TR200000720T2 - Kuinolin türevlerinin sentezi için metod. - Google Patents

Kuinolin türevlerinin sentezi için metod.

Info

Publication number
TR200000720T2
TR200000720T2 TR2000/00720T TR200000720T TR200000720T2 TR 200000720 T2 TR200000720 T2 TR 200000720T2 TR 2000/00720 T TR2000/00720 T TR 2000/00720T TR 200000720 T TR200000720 T TR 200000720T TR 200000720 T2 TR200000720 T2 TR 200000720T2
Authority
TR
Turkey
Prior art keywords
synthesis
quinoline derivatives
phenylquinolin
ethylbenzyl
carboxamide
Prior art date
Application number
TR2000/00720T
Other languages
English (en)
Inventor
Sisko Joseph
Mellinger Mark
Kowalski Conrad
Original Assignee
Smithkline Beecham Corporation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Smithkline Beecham Corporation filed Critical Smithkline Beecham Corporation
Publication of TR200000720T2 publication Critical patent/TR200000720T2/tr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/20—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/36—Sulfur atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/32—Oxygen atoms
    • C07D209/38—Oxygen atoms in positions 2 and 3, e.g. isatin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/38—Nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C07D215/50—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 4
    • C07D215/52—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 4 with aryl radicals attached in position 2

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Pulmonology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Quinoline Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

Abstract

Bu bulus, (-)-(S)-N-(alfa-etilbenzil) -3-hidroksi-2-fenilkuinolin- 4-karboksamid dahil, farmasötik olarak aktif kuinolin bilesiklerin hazirlanmasi için yeni ara maddeler ve prosesler ile ilgilidir.
TR2000/00720T 1997-09-17 1998-09-17 Kuinolin türevlerinin sentezi için metod. TR200000720T2 (tr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US5930397P 1997-09-17 1997-09-17

Publications (1)

Publication Number Publication Date
TR200000720T2 true TR200000720T2 (tr) 2000-08-21

Family

ID=22022126

Family Applications (1)

Application Number Title Priority Date Filing Date
TR2000/00720T TR200000720T2 (tr) 1997-09-17 1998-09-17 Kuinolin türevlerinin sentezi için metod.

Country Status (32)

Country Link
US (6) US6335448B1 (tr)
EP (1) EP1017676B1 (tr)
JP (1) JP2001516744A (tr)
KR (1) KR20010024031A (tr)
CN (1) CN1125815C (tr)
AP (1) AP1201A (tr)
AR (1) AR015445A1 (tr)
AT (1) ATE353879T1 (tr)
AU (1) AU744538B2 (tr)
BG (1) BG104243A (tr)
BR (1) BR9812085A (tr)
CA (1) CA2303026A1 (tr)
DE (1) DE69837100T2 (tr)
DZ (1) DZ2607A1 (tr)
EA (1) EA002633B1 (tr)
ES (1) ES2283072T3 (tr)
HU (1) HUP0004855A3 (tr)
ID (1) ID24140A (tr)
IL (1) IL134991A0 (tr)
MA (1) MA24644A1 (tr)
MY (1) MY120237A (tr)
NO (1) NO314303B1 (tr)
NZ (1) NZ503307A (tr)
OA (1) OA11340A (tr)
PE (1) PE129299A1 (tr)
PL (1) PL339340A1 (tr)
SK (1) SK3672000A3 (tr)
TR (1) TR200000720T2 (tr)
TW (1) TW509678B (tr)
UY (2) UY25174A1 (tr)
WO (1) WO1999014196A1 (tr)
ZA (1) ZA988455B (tr)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AP1201A (en) * 1997-09-17 2003-09-01 Smithkline Beecham Corp Method for the synthesis of quinoline derivatives.
ATE247652T1 (de) 1999-03-29 2003-09-15 Neurogen Corp 4-substituierte chinolinderivate als nk-3 und/oder gaba(a) rezeptor liganden
KR100799802B1 (ko) 2004-02-04 2008-01-31 화이자 프로덕츠 인크. 치환된 퀴놀린 화합물
CA2611060A1 (en) * 2005-06-03 2006-12-07 R. Thomas Simpson Quinoline derivatives as nk3 antagonists
US20080194623A1 (en) * 2005-08-02 2008-08-14 Labaw Clifford S Method for the Synthesis of Quinoline Derivatives
US20080280949A1 (en) * 2005-08-11 2008-11-13 Astrazeneca Ab Oxopyridyl Quinoline Amides as Nk3 Receptor Modulators
AR057130A1 (es) * 2005-09-21 2007-11-14 Astrazeneca Ab Quinolinas de alquilsulfoxido y una composicion farmaceutica
JP2009508944A (ja) * 2005-09-21 2009-03-05 アストラゼネカ・アクチエボラーグ Ｎｋ−３受容体リガンドとしてのｎ−オキソ複素環及びｎ−オキソ−アルキルキノリン−４−カルボキシアミド類
US20090054445A1 (en) * 2006-01-27 2009-02-26 Astrazeneca Ab Amide Substituted Quinolines
CN102702099A (zh) * 2012-06-21 2012-10-03 江苏恩华药业股份有限公司 (s)-3-羟基-2-苯基-n-(1-苯基丙基)喹啉-4-甲酰胺的制备方法
CN102924375B (zh) * 2012-06-21 2015-02-18 江苏恩华药业股份有限公司 Talnetant中间体及其制备方法和应用
CN103214416A (zh) * 2013-04-26 2013-07-24 扬州大学 一种合成多取代喹啉类化合物的方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2776290A (en) * 1957-01-01 Hydroxy cevchoninates and carboxylic
DE69531458T2 (de) * 1994-05-27 2004-08-05 Glaxosmithkline S.P.A. Chinolinderivate als tachykinin nk3 rezeptor antagonisten
US5627193A (en) * 1995-02-09 1997-05-06 Mitsui Toatsu Chemicals, Inc. Quinoline-4-carbonylguanidine derivatives, process for producing the same and pharmaceutical preparations containing the compounds
AP1201A (en) * 1997-09-17 2003-09-01 Smithkline Beecham Corp Method for the synthesis of quinoline derivatives.

Also Published As

Publication number Publication date
EP1017676B1 (en) 2007-02-14
MY120237A (en) 2005-09-30
UY25174A1 (es) 2001-07-31
NO20001387L (no) 2000-03-16
EP1017676A4 (en) 2002-12-04
AP2000001767A0 (en) 2000-03-31
ATE353879T1 (de) 2007-03-15
HUP0004855A2 (hu) 2001-06-28
EA200000322A1 (ru) 2000-10-30
US20020173657A1 (en) 2002-11-21
AR015445A1 (es) 2001-05-02
UY25407A1 (es) 1999-11-17
TW509678B (en) 2002-11-11
SK3672000A3 (en) 2000-09-12
ES2283072T3 (es) 2007-10-16
IL134991A0 (en) 2001-05-20
CN1125815C (zh) 2003-10-29
MA24644A1 (fr) 1999-04-01
KR20010024031A (ko) 2001-03-26
US20020038029A1 (en) 2002-03-28
PL339340A1 (en) 2000-12-18
PE129299A1 (es) 2000-02-19
CA2303026A1 (en) 1999-03-25
NZ503307A (en) 2002-04-26
HUP0004855A3 (en) 2001-08-28
US20060189809A1 (en) 2006-08-24
ID24140A (id) 2000-07-06
DZ2607A1 (fr) 2003-03-01
US20050171152A1 (en) 2005-08-04
AU744538B2 (en) 2002-02-28
ZA988455B (en) 1999-02-17
CN1278796A (zh) 2001-01-03
US6335448B1 (en) 2002-01-01
NO20001387D0 (no) 2000-03-16
EA002633B1 (ru) 2002-08-29
WO1999014196A1 (en) 1999-03-25
AP1201A (en) 2003-09-01
AU9395898A (en) 1999-04-05
US20040049031A1 (en) 2004-03-11
BR9812085A (pt) 2000-09-26
OA11340A (en) 2003-12-09
DE69837100D1 (de) 2007-03-29
JP2001516744A (ja) 2001-10-02
EP1017676A1 (en) 2000-07-12
BG104243A (en) 2001-05-31
NO314303B1 (no) 2003-03-03
DE69837100T2 (de) 2007-11-22

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