparation of sitagliptin and salts thereof WO2011025932A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
EP10812650.9A EP2470542A4 (en) 2009-08-28 2010-08-27 Preparation of sitagliptin and salts thereof

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
IN2090CH2009 2009-08-28
IN2090/CHE/2009 2009-08-28
US31090010P 2010-03-05 2010-03-05
US61/310,900 2010-03-05

Publications (2)

Publication Number Publication Date
WO2011025932A2 WO2011025932A2 (en) 2011-03-03
WO2011025932A3 true WO2011025932A3 (en) 2011-07-21

Family

ID=43628673

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2010/046938 WO2011025932A2 (en) 2009-08-28 2010-08-27 Preparation of sitagliptin and salts thereof

Country Status (2)

Country Link
EP (1) EP2470542A4 (en)
WO (1) WO2011025932A2 (en)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102838603B (en) * 2011-06-24 2015-05-13 上海医药工业研究院 Preparation method of intermediate compound of sitagliptin
AU2012277373A1 (en) 2011-06-29 2014-01-30 Sun Pharmaceutical Industries Limited Solid dispersions of sitagliptin and processes for their preparation
EP2726483A1 (en) 2011-06-30 2014-05-07 Ranbaxy Laboratories Limited Novel salts of sitagliptin
WO2013065066A1 (en) * 2011-11-02 2013-05-10 Cadila Healthcare Limited Processes for preparing 4-oxo-4-[3-(trifluoromethyl)-5,6- dihydro [l,2,41-triazolo[43-a]pyrazin-7(8h)-yl]-l-(2,4,5- trifluorophenyl)butan-2-amine
WO2013084210A1 (en) 2011-12-08 2013-06-13 Ranbaxy Laboratories Limited Amorphous form of sitagliptin salts
EP2674432A1 (en) 2012-06-14 2013-12-18 LEK Pharmaceuticals d.d. New synthetic route for the preparation of ß aminobutyryl substituted 5,6,7,8-tetrahydro[1,4]diazolo[4,3-alpha]pyrazin-7-yl compounds
CN104447753B (en) * 2013-09-17 2017-03-29 深圳翰宇药业股份有限公司 A kind of preparation method of sitagliptin and its intermediate
ES2792506T3 (en) 2014-02-03 2020-11-11 Galenicum Health Sl Stable pharmaceutical compositions containing sitagliptin in the form of immediate-release tablets
CA2947526A1 (en) * 2014-02-05 2015-08-13 Stereokem, Inc. (Usa) Expedient synthesis of sitagliptin
WO2015162506A1 (en) 2014-04-21 2015-10-29 Suven Life Sciences Limited Process for the preparation of sitagliptin and novel intermediates

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004085661A2 (en) * 2003-03-24 2004-10-07 Merck & Co., Inc Process to chiral beta-amino acid derivatives
WO2009085990A2 (en) * 2007-12-20 2009-07-09 Dr. Reddy's Laboratories Limited Processes for the preparation of sitagliptin and pharmaceutically acceptable salts thereof

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004085661A2 (en) * 2003-03-24 2004-10-07 Merck & Co., Inc Process to chiral beta-amino acid derivatives
WO2009085990A2 (en) * 2007-12-20 2009-07-09 Dr. Reddy's Laboratories Limited Processes for the preparation of sitagliptin and pharmaceutically acceptable salts thereof

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
See also references of EP2470542A4 *

Also Published As

Publication number Publication date
WO2011025932A2 (en) 2011-03-03
EP2470542A4 (en) 2013-04-24
EP2470542A2 (en) 2012-07-04

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