BR0213505A - Método de resolução de racemato de amlodipina - Google Patents

Método de resolução de racemato de amlodipina

Info

Publication number
BR0213505A
BR0213505A BR0213505-1A BR0213505A BR0213505A BR 0213505 A BR0213505 A BR 0213505A BR 0213505 A BR0213505 A BR 0213505A BR 0213505 A BR0213505 A BR 0213505A
Authority
BR
Brazil
Prior art keywords
amlodipine
resolution method
racemate resolution
tartaric acid
amlodipine racemate
Prior art date
Application number
BR0213505-1A
Other languages
English (en)
Inventor
Chris H Senanayake
Gerald J Tanoury
Harold S Wilkinson
Roger P Bakale
Andrei A Zlota
Kostas Saranteas
Original Assignee
Sepracor Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sepracor Inc filed Critical Sepracor Inc
Publication of BR0213505A publication Critical patent/BR0213505A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/44—Radicals substituted by doubly-bound oxygen, sulfur, or nitrogen atoms, or by two such atoms singly-bound to the same carbon atom
    • C07D213/46—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/80—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D211/84—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen directly attached to ring carbon atoms
    • C07D211/90—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Cardiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • General Health & Medical Sciences (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Hydrogenated Pyridines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

"MéTODO DE RESOLUçãO DE RACEMATO DE AMLODIPINA". Trata a invenção de métodos para resolução de amlodipina racêmico em composições enantiomorfas enriquecidas, pela precipitação com ácido tartárico, na presença de um solvente não-aquoso, como N,N<39>-dimetilacetamida. A relação molar de ácido tartárico:amlodipina, é, preferivelmente, menor que 0,25:1,0, maior que 0,75:1,0.
BR0213505-1A 2001-10-24 2002-10-23 Método de resolução de racemato de amlodipina BR0213505A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US34625001P 2001-10-24 2001-10-24
PCT/US2002/033894 WO2003035623A1 (en) 2001-10-24 2002-10-23 Method of resolving amlodipine racemate

Publications (1)

Publication Number Publication Date
BR0213505A true BR0213505A (pt) 2004-10-19

Family

ID=23358583

Family Applications (1)

Application Number Title Priority Date Filing Date
BR0213505-1A BR0213505A (pt) 2001-10-24 2002-10-23 Método de resolução de racemato de amlodipina

Country Status (16)

Country Link
US (2) US6822099B2 (pt)
EP (1) EP1448527A1 (pt)
JP (1) JP2005509637A (pt)
KR (1) KR20040062575A (pt)
CN (1) CN1608051A (pt)
BR (1) BR0213505A (pt)
CA (1) CA2466806A1 (pt)
CZ (1) CZ2004531A3 (pt)
HU (1) HUP0401887A3 (pt)
IL (1) IL161448A0 (pt)
MX (1) MXPA04003877A (pt)
NZ (1) NZ532316A (pt)
PL (1) PL369406A1 (pt)
RU (1) RU2004116064A (pt)
WO (1) WO2003035623A1 (pt)
ZA (1) ZA200403052B (pt)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2287110T3 (es) * 2000-04-11 2007-12-16 Sankyo Company, Limited Composicion farmaceutica estabilizada que contiene un bloqueador de calcio consistente en azelnidipina.
BE1014922A3 (nl) * 2002-03-01 2004-06-01 Pfizer Ltd Amlodipine als vrije base.
US20030176706A1 (en) * 2002-03-18 2003-09-18 Joshi Rohini Ramesh Process for the preparation of [S(-) amlodipine - L (+)- hemitartarate]
CN1231469C (zh) * 2003-12-05 2005-12-14 石家庄制药集团欧意药业有限公司 一种光学活性氨氯地平的拆分方法
BRPI0511095B8 (pt) * 2004-10-20 2021-05-25 Emcure Pharmaceuticals Ltd um processo para produção de enantiômero de anlodipino em alta pureza ótica
JP5124281B2 (ja) * 2004-12-02 2013-01-23 エスケー ケミカルズ カンパニー リミテッド アムロジピンの光学分離方法
KR101152608B1 (ko) * 2004-12-02 2012-06-07 에스케이케미칼주식회사 (ｒ,ｓ)-암로디핀으로부터 암로디핀 이성질체의 분리방법
HUP0500570A3 (en) * 2005-06-08 2008-03-28 Richter Gedeon Nyrt Process for the preparation of (s)-(-)-amlodipine
KR101235116B1 (ko) * 2005-10-17 2013-02-20 에스케이케미칼주식회사 광학활성 암로디핀 겐티세이트 염의 제조방법
TW200806648A (en) * 2005-11-29 2008-02-01 Sankyo Co Acid addition salts of dihydropyridine derivatives
TW200736245A (en) * 2005-11-29 2007-10-01 Sankyo Co Acid addition salts of optically active dihydropyridine derivatives
CN100436417C (zh) * 2006-04-11 2008-11-26 石药集团中奇制药技术（石家庄）有限公司 一种光学活性氨氯地平的拆分方法
WO2008026838A1 (en) * 2006-08-30 2008-03-06 Chemtech Research Incorporation Method for preparing an optically active amlodipine
KR100828883B1 (ko) * 2006-10-27 2008-05-09 씨제이제일제당 (주) 라세믹 암로디핀으로부터 ｓ-(-)-암로디핀의 분리방법
KR100868160B1 (ko) 2007-02-14 2008-11-12 한미약품 주식회사 Ｓ-(-)-암로디핀 또는 이의 염의 제조방법 및 이에사용되는 중간체
KR100989970B1 (ko) * 2008-07-01 2010-10-26 미래파인켐 주식회사 (ｓ)-(-)-암로디핀의 분리방법
KR101085169B1 (ko) 2009-03-25 2011-11-18 (주)켐트로스 암로디핀 광학 이성질체의 분리방법
CN101544597B (zh) * 2009-05-15 2012-09-05 北京天衡药物研究院 S-(-)-氨氯地平的制备方法
CN101798280B (zh) * 2010-03-22 2012-05-02 河北师范大学 一种手性拆分消旋体氨氯地平制备s-(-)-氨氯地平和r-(+)-氨氯地平的方法
US10695329B2 (en) 2016-10-07 2020-06-30 Silvergate Pharmaceuticals, Inc. Amlodipine formulations
EP3773574A4 (en) 2018-04-11 2022-03-02 Silvergate Pharmaceuticals, Inc. AMLODIPINE FORMULATIONS

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8714180D0 (en) * 1987-06-17 1987-07-22 Rifar Srl Anhydrous crystalline cefadroxil
AU1570588A (en) * 1987-03-27 1988-11-02 Byk Gulden Lomberg Chemische Fabrik Gmbh New intermediate products and process
US6057344A (en) * 1991-11-26 2000-05-02 Sepracor, Inc. Methods for treating hypertension, and angina using optically pure (-) amlodipine
GB9405833D0 (en) * 1994-03-24 1994-05-11 Pfizer Ltd Separation of the enantiomers of amlodipine
CN1100038C (zh) * 2000-02-21 2003-01-29 张喜田 氨氯地平对映体的拆分
GB0020842D0 (en) * 2000-08-23 2000-10-11 Pfizer Ltd Therapeutic compositions

Also Published As

Publication number Publication date
MXPA04003877A (es) 2005-02-17
EP1448527A1 (en) 2004-08-25
US6822099B2 (en) 2004-11-23
PL369406A1 (en) 2005-04-18
CN1608051A (zh) 2005-04-20
KR20040062575A (ko) 2004-07-07
RU2004116064A (ru) 2005-11-20
US20050009887A1 (en) 2005-01-13
NZ532316A (en) 2005-10-28
ZA200403052B (en) 2005-11-18
WO2003035623A1 (en) 2003-05-01
IL161448A0 (en) 2004-09-27
JP2005509637A (ja) 2005-04-14
CA2466806A1 (en) 2003-05-01
CZ2004531A3 (cs) 2004-10-13
HUP0401887A2 (hu) 2005-01-28
US20030130321A1 (en) 2003-07-10
HUP0401887A3 (en) 2005-05-30

Similar Documents

Publication Publication Date Title
BR0213505A (pt) Método de resolução de racemato de amlodipina
BR0205767A (pt) Sais de sulfÈnio, composições curáveis por radiação, formulaçães lìquidas, e, método para a preparação dos sais de sulfÈnio
BRPI0508758A (pt) processo para a preparação de cloridrato de oxicodona tendo menos que 25 ppm de 14 - hidroxicodeinona
EA200400368A1 (ru) Новые дигидроптеридиноны, способы их получения и их применение в качестве лекарственных средств
BR0005488A (pt) Processo para a preparação de carbonato de vinileno, e o uso do mesmo
GT200800248A (es) Derivados de alcanos azabicíclicos sustituidos con bicicloheterociclos fusionados
IS5670A (is) Nýjar afleiður af 3,3-dífenýlprópýlamínum
BR9809834A (pt) Acelerador de removedor de oxigênio.
BRPI0212733B8 (pt) composição farmacêutica compreendendo composto inibidor da recaptação de serotonina, e, uso do mesmo
CY1114303T1 (el) Νεο οξινο θειικο αλας
BR0314095A (pt) Catalisador para a produção de olefinas leves
BR0315335A (pt) Processo para a preparação de (s,s)-cis-2-benzidril-3-benzilaminoquinuclina
BRPI0416534A (pt) composições multiparticuladas com estabilidade melhorada
BRPI0515129A (pt) processo para telomerização de olefinas não cìclicas
ATE238238T1 (de) Zeolithe und verfahren zu ihrer herstellung
BRPI0410857A (pt) método para o tratamento de depressão, uso de gaboxadol, e, composição farmacêutica
BR0210348A (pt) Material polimérico, contendo um ácido latente
ATE302813T1 (de) Fein verteilte stabilisatorzusammensetzung für halogenhaltige polymere
WO2007120725A3 (en) Pharmaceutical composition containing sympathomimetic amine salt and co-distillable additive
BR0214493A (pt) Acelerador de cimento e processo
BR0213561A (pt) Processo para a preparação de amidas de ácido 2-halopiridincarboxìlico
BR9915868A (pt) Processo para a decomposição de tramadol
EA200301292A1 (ru) Способ синтеза тропенола для его получения в промышленном масштабе
ES2154725T3 (es) Nuevos compuestos de sililo y su utilizacion.
BR0115301A (pt) Uso de um inibidor seletivo da recaptação de norepinefrina

Legal Events

Date Code Title Description
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE 5A., 6A. E 7A. ANUIDADES.

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: REFERENTE AO DESPACHO PUBLICADO NA RPI 2034 DE 29/12/2009.