RS50767B - Piperidinski derivati kao antagonisti nmda receptora - Google Patents

Piperidinski derivati kao antagonisti nmda receptora

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Publication number
RS50767B
RS50767B YUP-1039/03A YUP103903A RS50767B RS 50767 B RS50767 B RS 50767B YU P103903 A YUP103903 A YU P103903A RS 50767 B RS50767 B RS 50767B
Authority
RS
Serbia
Prior art keywords
alkyl
group
oxo
thioxo
groups
Prior art date
Application number
YUP-1039/03A
Other languages
English (en)
Inventor
István BORZA
Csilla HORVÁTH
Sándor FARKAS
József Nagy
Sándor KOLOK
István VÁGO
György DOMÁNY
Gizella BARTÁNÉ SZALAI
György Keseru
Éva KOVÁCSNÉ BOZÓ
Attila Bielik
Györgyi IGNÁCZNÉ SZENDREI
Original Assignee
Richter Gedeon Vegyeszeti Gyar Rt.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from HU0103055A external-priority patent/HU226978B1/hu
Priority claimed from HU0202213A external-priority patent/HU225905B1/hu
Application filed by Richter Gedeon Vegyeszeti Gyar Rt. filed Critical Richter Gedeon Vegyeszeti Gyar Rt.
Publication of RS103903A publication Critical patent/RS103903A/sr
Publication of RS50767B publication Critical patent/RS50767B/sr

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    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/10—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with radicals containing only carbon and hydrogen atoms attached to ring carbon atoms
    • C07D211/14—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with radicals containing only carbon and hydrogen atoms attached to ring carbon atoms with hydrocarbon or substituted hydrocarbon radicals attached to the ring nitrogen atom
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    • C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
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    • C07D211/16—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with radicals containing only carbon and hydrogen atoms attached to ring carbon atoms with acylated ring nitrogen atom
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Abstract

Novi derivati amida karboksilne kiseline formule (I) gdei -(CHRl)m- i -(CHR2)n- predstavljaju -CH2-CH2 grupe, gde susedne V i U grupe grade zajedno i sa jednim ili više istih ili različitih dodatnih heteroatoma i -CH= i/ ili -CH2 grupama, ili 4-7 -očlani homo ili heterociklični prsten, koji je po mogućstvu supstituisan sa okso, tiokso, metil ili trifluorometil, najbolje morfolin, pirol, pirolidin, okso- ili tiokso-pirolidin, pirazol, pirazolidin, imidazol, imidazolidin, okso- ili tiokso-imidazol ili imidazolidin, 1,4-oksazin, oksazol, oksazolidin, okso- ili tiokso-oksazolidin, ili 3-okso-l,4-oksazinski prsten,gde X predstavlja -CO grupu,W je -CO-, -CH2, ili -CH(alkil)-grupa- u kojoj je alkil C1-4 alkil grupa, Y je kiseonikov atom, kao i C1-C4 alkilen, C2-C4 alkinilen, cikloalkilen, aminokarbonil, -NH-, -N(alkil)-, -CH20-, -CH(OH)-, -OCH2- grupa, u kojoj je Cl-4 alkil grupa,Z je vodonik ili atom halogena, nitro, amino, C1-C4 alkil, C1-C4 alkoksi, cijano, triflurometil, hidroksilna ili karboksilna grupa,i optički antipodi ili racemati i/ ili farmaceutski prihvatljive soli koje se grade sa kiselinama i bazama.Prijava sadrži još 9 patentnih zahteva.
YUP-1039/03A 2001-07-24 2002-07-23 Piperidinski derivati kao antagonisti nmda receptora RS50767B (sr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
HU0103055A HU226978B1 (en) 2001-07-24 2001-07-24 New carboxylic acid amide compounds, process for their preparation and pharmaceutical compositions containing them and their use
HU0202213A HU225905B1 (en) 2002-07-10 2002-07-10 Solid-supported parallel synthesis of new carboxylic acid amide derivatives
PCT/HU2002/000071 WO2003010159A1 (en) 2001-07-24 2002-07-23 Piperidine derivatives as nmda receptor antagonists

Publications (2)

Publication Number Publication Date
RS103903A RS103903A (en) 2007-02-05
RS50767B true RS50767B (sr) 2010-08-31

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YUP-1039/03A RS50767B (sr) 2001-07-24 2002-07-23 Piperidinski derivati kao antagonisti nmda receptora

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DE10210779A1 (de) * 2002-03-12 2003-10-09 Merck Patent Gmbh Cyclische Amide
PA8575901A1 (es) * 2002-07-18 2004-07-20 Pfizer Prod Inc Derivados de piperidina novedosos
ES2222833B1 (es) * 2003-07-30 2006-03-01 Laboratorios Del Dr. Esteve, S.A. Compuestos piperidinicos 1,4-disustituidos, su preparacion y su uso como medicamentos.
MXPA06002853A (es) 2003-09-11 2006-06-14 Kemia Inc Inhibidores citoquina.
WO2005030720A1 (ja) * 2003-09-25 2005-04-07 Shionogi & Co., Ltd. Ｎｍｄａ受容体拮抗作用を有するピペリジン誘導体
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