RS52212B - Hydroxylated and methoxylated cyclopenta [d] pyrimidines as akt protein kinase inhibitors - Google Patents

Hydroxylated and methoxylated cyclopenta [d] pyrimidines as akt protein kinase inhibitors

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Publication number
RS52212B
RS52212B RS20110551A RSP20110551A RS52212B RS 52212 B RS52212 B RS 52212B RS 20110551 A RS20110551 A RS 20110551A RS P20110551 A RSP20110551 A RS P20110551A RS 52212 B RS52212 B RS 52212B
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RS
Serbia
Prior art keywords
alkyl
optionally substituted
cycloalkyl
phenyl
groups
Prior art date
Application number
RS20110551A
Other languages
Serbian (sr)
Inventor
Rui Xu
Dengming Xiao
Jun Liang
Brian Safina
Christine Chabot
Ian S. Mitchell
James F. Blake
Nicholas C. Kallan
Keith Lee Spencer
Josef R. Bencsik
Birong Zhang
Steven Do
Anna L. Banka
Stephen T. Schlachter
Eli. W. Wallace
Original Assignee
Array Biopharma, Inc.
Genentech, Inc.
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Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=38686743&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=RS52212(B) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Array Biopharma, Inc., Genentech, Inc. filed Critical Array Biopharma, Inc.
Priority claimed from PCT/US2007/072876 external-priority patent/WO2008006032A1/en
Publication of RS52212B publication Critical patent/RS52212B/en

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Abstract

Jedinjenje Formule I:i razloženi enantiomeri, razloženi diastereomeri i soli, gde:R1 je Me;R2 je H;R5 je H A je G je fenil opciono zamenjen jednom do četiri R9 grupe ili 5- ili 6-člani heteroaril opciono zamenjen halogenom;R6 i R7 su nezavisno H, OCH3, ( C3-C6 cikloalkil)-(CH2), ( C3-C6 cikloalkil)-(CH2CH2), V-(CH2)0-1 gde V je 5- ili 6-člani heteroaril, W-(CH2)))1-2 gde W je fenil opciono zamenjen sa F, Cl, Br, I, OMe, CF3 ili Me, C3-C6-cikloalkil opciono zamenjen sa C1-C3 alkil grupom ili O(C1-C3 alkil), hidroksi-(C3-C6-cikloalkil), fluoro-(C3-C6-cikloalkil), CH(CH3)CH(OH)fenil grupom, 4- do 6-člani heterocikl opciono zamenjen sa F, OH, C1-C3 alkil, ciklopropilmetil ili C(=O)(C1-C3 alkil) grupom, ili C1-C6-alkil opciono zamenjen sa jednom ili više grupa nezavisno odabranih medu OH, okso, O(C1-C6-alkil), CN, F, NH2, NH(C1-C6-alkil), N (C1-C6-alkil)2, ciklopropil, fenil, imidazolil, piperidinil, pirolidinil, morfolinil, tetrahidrofuranil, oksetanil ili tetrahidropiranil,ili R6 i R7 zajedno sa azotom za koji su prikačeni formiraju 4- do 7-člani heterociklični prsten opciono zamenjen sa jednom ili više grupa nezavisno odabranih medu OH, halogen, okso, CF3, CH2CF3, CH2CH2OH, O(C1-C3 alkil), C(=O)CH3, NH2, NHMe, N(Me)2, S(O)2CH3, ciklopropilmetil i C1-C3 alkil grupe; Rc i Rd su H, R8 je H;svaki R9 je nezavisno halogen, C1-C6-alkil, C3-C6-cikloalkil, O-(C1-C6-alkil), CF-3, OCF3, S(C1-C6-alkil),CN, OCH2-fenil, CH2O-fenil, NH2, NH-(C1-C6-alkil), N-(C1-C6-alkil)2, piperidin, pirolidin, CH2F,CHF2, OCH2F, OCHF2, OH, SO2(C1-C6-alkil), C(O)NH2, C(O)NH(C1-C6-alkil), i C(O)N(C1-C6-alkil)2;R10 je H. Prijava sadrži još 16 patentnih zahteva.A compound of Formula I: and decomposed enantiomers, decomposed diastereomers and salts, wherein: R 1 is Me, R 2 is H, R 5 is HA is G is phenyl optionally substituted with one to four R 9 groups or 5- or 6-membered heteroaryl optionally substituted with halogen; and R7 are independently H, OCH3, (C3-C6 cycloalkyl) - (CH2), (C3-C6 cycloalkyl) - (CH2CH2), V- (CH2) 0-1 wherein V is 5- or 6-membered heteroaryl, W - (CH2))) 1-2 wherein W is phenyl optionally substituted with F, Cl, Br, I, OMe, CF3 or Me, C3-C6-cycloalkyl optionally substituted with a C1-C3 alkyl group or O (C1-C3 alkyl ), hydroxy- (C3-C6-cycloalkyl), fluoro- (C3-C6-cycloalkyl), CH (CH3) CH (OH) phenyl group, 4- to 6-membered heterocycle optionally substituted with F, OH, C1-C3 alkyl, cyclopropylmethyl or a C (= O) (C1-C3 alkyl) group, or C1-C6-alkyl optionally substituted with one or more groups independently selected from OH, oxo, O (C1-C6-alkyl), CN, F, NH2, NH (C1-C6-alkyl), N (C1-C6-alkyl) 2, cyclopropyl, phenyl, imidazolyl, piperidinyl, pyrrolidinyl, morpholinyl, tetrahydrofuranyl, oxetanyl or tetrahydropyranyl, or R6 and R7 together with the nitrogen to which they are attached form a 4- to 7-membered heterocyclic ring optionally substituted with one or more groups independently selected from OH, halogen, oxo, CF3, CH2CF3, CH2CH2OH, O (C1-C3 alkyl), C (= O ) CH3, NH2, NHMe, N (Me) 2, S (O) 2CH3, cyclopropylmethyl and C1-C3 alkyl groups; Rc and Rd are H, R8 is H, each R9 is independently halogen, C1-C6-alkyl, C3-C6-cycloalkyl, O- (C1-C6-alkyl), CF-3, OCF3, S (C1-C6- alkyl), CN, OCH2-phenyl, CH2O-phenyl, NH2, NH- (C1-C6-alkyl), N- (C1-C6-alkyl) 2, piperidine, pyrrolidine, CH2F, CHF2, OCH2F, OCHF2, OH, SO2 (C1-C6-alkyl), C (O) NH2, C (O) NH (C1-C6-alkyl), and C (O) N (C1-C6-alkyl) 2; R10 is H. The application contains more 16 patent claims.

RS20110551A 2006-07-06 2007-07-05 Hydroxylated and methoxylated cyclopenta [d] pyrimidines as akt protein kinase inhibitors RS52212B (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US81871806P 2006-07-06 2006-07-06
PCT/US2007/072876 WO2008006032A1 (en) 2006-07-06 2007-07-05 Cyclopenta [d] pyrimidines as akt protein kinase inhibitors

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RS52212B true RS52212B (en) 2012-10-31

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