WO2011060213A3 - Preparation of sitagliptin and salts thereof - Google Patents

Preparation of sitagliptin and salts thereof Download PDF

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Publication number
WO2011060213A3
WO2011060213A3 PCT/US2010/056443 US2010056443W WO2011060213A3 WO 2011060213 A3 WO2011060213 A3 WO 2011060213A3 US 2010056443 W US2010056443 W US 2010056443W WO 2011060213 A3 WO2011060213 A3 WO 2011060213A3
Authority
WO
WIPO (PCT)
Prior art keywords
sitagliptin
salts
preparation
processes
pharmaceutically acceptable
Prior art date
Application number
PCT/US2010/056443
Other languages
French (fr)
Other versions
WO2011060213A2 (en
Inventor
Srinivas Reddy Gade
Bindu Srivastava
Venkateswarlu Muvva
Original Assignee
Dr. Reddy's Laboratories Ltd.
Dr. Reddy's Laboratories, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dr. Reddy's Laboratories Ltd., Dr. Reddy's Laboratories, Inc. filed Critical Dr. Reddy's Laboratories Ltd.
Publication of WO2011060213A2 publication Critical patent/WO2011060213A2/en
Publication of WO2011060213A3 publication Critical patent/WO2011060213A3/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Diabetes (AREA)
  • General Chemical & Material Sciences (AREA)
  • Emergency Medicine (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Endocrinology (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Processes for preparing sitagliptin and its pharmaceutically acceptable salts, and process intermediates.
PCT/US2010/056443 2009-11-12 2010-11-12 Preparation of sitagliptin and salts thereof WO2011060213A2 (en)

Applications Claiming Priority (8)

Application Number Priority Date Filing Date Title
IN2786CH2009 2009-11-12
IN2786/CHE/2009 2009-11-12
US31286010P 2010-03-11 2010-03-11
US61/312,860 2010-03-11
IN1337CH2010 2010-05-13
IN1337/CHE/2010 2010-05-13
US36371210P 2010-07-13 2010-07-13
US61/363,712 2010-07-13

Publications (2)

Publication Number Publication Date
WO2011060213A2 WO2011060213A2 (en) 2011-05-19
WO2011060213A3 true WO2011060213A3 (en) 2011-09-29

Family

ID=43992408

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2010/056443 WO2011060213A2 (en) 2009-11-12 2010-11-12 Preparation of sitagliptin and salts thereof

Country Status (1)

Country Link
WO (1) WO2011060213A2 (en)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2012076973A2 (en) * 2010-12-09 2012-06-14 Aurobindo Pharma Limited Novel salts of dipeptidyl peptidase iv inhibitor
CN102838603B (en) * 2011-06-24 2015-05-13 上海医药工业研究院 Preparation method of intermediate compound of sitagliptin
EP2726483A1 (en) 2011-06-30 2014-05-07 Ranbaxy Laboratories Limited Novel salts of sitagliptin
WO2013084210A1 (en) 2011-12-08 2013-06-13 Ranbaxy Laboratories Limited Amorphous form of sitagliptin salts
CN102627648B (en) * 2012-04-14 2014-11-12 江苏施美康药业股份有限公司 Preparation method of sitagliptin
EP2674432A1 (en) 2012-06-14 2013-12-18 LEK Pharmaceuticals d.d. New synthetic route for the preparation of ß aminobutyryl substituted 5,6,7,8-tetrahydro[1,4]diazolo[4,3-alpha]pyrazin-7-yl compounds
CN104418861B (en) * 2013-09-10 2017-11-10 浙江医药股份有限公司新昌制药厂 A kind of preparation method of Xi Gelieting midbody compound
CN104447753B (en) * 2013-09-17 2017-03-29 深圳翰宇药业股份有限公司 A kind of preparation method of sitagliptin and its intermediate
CA2947526A1 (en) * 2014-02-05 2015-08-13 Stereokem, Inc. (Usa) Expedient synthesis of sitagliptin
WO2015162506A1 (en) 2014-04-21 2015-10-29 Suven Life Sciences Limited Process for the preparation of sitagliptin and novel intermediates
CN104628732B (en) * 2015-01-30 2017-02-22 吉林修正药业新药开发有限公司 Synthetic method of triazole pyrazine
CN107245078A (en) * 2017-08-15 2017-10-13 苏州信恩医药科技有限公司 A kind of synthetic method of sitagliptin
WO2019186260A1 (en) * 2018-03-28 2019-10-03 Hikal Limited An improved process for the preparation of sitagliptin and pharmaceutically acceptable salts thereof
WO2019207443A1 (en) * 2018-04-24 2019-10-31 Unichem Laboratories Ltd An enzymatic process for the preparation of (r)-sitagliptin
WO2020109938A1 (en) * 2018-11-27 2020-06-04 Dr. Reddy's Laboratories Limited Processes for the preparation of sitagliptin and pharmaceutically acceptable salts thereof
CN109824546B (en) * 2019-03-19 2021-07-02 浙江永太科技股份有限公司 BOC- (R) -3-amino-4- (2,4, 5-trifluorophenyl) butyric acid condensation impurity and preparation method thereof

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004085661A2 (en) * 2003-03-24 2004-10-07 Merck & Co., Inc Process to chiral beta-amino acid derivatives
WO2009085990A2 (en) * 2007-12-20 2009-07-09 Dr. Reddy's Laboratories Limited Processes for the preparation of sitagliptin and pharmaceutically acceptable salts thereof
US20090247532A1 (en) * 2008-03-28 2009-10-01 Mae De Ltd. Crystalline polymorph of sitagliptin phosphate and its preparation

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004085661A2 (en) * 2003-03-24 2004-10-07 Merck & Co., Inc Process to chiral beta-amino acid derivatives
WO2009085990A2 (en) * 2007-12-20 2009-07-09 Dr. Reddy's Laboratories Limited Processes for the preparation of sitagliptin and pharmaceutically acceptable salts thereof
US20090247532A1 (en) * 2008-03-28 2009-10-01 Mae De Ltd. Crystalline polymorph of sitagliptin phosphate and its preparation

Also Published As

Publication number Publication date
WO2011060213A2 (en) 2011-05-19

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