WO2013111161A3 - Process for the preparation of 3-aryl-2-methyl-propanamine derivatives and polymorphs thereof - Google Patents

Process for the preparation of 3-aryl-2-methyl-propanamine derivatives and polymorphs thereof Download PDF

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Publication number
WO2013111161A3
WO2013111161A3 PCT/IN2013/000017 IN2013000017W WO2013111161A3 WO 2013111161 A3 WO2013111161 A3 WO 2013111161A3 IN 2013000017 W IN2013000017 W IN 2013000017W WO 2013111161 A3 WO2013111161 A3 WO 2013111161A3
Authority
WO
WIPO (PCT)
Prior art keywords
preparation
polymorphs
aryl
methyl
propanamine derivatives
Prior art date
Application number
PCT/IN2013/000017
Other languages
French (fr)
Other versions
WO2013111161A2 (en
Inventor
Srinivasan Thirumalai Rajan
Sajja Eswaraiah
Gogulapati Venkata Panakala Rao
Peri SEETHA RAMA SHARMA
Original Assignee
Msn Laboratories Limited
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Msn Laboratories Limited filed Critical Msn Laboratories Limited
Publication of WO2013111161A2 publication Critical patent/WO2013111161A2/en
Publication of WO2013111161A3 publication Critical patent/WO2013111161A3/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C213/00—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C213/00—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton
    • C07C213/08—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton by reactions not involving the formation of amino groups, hydroxy groups or etherified or esterified hydroxy groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C215/00—Compounds containing amino and hydroxy groups bound to the same carbon skeleton
    • C07C215/46—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
    • C07C215/48—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by carbon chains not further substituted by hydroxy groups
    • C07C215/54—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by carbon chains not further substituted by hydroxy groups linked by carbon chains having at least three carbon atoms between the amino groups and the six-membered aromatic ring or the condensed ring system containing that ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C217/00—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
    • C07C217/54—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
    • C07C217/64—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by carbon chains further substituted by singly-bound oxygen atoms
    • C07C217/66—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by carbon chains further substituted by singly-bound oxygen atoms with singly-bound oxygen atoms and six-membered aromatic rings bound to the same carbon atom of the carbon chain
    • C07C217/72—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by carbon chains further substituted by singly-bound oxygen atoms with singly-bound oxygen atoms and six-membered aromatic rings bound to the same carbon atom of the carbon chain linked by carbon chains having at least three carbon atoms between the amino groups and the six-membered aromatic ring or the condensed ring system containing that ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/07—Optical isomers

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

The present invention relates to novel process for the preparation of 3-[(lR,2R)-3- (dimethylamino)-l-ethyl-2-methylpropyl]phenol and its pharmaceutically acceptable salts.
PCT/IN2013/000017 2012-01-10 2013-01-09 Process for the preparation of 3-aryl-2-methyl-propanamine derivatives and polymorphs thereof WO2013111161A2 (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
IN97/CHE/2012 2012-01-10
IN97CH2012 2012-01-10
IN3403/CHE/2012 2012-08-17
IN3403CH2012 2012-08-17

Publications (2)

Publication Number Publication Date
WO2013111161A2 WO2013111161A2 (en) 2013-08-01
WO2013111161A3 true WO2013111161A3 (en) 2013-11-28

Family

ID=48874031

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IN2013/000017 WO2013111161A2 (en) 2012-01-10 2013-01-09 Process for the preparation of 3-aryl-2-methyl-propanamine derivatives and polymorphs thereof

Country Status (1)

Country Link
WO (1) WO2013111161A2 (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2523089A (en) * 2014-02-12 2015-08-19 Azad Pharmaceutical Ingredients Ag Stable polymorph form B of tapentadol hydrochloride
SK812017A3 (en) 2017-08-18 2019-03-01 Saneca Pharmaceuticals A. S. Method for preparing of tapentadol and its intermediates

Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0693475A1 (en) * 1994-07-23 1996-01-24 Grünenthal GmbH 1-Phenyl-3-dimethylamino-propane derivatives having pharmacological activity
EP1612203A1 (en) * 2004-06-28 2006-01-04 Grünenthal GmbH Crystalline forms of (-)-(1R,2R)-3-(3-dimethylamino-1-ethyl-2-methylpropyl)-phenol hydrochloride
US20090149534A1 (en) * 2007-12-07 2009-06-11 Gruenenthal Gmbh Crystalline modifications of (1R,2R)-3-(3-Dimethylamino-1-ethyl-2-methyl-propyl)-phenol
US20110071120A1 (en) * 2009-09-22 2011-03-24 Actavis Group Ptc Ehf Solid state forms of tapentadol salts
WO2011138037A2 (en) * 2010-05-05 2011-11-10 Ratiopharm Gmbh Solid tapentadol in non-crystalline form
WO2012001571A1 (en) * 2010-07-02 2012-01-05 Archimica Srl New process for the synthesis of tapentadol and intermediates thereof
WO2012010316A1 (en) * 2010-07-23 2012-01-26 Grünenthal GmbH Salts or co-crystals of 3-(3-dimethylamino-1-ethyl-2-methyl-propyl)-phenol

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0693475A1 (en) * 1994-07-23 1996-01-24 Grünenthal GmbH 1-Phenyl-3-dimethylamino-propane derivatives having pharmacological activity
EP1612203A1 (en) * 2004-06-28 2006-01-04 Grünenthal GmbH Crystalline forms of (-)-(1R,2R)-3-(3-dimethylamino-1-ethyl-2-methylpropyl)-phenol hydrochloride
US20090149534A1 (en) * 2007-12-07 2009-06-11 Gruenenthal Gmbh Crystalline modifications of (1R,2R)-3-(3-Dimethylamino-1-ethyl-2-methyl-propyl)-phenol
US20110071120A1 (en) * 2009-09-22 2011-03-24 Actavis Group Ptc Ehf Solid state forms of tapentadol salts
WO2011138037A2 (en) * 2010-05-05 2011-11-10 Ratiopharm Gmbh Solid tapentadol in non-crystalline form
WO2012001571A1 (en) * 2010-07-02 2012-01-05 Archimica Srl New process for the synthesis of tapentadol and intermediates thereof
WO2012010316A1 (en) * 2010-07-23 2012-01-26 Grünenthal GmbH Salts or co-crystals of 3-(3-dimethylamino-1-ethyl-2-methyl-propyl)-phenol

Also Published As

Publication number Publication date
WO2013111161A2 (en) 2013-08-01

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