AR026338A1 - Dihidrotiazoles policiclicos, provistos en posicion 2 de radicales alquilo sustituidos, procedimiento para su preparacion y su utilizacion comomedicamentos - Google Patents

Dihidrotiazoles policiclicos, provistos en posicion 2 de radicales alquilo sustituidos, procedimiento para su preparacion y su utilizacion comomedicamentos

Info

Publication number
AR026338A1
AR026338A1 ARP000105782A ARP000105782A AR026338A1 AR 026338 A1 AR026338 A1 AR 026338A1 AR P000105782 A ARP000105782 A AR P000105782A AR P000105782 A ARP000105782 A AR P000105782A AR 026338 A1 AR026338 A1 AR 026338A1
Authority
AR
Argentina
Prior art keywords
preparation
polycyclic
radicals
dihydrotiazols
rental
Prior art date
Application number
ARP000105782A
Other languages
English (en)
Original Assignee
Sanofi Aventis Deutschland
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE2000113306 external-priority patent/DE10013306A1/de
Application filed by Sanofi Aventis Deutschland filed Critical Sanofi Aventis Deutschland
Publication of AR026338A1 publication Critical patent/AR026338A1/es

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D277/00Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/60Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings condensed with carbocyclic rings or ring systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425Thiazoles
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425Thiazoles
    • A61K31/428Thiazoles condensed with carbocyclic rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/04Anorexiants; Antiobesity agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/08Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Diabetes (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Emergency Medicine (AREA)
  • Child & Adolescent Psychology (AREA)
  • Endocrinology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

La presente se refiere a dihidrotiazoles policíclicos así como a sus sales fisiologicamente tolerables y a derivados fisiologicamente funcionales. Sedescriben compuestos de la formula (1), en lo que los radicales tienen los significados indicados en la descripcion así como sus sales fisiologicamentetolerables y un procedimiento para su preparacion. Los compuestos son apropiados por ej. como anoréticos. Se describen también medicamentos que contienen uno ovarios de los compuestos activos y el pro cedimiento de preparacion de un medicamento.
ARP000105782A 1999-11-05 2000-11-02 Dihidrotiazoles policiclicos, provistos en posicion 2 de radicales alquilo sustituidos, procedimiento para su preparacion y su utilizacion comomedicamentos AR026338A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19953205 1999-11-05
DE2000113306 DE10013306A1 (de) 2000-03-17 2000-03-17 Polycyclische, in 2-Stellung mit substituierten Alkylresten versehene Dihydrothiazole, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel

Publications (1)

Publication Number Publication Date
AR026338A1 true AR026338A1 (es) 2003-02-05

Family

ID=26004890

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP000105782A AR026338A1 (es) 1999-11-05 2000-11-02 Dihidrotiazoles policiclicos, provistos en posicion 2 de radicales alquilo sustituidos, procedimiento para su preparacion y su utilizacion comomedicamentos

Country Status (27)

Country Link
US (1) US6387935B1 (es)
EP (1) EP1230230B1 (es)
JP (1) JP2003524632A (es)
KR (1) KR20020047331A (es)
CN (1) CN1176080C (es)
AR (1) AR026338A1 (es)
AT (1) ATE250045T1 (es)
AU (1) AU777569B2 (es)
BR (1) BR0015322A (es)
CA (1) CA2389703A1 (es)
CZ (1) CZ20021528A3 (es)
DE (1) DE50003761D1 (es)
DK (1) DK1230230T3 (es)
EE (1) EE200200235A (es)
ES (1) ES2206320T3 (es)
HK (1) HK1050524A1 (es)
HR (1) HRP20020379A2 (es)
HU (1) HUP0203290A3 (es)
IL (1) IL149400A0 (es)
MX (1) MXPA02003477A (es)
NO (1) NO322309B1 (es)
NZ (1) NZ518751A (es)
PL (1) PL354533A1 (es)
PT (1) PT1230230E (es)
SK (1) SK6132002A3 (es)
WO (1) WO2001032638A1 (es)
YU (1) YU29602A (es)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7772188B2 (en) 2003-01-28 2010-08-10 Ironwood Pharmaceuticals, Inc. Methods and compositions for the treatment of gastrointestinal disorders
EP1734963A4 (en) 2004-04-02 2008-06-18 Merck & Co Inc METHOD FOR TREATING PEOPLE WITH METABOLIC AND ANTHROPOMETRIC DISORDER
US7879802B2 (en) 2007-06-04 2011-02-01 Synergy Pharmaceuticals Inc. Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders
US8034782B2 (en) 2008-07-16 2011-10-11 Synergy Pharmaceuticals, Inc. Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders
US8969514B2 (en) 2007-06-04 2015-03-03 Synergy Pharmaceuticals, Inc. Agonists of guanylate cyclase useful for the treatment of hypercholesterolemia, atherosclerosis, coronary heart disease, gallstone, obesity and other cardiovascular diseases
JP2011522828A (ja) 2008-06-04 2011-08-04 シナジー ファーマシューティカルズ インコーポレイテッド 胃腸障害、炎症、癌、およびその他の障害の治療のために有用なグアニル酸シクラーゼのアゴニスト
CN102264228A (zh) 2008-10-22 2011-11-30 默沙东公司 用于抗糖尿病药的新的环状苯并咪唑衍生物
CN102271509A (zh) 2008-10-31 2011-12-07 默沙东公司 用于抗糖尿病药的新型环苯并咪唑衍生物
CA2786314A1 (en) 2010-02-25 2011-09-01 Merck Sharp & Dohme Corp. Novel cyclic benzimidazole derivatives useful anti-diabetic agents
US9616097B2 (en) 2010-09-15 2017-04-11 Synergy Pharmaceuticals, Inc. Formulations of guanylate cyclase C agonists and methods of use
CN103476258B (zh) 2011-02-25 2017-04-26 默沙东公司 用作抗糖尿病药剂的新的环状氮杂苯并咪唑衍生物
EP2681236B1 (en) 2011-03-01 2018-01-03 Synergy Pharmaceuticals Inc. Process of preparing guanylate cyclase c agonists
JP2015525782A (ja) 2012-08-02 2015-09-07 メルク・シャープ・アンド・ドーム・コーポレーションMerck Sharp & Dohme Corp. 抗糖尿病性三環式化合物
MX2015010935A (es) 2013-02-22 2015-10-29 Merck Sharp & Dohme Compuestos biciclicos antidiabeticos.
US9650375B2 (en) 2013-03-14 2017-05-16 Merck Sharp & Dohme Corp. Indole derivatives useful as anti-diabetic agents
US9708367B2 (en) 2013-03-15 2017-07-18 Synergy Pharmaceuticals, Inc. Agonists of guanylate cyclase and their uses
WO2014151200A2 (en) 2013-03-15 2014-09-25 Synergy Pharmaceuticals Inc. Compositions useful for the treatment of gastrointestinal disorders
AU2014274812B2 (en) 2013-06-05 2018-09-27 Bausch Health Ireland Limited Ultra-pure agonists of guanylate cyclase C, method of making and using same
WO2015051496A1 (en) 2013-10-08 2015-04-16 Merck Sharp & Dohme Corp. Antidiabetic tricyclic compounds
US11072602B2 (en) 2016-12-06 2021-07-27 Merck Sharp & Dohme Corp. Antidiabetic heterocyclic compounds
US10968232B2 (en) 2016-12-20 2021-04-06 Merck Sharp & Dohme Corp. Antidiabetic spirochroman compounds

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3507868A (en) * 1968-10-21 1970-04-21 Sandoz Ag Imidazo(2,1-b)thiazoles and thiazolo(3,2-a)pyrimidines
DE2640358A1 (de) * 1976-09-08 1978-03-16 Hoechst Ag Thiazolidinderivate und verfahren zu ihrer herstellung
DE19831878C2 (de) * 1998-07-17 2001-05-17 Aventis Pharma Gmbh Polycyclische Thiazolidin-2-yliden Amine, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel
DE19844547C2 (de) * 1998-09-29 2002-11-07 Aventis Pharma Gmbh Polycyclische Dihydrothiazole, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel
DE19908539A1 (de) * 1999-02-26 2000-08-31 Aventis Pharma Gmbh Polycyclische 2-Amino-Dihydrothiazolsysteme, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel

Also Published As

Publication number Publication date
CN1176080C (zh) 2004-11-17
PL354533A1 (en) 2004-01-26
HK1050524A1 (en) 2003-06-27
JP2003524632A (ja) 2003-08-19
CN1384827A (zh) 2002-12-11
NZ518751A (en) 2004-06-25
SK6132002A3 (en) 2002-11-06
CA2389703A1 (en) 2001-05-10
US6387935B1 (en) 2002-05-14
PT1230230E (pt) 2003-12-31
HUP0203290A3 (en) 2004-12-28
EP1230230A1 (de) 2002-08-14
IL149400A0 (en) 2002-11-10
HRP20020379A2 (en) 2004-02-29
ATE250045T1 (de) 2003-10-15
YU29602A (sh) 2006-01-16
DE50003761D1 (de) 2003-10-23
NO322309B1 (no) 2006-09-11
MXPA02003477A (es) 2002-08-20
AU1274601A (en) 2001-05-14
DK1230230T3 (da) 2003-12-15
EE200200235A (et) 2003-06-16
HUP0203290A2 (hu) 2003-01-28
ES2206320T3 (es) 2004-05-16
AU777569B2 (en) 2004-10-21
BR0015322A (pt) 2002-07-09
NO20022021D0 (no) 2002-04-29
EP1230230B1 (de) 2003-09-17
KR20020047331A (ko) 2002-06-21
CZ20021528A3 (cs) 2002-07-17
NO20022021L (no) 2002-04-29
WO2001032638A1 (de) 2001-05-10

Similar Documents

Publication Publication Date Title
AR026338A1 (es) Dihidrotiazoles policiclicos, provistos en posicion 2 de radicales alquilo sustituidos, procedimiento para su preparacion y su utilizacion comomedicamentos
AR025444A1 (es) Derivados de sulfonil-carboxamida, procedimientos para su preparacion y su utilizacion como medicamentos
UY28369A1 (es) Agentes terapéuticos
AR023401A1 (es) Derivados de 1,4-benzotiazepina-1,1-dioxido sustituidos con restos de azucar, procedimientos para su preparacion, medicamentos que contienen estoscompuestos, y su empleo para preparar un medicamento
AR023346A1 (es) Compuestos derivados biciclicos substituidos utiles como agentes contra el cancer, uso de los mismos para preparar un medicamento, composicionesfarmaceuticas y procedimiento de preparacion de los compuestos
PA8557001A1 (es) Nuevos derivados de pirrolidina
BR0317283A (pt) Derivados heterocìclicos de flúor-glicosìdeo, medicamentos contendo estes compostos e seu uso
CU23132A3 (es) Nuevos derivados de benzoimidazol utiles como agentes antiproliferativos
AR028833A1 (es) Compuestos inhibidores de metaloproteasas, composiciones farmaceuticas, uso para la manufactura de medicamentos, metodo de tratamiento y procedimiento para su preparacion
UY26872A1 (es) Derivados de la 4- fenil piridina
AR021844A1 (es) Derivados de propanolamina aril-sustituidos, procedimientos para su preparacion, medicamentos que contienen estos compuestos y su utilizacion
BRPI0407387A (pt) Derivados de hexahidro-pirazino[1,2-a]pirimidin-4,7-diona substituìdos por nitrogênio, processos para a sua preparação e sua aplicação com medicamento
AR020662A1 (es) Compuestos dihidrotiazoles policiclicos, procedimientos para su preparacion, medicamento, procedimiento para la preparacion de dicho medicamento y lautilizacion de dichos compuestos para la preparacion de un medicamento.
UY26513A1 (es) Nuevas piperidinas sustituidas, medicamentos que contienen estos compuestos y procedimiento para su preparación.
AR024462A1 (es) Tabletas farmaceuticas
AR018162A1 (es) Pirroles substituidos, composicion farmaceutica y el uso de los mismos para la preparacion de dicha composicion farmaceutica
UY28357A1 (es) Derivados de benzimidazol, composiciones que los contienen, preparación de los mismos y sus usos
AR042547A1 (es) Uso de acidos alfa - feniltiocaboxilico y alfa - feniloxicarboxilico con actividad disminuidora de la glucosa en el suero y de los lipidos en el suero
BR9911250A (pt) Processo para preparação de compostos
ECSP056190A (es) Compuestos utiles en la terapia de la enfermedad de alzheimer y formulaciones que los contienen
MX9300423A (es) Derivados heterociclicos.
UY28828A1 (es) Nueva forma cristalina de ácido 8-ciano-1-ciclopropil-7-(1s, 6s-2,8-diazabiciclo(4.3.0)nonan-8-il)-6-fluoro-1,4-dihidro-4-oxo-3-quinolincarboxílico
PA8474401A1 (es) 3-ceto derivados triciclicos de 6-0-metileritromicina
UY28370A1 (es) Agentes terapéuticos
AR023282A1 (es) Derivados de higromicina

Legal Events

Date Code Title Description
FB Suspension of granting procedure