YU29602A - Derivati indeno-, nafto- i benzociklohepta-dihidrotiazola, njihova proizvodnja i njihova primena kao anorektičnih lekova - Google Patents

Derivati indeno-, nafto- i benzociklohepta-dihidrotiazola, njihova proizvodnja i njihova primena kao anorektičnih lekova

Info

Publication number
YU29602A
YU29602A YU29602A YUP29602A YU29602A YU 29602 A YU29602 A YU 29602A YU 29602 A YU29602 A YU 29602A YU P29602 A YUP29602 A YU P29602A YU 29602 A YU29602 A YU 29602A
Authority
YU
Yugoslavia
Prior art keywords
substituted
aryl
alkyl
phenyl
hydrogen
Prior art date
Application number
YU29602A
Other languages
English (en)
Inventor
Gerhard Jaehne
Mathias Gossel
Hans-Jochen Lang
Martin Bickel
Original Assignee
Aventis Pharma Deutschland Gmbh.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE2000113306 external-priority patent/DE10013306A1/de
Application filed by Aventis Pharma Deutschland Gmbh. filed Critical Aventis Pharma Deutschland Gmbh.
Publication of YU29602A publication Critical patent/YU29602A/sh

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/60—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings condensed with carbocyclic rings or ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/428—Thiazoles condensed with carbocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics

Abstract

Policiklicni dihidrotiazoli, postupak za njihovu proizvodnju i njihova primena kao lekova. Pronalazak se odnosi na policiklicne dihidrotiazole kao i na njihove fizioloski prihvatljive soli i fizioloski funkcionalne derivate. Opisana su jedinjenja Formule I, u kojoj ostaci imaju navedena znacenja. Opisane su i njihove fizioloski prihvatljive soli i postupak za njihovu proizvodnju. Ova jedinjenja su pogodna da se koriste naprimer kao anorekticna sredstva.
YU29602A 1999-11-05 2000-10-21 Derivati indeno-, nafto- i benzociklohepta-dihidrotiazola, njihova proizvodnja i njihova primena kao anorektičnih lekova YU29602A (sh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19953205 1999-11-05
DE2000113306 DE10013306A1 (de) 2000-03-17 2000-03-17 Polycyclische, in 2-Stellung mit substituierten Alkylresten versehene Dihydrothiazole, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel

Publications (1)

Publication Number Publication Date
YU29602A true YU29602A (sh) 2006-01-16

Family

ID=26004890

Family Applications (1)

Application Number Title Priority Date Filing Date
YU29602A YU29602A (sh) 1999-11-05 2000-10-21 Derivati indeno-, nafto- i benzociklohepta-dihidrotiazola, njihova proizvodnja i njihova primena kao anorektičnih lekova

Country Status (27)

Country Link
US (1) US6387935B1 (sh)
EP (1) EP1230230B1 (sh)
JP (1) JP2003524632A (sh)
KR (1) KR20020047331A (sh)
CN (1) CN1176080C (sh)
AR (1) AR026338A1 (sh)
AT (1) ATE250045T1 (sh)
AU (1) AU777569B2 (sh)
BR (1) BR0015322A (sh)
CA (1) CA2389703A1 (sh)
CZ (1) CZ20021528A3 (sh)
DE (1) DE50003761D1 (sh)
DK (1) DK1230230T3 (sh)
EE (1) EE200200235A (sh)
ES (1) ES2206320T3 (sh)
HK (1) HK1050524A1 (sh)
HR (1) HRP20020379A2 (sh)
HU (1) HUP0203290A3 (sh)
IL (1) IL149400A0 (sh)
MX (1) MXPA02003477A (sh)
NO (1) NO322309B1 (sh)
NZ (1) NZ518751A (sh)
PL (1) PL354533A1 (sh)
PT (1) PT1230230E (sh)
SK (1) SK6132002A3 (sh)
WO (1) WO2001032638A1 (sh)
YU (1) YU29602A (sh)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7772188B2 (en) 2003-01-28 2010-08-10 Ironwood Pharmaceuticals, Inc. Methods and compositions for the treatment of gastrointestinal disorders
WO2005097127A2 (en) 2004-04-02 2005-10-20 Merck & Co., Inc. Method of treating men with metabolic and anthropometric disorders
US8969514B2 (en) 2007-06-04 2015-03-03 Synergy Pharmaceuticals, Inc. Agonists of guanylate cyclase useful for the treatment of hypercholesterolemia, atherosclerosis, coronary heart disease, gallstone, obesity and other cardiovascular diseases
CA3089569C (en) 2007-06-04 2023-12-05 Synergy Pharmaceuticals Inc. Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders
JP2011522828A (ja) 2008-06-04 2011-08-04 シナジー ファーマシューティカルズ インコーポレイテッド 胃腸障害、炎症、癌、およびその他の障害の治療のために有用なグアニル酸シクラーゼのアゴニスト
EP2321341B1 (en) 2008-07-16 2017-02-22 Synergy Pharmaceuticals Inc. Agonists of guanylate cyclase useful for the treatment of gastrointestinal, inflammation, cancer and other disorders
MX2011004258A (es) 2008-10-22 2011-06-01 Merck Sharp & Dohme Derivados de bencimidazol ciclicos novedosos utiles como agentes anti-diabeticos.
JP5557845B2 (ja) 2008-10-31 2014-07-23 メルク・シャープ・アンド・ドーム・コーポレーション 糖尿病用剤として有用な新規環状ベンゾイミダゾール誘導体
EP2538784B1 (en) 2010-02-25 2015-09-09 Merck Sharp & Dohme Corp. Benzimidazole derivatives useful anti-diabetic agents
US9616097B2 (en) 2010-09-15 2017-04-11 Synergy Pharmaceuticals, Inc. Formulations of guanylate cyclase C agonists and methods of use
KR20150075120A (ko) 2011-02-25 2015-07-02 머크 샤프 앤드 돔 코포레이션 항당뇨병제로서 유용한 신규 시클릭 아자벤즈이미다졸 유도체
CA2828346C (en) 2011-03-01 2021-01-26 Synergy Pharmaceuticals Inc. Process of preparing guanylate cyclase c agonists
RU2015106909A (ru) 2012-08-02 2016-09-27 Мерк Шарп И Доум Корп. Антидиабетические трициклические соединения
KR20150118158A (ko) 2013-02-22 2015-10-21 머크 샤프 앤드 돔 코포레이션 항당뇨병 비시클릭 화합물
EP2970119B1 (en) 2013-03-14 2021-11-03 Merck Sharp & Dohme Corp. Novel indole derivatives useful as anti-diabetic agents
EP2970384A1 (en) 2013-03-15 2016-01-20 Synergy Pharmaceuticals Inc. Agonists of guanylate cyclase and their uses
US9486494B2 (en) 2013-03-15 2016-11-08 Synergy Pharmaceuticals, Inc. Compositions useful for the treatment of gastrointestinal disorders
JP6606491B2 (ja) 2013-06-05 2019-11-13 シナジー ファーマシューティカルズ インコーポレイテッド グアニル酸シクラーゼｃの超高純度アゴニスト、その作成および使用方法
WO2015051496A1 (en) 2013-10-08 2015-04-16 Merck Sharp & Dohme Corp. Antidiabetic tricyclic compounds
EP3551176A4 (en) 2016-12-06 2020-06-24 Merck Sharp & Dohme Corp. ANTIDIABETIC HETEROCYCLIC COMPOUNDS
US10968232B2 (en) 2016-12-20 2021-04-06 Merck Sharp & Dohme Corp. Antidiabetic spirochroman compounds

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3507868A (en) * 1968-10-21 1970-04-21 Sandoz Ag Imidazo(2,1-b)thiazoles and thiazolo(3,2-a)pyrimidines
DE2640358A1 (de) * 1976-09-08 1978-03-16 Hoechst Ag Thiazolidinderivate und verfahren zu ihrer herstellung
DE19831878C2 (de) * 1998-07-17 2001-05-17 Aventis Pharma Gmbh Polycyclische Thiazolidin-2-yliden Amine, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel
DE19844547C2 (de) * 1998-09-29 2002-11-07 Aventis Pharma Gmbh Polycyclische Dihydrothiazole, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel
DE19908539A1 (de) * 1999-02-26 2000-08-31 Aventis Pharma Gmbh Polycyclische 2-Amino-Dihydrothiazolsysteme, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel

Also Published As

Publication number Publication date
US6387935B1 (en) 2002-05-14
KR20020047331A (ko) 2002-06-21
DE50003761D1 (de) 2003-10-23
HUP0203290A3 (en) 2004-12-28
BR0015322A (pt) 2002-07-09
MXPA02003477A (es) 2002-08-20
CN1384827A (zh) 2002-12-11
DK1230230T3 (da) 2003-12-15
EE200200235A (et) 2003-06-16
HUP0203290A2 (hu) 2003-01-28
HRP20020379A2 (en) 2004-02-29
HK1050524A1 (en) 2003-06-27
IL149400A0 (en) 2002-11-10
CA2389703A1 (en) 2001-05-10
JP2003524632A (ja) 2003-08-19
NO322309B1 (no) 2006-09-11
SK6132002A3 (en) 2002-11-06
AR026338A1 (es) 2003-02-05
NO20022021D0 (no) 2002-04-29
NO20022021L (no) 2002-04-29
AU777569B2 (en) 2004-10-21
PL354533A1 (en) 2004-01-26
NZ518751A (en) 2004-06-25
CN1176080C (zh) 2004-11-17
CZ20021528A3 (cs) 2002-07-17
EP1230230A1 (de) 2002-08-14
ES2206320T3 (es) 2004-05-16
WO2001032638A1 (de) 2001-05-10
AU1274601A (en) 2001-05-14
PT1230230E (pt) 2003-12-31
ATE250045T1 (de) 2003-10-15
EP1230230B1 (de) 2003-09-17

Similar Documents

Publication Publication Date Title
YU29602A (sh) Derivati indeno-, nafto- i benzociklohepta-dihidrotiazola, njihova proizvodnja i njihova primena kao anorektičnih lekova
ATE139778T1 (de) Xanthinverbindungen
HUT70159A (en) Oxazolidinedion derivatives, pharmaceutical compositions containing them, their production and use
DK0667852T3 (da) Hidtil ukendte 3,3-diphenylpropylaminer samt deres anvendelse og fremstilling
PH17740A (en) Substituted acyl derivatives of 1-2,3,4 tetrahydro-isoquinoline-3-carboxylic acids,their pharmaceutical compositions and use
CZ332599A3 (cs) Cyklické deriváty amidů acylaminokyselin substituované thioskupinou a způsob jejich přípravy
DE3869258D1 (de) Benzopyran-derivate, deren herstellung und diese enthaltende pharmazeutische zusammenstellungen.
DK0518558T3 (da) 1-methylcarbapenemderivater, deres fremstilling og deres anvendelse som antibiotika
EP0031567A3 (en) Tetrapeptidesemicarbazide derivatives and their production and use
EP0359276A3 (en) Stabilized synthetic resin composition
DK0790248T3 (da) 3-Aza-piperidon-(tetrahydropyrimidin-2-on)- og 3-oxa-piperidon-(1,3-oxazin-2-on)-derivater, deres fremstilling og deres anvendelse som tachykinin/neurokinin-antagonister
ATE141606T1 (de) Cephemverbindungen und verfahren zu ihrer herstellung
ATE71944T1 (de) Thiazolderivate, verfahren zu ihrer herstellung und pharmazeutische zusammensetzungen, die sie enthalten.
ATE148128T1 (de) Anthracyclinglycosid-derivate und verfahren zu ihrer herstellung
ATE212637T1 (de) Anitbiotisch wirksame cephalosporine und verfahren zu ihrer herstellung
WO2002059089A3 (en) Process for the preparation of heterocyclic indene analogs
NZ335055A (en) Bis(acridinecarboxamide) and bis(phenazinecarboxamide) as antitumour agents and process for its production
YU13003A (sh) Prolekovi za ligande nmda receptora
DE69011748D1 (de) Biphenyl-Derivate, Verfahren zu deren Herstellung und deren Zwischenprodukte.
DE3671016D1 (de) Thiazolidinderivate und verfahren zu ihrer herstellung.
DE3578168D1 (de) Aminoalkylnaphthalen-derivate mit pharmakologischer wirkung.
IE820160L (en) Heterocyclic benzamide derivatives
ES8201541A1 (es) Un procedimiento para la preparacion de nuevas guanilamidi- nas
HU893626D0 (en) New derivatives of leucotriene-b4, process for producing them and their application as medicament
ATE44741T1 (de) 2-(n-substituierte guanidino)-4heteroarylthiazole als mittel gegen geschwuere.