CY1107524T1 - 9- υποκατεστημeνα συστατικa της μινοκυκλiνης - Google Patents

9- υποκατεστημeνα συστατικa της μινοκυκλiνης

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Publication number
CY1107524T1
CY1107524T1 CY20061101475T CY061101475T CY1107524T1 CY 1107524 T1 CY1107524 T1 CY 1107524T1 CY 20061101475 T CY20061101475 T CY 20061101475T CY 061101475 T CY061101475 T CY 061101475T CY 1107524 T1 CY1107524 T1 CY 1107524T1
Authority
CY
Cyprus
Prior art keywords
components
minocycline
tetracycline
ingredients
substituted minocycline
Prior art date
Application number
CY20061101475T
Other languages
English (en)
Inventor
Mark L Nelson
Roger Frechette
Peter Viski
Mohamed Ismail
Todd Bowser
Jimmy Dumornay
Glen Rennie
Gui Liu
Darrell Koza
Paul Sheahan
Karen Stapleton
Paul Hawkins
Beena Bhatia
Atul Verma
Laura Mcintyre
Tad Warchol
Original Assignee
Trustees Of Tufts College
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Trustees Of Tufts College filed Critical Trustees Of Tufts College
Publication of CY1107524T1 publication Critical patent/CY1107524T1/el

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    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/65—Tetracyclines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
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    • C07C237/24—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a ring other than a six-membered aromatic ring of the carbon skeleton
    • C07C237/26—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a ring other than a six-membered aromatic ring of the carbon skeleton of a ring being part of a condensed ring system formed by at least four rings, e.g. tetracycline
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    • C07C255/58—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton containing cyano groups and singly-bound nitrogen atoms, not being further bound to other hetero atoms, bound to the carbon skeleton
    • C07C255/59—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton containing cyano groups and singly-bound nitrogen atoms, not being further bound to other hetero atoms, bound to the carbon skeleton the carbon skeleton being further substituted by singly-bound oxygen atoms
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    • C07C271/30—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atom of at least one of the carbamate groups bound to a carbon atom of a six-membered aromatic ring to a carbon atom of a six-membered aromatic ring being part of a condensed ring system
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    • C07C275/40—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton being further substituted by nitrogen atoms not being part of nitro or nitroso groups
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Abstract

Η παρούσα εφεύρεση αναφέρεται, τουλάχιστον εν μέρει, σε καινούργια 9 -υποκατεστημένα συστατικά της μινοκυκλίνης. Αυτά τα συστατικά της μινοκυκλίνης μπορούν να χρησιμοποιηθούν για να αντιμετωπιστούν πολυάριθμες καταστάσεις που αποκρίνονται σε συστατικά της τετρακυκλίνης, όπως είναι οι βακτηριακές λοιμώξεις και τα νεοπλάσματα, καθώς και σε γενικές γραμμές και για άλλες γνωστές εφαρμογές της μινοκυκλίνης και τον συστατικών της τετρακυκλίνης, όπως είναι η παρεμπόδιση των συστατικών της τετρακυκλίνης σε γενικές γραμμές, όπως είναι η παρεμπόδιση της εκροής της τετρακυκλίνης και η τροποποίηση της γονιδιακής έκφρασης.
CY20061101475T 2000-07-07 2006-10-13 9- υποκατεστημeνα συστατικa της μινοκυκλiνης CY1107524T1 (el)

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US21665900P 2000-07-07 2000-07-07
US27562101P 2001-03-13 2001-03-13
EP01965828A EP1301467B1 (en) 2000-07-07 2001-06-29 9-substituted minocycline compounds

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CY1107524T1 true CY1107524T1 (el) 2013-03-13

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US (5) US6846939B2 (el)
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ES2271070T3 (es) 2007-04-16
CN1690047B (zh) 2010-10-06
AU2005201623B8 (en) 2009-03-12
ATE336481T1 (de) 2006-09-15
US6846939B2 (en) 2005-01-25
AU8638801A (en) 2002-01-21
ATE544745T1 (de) 2012-02-15
PT1301467E (pt) 2006-12-29
AU2009201857B2 (en) 2011-12-22
IL153639A0 (en) 2003-07-06
JP5037436B2 (ja) 2012-09-26
HUP0301169A2 (hu) 2003-08-28
DE60122341D1 (de) 2006-09-28
CZ303702B6 (cs) 2013-03-20
EA009175B1 (ru) 2007-12-28
US20120283201A1 (en) 2012-11-08
AU2005201623A1 (en) 2005-05-05
EP3461808A1 (en) 2019-04-03
WO2002004406A2 (en) 2002-01-17
EP2308832B8 (en) 2019-04-24
EP2308832B1 (en) 2018-09-12
CA2415178A1 (en) 2002-01-17
HRP20030091B1 (en) 2011-10-31
KR100674047B1 (ko) 2007-01-25
DE60122341T2 (de) 2007-08-09
ZA200300749B (en) 2005-08-31
AU2009201857A8 (en) 2011-01-06
SI1301467T1 (sl) 2007-02-28
EA013908B1 (ru) 2010-08-30
JP2012107045A (ja) 2012-06-07
CN1471509A (zh) 2004-01-28
TWI305528B (en) 2009-01-21
WO2002004406A3 (en) 2002-06-06
IL177854A0 (en) 2006-12-31
HU229577B1 (en) 2014-02-28
KR20060014446A (ko) 2006-02-15
EA201000496A1 (ru) 2010-10-29
CN100473644C (zh) 2009-04-01
HUP0301169A3 (en) 2009-08-28
TW200519070A (en) 2005-06-16
AU2005201623B2 (en) 2009-02-12
CZ2003344A3 (cs) 2003-05-14
US20040214801A1 (en) 2004-10-28
AU2009201857B9 (en) 2012-05-10
US9090541B2 (en) 2015-07-28
KR20030017610A (ko) 2003-03-03
JP4925549B2 (ja) 2012-04-25
EP1301467B1 (en) 2006-08-16
IL177854A (en) 2013-02-28
DK1301467T3 (da) 2006-12-27
HRP20030091A2 (en) 2005-02-28
MXPA03000055A (es) 2003-07-14
US20030125348A1 (en) 2003-07-03
AU2001286388B2 (en) 2005-07-14
AU2009201857A1 (en) 2009-06-04
US20150265635A1 (en) 2015-09-24
EP1679305A1 (en) 2006-07-12
ES2701599T3 (es) 2019-02-25
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CN1690047A (zh) 2005-11-02
KR100699390B1 (ko) 2007-03-28

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