EA200301133A1 - Способ получения дифторбензилэпоксидов и промежуточные соединения - Google Patents
Способ получения дифторбензилэпоксидов и промежуточные соединенияInfo
- Publication number
- EA200301133A1 EA200301133A1 EA200301133A EA200301133A EA200301133A1 EA 200301133 A1 EA200301133 A1 EA 200301133A1 EA 200301133 A EA200301133 A EA 200301133A EA 200301133 A EA200301133 A EA 200301133A EA 200301133 A1 EA200301133 A1 EA 200301133A1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- diftorbenzylepoxides
- obtaining
- intermediate connections
- epoxides
- prot
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
- C07C229/34—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton containing six-membered aromatic rings
- C07C229/36—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton containing six-membered aromatic rings with at least one amino group and one carboxyl group bound to the same carbon atom of the carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D303/00—Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
- C07D303/02—Compounds containing oxirane rings
- C07D303/36—Compounds containing oxirane rings with hydrocarbon radicals, substituted by nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D301/00—Preparation of oxiranes
- C07D301/02—Synthesis of the oxirane ring
- C07D301/24—Synthesis of the oxirane ring by splitting off HAL—Y from compounds containing the radical HAL—C—C—OY
- C07D301/26—Y being hydrogen
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Epoxy Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
Изобретение относится к промежуточным соединениям и способам получения эпоксидов формулы V, где R и PROT такие, как изложено в описании изобретения. Эти эпоксиды используют в качестве промежуточных соединений для получения биологически активных соединений, т.е. для получения фармацевтических агентов.Отчет о международном поиске был опубликован 2003.03.06.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US28577201P | 2001-04-23 | 2001-04-23 | |
| PCT/US2002/012591 WO2002085877A2 (en) | 2001-04-23 | 2002-04-23 | Processes and intermediates for preparing benzyl substituted epoxides |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| EA200301133A1 true EA200301133A1 (ru) | 2004-04-29 |
| EA007535B1 EA007535B1 (ru) | 2006-10-27 |
Family
ID=23095626
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| EA200301133A EA007535B1 (ru) | 2001-04-23 | 2002-04-23 | Способ получения бензилэпоксидов и промежуточные соединения |
Country Status (23)
| Country | Link |
|---|---|
| US (3) | US6849750B2 (ru) |
| EP (1) | EP1381597B1 (ru) |
| JP (1) | JP2004529152A (ru) |
| KR (1) | KR20040047750A (ru) |
| CN (1) | CN1612871A (ru) |
| AP (1) | AP2003002897A0 (ru) |
| AR (1) | AR035960A1 (ru) |
| AT (1) | ATE401299T1 (ru) |
| BR (1) | BR0209163A (ru) |
| CA (1) | CA2445163A1 (ru) |
| CO (1) | CO5650163A2 (ru) |
| DE (1) | DE60227652D1 (ru) |
| EA (1) | EA007535B1 (ru) |
| ES (1) | ES2309170T3 (ru) |
| IL (2) | IL158585A0 (ru) |
| MX (1) | MXPA03009723A (ru) |
| NO (1) | NO20034738L (ru) |
| NZ (1) | NZ529169A (ru) |
| OA (1) | OA12597A (ru) |
| PE (1) | PE20021068A1 (ru) |
| PL (1) | PL365058A1 (ru) |
| WO (1) | WO2002085877A2 (ru) |
| ZA (1) | ZA200308261B (ru) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0228410D0 (en) * | 2002-12-05 | 2003-01-08 | Glaxo Group Ltd | Novel Compounds |
| US20050239836A1 (en) | 2004-03-09 | 2005-10-27 | Varghese John | Substituted hydroxyethylamine aspartyl protease inhibitors |
| US7385085B2 (en) | 2004-07-09 | 2008-06-10 | Elan Pharmaceuticals, Inc. | Oxime derivative substituted hydroxyethylamine aspartyl protease inhibitors |
| WO2007047305A1 (en) | 2005-10-12 | 2007-04-26 | Elan Pharmaceuticals, Inc. | Methods of treating amyloidosis using cyclopropyl derivative aspartyl protease inhibitors |
| WO2019168874A1 (en) | 2018-02-27 | 2019-09-06 | The Research Foundation For The State University Of New York | Difluoromethoxylation and trifluoromethoxylation compositions and methods for synthesizing same |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2788044B2 (ja) | 1989-02-06 | 1998-08-20 | サントリー株式会社 | マレイミド誘導体およびそれを有効成分として含有する農園芸用殺菌剤 |
| US5583238A (en) | 1990-11-19 | 1996-12-10 | G. D. Searle & Co. | Method for making intermediates useful in synthesis of retroviral protease inhibitors |
| US5482947A (en) | 1990-11-19 | 1996-01-09 | Talley; John J. | Retroviral protease inhibitors |
| US5559256A (en) * | 1992-07-20 | 1996-09-24 | E. R. Squibb & Sons, Inc. | Aminediol protease inhibitors |
| AU669223B2 (en) | 1992-08-25 | 1996-05-30 | G.D. Searle & Co. | Sulfonylalkanoylamino hydroxyethylamino sulfonamides useful as retroviral protease inhibitors |
| US5481011A (en) * | 1994-12-13 | 1996-01-02 | Bristol-Myers Squibb Company | Process for preparing N-protected amino acid α-halomethyl ketones and alcohols from N-protected amino acid esters |
| US5985911A (en) * | 1997-01-07 | 1999-11-16 | Abbott Laboratories | C-terminal ketone inhibitors of matrix metalloproteinases and TNFα secretion |
| WO1998033795A1 (en) * | 1997-02-04 | 1998-08-06 | The Regents Of The University Of California | Nanomolar, non-peptide inhibitors of cathepsin d |
| CA2273643A1 (en) | 1998-06-09 | 1999-12-09 | F. Hoffmann-La Roche Ag | Stereoselective reduction of carbonyl compounds |
| DE60124080T2 (de) | 2000-03-23 | 2007-03-01 | Elan Pharmaceuticals, Inc., San Francisco | Verbindungen und verfahren zur behandlung der alzheimerschen krankheit |
| EP1299352B1 (en) | 2000-06-30 | 2005-12-28 | Elan Pharmaceuticals, Inc. | Compounds to treat alzheimer's disease |
| PE20020276A1 (es) | 2000-06-30 | 2002-04-06 | Elan Pharm Inc | COMPUESTOS DE AMINA SUSTITUIDA COMO INHIBIDORES DE ß-SECRETASA PARA EL TRATAMIENTO DE ALZHEIMER |
| US20030096864A1 (en) | 2000-06-30 | 2003-05-22 | Fang Lawrence Y. | Compounds to treat alzheimer's disease |
| US6846813B2 (en) | 2000-06-30 | 2005-01-25 | Pharmacia & Upjohn Company | Compounds to treat alzheimer's disease |
| AU2002360508A1 (en) | 2001-12-06 | 2003-06-23 | Elan Pharmaceuticals, Inc. | Substituted hydroxyethylamines |
-
2002
- 2002-04-19 AR ARP020101444A patent/AR035960A1/es unknown
- 2002-04-23 AT AT02728882T patent/ATE401299T1/de not_active IP Right Cessation
- 2002-04-23 OA OA1200300276A patent/OA12597A/en unknown
- 2002-04-23 NZ NZ529169A patent/NZ529169A/en unknown
- 2002-04-23 PE PE2002000343A patent/PE20021068A1/es not_active Application Discontinuation
- 2002-04-23 MX MXPA03009723A patent/MXPA03009723A/es active IP Right Grant
- 2002-04-23 CA CA002445163A patent/CA2445163A1/en not_active Abandoned
- 2002-04-23 KR KR10-2003-7013902A patent/KR20040047750A/ko not_active Application Discontinuation
- 2002-04-23 CN CNA02812636XA patent/CN1612871A/zh active Pending
- 2002-04-23 WO PCT/US2002/012591 patent/WO2002085877A2/en active IP Right Grant
- 2002-04-23 JP JP2002583404A patent/JP2004529152A/ja active Pending
- 2002-04-23 ES ES02728882T patent/ES2309170T3/es not_active Expired - Lifetime
- 2002-04-23 EP EP02728882A patent/EP1381597B1/en not_active Expired - Lifetime
- 2002-04-23 DE DE60227652T patent/DE60227652D1/de not_active Expired - Fee Related
- 2002-04-23 AP APAP/P/2003/002897A patent/AP2003002897A0/en unknown
- 2002-04-23 PL PL02365058A patent/PL365058A1/xx not_active Application Discontinuation
- 2002-04-23 EA EA200301133A patent/EA007535B1/ru not_active IP Right Cessation
- 2002-04-23 US US10/128,122 patent/US6849750B2/en not_active Expired - Fee Related
- 2002-04-23 IL IL15858502A patent/IL158585A0/xx unknown
- 2002-04-23 BR BR0209163-1A patent/BR0209163A/pt not_active IP Right Cessation
-
2003
- 2003-10-23 IL IL158585A patent/IL158585A/en not_active IP Right Cessation
- 2003-10-23 ZA ZA200308261A patent/ZA200308261B/en unknown
- 2003-10-23 NO NO20034738A patent/NO20034738L/no not_active Application Discontinuation
- 2003-11-20 CO CO03102567A patent/CO5650163A2/es not_active Application Discontinuation
-
2005
- 2005-02-01 US US11/048,389 patent/US7638646B2/en not_active Expired - Fee Related
-
2009
- 2009-12-23 US US12/646,526 patent/US20100099898A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| CA2445163A1 (en) | 2002-10-31 |
| EP1381597B1 (en) | 2008-07-16 |
| BR0209163A (pt) | 2004-08-24 |
| US7638646B2 (en) | 2009-12-29 |
| KR20040047750A (ko) | 2004-06-05 |
| WO2002085877A2 (en) | 2002-10-31 |
| CO5650163A2 (es) | 2006-06-30 |
| IL158585A (en) | 2009-06-15 |
| AR035960A1 (es) | 2004-07-28 |
| NO20034738D0 (no) | 2003-10-23 |
| NZ529169A (en) | 2005-06-24 |
| ES2309170T3 (es) | 2008-12-16 |
| AP2003002897A0 (en) | 2003-12-31 |
| OA12597A (en) | 2006-06-08 |
| US20050130936A1 (en) | 2005-06-16 |
| MXPA03009723A (es) | 2004-03-16 |
| EA007535B1 (ru) | 2006-10-27 |
| US20030004360A1 (en) | 2003-01-02 |
| ATE401299T1 (de) | 2008-08-15 |
| NO20034738L (no) | 2003-12-04 |
| EP1381597A2 (en) | 2004-01-21 |
| IL158585A0 (en) | 2004-05-12 |
| PE20021068A1 (es) | 2002-12-11 |
| US6849750B2 (en) | 2005-02-01 |
| DE60227652D1 (de) | 2008-08-28 |
| US20100099898A1 (en) | 2010-04-22 |
| ZA200308261B (en) | 2004-05-24 |
| WO2002085877A3 (en) | 2003-03-06 |
| PL365058A1 (en) | 2004-12-27 |
| CN1612871A (zh) | 2005-05-04 |
| JP2004529152A (ja) | 2004-09-24 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MM4A | Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s) |
Designated state(s): AM AZ BY KZ KG MD TJ TM RU |