EA200300705A1 - Смеси соединения модафинила и циклодекстрина - Google Patents

Смеси соединения модафинила и циклодекстрина

Info

Publication number
EA200300705A1
EA200300705A1 EA200300705A EA200300705A EA200300705A1 EA 200300705 A1 EA200300705 A1 EA 200300705A1 EA 200300705 A EA200300705 A EA 200300705A EA 200300705 A EA200300705 A EA 200300705A EA 200300705 A1 EA200300705 A1 EA 200300705A1
Authority
EA
Eurasian Patent Office
Prior art keywords
modafinil
cyclodextrin
compound
mixtures
masked
Prior art date
Application number
EA200300705A
Other languages
English (en)
Inventor
Мартин Дж. Джейкобз
Пиюш Р. Пейтел
Original Assignee
Сефалон, Инк.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Сефалон, Инк. filed Critical Сефалон, Инк.
Publication of EA200300705A1 publication Critical patent/EA200300705A1/ru

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y5/00—Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/69—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
    • A61K47/6949—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit inclusion complexes, e.g. clathrates, cavitates or fullerenes
    • A61K47/6951—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit inclusion complexes, e.g. clathrates, cavitates or fullerenes using cyclodextrin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/16—Central respiratory analeptics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/02—Nutrients, e.g. vitamins, minerals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Abstract

Настоящее изобретение относится к смесям соединения модафинила с циклодекстрином, способам их применения и композиции на их основе, а также к комплексам, включающим соединение модафинила и циклодекстрин, вкус которых замаскирован и которые пригодны для перорального употребления в водном растворе.Отчет о международном поиске был опубликован 2003.01.03.
EA200300705A 2000-12-19 2001-12-19 Смеси соединения модафинила и циклодекстрина EA200300705A1 (ru)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US25668100P 2000-12-19 2000-12-19
US10/023,441 US7141555B2 (en) 2000-12-19 2001-12-18 Modafinil compound and cyclodextrin mixtures
PCT/US2001/049189 WO2002056915A2 (en) 2000-12-19 2001-12-19 Complex of modafinil and cyclodextrin

Publications (1)

Publication Number Publication Date
EA200300705A1 true EA200300705A1 (ru) 2003-12-25

Family

ID=26697157

Family Applications (1)

Application Number Title Priority Date Filing Date
EA200300705A EA200300705A1 (ru) 2000-12-19 2001-12-19 Смеси соединения модафинила и циклодекстрина

Country Status (23)

Country Link
US (1) US7141555B2 (ru)
EP (1) EP1368063B1 (ru)
JP (1) JP4094428B2 (ru)
KR (1) KR20040012696A (ru)
CN (1) CN100384477C (ru)
AT (1) ATE396745T1 (ru)
AU (1) AU2002246711B2 (ru)
BG (1) BG108009A (ru)
BR (1) BR0116698A (ru)
CA (1) CA2432126C (ru)
CZ (1) CZ20031878A3 (ru)
DE (1) DE60134274D1 (ru)
EA (1) EA200300705A1 (ru)
ES (1) ES2305128T3 (ru)
HK (1) HK1059055A1 (ru)
HU (1) HUP0401592A2 (ru)
IL (1) IL156470A0 (ru)
MX (1) MXPA03005505A (ru)
NO (1) NO20032788L (ru)
NZ (1) NZ526780A (ru)
PL (1) PL362474A1 (ru)
SK (1) SK9012003A3 (ru)
WO (1) WO2002056915A2 (ru)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP4906233B2 (ja) 2002-03-01 2012-03-28 ユニバーシティー オブ サウス フロリダ 少なくとも１種の有効薬剤成分を含有する多構成要素固相
US20040116532A1 (en) 2002-09-13 2004-06-17 Craig Heacock Pharmaceutical formulations of modafinil
JP2004250390A (ja) * 2003-02-21 2004-09-09 Taisho Pharmaceut Co Ltd 鉄化合物配合内服液剤
DK2272503T3 (da) * 2003-03-28 2013-05-21 Ares Trading Sa Orale formuleringer af cladribin
CN101912615B (zh) * 2003-03-28 2013-03-27 阿莱斯贸易有限公司 用于改善的经口和透粘膜输送的克拉屈滨制剂
US7566805B2 (en) 2003-09-04 2009-07-28 Cephalon, Inc. Modafinil compositions
BRPI0413777A (pt) * 2003-09-04 2006-11-07 Cephalon Inc composições de modafinil
CA2534664C (en) * 2003-09-04 2012-10-30 Cephalon, Inc. Modafinil compositions
US8153159B2 (en) 2003-09-18 2012-04-10 Cephalon, Inc. Modafinil modified release pharmaceutical compositions
US20090018202A1 (en) 2004-02-06 2009-01-15 Cephalon, Inc. Modafinil compositions
WO2005117911A2 (en) * 2004-05-06 2005-12-15 Cydex, Inc. Taste-masked formulations containing sertraline and sulfoalkyl ether cyclodextrin
US20060024370A1 (en) * 2004-07-29 2006-02-02 Cephalon France Modafinil oral lyophilizate
CN100503647C (zh) * 2005-11-02 2009-06-24 南京师范大学 羟丙基-磺丁基-β-环糊精及其制备方法、分析方法以及在药学上的应用
JP2009543803A (ja) * 2006-07-12 2009-12-10 エラン・ファルマ・インターナショナル・リミテッド モダフィニルのナノ粒子製剤
JP2009091309A (ja) * 2007-10-10 2009-04-30 Japan Organo Co Ltd バコパモニエラエキスを含有する組成物およびその製造方法ならびに飲食品
US10463677B2 (en) 2008-11-07 2019-11-05 Cydex Pharmaceuticals, Inc. Composition containing sulfoalkyl ether cyclodextrin and latanoprost
US8975241B2 (en) 2009-10-08 2015-03-10 Song Ho Biomed Co., Ltd. Composition for treating and preventing obesity including high water-soluble 2-hydroxypropyl-betacyclodextrin as effective component
KR101026864B1 (ko) * 2009-10-08 2011-04-12 (주)송호바이오메드 고 수용성 ２―하이드록시프로필―베타사이클로덱스트린을 유효성분으로 함유하는 비만 질환 예방 및 치료용 조성물
NZ608239A (en) 2010-09-13 2015-05-29 Bev Rx Inc Aqueous drug delivery system comprising off - flavor masking agent
US9364549B2 (en) 2011-11-30 2016-06-14 Andreas Voigt Hydrophobic drug-delivery material, method for manufacturing thereof and methods for delivery of a drug-delivery composition
US9474715B2 (en) 2011-11-30 2016-10-25 Andreas Voigt Polymeric drug-delivery material, method for manufacturing thereof and method for delivery of a drug-delivery composition
US9616068B2 (en) 2014-10-27 2017-04-11 Pohela LLC Animal training using cognitive enhancement
KR101719987B1 (ko) 2015-08-03 2017-03-27 (주)상전정공 화물차량의 잠금장치
US9855228B1 (en) * 2016-12-14 2018-01-02 Taho Pharmaceuticals Ltd. Oral solution comprising atomoxetine hydrochloride and methods thereof

Family Cites Families (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5835968B2 (ja) * 1974-02-25 1983-08-05 帝人株式会社 サイクロデキストリン包接化合物の製造法
GB1584462A (en) 1977-03-31 1981-02-11 Lafon Labor N-diaryl-malonamide and diarylmethyl-sulphinyl-acetamide derivatives and pharmaceutical compositions containing them
JPS5920230A (ja) 1982-07-19 1984-02-01 チバ−ガイギ−・アクチエンゲゼルシヤフト ピルプロフエン含有薬剤
US4727064A (en) 1984-04-25 1988-02-23 The United States Of America As Represented By The Department Of Health And Human Services Pharmaceutical preparations containing cyclodextrin derivatives
FR2593809B1 (fr) * 1986-01-31 1988-07-22 Lafon Labor Benzhydrylsulfinylacetamide, procede de preparation et utilisation en therapeutique
JPS62281855A (ja) * 1986-05-29 1987-12-07 Daikin Ind Ltd ビタミン，ビタミン誘導体，またはホルモンを含有する包接化合物
GB8813682D0 (en) * 1988-06-09 1988-07-13 Reckitt & Colmann Prod Ltd Pharmaceutical compositions
JPH035438A (ja) * 1989-05-31 1991-01-11 Kaken Pharmaceut Co Ltd フルルビプロフェン包接化合物およびこの包接化合物を用いる消炎鎮痛剤
SE8902235D0 (sv) * 1989-06-20 1989-06-20 Haessle Ab Novel cyclodextrin inclusion complexes
FR2663225B1 (fr) 1990-06-14 1994-11-04 Lafon Labor Nouvelle utilisation du modafinil.
US5024997A (en) 1990-06-22 1991-06-18 American Home Products Corporation Palatable ibuprofen solutions
FR2684875B1 (fr) * 1991-12-13 1995-05-24 Lafon Labor Utilisation du modafinil pour la fabrication d'un medicament ayant un effet anti-ischemique.
FR2702968B1 (fr) 1993-03-23 1995-06-23 Lafon Labor Procédé de préparation de particules renfermant un ingrédient actif par extrusion et lyophilisation .
US5843347A (en) 1993-03-23 1998-12-01 Laboratoire L. Lafon Extrusion and freeze-drying method for preparing particles containing an active ingredient
US5866162A (en) 1993-08-10 1999-02-02 Smithkline Beecham P.L.C. Pharmaceutical composition containing a drug/β-cyclodextrin complex in combination with an acid-base couple
US5618845A (en) 1994-10-06 1997-04-08 Cephalon, Inc. Acetamide derivative having defined particle size
US6077871A (en) 1997-11-26 2000-06-20 Pfizer Inc. Droloxifene pharmaceutical compositions
US6200968B1 (en) 1998-08-06 2001-03-13 Cephalon, Inc. Particle-forming compositions containing fused pyrrolocarbazoles
US6346548B1 (en) * 1999-08-16 2002-02-12 Cephalon, Inc. Compositions including modafinil for treatment of attention deficit hyperactivity disorder and multiple sclerosis fatigue
US6455588B1 (en) * 1999-08-20 2002-09-24 Cephalon, Inc. Compositions including modafinil for treatment of eating disorders and for appetite stimulation

Also Published As

Publication number Publication date
ES2305128T3 (es) 2008-11-01
EP1368063B1 (en) 2008-05-28
CA2432126C (en) 2011-03-08
NZ526780A (en) 2005-07-29
HUP0401592A2 (hu) 2004-11-29
WO2002056915A3 (en) 2003-01-03
BR0116698A (pt) 2003-10-21
DE60134274D1 (en) 2008-07-10
PL362474A1 (en) 2004-11-02
IL156470A0 (en) 2004-01-04
BG108009A (en) 2004-09-30
CN100384477C (zh) 2008-04-30
CZ20031878A3 (cs) 2004-10-13
EP1368063A2 (en) 2003-12-10
NO20032788D0 (no) 2003-06-18
ATE396745T1 (de) 2008-06-15
CN1486196A (zh) 2004-03-31
JP4094428B2 (ja) 2008-06-04
NO20032788L (no) 2003-07-07
US20020160982A1 (en) 2002-10-31
KR20040012696A (ko) 2004-02-11
SK9012003A3 (en) 2003-12-02
JP2004525104A (ja) 2004-08-19
HK1059055A1 (en) 2004-06-18
AU2002246711B2 (en) 2006-12-14
CA2432126A1 (en) 2002-07-25
US7141555B2 (en) 2006-11-28
WO2002056915A2 (en) 2002-07-25
MXPA03005505A (es) 2003-10-06

Similar Documents

Publication Publication Date Title
EA200300705A1 (ru) Смеси соединения модафинила и циклодекстрина
EA200201214A1 (ru) Замещенные тиоацетамиды
EA200300171A1 (ru) Циклопентаноиндолы, композиции, содержащие данные соединения, и способы лечения
EA200400648A1 (ru) N, n'-замещенные производные 1,3-диамино-2-гидроксипропана
EA200000920A1 (ru) Производные бициклических гидроксамовых кислот
EA200100971A1 (ru) Новые соединения и композиции в качестве ингибиторов протеазы
EA201000496A1 (ru) Замещенное соединение миноциклина, способ получения замещенных соединений миноциклина (варианты)
EA200300065A1 (ru) Окисленные сложные эфиры 4-йодфениламинобензгидроксамовых кислот
EA200100412A1 (ru) Замещенные 3-цианохинолины в качестве ингибиторов протеинтирозинкиназ
EA199901026A1 (ru) Соединения и способы ингибирования экспрессии vcam-1
EA200201271A1 (ru) Ингибиторы 11-бета-гидроксистероиддегидрогеназы типа 1
EA200200938A1 (ru) Фармацевтические композиции, содержащие производные азетидина, новые производные азетидина и их получение
EA200300050A1 (ru) Гликопептидфосфонатные производные
EA200400241A1 (ru) Направленные к мишени мультимерные контрастные вещества, основанные на пептидах
EE03869B1 (et) Sulfiinhappe derivaadid, nende valmistamine ja kasutamine
EA199900936A1 (ru) Фунгицидные трифторметилалкиламинотриазолопиримидины
EA200200479A1 (ru) Новые олигосахариды, их получение и содержащие их фармацевтические композиции
EA200400586A1 (ru) Замещённые тиоацетамиды
EA200100315A1 (ru) Простые тетрагидропиридовые эфиры
EA200401522A1 (ru) Противотуберкулёзный препарат: композиции и способы
EA200300450A1 (ru) Фармацевтические растворы соединений модафинила
EA200200625A1 (ru) Антипикорнавирусные соединения и композиции, их фармацевтическое применение и вещества для их синтеза
EA200100297A1 (ru) Моногидрат гидробромида элетриптана
EA200400707A1 (ru) Ингибиторы 11-бета-гидроксистероиддегидрогеназы типа 1
EA200300448A1 (ru) Композиции, включающие соединения модафинила