WO2012176218A8 - Process for preparing rosuvastatin calcium through novel amine salt - Google Patents

Process for preparing rosuvastatin calcium through novel amine salt Download PDF

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Publication number
WO2012176218A8
WO2012176218A8 PCT/IN2012/000442 IN2012000442W WO2012176218A8 WO 2012176218 A8 WO2012176218 A8 WO 2012176218A8 IN 2012000442 W IN2012000442 W IN 2012000442W WO 2012176218 A8 WO2012176218 A8 WO 2012176218A8
Authority
WO
WIPO (PCT)
Prior art keywords
amine salt
rosuvastatin calcium
novel amine
preparing rosuvastatin
preparing
Prior art date
Application number
PCT/IN2012/000442
Other languages
French (fr)
Other versions
WO2012176218A1 (en
Inventor
Shekhar Bhaskar Bhirud
Anshul Kumar Jain
Vinay Kumar SAINI
Alok Sharma
Original Assignee
Ind-Swift Laboratories Limited
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ind-Swift Laboratories Limited filed Critical Ind-Swift Laboratories Limited
Publication of WO2012176218A1 publication Critical patent/WO2012176218A1/en
Publication of WO2012176218A8 publication Critical patent/WO2012176218A8/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/32—One oxygen, sulfur or nitrogen atom
    • C07D239/42—One nitrogen atom

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

Abstract

The present invention provides a process for preparing pure rosuvastatin of formula (I), or pharmaceutically acceptable salts thereof through rosuvastatin l-(l-naphthyl)ethyl salt of formula (II) wherein wavy line (〰) represent (R), (S) stereochemistry or racemate thereof.
PCT/IN2012/000442 2011-06-24 2012-06-21 Process for preparing rosuvastatin calcium through novel amine salt WO2012176218A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IN1812DE2011 2011-06-24
IN1812/DEL/2011 2011-06-24

Publications (2)

Publication Number Publication Date
WO2012176218A1 WO2012176218A1 (en) 2012-12-27
WO2012176218A8 true WO2012176218A8 (en) 2013-07-25

Family

ID=47422112

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IN2012/000442 WO2012176218A1 (en) 2011-06-24 2012-06-21 Process for preparing rosuvastatin calcium through novel amine salt

Country Status (1)

Country Link
WO (1) WO2012176218A1 (en)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2978743B1 (en) * 2013-03-29 2019-11-27 Centrient Pharmaceuticals Netherlands B.V. Amine salts of pravastatin and rosuvastatin
CN104370827B (en) * 2013-08-13 2016-09-07 天津汉瑞药业有限公司 Rosuvastatin calcium compound
EP3103878A4 (en) 2014-02-06 2017-08-16 API Corporation Rosuvastatin calcium and process for producing intermediate thereof
WO2019008593A1 (en) * 2017-07-05 2019-01-10 Melody Healthcare Pvt. Ltd Process for manufacture of rosuvastatin calcium amorphous
JP7113397B2 (en) * 2018-06-15 2022-08-05 金剛化学株式会社 Process for producing intermediate of rosuvastatin calcium
CN108586358A (en) * 2018-07-06 2018-09-28 苏州中联化学制药有限公司 The preparation process of Rosuvastatin calcium preparation
CN108948078A (en) * 2018-09-11 2018-12-07 浙江乐普药业股份有限公司 A kind of synthetic method of rosuvastatin intermediate

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0003305D0 (en) * 2000-02-15 2000-04-05 Zeneca Ltd Pyrimidine derivatives
CN1906175A (en) * 2003-11-24 2007-01-31 特瓦制药工业有限公司 Crystalline ammonium salts of rosuvastatin
WO2005077916A1 (en) * 2004-01-19 2005-08-25 Ranbaxy Laboratories Limited Salts of hmg-coa reductase inhibitors and use thereof
JP5146965B2 (en) * 2005-06-24 2013-02-20 レツク・フアーマシユーテイカルズ・デー・デー Method for preparing amorphous rosuvastatin calcium free of impurities

Also Published As

Publication number Publication date
WO2012176218A1 (en) 2012-12-27

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