EA200000322A1 - Способ синтеза производных хинолина - Google Patents

Способ синтеза производных хинолина

Info

Publication number
EA200000322A1
EA200000322A1 EA200000322A EA200000322A EA200000322A1 EA 200000322 A1 EA200000322 A1 EA 200000322A1 EA 200000322 A EA200000322 A EA 200000322A EA 200000322 A EA200000322 A EA 200000322A EA 200000322 A1 EA200000322 A1 EA 200000322A1
Authority
EA
Eurasian Patent Office
Prior art keywords
synthesis
quinoline derivatives
carboxamine
phenylquinoline
ethylbenzyl
Prior art date
Application number
EA200000322A
Other languages
English (en)
Other versions
EA002633B1 (ru
Inventor
Джозеф Сиско
Марк Меллинджер
Конрад Ковальски
Original Assignee
Смитклайн Бичам Корпорейшн
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Смитклайн Бичам Корпорейшн filed Critical Смитклайн Бичам Корпорейшн
Publication of EA200000322A1 publication Critical patent/EA200000322A1/ru
Publication of EA002633B1 publication Critical patent/EA002633B1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/20—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/36—Sulfur atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/32—Oxygen atoms
    • C07D209/38—Oxygen atoms in positions 2 and 3, e.g. isatin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/38—Nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C07D215/50—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 4
    • C07D215/52—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 4 with aryl radicals attached in position 2

Abstract

Данное изобретение относится к новым промежуточным веществам и способам получения фармацевтически активных соединений хинолина, включая (-)-(S)-N-(α-этилбензил)-3-гидрокси-2-фенилхинолин-4-карбоксамид.Международная заявка была опубликована вместе с отчетом о международном поиске.
EA200000322A 1997-09-17 1998-09-17 Способ синтеза производных хинолина EA002633B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US5930397P 1997-09-17 1997-09-17
PCT/US1998/019434 WO1999014196A1 (en) 1997-09-17 1998-09-17 Method for the synthesis of quinoline derivatives

Publications (2)

Publication Number Publication Date
EA200000322A1 true EA200000322A1 (ru) 2000-10-30
EA002633B1 EA002633B1 (ru) 2002-08-29

Family

ID=22022126

Family Applications (1)

Application Number Title Priority Date Filing Date
EA200000322A EA002633B1 (ru) 1997-09-17 1998-09-17 Способ синтеза производных хинолина

Country Status (32)

Country Link
US (6) US6335448B1 (ru)
EP (1) EP1017676B1 (ru)
JP (1) JP2001516744A (ru)
KR (1) KR20010024031A (ru)
CN (1) CN1125815C (ru)
AP (1) AP1201A (ru)
AR (1) AR015445A1 (ru)
AT (1) ATE353879T1 (ru)
AU (1) AU744538B2 (ru)
BG (1) BG104243A (ru)
BR (1) BR9812085A (ru)
CA (1) CA2303026A1 (ru)
DE (1) DE69837100T2 (ru)
DZ (1) DZ2607A1 (ru)
EA (1) EA002633B1 (ru)
ES (1) ES2283072T3 (ru)
HU (1) HUP0004855A3 (ru)
ID (1) ID24140A (ru)
IL (1) IL134991A0 (ru)
MA (1) MA24644A1 (ru)
MY (1) MY120237A (ru)
NO (1) NO314303B1 (ru)
NZ (1) NZ503307A (ru)
OA (1) OA11340A (ru)
PE (1) PE129299A1 (ru)
PL (1) PL339340A1 (ru)
SK (1) SK3672000A3 (ru)
TR (1) TR200000720T2 (ru)
TW (1) TW509678B (ru)
UY (2) UY25174A1 (ru)
WO (1) WO1999014196A1 (ru)
ZA (1) ZA988455B (ru)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AP1201A (en) * 1997-09-17 2003-09-01 Smithkline Beecham Corp Method for the synthesis of quinoline derivatives.
CA2368455A1 (en) 1999-03-29 2000-10-05 Neurogen Corporation 4-substituted quinoline derivatives as nk-3 and/or gaba(a) receptor ligands
CA2555133A1 (en) 2004-02-04 2005-09-01 Pfizer Products Inc. Substituted quinoline compounds
KR20080016591A (ko) * 2005-06-03 2008-02-21 아스트라제네카 아베 Ｎｋ3 길항제로서의 퀴놀린 유도체
US20080194623A1 (en) * 2005-08-02 2008-08-14 Labaw Clifford S Method for the Synthesis of Quinoline Derivatives
EP1915363A1 (en) * 2005-08-11 2008-04-30 AstraZeneca AB Oxopyridyl quinoline amides as nk3 receptor modulators
CN101268052A (zh) * 2005-09-21 2008-09-17 阿斯利康(瑞典)有限公司 作为nk-3受体配体的n-氧代-杂环和n-氧代-烷基喹啉-4-甲酰胺
AR057130A1 (es) * 2005-09-21 2007-11-14 Astrazeneca Ab Quinolinas de alquilsulfoxido y una composicion farmaceutica
WO2007086799A1 (en) * 2006-01-27 2007-08-02 Astrazeneca Ab Amide substituted quinolines
CN102924375B (zh) * 2012-06-21 2015-02-18 江苏恩华药业股份有限公司 Talnetant中间体及其制备方法和应用
CN102702099A (zh) * 2012-06-21 2012-10-03 江苏恩华药业股份有限公司 (s)-3-羟基-2-苯基-n-(1-苯基丙基)喹啉-4-甲酰胺的制备方法
CN103214416A (zh) * 2013-04-26 2013-07-24 扬州大学 一种合成多取代喹啉类化合物的方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2776290A (en) * 1957-01-01 Hydroxy cevchoninates and carboxylic
NZ287442A (en) * 1994-05-27 1998-05-27 Smithkline Beecham Spa 4-substituted quinoline derivatives; medicaments; use as an nk3 receptor antagonist
US5627193A (en) * 1995-02-09 1997-05-06 Mitsui Toatsu Chemicals, Inc. Quinoline-4-carbonylguanidine derivatives, process for producing the same and pharmaceutical preparations containing the compounds
AP1201A (en) * 1997-09-17 2003-09-01 Smithkline Beecham Corp Method for the synthesis of quinoline derivatives.

Also Published As

Publication number Publication date
NO20001387D0 (no) 2000-03-16
BR9812085A (pt) 2000-09-26
ID24140A (id) 2000-07-06
WO1999014196A1 (en) 1999-03-25
CN1278796A (zh) 2001-01-03
JP2001516744A (ja) 2001-10-02
HUP0004855A3 (en) 2001-08-28
US20020038029A1 (en) 2002-03-28
DE69837100T2 (de) 2007-11-22
BG104243A (en) 2001-05-31
IL134991A0 (en) 2001-05-20
UY25174A1 (es) 2001-07-31
OA11340A (en) 2003-12-09
AP2000001767A0 (en) 2000-03-31
MY120237A (en) 2005-09-30
MA24644A1 (fr) 1999-04-01
EP1017676B1 (en) 2007-02-14
KR20010024031A (ko) 2001-03-26
EP1017676A4 (en) 2002-12-04
DZ2607A1 (fr) 2003-03-01
US20050171152A1 (en) 2005-08-04
AR015445A1 (es) 2001-05-02
NO20001387L (no) 2000-03-16
TR200000720T2 (tr) 2000-08-21
DE69837100D1 (de) 2007-03-29
TW509678B (en) 2002-11-11
ZA988455B (en) 1999-02-17
NZ503307A (en) 2002-04-26
EP1017676A1 (en) 2000-07-12
AU9395898A (en) 1999-04-05
ATE353879T1 (de) 2007-03-15
ES2283072T3 (es) 2007-10-16
HUP0004855A2 (hu) 2001-06-28
US20060189809A1 (en) 2006-08-24
EA002633B1 (ru) 2002-08-29
CA2303026A1 (en) 1999-03-25
US20020173657A1 (en) 2002-11-21
AU744538B2 (en) 2002-02-28
UY25407A1 (es) 1999-11-17
CN1125815C (zh) 2003-10-29
US6335448B1 (en) 2002-01-01
PL339340A1 (en) 2000-12-18
NO314303B1 (no) 2003-03-03
AP1201A (en) 2003-09-01
SK3672000A3 (en) 2000-09-12
PE129299A1 (es) 2000-02-19
US20040049031A1 (en) 2004-03-11

Similar Documents

Publication Publication Date Title
EA200100971A1 (ru) Новые соединения и композиции в качестве ингибиторов протеазы
DE69926806D1 (de) N-ureidoalkylpiperidine als modulatoren der aktivität der chemokinrezeptoren
EA200100780A1 (ru) Антагонисты tweak и рецептора tweak и их использование для лечения иммунологических заболеваний
EA200200873A1 (ru) Новые пиперазиновые производные
NO20030845D0 (no) Utvalgte fusjonerte pyrrolokarbazoler
DE69926919D1 (de) N-ureidoalkylpiperidine als modulatoren der aktivität der chemokinrezeptoren
BG66085B1 (bg) Фенилаланинови производни
BR9712085A (pt) Inibidores de metaloprotease heterocìclicos
EA200100012A1 (ru) Мостиковые инденопирролокарбазолы
EA200301223A1 (ru) Лекарственные формы окскарбазепина
EA199900279A1 (ru) Производные бензамида и их применение в качестве лекарственных средств с лтв4-антагонистической активностью
EA200000322A1 (ru) Способ синтеза производных хинолина
EA199700253A1 (ru) Производные нодулиспоровой кислоты
EA200301276A1 (ru) Новые производные сульфоновых кислот
NO20061575L (no) Fremgangsmate for fremstilling av renzapride og mellomprodukter derav
EA200000094A1 (ru) Способ получения замещенного пергидроизоиндола
DK1274685T3 (da) Et pyridin-N-oxid-derivat og fremgangsmåde til omdannelse deraf til farmaceutisk effektive forbindelser
EA199800034A1 (ru) Способ получения n-монозамещенных и n,n'-дизамещенных асимметричных циклических мочевин
EA200200101A1 (ru) Получение замещенных пиперидин-4-онов
EA199900235A1 (ru) Аморфные бензотиофены, способы получения и способы применения
EA200101106A1 (ru) Фармацевтический комплекс
EA200201232A1 (ru) Производные сульфонамида
EA200200749A1 (ru) Производные гетероциклического амида
EA200101180A1 (ru) Производные тио-оксиндола
EA200301133A1 (ru) Способ получения дифторбензилэпоксидов и промежуточные соединения

Legal Events

Date Code Title Description
MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): AM AZ BY KZ KG MD TJ TM RU