EP2470542A4 - Preparation of sitagliptin and salts thereof - Google Patents

Preparation of sitagliptin and salts thereof

Info

Publication number
EP2470542A4
EP2470542A4 EP10812650.9A EP10812650A EP2470542A4 EP 2470542 A4 EP2470542 A4 EP 2470542A4 EP 10812650 A EP10812650 A EP 10812650A EP 2470542 A4 EP2470542 A4 EP 2470542A4
Authority
EP
European Patent Office
Prior art keywords
sitagliptin
salts
preparation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP10812650.9A
Other languages
German (de)
French (fr)
Other versions
EP2470542A2 (en
Inventor
Rakeshwar Bandichhor
Nagaraju Gudimalla
Namrata Dwivedi
Kiran Kumar Chetluru
Srinivas Reddy Gade
Venkateswarlu Muvva
Bindu Srivastava
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Dr Reddys Laboratories Ltd
Dr Reddys Laboratories Inc
Original Assignee
Dr Reddys Laboratories Ltd
Dr Reddys Laboratories Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dr Reddys Laboratories Ltd, Dr Reddys Laboratories Inc filed Critical Dr Reddys Laboratories Ltd
Publication of EP2470542A2 publication Critical patent/EP2470542A2/en
Publication of EP2470542A4 publication Critical patent/EP2470542A4/en
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
EP10812650.9A 2009-08-28 2010-08-27 Preparation of sitagliptin and salts thereof Withdrawn EP2470542A4 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
IN2090CH2009 2009-08-28
US31090010P 2010-03-05 2010-03-05
PCT/US2010/046938 WO2011025932A2 (en) 2009-08-28 2010-08-27 Preparation of sitagliptin and salts thereof

Publications (2)

Publication Number Publication Date
EP2470542A2 EP2470542A2 (en) 2012-07-04
EP2470542A4 true EP2470542A4 (en) 2013-04-24

Family

ID=43628673

Family Applications (1)

Application Number Title Priority Date Filing Date
EP10812650.9A Withdrawn EP2470542A4 (en) 2009-08-28 2010-08-27 Preparation of sitagliptin and salts thereof

Country Status (2)

Country Link
EP (1) EP2470542A4 (en)
WO (1) WO2011025932A2 (en)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102838603B (en) * 2011-06-24 2015-05-13 上海医药工业研究院 Preparation method of intermediate compound of sitagliptin
WO2013001514A1 (en) 2011-06-29 2013-01-03 Ranbaxy Laboratories Limited Solid dispersions of sitagliptin and processes for their preparation
WO2013001457A1 (en) 2011-06-30 2013-01-03 Ranbaxy Laboratories Limited Novel salts of sitagliptin
WO2013065066A1 (en) * 2011-11-02 2013-05-10 Cadila Healthcare Limited Processes for preparing 4-oxo-4-[3-(trifluoromethyl)-5,6- dihydro [l,2,41-triazolo[43-a]pyrazin-7(8h)-yl]-l-(2,4,5- trifluorophenyl)butan-2-amine
EP2788352A1 (en) 2011-12-08 2014-10-15 Ranbaxy Laboratories Limited Amorphous form of sitagliptin salts
EP2674432A1 (en) 2012-06-14 2013-12-18 LEK Pharmaceuticals d.d. New synthetic route for the preparation of ß aminobutyryl substituted 5,6,7,8-tetrahydro[1,4]diazolo[4,3-alpha]pyrazin-7-yl compounds
CN104447753B (en) * 2013-09-17 2017-03-29 深圳翰宇药业股份有限公司 A kind of preparation method of sitagliptin and its intermediate
RS60393B1 (en) 2014-02-03 2020-07-31 Galenicum Health Sl Stable pharmaceutical compositions containing sitagliptin in the form of immediate release tablets
WO2015120111A2 (en) * 2014-02-05 2015-08-13 Stereokem, Inc. (Usa) Expedient synthesis of sitagliptin
WO2015162506A1 (en) 2014-04-21 2015-10-29 Suven Life Sciences Limited Process for the preparation of sitagliptin and novel intermediates

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004085661A2 (en) * 2003-03-24 2004-10-07 Merck & Co., Inc Process to chiral beta-amino acid derivatives
WO2009085990A2 (en) * 2007-12-20 2009-07-09 Dr. Reddy's Laboratories Limited Processes for the preparation of sitagliptin and pharmaceutically acceptable salts thereof

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004085661A2 (en) * 2003-03-24 2004-10-07 Merck & Co., Inc Process to chiral beta-amino acid derivatives
WO2009085990A2 (en) * 2007-12-20 2009-07-09 Dr. Reddy's Laboratories Limited Processes for the preparation of sitagliptin and pharmaceutically acceptable salts thereof

Also Published As

Publication number Publication date
WO2011025932A2 (en) 2011-03-03
WO2011025932A3 (en) 2011-07-21
EP2470542A2 (en) 2012-07-04

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Legal Events

Date Code Title Description
PUAI Public reference made under article 153(3) epc to a published international application that has entered the european phase

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17P Request for examination filed

Effective date: 20120315

AK Designated contracting states

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Designated state(s): AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO SE SI SK SM TR

DAX Request for extension of the european patent (deleted)
A4 Supplementary search report drawn up and despatched

Effective date: 20130325

RIC1 Information provided on ipc code assigned before grant

Ipc: C07D 487/04 20060101AFI20130319BHEP

Ipc: A61P 3/10 20060101ALI20130319BHEP

Ipc: A61K 31/4985 20060101ALI20130319BHEP

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: THE APPLICATION IS DEEMED TO BE WITHDRAWN

18D Application deemed to be withdrawn

Effective date: 20131022