MA24644A1 - Methode pour la synthese des derives de la quinoline - Google Patents

Methode pour la synthese des derives de la quinoline

Info

Publication number
MA24644A1
MA24644A1 MA25246A MA25246A MA24644A1 MA 24644 A1 MA24644 A1 MA 24644A1 MA 25246 A MA25246 A MA 25246A MA 25246 A MA25246 A MA 25246A MA 24644 A1 MA24644 A1 MA 24644A1
Authority
MA
Morocco
Prior art keywords
synthesis
quinoline derivatives
quinoline
derivatives
Prior art date
Application number
MA25246A
Other languages
English (en)
Inventor
Sisko Joseph
Millinger Mark
Kowalski Conrad
Original Assignee
Smithkline Beecham Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Smithkline Beecham Corp filed Critical Smithkline Beecham Corp
Publication of MA24644A1 publication Critical patent/MA24644A1/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/20—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/36—Sulfur atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/32—Oxygen atoms
    • C07D209/38—Oxygen atoms in positions 2 and 3, e.g. isatin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/38—Nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C07D215/50—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 4
    • C07D215/52—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 4 with aryl radicals attached in position 2
MA25246A 1997-09-17 1998-09-08 Methode pour la synthese des derives de la quinoline MA24644A1 (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US5930397P 1997-09-17 1997-09-17

Publications (1)

Publication Number Publication Date
MA24644A1 true MA24644A1 (fr) 1999-04-01

Family

ID=22022126

Family Applications (1)

Application Number Title Priority Date Filing Date
MA25246A MA24644A1 (fr) 1997-09-17 1998-09-08 Methode pour la synthese des derives de la quinoline

Country Status (32)

Country Link
US (6) US6335448B1 (fr)
EP (1) EP1017676B1 (fr)
JP (1) JP2001516744A (fr)
KR (1) KR20010024031A (fr)
CN (1) CN1125815C (fr)
AP (1) AP1201A (fr)
AR (1) AR015445A1 (fr)
AT (1) ATE353879T1 (fr)
AU (1) AU744538B2 (fr)
BG (1) BG104243A (fr)
BR (1) BR9812085A (fr)
CA (1) CA2303026A1 (fr)
DE (1) DE69837100T2 (fr)
DZ (1) DZ2607A1 (fr)
EA (1) EA002633B1 (fr)
ES (1) ES2283072T3 (fr)
HU (1) HUP0004855A3 (fr)
ID (1) ID24140A (fr)
IL (1) IL134991A0 (fr)
MA (1) MA24644A1 (fr)
MY (1) MY120237A (fr)
NO (1) NO314303B1 (fr)
NZ (1) NZ503307A (fr)
OA (1) OA11340A (fr)
PE (1) PE129299A1 (fr)
PL (1) PL339340A1 (fr)
SK (1) SK3672000A3 (fr)
TR (1) TR200000720T2 (fr)
TW (1) TW509678B (fr)
UY (2) UY25174A1 (fr)
WO (1) WO1999014196A1 (fr)
ZA (1) ZA988455B (fr)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AP1201A (en) * 1997-09-17 2003-09-01 Smithkline Beecham Corp Method for the synthesis of quinoline derivatives.
CA2368455A1 (fr) 1999-03-29 2000-10-05 Neurogen Corporation Derives de quinoline 4-substitues comme ligands de recepteurs de nk-3 et/ou de gabaa
CA2555133A1 (fr) 2004-02-04 2005-09-01 Pfizer Products Inc. Composes de quinoline substitues
KR20080016591A (ko) * 2005-06-03 2008-02-21 아스트라제네카 아베 Ｎｋ3 길항제로서의 퀴놀린 유도체
US20080194623A1 (en) * 2005-08-02 2008-08-14 Labaw Clifford S Method for the Synthesis of Quinoline Derivatives
EP1915363A1 (fr) * 2005-08-11 2008-04-30 AstraZeneca AB Modulateurs récépteurs nk3 en tant qu'amides de quinoléine oxopyridyl
CN101268052A (zh) * 2005-09-21 2008-09-17 阿斯利康(瑞典)有限公司 作为nk-3受体配体的n-氧代-杂环和n-氧代-烷基喹啉-4-甲酰胺
AR057130A1 (es) * 2005-09-21 2007-11-14 Astrazeneca Ab Quinolinas de alquilsulfoxido y una composicion farmaceutica
WO2007086799A1 (fr) * 2006-01-27 2007-08-02 Astrazeneca Ab Quinoléines substituées par un amide
CN102924375B (zh) * 2012-06-21 2015-02-18 江苏恩华药业股份有限公司 Talnetant中间体及其制备方法和应用
CN102702099A (zh) * 2012-06-21 2012-10-03 江苏恩华药业股份有限公司 (s)-3-羟基-2-苯基-n-(1-苯基丙基)喹啉-4-甲酰胺的制备方法
CN103214416A (zh) * 2013-04-26 2013-07-24 扬州大学 一种合成多取代喹啉类化合物的方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2776290A (en) * 1957-01-01 Hydroxy cevchoninates and carboxylic
NZ287442A (en) * 1994-05-27 1998-05-27 Smithkline Beecham Spa 4-substituted quinoline derivatives; medicaments; use as an nk3 receptor antagonist
US5627193A (en) * 1995-02-09 1997-05-06 Mitsui Toatsu Chemicals, Inc. Quinoline-4-carbonylguanidine derivatives, process for producing the same and pharmaceutical preparations containing the compounds
AP1201A (en) * 1997-09-17 2003-09-01 Smithkline Beecham Corp Method for the synthesis of quinoline derivatives.

Also Published As

Publication number Publication date
NO20001387D0 (no) 2000-03-16
BR9812085A (pt) 2000-09-26
ID24140A (id) 2000-07-06
WO1999014196A1 (fr) 1999-03-25
CN1278796A (zh) 2001-01-03
JP2001516744A (ja) 2001-10-02
HUP0004855A3 (en) 2001-08-28
US20020038029A1 (en) 2002-03-28
DE69837100T2 (de) 2007-11-22
BG104243A (en) 2001-05-31
IL134991A0 (en) 2001-05-20
UY25174A1 (es) 2001-07-31
OA11340A (en) 2003-12-09
AP2000001767A0 (en) 2000-03-31
MY120237A (en) 2005-09-30
EP1017676B1 (fr) 2007-02-14
KR20010024031A (ko) 2001-03-26
EP1017676A4 (fr) 2002-12-04
DZ2607A1 (fr) 2003-03-01
US20050171152A1 (en) 2005-08-04
AR015445A1 (es) 2001-05-02
NO20001387L (no) 2000-03-16
TR200000720T2 (tr) 2000-08-21
DE69837100D1 (de) 2007-03-29
TW509678B (en) 2002-11-11
ZA988455B (en) 1999-02-17
NZ503307A (en) 2002-04-26
EP1017676A1 (fr) 2000-07-12
AU9395898A (en) 1999-04-05
ATE353879T1 (de) 2007-03-15
ES2283072T3 (es) 2007-10-16
EA200000322A1 (ru) 2000-10-30
HUP0004855A2 (hu) 2001-06-28
US20060189809A1 (en) 2006-08-24
EA002633B1 (ru) 2002-08-29
CA2303026A1 (fr) 1999-03-25
US20020173657A1 (en) 2002-11-21
AU744538B2 (en) 2002-02-28
UY25407A1 (es) 1999-11-17
CN1125815C (zh) 2003-10-29
US6335448B1 (en) 2002-01-01
PL339340A1 (en) 2000-12-18
NO314303B1 (no) 2003-03-03
AP1201A (en) 2003-09-01
SK3672000A3 (en) 2000-09-12
PE129299A1 (es) 2000-02-19
US20040049031A1 (en) 2004-03-11

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