BRPI0212733B8 - composição farmacêutica compreendendo composto inibidor da recaptação de serotonina, e, uso do mesmo - Google Patents

composição farmacêutica compreendendo composto inibidor da recaptação de serotonina, e, uso do mesmo

Info

Publication number
BRPI0212733B8
BRPI0212733B8 BRPI0212733A BR0212733A BRPI0212733B8 BR PI0212733 B8 BRPI0212733 B8 BR PI0212733B8 BR PI0212733 A BRPI0212733 A BR PI0212733A BR 0212733 A BR0212733 A BR 0212733A BR PI0212733 B8 BRPI0212733 B8 BR PI0212733B8
Authority
BR
Brazil
Prior art keywords
pharmaceutical composition
disorder
inhibitor compound
serotonin reuptake
reuptake inhibitor
Prior art date
Application number
BRPI0212733A
Other languages
English (en)
Other versions
BR0212733B1 (pt
BR0212733A (pt
Inventor
Püschl Ask
Bang-Andersen Benny
Knud Moltzen Ejner
Paul Smith Garrick
Andersen Kim
Ruhland Thomas
Original Assignee
H Lundbeck As
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=8160750&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=BRPI0212733(B8) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by H Lundbeck As filed Critical H Lundbeck As
Publication of BR0212733A publication Critical patent/BR0212733A/pt
Publication of BR0212733B1 publication Critical patent/BR0212733B1/pt
Publication of BRPI0212733B8 publication Critical patent/BRPI0212733B8/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/14—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D295/145—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
    • C07D295/096—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D211/20—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/68—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D211/70—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
    • C07D243/06—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4
    • C07D243/08—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 not condensed with other rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/02—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms containing only hydrogen and carbon atoms in addition to the ring hetero elements
    • C07D295/027—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms containing only hydrogen and carbon atoms in addition to the ring hetero elements containing only one hetero ring
    • C07D295/033—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms containing only hydrogen and carbon atoms in addition to the ring hetero elements containing only one hetero ring with the ring nitrogen atoms directly attached to carbocyclic rings

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)

Abstract

"composto, composição farmacêutica, uso de um composto, e, método para o tratamento de um distúrbio afetivo". a invenção proporciona compostos representados pela fórmula geral i na qual os substituintes são definidos no pedido. os compostos são úteis no tratamento de um distúrbio afetivo, incluindo depressão, distúrbios de ansiedade incluindo distúrbio de ansiedade geral e distúrbio de pânico e distúrbio obsessivo compulsivo.
BRPI0212733A 2001-10-04 2002-10-02 composição farmacêutica compreendendo composto inibidor da recaptação de serotonina, e, uso do mesmo BRPI0212733B8 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DKPA200101466 2001-10-04
DKPA200101466 2001-10-04
PCT/DK2002/000659 WO2003029232A1 (en) 2001-10-04 2002-10-02 Phenyl-piperazine derivatives as serotonin reuptake inhibitors

Publications (3)

Publication Number Publication Date
BR0212733A BR0212733A (pt) 2004-11-16
BR0212733B1 BR0212733B1 (pt) 2014-05-13
BRPI0212733B8 true BRPI0212733B8 (pt) 2021-05-25

Family

ID=8160750

Family Applications (3)

Application Number Title Priority Date Filing Date
BRPI0212733A BRPI0212733B8 (pt) 2001-10-04 2002-10-02 composição farmacêutica compreendendo composto inibidor da recaptação de serotonina, e, uso do mesmo
BR122012023120A BR122012023120B8 (pt) 2001-10-04 2002-10-02 Composto inibidor da recaptação de serotonina
BR122012009534D BR122012009534C8 (pt) 2001-10-04 2002-10-02 4-[2-(4-metil-fenil-sulfanil)-fenil]-piperidina, seu uso e composição farmacêutica compreendendo o referido composto

Family Applications After (2)

Application Number Title Priority Date Filing Date
BR122012023120A BR122012023120B8 (pt) 2001-10-04 2002-10-02 Composto inibidor da recaptação de serotonina
BR122012009534D BR122012009534C8 (pt) 2001-10-04 2002-10-02 4-[2-(4-metil-fenil-sulfanil)-fenil]-piperidina, seu uso e composição farmacêutica compreendendo o referido composto

Country Status (38)

Country Link
US (10) US7144884B2 (pt)
EP (2) EP1749818B1 (pt)
JP (3) JP3896116B2 (pt)
KR (3) KR100783346B1 (pt)
CN (1) CN1319958C (pt)
AR (2) AR036659A1 (pt)
AT (2) ATE386730T1 (pt)
AU (2) AU2002333220C1 (pt)
BE (1) BE2014C036I2 (pt)
BR (3) BRPI0212733B8 (pt)
CA (1) CA2462110C (pt)
CO (1) CO5580746A2 (pt)
CY (3) CY1107924T1 (pt)
DE (2) DE60233608D1 (pt)
DK (2) DK1436271T6 (pt)
EA (2) EA011096B1 (pt)
EG (1) EG25095A (pt)
ES (2) ES2328725T3 (pt)
FR (1) FR14C0033I2 (pt)
HR (1) HRP20040220A2 (pt)
HU (3) HU228956B1 (pt)
IL (1) IL160655A0 (pt)
IS (2) IS2578B (pt)
LT (1) LTC1436271I2 (pt)
LU (1) LU92397I2 (pt)
ME (1) ME00039B (pt)
MX (1) MXPA04002959A (pt)
MY (1) MY140950A (pt)
NL (1) NL300652I1 (pt)
NO (3) NO326443B1 (pt)
NZ (1) NZ531556A (pt)
PL (2) PL210551B1 (pt)
PT (2) PT1436271E (pt)
RS (2) RS52865B (pt)
SI (1) SI1436271T1 (pt)
UA (2) UA81749C2 (pt)
WO (1) WO2003029232A1 (pt)
ZA (1) ZA200401583B (pt)

Families Citing this family (104)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
UA81749C2 (uk) 2001-10-04 2008-02-11 Х. Луннбек А/С Фенілпіперазинові похідні як інгібітори зворотного захоплення серотоніну
GB0305575D0 (en) * 2003-03-11 2003-04-16 Glaxo Group Ltd Novel compounds
AR043965A1 (es) * 2003-04-04 2005-08-17 Lundbeck & Co As H Derivados de 4- (2-fenilsulfanil -fenil) - piperidina como anhibidores de recaptacion de serotonina
MXPA05010627A (es) * 2003-04-04 2005-12-12 Lundbeck & Co As H Derivados de 4-(2-feniloxifenil)-piperidina o 1,2,3,6-tetrahidropiridina como inhibidores de la recaptacion de serotonina.
KR20050119682A (ko) * 2003-04-04 2005-12-21 하. 룬트벡 아크티에 셀스카브 세로토닌 재흡수 억제제로서 4-(2-페닐옥시페닐)-피페리딘또는 -1,2,3,6-테트라히드로피리딘 유도체
DE602004016316D1 (de) * 2003-04-04 2008-10-16 Lundbeck & Co As H 4-(2-phenylsulfanyl-phenyl)-piperidin-derivate als serotonin-wiederaufnahme-hemmer
UA81300C2 (en) * 2003-04-04 2007-12-25 Lundbeck & Co As H Derivates of 4-(2-fenilsulfanilfenil)-1,2,3,6-tetrahydropiridin as retarding agents of serotonin recapture
ES2303960T3 (es) 2003-12-23 2008-09-01 H. Lundbeck A/S Derivados de 2-(1h-indolilsulfanil)-bencilamina como isrs.
AR052308A1 (es) * 2004-07-16 2007-03-14 Lundbeck & Co As H Derivados de 2-(1h-indolilsulfanil)-arilamina y una composicion farmaceutica que contiene al compuesto
ATE435216T1 (de) * 2005-02-10 2009-07-15 Neurosearch As Alkylsubstituierte homopiperazinderivate und deren verwendung als monoamin neurotransmitter wiederaufnahmeinhibitoren
US7629473B2 (en) 2005-06-17 2009-12-08 H. Lundbeck A/S 2-(1H-indolylsulfanyl)-aryl amine derivatives
AR054393A1 (es) 2005-06-17 2007-06-20 Lundbeck & Co As H Derivados de benzo(b)furano y benzo(b)tiofeno, composiciones farmaceuticas que los contienen y su uso en la fabricacion de un medicamento para el tratamiento de enfermedades mediadas por la inhibicion de la reabsorcion de neurotransmisores de amina biogenicos.
AR054394A1 (es) * 2005-06-17 2007-06-20 Lundbeck & Co As H Derivados de 2- (1h-indolilsulfanil)-aril amina
JP2007106746A (ja) * 2005-09-13 2007-04-26 Tosoh Corp 新規アリールホモピペラジン類、またはその塩と製造方法
ZA200809917B (en) * 2006-06-16 2010-08-25 Lundbeck & Co As H Crystalline forms of 4- [2-(4-Methylphenylsulfanyl) - Phenyl] piperidine with combined serotonin and norepinephrine reuptake inhibition for the treatment of neuropathic pain
AR061480A1 (es) * 2006-06-16 2008-08-27 Lundbeck & Co As H 4-[2-(4-metilfenilsulfanil)-fenil]piperidina como inhibidor combinado de la recaptacion de serotonina y norepinefrina.
JP7179035B2 (ja) * 2006-06-16 2022-11-28 ハー・ルンドベック・アクチエゼルスカベット 認識機能障害（ｃｏｇｎｉｔｉｖｅ ｉｍｐａｉｒｍｅｎｔ）を治療するための、組み合わされたセロトニン再取り込み、５－ＨＴ３および５－ＨＴ１Ａ活性を有する化合物としての１－［２－（２，４－ジメチルフェニルスルファニル）－フェニル］ピペラジン
WO2007144006A1 (en) * 2006-06-16 2007-12-21 H. Lundbeck A/S Crystalline forms of 4- [2- (4-methylphenylsulfanyl) -phenyl] piperidine with combined serotonin and norepinephrine reuptake inhibition for the treatment of neuropathic pain
US8722684B2 (en) 2006-06-16 2014-05-13 H. Lundbeck A/S 1-[2-(2,4-dimethylphenylsulfanyl)-phenyl] piperazine as a compound with combined serotonin reuptake, 5-HT3 and 5-HT1A activity for the treatment of cognitive impairment
TW200848411A (en) * 2007-03-20 2008-12-16 Lundbeck & Co As H Novel therapeutic uses of 1-[2-(2, 4-dimethylphenylsulfanyl)phenyl]-piperazine
TWI432194B (zh) * 2007-03-20 2014-04-01 Lundbeck & Co As H ４-〔２-（４-甲基苯硫基）苯基〕哌啶之新穎治療用途
TWI405588B (zh) 2007-03-20 2013-08-21 Lundbeck & Co As H ４-〔２-（４-甲苯基硫基）-苯基〕哌啶之鹽類的液體調配物
WO2008151632A1 (en) 2007-06-15 2008-12-18 H.Lundbeck A/S 4- [2- (4-methylphenylsulfanyl) phenyl] piperidine for the treatment of irritable bowel syndrome (ibs)
TW200932233A (en) * 2007-11-13 2009-08-01 Lundbeck & Co As H Therapeutic uses of compounds having combined SERT, 5-HT3 and 5-HT1a activity
AU2014200364B2 (en) * 2007-11-13 2015-09-17 H. Lundbeck A/S Therapeutic uses of compounds having combined SERT, 5-HT3 and 5-HT1A activity
TW200932225A (en) * 2007-12-14 2009-08-01 Lundbeck & Co As H 4-[2,3-difluoro-6-(2-fluoro-4-methyl-phenylsulfanyl)-phenyl]-piperidine
TW200938194A (en) * 2007-12-14 2009-09-16 Lundbeck & Co As H Therapeutic uses of compounds having affinity to the serotonin transporter, serotonin receptors and noradrenalin transporter
WO2009081259A1 (en) * 2007-12-21 2009-07-02 Pfizer Inc. Phenoxy-pyridyl derivatives
UA98698C2 (en) * 2008-03-03 2012-06-11 Х. Луннбек А/С Phenylsulfanylphenyl-piperidines and process for the preparation thereof
WO2010056941A1 (en) 2008-11-14 2010-05-20 Theravance, Inc. 4-[2-(2-fluorophenoxymethyl)phenyl]piperidine compounds
TW201033181A (en) 2009-02-17 2010-09-16 Lundbeck & Co As H Purification of 1-[2-(2,4-dimethylphenylsulfanyl)phenyl]piperazine
CA2759456C (en) 2009-04-24 2017-10-31 H. Lundbeck A/S Liquid formulations of salts of 1-[2-(2,4-dimethylphenylsulfanyl)phenyl]piperazine
DK2470166T3 (da) 2009-08-24 2013-09-08 Lundbeck & Co As H Nye sammensætninger af 1-[2-(2,4-dimethyl-phenylsulfanyl)-phenyl]piperazin
CA2779108C (en) * 2009-10-30 2018-01-02 Janssen Pharmaceutica Nv 4-substituted-2-phenoxy-phenylamine delta opioid receptor modulators
JP5705239B2 (ja) 2010-01-11 2015-04-22 セラヴァンス バイオファーマ アール＆ディー アイピー， エルエルシー セロトニンおよびノルエピネフリン再取込みインヒビターとしての１−（２−フェノキシメチルフェニル）ピペラジン化合物
EP2550252B1 (en) * 2010-03-22 2015-05-06 Theravance Biopharma R&D IP, LLC 1-(2-phenoxymethylheteroaryl)piperidine and piperazine compounds
EP2564838A4 (en) * 2010-04-30 2014-06-04 Takeda Pharmaceutical ENTERICIAN TABLET
KR20130060220A (ko) 2010-04-30 2013-06-07 다케다 야쿠힌 고교 가부시키가이샤 장용성 정제
EP2407467A1 (de) 2010-07-14 2012-01-18 Sandoz Ag Kristalline Verbindung von 1-[4-(2-azepan-1-yl-ethoxy)-benzyl]-2-(4-hydroxyphenyl)-3-methyl-1H-indol-5-ol und Milchsäure
TW201212918A (en) * 2010-08-23 2012-04-01 Lundbeck & Co As H Therapeutic uses of 1-[2-(2,4-dimethyl-phenylsulfanyl)phenyl]piperazine
PT2720989T (pt) 2011-06-20 2016-11-07 H Lundbeck As 1-piperazino-3-fenil-indanos deuterados para o tratamento da esquizofrenia
BR112014011491A2 (pt) 2011-11-14 2017-05-09 Nestec Sa ensaios e métodos para seleção de um regime de tratamento para um indivíduo com depressão
MX344144B (es) * 2012-01-03 2016-12-07 H Lundbeck As Proceso para la fabricacion de 1-[2-(2,4-dimetilfenilsulfanil)feni l] piperazina.
EP2897943B1 (en) 2012-09-19 2019-04-24 Sandoz AG Crystalline form of vortioxetine hydrobromide
CA2893468C (en) 2012-12-13 2021-01-12 H. Lundbeck A/S Use of vortioxetine and donepezil in the treatment of cognitive impairment
CN104995181B (zh) * 2013-02-22 2017-03-08 H.隆德贝克有限公司 沃替西汀生产方法
ES2724246T3 (es) 2013-04-04 2019-09-09 Lek Pharmaceuticals Nuevo proceso para la síntesis de 1-(2-((2,4-dimetilfenil)tio)fenil)piperazina
CN104109135B (zh) * 2013-04-22 2018-10-26 江苏豪森药业集团有限公司 1-[2-(2,4-二甲基苯基硫烷基)-苯基]哌嗪的制备方法
WO2015044963A1 (en) 2013-09-30 2015-04-02 Cadila Healthcare Limited An amorphous vortioxetine and salts thereof
EP2878596A1 (en) * 2013-11-29 2015-06-03 LEK Pharmaceuticals d.d. Synthesis of vortioxetine via (2-(piperazine-1-yl)phenyl)lithium intermediates
CN104710345B (zh) * 2013-12-17 2017-09-05 江苏恩华药业股份有限公司 用于制备4‑（2‑（4‑甲基苯基硫基））苯基哌啶的化合物、其制备方法及应用
AU2014368548B2 (en) 2013-12-20 2019-09-19 H. Lundbeck A/S Use of an opioid receptor antagonist with kappa-activity and vortioxetine for treatment of depressive disorder with melancholic features
EP2894154A1 (en) * 2014-01-14 2015-07-15 LEK Pharmaceuticals d.d. Synthesis of vortioxetine via (2-(piperazine-1-yl)phenyl)aniline intermediates
CN103788019B (zh) * 2014-01-22 2015-10-07 苏州明锐医药科技有限公司 沃替西汀的制备方法
US9822086B2 (en) 2014-01-31 2017-11-21 Egis Gyogyszergyar Zrt. Process for the preparation of vortioxetine salts
EP2930171A1 (en) 2014-04-07 2015-10-14 LEK Pharmaceuticals d.d. Synthesis of vortioxetine via (2,4-dimethylphenyl)(2-iodophenyl)sulfane intermediate
CN104059030B (zh) 2014-05-30 2016-05-04 镇江圣安医药有限公司 [(苯硫烷基)-苯基]哌嗪的衍生物及其药物组合物和用途
FR3023320B1 (fr) * 2014-07-03 2017-03-10 Ifp Energies Now Systeme et procede de stockage et de recuperation d'energie par gaz comprime avec stockage de la chaleur au moyen d'un echangeur radial
CZ2014471A3 (cs) 2014-07-08 2016-01-20 Zentiva, K.S. Způsob přípravy vortioxetinu
US9687484B2 (en) 2014-07-18 2017-06-27 Dipharma Francis S.R.L. Crystalline forms of an antidepressant compound
CN104146953A (zh) * 2014-07-24 2014-11-19 李雪梅 一种氢溴酸沃替西汀注射液
CN104292183B (zh) * 2014-09-29 2016-01-06 杨献美 一种抗抑郁药物沃替西汀的制备方法
WO2016079751A2 (en) 2014-11-17 2016-05-26 Megafine Pharma (P) Ltd. A process for preparation of vortioxetine and polymorphs thereof
ES2634496T3 (es) 2014-11-21 2017-09-28 Dipharma Francis S.R.L. Proceso para la preparación de un antidepresivo y los intermedios del mismo
CN104447622B (zh) * 2014-11-28 2017-01-04 郑州大明药物科技有限公司 氢溴酸沃替西汀β晶型的制备方法
CN104586756A (zh) * 2015-01-05 2015-05-06 万特制药(海南)有限公司 一种含沃替西汀的口服溶液及其制备方法
CZ201531A3 (cs) 2015-01-21 2016-08-03 Zentiva, K.S. Polymerem stabilizované amorfní formy vortioxetinu
CN104610195B (zh) * 2015-01-30 2017-06-27 上虞京新药业有限公司 沃替西汀的天冬氨酸盐或其水合物及其制备方法和用途
WO2016125190A2 (en) 2015-02-04 2016-08-11 Mylan Laboratories Limited Novel crystalline forms of vortioxetine, premixes, and processes for the preparation thereof
WO2016125191A2 (en) 2015-02-04 2016-08-11 Mylan Laboratories Limited Processes for the preparation of vortioxetine hydrobromide
AU2016224930A1 (en) 2015-02-25 2017-09-07 Lupin Limited Process for the preparation of Vortioxetine
US20180072690A1 (en) 2015-03-26 2018-03-15 Cipla Limited Methods for Making Serotonin Reuptake Inhibitors
CN104829557B (zh) * 2015-04-23 2017-06-27 山东百诺医药股份有限公司 一种新化合物1‑[2‑（2,4‑二甲基苯基硫基）苯基]‑2‑氧哌嗪及其制备方法和在沃替西汀合成中的应用
JO3456B1 (ar) 2015-05-13 2020-07-05 H Lundbeck As فيروتيوكسيتين بيروجلوتامات
AU2016296205B2 (en) 2015-07-17 2021-11-11 Centre Hospitalier Sainte Anne Paris 5-hydroxytryptamine 1B receptor-stimulating agent for use as a promoter of satellite cells self-renewal and/or differentiation
EP3337789A1 (en) * 2015-08-19 2018-06-27 Amneal Pharmaceuticals Company GmbH Process for preparation of vortioxetine hydrobromide
US20180303772A1 (en) * 2015-10-14 2018-10-25 Institut Pasteur 5-hydroxytryptamine 1b receptor-stimulating agent for the treatment of myocardial infarction
CN105461635B (zh) * 2015-11-18 2018-06-08 乳源瑶族自治县大众药品贸易有限公司 苯基哌嗪衍生物及其使用方法和用途
CN105348204B (zh) * 2015-11-18 2018-09-14 乳源瑶族自治县大众药品贸易有限公司 1-杂环基-2-(杂芳基硫基)苯衍生物及其使用方法和用途
US11013830B2 (en) 2015-11-20 2021-05-25 Institut Pasteur 5-hydroxytryptamine 1B receptor-stimulating agent for enhancing in vivo engraftment potential
WO2017162536A1 (en) 2016-03-21 2017-09-28 H. Lundbeck A/S Vortioxetine prodrugs
WO2018002115A1 (en) * 2016-07-01 2018-01-04 H. Lundbeck A/S Vortioxetine dosing regimes for fast onset of antidepressant effect
BR112019000706A8 (pt) * 2016-07-15 2022-12-06 Pasteur Institut Agente de estímulo do receptor 1b de 5-hidroxitriptamina para reparo de pele e/ou cabelo
JP2019523256A (ja) * 2016-07-22 2019-08-22 ジアンス・エンファルオカン・ファーマスーティカル・リサーチ・アンド・デベロップメント・カンパニー・リミテッドＪｉａｎｇｓｕ Ｎｈｗａｌｕｏｋａｎｇ Ｐｈａｒｍｃｅｕｔｉｃａｌ Ｒｅｓｅａｒｃｈ Ａｎｄ Ｄｅｖｅｌｏｐｍｅｎｔ Ｃｏ．，Ｌｔｄ． ボルチオキサチン類似化合物、その用途及びその製造
WO2018042168A1 (en) 2016-08-29 2018-03-08 King, Lawrence Stable pharmaceutical composition of vortioxetine hydrobromide
CN106349132B (zh) * 2016-08-30 2018-02-02 重庆植恩药业有限公司 沃替西汀中间体杂质及其制备方法和用途
US10519121B2 (en) 2016-12-30 2019-12-31 Apicore Us Llc Process and novel polymorphic form of vortioxetine and its pharmaceutically acceptable salts
CN108409728B (zh) * 2017-02-09 2020-11-24 广东东阳光药业有限公司 苯基八氢-1H-吡啶并[1,2-a]吡嗪衍生物及其用途
CN108409729B (zh) * 2017-02-09 2020-11-24 广东东阳光药业有限公司 苯基八氢-1H-吡啶并[1,2-a]吡嗪衍生物及其用途
US10428033B2 (en) 2017-02-15 2019-10-01 Piramal Enterprises Limited Process for the preparation of vortioxetine and salts thereof
US11020390B2 (en) 2017-02-17 2021-06-01 Unichem Laboratories Ltd Bioequivalent pharmaceutical composition of vortioxetine hydrobromide
US10836730B2 (en) 2017-02-23 2020-11-17 Unichem Laboratories Ltd. Process for preparation and purification of vortioxetine hydrobromide
PL3615518T3 (pl) * 2017-04-25 2022-03-07 H. Lundbeck A/S Sposób wytwarzania postaci alfa wortioksetyny hbr
EP3412661A1 (en) 2017-06-08 2018-12-12 Enantia, S.L. Cocrystals of vortioxetine hydrobromide and resorcinol
KR102026337B1 (ko) 2017-07-07 2019-09-27 영진약품 주식회사 1-[2-(2,4-디메틸페닐설파닐)페닐]피페라진의 신규염 및 이의 제조방법
CN107915685A (zh) * 2017-12-11 2018-04-17 重庆植恩药业有限公司 一种氢溴酸沃替西汀中间体的制备方法
CN108017595A (zh) * 2017-12-20 2018-05-11 安徽源久源科技有限公司 一种1-[2-(2,5-二甲基苯硫基)苯基]哌嗪的制备方法
EP3810582B1 (en) 2018-06-20 2024-01-03 Vio Ag Pharmaceuticals S.A. A one-pot organo-pseudocatalytic c-h activation approach for the preparation of vortioxetine and vortioxetine intermediate
CN108863986B (zh) * 2018-08-06 2020-01-21 广东东阳光药业有限公司 二氟甲基取代的苯基哌嗪衍生物及其用途
CN108727393B (zh) * 2018-08-06 2019-10-29 广东东阳光药业有限公司 苯基二氮杂双环衍生物及其用途
JP2023520016A (ja) 2020-04-03 2023-05-15 ハー・ルンドベック・アクチエゼルスカベット 感情鈍麻の予防又は処置のための１－［２－（２，４－ジメチルフェニルスルファニル）－フェニル］ピペラジン
WO2022052391A1 (zh) 2020-09-10 2022-03-17 苏州富德兆丰生化科技有限公司 伏硫西汀的合成方法
GB2622880A (en) 2022-09-30 2024-04-03 Alkaloid Ad Skopje Palatable orodispersible formulation of vortioxetine
WO2025132869A1 (en) 2023-12-21 2025-06-26 H. Lundbeck A/S Method for the preparation of vortioxetine pharmaceutical compositions with low amounts of nitrosamine impurities

Family Cites Families (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CS151751B1 (pt) 1971-04-13 1973-11-19
CS151755B1 (pt) 1971-04-13 1973-11-19
CS151752B1 (pt) 1971-04-13 1973-11-19
CS151753B1 (pt) 1971-04-13 1973-11-19
YU163075A (en) 1975-07-21 1982-05-31 Science Union & Cie Process for preparing new phenoxy derivatives
US4241071A (en) * 1977-01-27 1980-12-23 American Hoechst Corporation Antidepressant (α-phenyl-2-tolyl)azacycloalkanes
US4198417A (en) * 1979-01-10 1980-04-15 American Hoechst Corporation Phenoxyphenylpiperidines
US4198419A (en) * 1979-01-10 1980-04-15 American Hoechst Corporation Phenylthiophenylpiperidines
ES2004809A6 (es) 1987-07-29 1989-02-01 Ferrer Int Procedimiento de obtencion de nuevas 1-(2-(fenilmetil)fenil)piperazinas
GB9126311D0 (en) 1991-12-11 1992-02-12 Wellcome Found Substituted diphenylsulfides
DE69634678T2 (de) * 1995-01-23 2006-01-19 Daiichi Suntory Pharma Co., Ltd. Verbesserung oder heilung von durch ischämischen krankheiten hervorgerufenen symtomen und dafür verwendbare phenylpiperidinverbingungen
CZ293595A3 (cs) 1995-11-09 1999-12-15 Farmak A. S. Deriváty N,N-dimethyl-2-(arylthio)benzylaminu, jejich soli, způsoby jejich přípravy a jejich použití v léčivých přípravcích
FR2757160B1 (fr) * 1996-12-13 1999-03-12 Sanofi Sa 1-phenylalkyl-1,2,3,6-tetrahydropyridines
US6297239B1 (en) 1997-10-08 2001-10-02 Merck & Co., Inc. Inhibitors of prenyl-protein transferase
ES2230209T3 (es) * 1997-10-31 2005-05-01 Daiichi Suntory Pharma Co., Ltd. Procedimiento para preparar n-((4-fenil)metilfenil)piperazinas.
SK14022001A3 (sk) 1999-04-02 2002-03-05 Icos Corporation Inhibítory väzby LFA-1 na ICAM a ich použitie
MXPA02001160A (es) 1999-08-04 2002-07-02 Millennium Pharm Inc Compuestos que se unen a los receptores para melanocortina-4, y metodo de uso de estos.
EP1220780A4 (en) * 1999-09-14 2004-03-24 Pharmacopeia Inc ARTICLE COMPRISING A DISPENSING HEAD COMPRISING MULTIPLE CHANNELS
CN1230432C (zh) * 1999-12-30 2005-12-07 H·隆德贝克有限公司 取代的苯基－哌嗪衍生物及其制备和用途
JP2003519227A (ja) 1999-12-30 2003-06-17 ハー・ルンドベック・アクチエゼルスカベット 置換されたベンゼン誘導体の製造方法
US6813639B2 (en) 2000-01-26 2004-11-02 Viaclix, Inc. Method for establishing channel-based internet access network
DE10033548C2 (de) 2000-07-11 2002-05-16 Wolfgang Papenbrock Verfahren zur Vorschau von Internetseiten
JP2004523529A (ja) * 2001-01-23 2004-08-05 イーライ・リリー・アンド・カンパニー メラノコルチンレセプターアゴニスト
EP1363890A4 (en) 2001-02-07 2009-06-10 Ore Pharmaceuticals Inc MELANOCORTIN-4-RECEPTOR BINDING COMPOUNDS AND METHOD FOR THEIR APPLICATION
UA81749C2 (uk) 2001-10-04 2008-02-11 Х. Луннбек А/С Фенілпіперазинові похідні як інгібітори зворотного захоплення серотоніну
CN100457738C (zh) * 2001-12-20 2009-02-04 H·隆德贝克有限公司 芳氧基苯基和芳硫基苯基衍生物
AR043633A1 (es) 2003-03-20 2005-08-03 Schering Corp Ligandos de receptores de canabinoides
DE602004016316D1 (de) * 2003-04-04 2008-10-16 Lundbeck & Co As H 4-(2-phenylsulfanyl-phenyl)-piperidin-derivate als serotonin-wiederaufnahme-hemmer
WO2005000309A2 (en) 2003-06-27 2005-01-06 Ionix Pharmaceuticals Limited Chemical compounds
US8722684B2 (en) * 2006-06-16 2014-05-13 H. Lundbeck A/S 1-[2-(2,4-dimethylphenylsulfanyl)-phenyl] piperazine as a compound with combined serotonin reuptake, 5-HT3 and 5-HT1A activity for the treatment of cognitive impairment

Also Published As

Publication number Publication date
US7148238B2 (en) 2006-12-12
EP1749818A2 (en) 2007-02-07
BE2014C036I2 (pt) 2021-11-22
ES2298425T7 (es) 2022-06-27
JP2007051149A (ja) 2007-03-01
HUP0402313A3 (en) 2010-03-29
AR066460A2 (es) 2009-08-19
DE60233608D1 (de) 2009-10-15
US9090575B2 (en) 2015-07-28
US8110567B2 (en) 2012-02-07
AU2006215994A2 (en) 2006-10-05
CY2014022I1 (el) 2015-12-09
US20180127389A1 (en) 2018-05-10
ZA200401583B (en) 2005-05-25
UA81749C2 (uk) 2008-02-11
EP1436271B1 (en) 2008-02-20
CA2462110A1 (en) 2003-04-10
AR036659A1 (es) 2004-09-22
ES2328725T3 (es) 2009-11-17
BR122012009534B1 (pt) 2018-02-27
MY140950A (en) 2010-02-12
IS2732B (is) 2011-04-15
RS52865B (en) 2013-12-31
NO20083446L (no) 2004-04-21
CY1107924T1 (el) 2013-09-04
CN1319958C (zh) 2007-06-06
US20110009423A1 (en) 2011-01-13
EA200400498A1 (ru) 2004-08-26
US7144884B2 (en) 2006-12-05
KR20070103515A (ko) 2007-10-23
ES2298425T3 (es) 2008-05-16
FR14C0033I1 (pt) 2014-06-13
US10844029B2 (en) 2020-11-24
NL300652I2 (pt) 2016-01-18
NO326443B1 (no) 2008-12-08
PL210551B1 (pl) 2012-02-29
BR122012009534C8 (pt) 2021-05-25
DE60225162D1 (de) 2008-04-03
IS8806A (is) 2009-03-10
MEP6508A (xx) 2010-02-10
JP2005505585A (ja) 2005-02-24
EA007537B1 (ru) 2006-10-27
US20050014740A1 (en) 2005-01-20
KR100783346B1 (ko) 2007-12-07
HUS1400012I1 (hu) 2020-12-28
LU92397I2 (fr) 2014-05-12
AU2006215994B2 (en) 2008-11-13
PL209253B1 (pl) 2011-08-31
AU2006215994A9 (en) 2006-10-05
KR100770194B1 (ko) 2007-10-25
DK1436271T6 (da) 2022-06-27
KR20060118020A (ko) 2006-11-17
LTC1436271I2 (lt) 2016-09-12
US20060089368A1 (en) 2006-04-27
US20160137620A1 (en) 2016-05-19
JP2007031447A (ja) 2007-02-08
HRP20040220A2 (en) 2005-02-28
US8476279B2 (en) 2013-07-02
US20060084662A1 (en) 2006-04-20
EP1436271B3 (en) 2022-04-20
NO2014011I1 (no) 2014-05-13
US7683053B2 (en) 2010-03-23
EA011096B1 (ru) 2008-12-30
PL368442A1 (pl) 2005-03-21
AU2002333220C1 (en) 2023-10-05
EG25095A (en) 2011-08-17
BR0212733B1 (pt) 2014-05-13
DK1436271T3 (da) 2008-06-09
HK1072600A1 (en) 2005-09-02
NO2014011I2 (no) 2015-08-31
PT1436271E (pt) 2008-04-10
NL300652I1 (pt) 2016-01-18
CA2462110C (en) 2010-05-11
RS20120158A3 (en) 2013-10-31
DK1749818T3 (da) 2009-10-12
HU230189B1 (hu) 2015-09-28
US20070060574A1 (en) 2007-03-15
ME00039B (me) 2010-06-10
IL160655A0 (en) 2004-07-25
IS7164A (is) 2004-02-26
US7138407B2 (en) 2006-11-21
JP3955614B2 (ja) 2007-08-08
CN1561336A (zh) 2005-01-05
SI1436271T1 (sl) 2008-06-30
CO5580746A2 (es) 2005-11-30
PT1749818E (pt) 2009-10-06
CY1110064T1 (el) 2015-01-14
KR100842702B1 (ko) 2008-07-01
IS2578B (is) 2010-02-15
ATE386730T1 (de) 2008-03-15
WO2003029232A1 (en) 2003-04-10
RS20120158A2 (en) 2012-10-31
JP3896116B2 (ja) 2007-03-22
DE60225162T3 (de) 2022-08-11
NO332355B1 (no) 2012-09-03
KR20040047886A (ko) 2004-06-05
NZ531556A (en) 2005-12-23
RS52326B (en) 2012-12-31
CY2014022I2 (el) 2015-12-09
US20120302553A1 (en) 2012-11-29
JP3955613B2 (ja) 2007-08-08
BR122012009534B8 (pt) 2019-01-29
DE60225162T2 (de) 2009-02-12
MXPA04002959A (es) 2004-07-05
NO20041628L (no) 2004-04-21
EP1749818A3 (en) 2008-04-02
HUP0402313A2 (hu) 2005-02-28
US20210276966A1 (en) 2021-09-09
AU2002333220A2 (en) 2003-04-14
EA200601269A1 (ru) 2007-02-27
BR122012023120B1 (pt) 2017-03-21
AU2002333220B2 (en) 2008-02-07
BR122012023120B8 (pt) 2022-01-18
CA2462110E (en) 2003-04-10
UA93857C2 (uk) 2011-03-25
EA007537B3 (ru) 2015-02-27
ATE441631T1 (de) 2009-09-15
BR0212733A (pt) 2004-11-16
RS27704A (en) 2006-10-27
US20140163043A1 (en) 2014-06-12
EP1436271A1 (en) 2004-07-14
EP1749818B1 (en) 2009-09-02
US9708280B2 (en) 2017-07-18
FR14C0033I2 (fr) 2014-11-14
HU228956B1 (en) 2013-07-29
AU2006215994A1 (en) 2006-10-05

Similar Documents

Publication Publication Date Title
BRPI0212733B8 (pt) composição farmacêutica compreendendo composto inibidor da recaptação de serotonina, e, uso do mesmo
BR0209580A (pt) Derivados de ciclohexan-1, 4 diamina substituìdos
BR0307351A (pt) Composto, composição farmacêutica, método para tratar uma condição ou estado de doença mediados pela atividade de p38 quinase ou mediados por citocinas produzidas pela atividade de p38 quinase, uso de um composto, e, processo para preparar um composto
BR9915727A (pt) ésteres derivados de compostos de fenil-ciclohexila substituìdos
BR0315296A (pt) Derivados do ciclohexanol espirocìclicos
AR026173A1 (es) Inhibidores de neuraminidasas.
UY24949A1 (es) Compuestos calcilíticos
BR0316723A (pt) Derivados de anilinopirazol úteis para o tratamento de diabetes
DK1626720T3 (da) 4-(2-Phenylsulfanyl-phenyl)-piperidinderivater som serotonin-genoptagelseshæmmer
BR0213481A (pt) Sondas
BRPI0408453A (pt) composto, composição farmacêutica, uso de um composto, e, método para o tratamento de um distúrbio afetivo
BR9916807A (pt) Antagonistas de 5ht1 para terapia antidepressiva
BRPI0408320A (pt) composto, composição farmacêutica, uso de um composto, e, método para o tratamento de um distúrbio afetivo
BR0111897A (pt) Composto, método para tratar um indivìduo afligido por alguns distúrbios dos sistemas nervosos periférico e central, composição farmacêutica, e, uso de um composto
DE60207857D1 (de) Neue heteroarylderivate, deren herstellung und verwendung
BR0115301A (pt) Uso de um inibidor seletivo da recaptação de norepinefrina
BR0214529A (pt) compostos terapêuticos
BR0308364A (pt) Composição para tratamento capilar, método de incorporação de gotìculas discretas, uso de composição de tratamento capilar
BRPI0408647A (pt) composto, composição farmacêutica, uso de um composto, e, método para o tratamento de um distúrbio afetivo
AR032711A1 (es) Derivados de fenilpiperazina, un metodo para la preparacion de los mismos y una composicion farmaceutica que los contiene
BRPI0412268A (pt) compostos contendo um inibidor seletivo da recaptação de serotonina e antagonista de receptor 5-ht2a
BR0315348A (pt) Processo para a preparação de um composto, e composto
BRPI0513386A (pt) inibidores de reabsorção de norepinefrina de quinoxalinona para o tratamento de distúrbios do sistema nervoso central
BRPI0414637A (pt) processo para a preparação de um composto éter difenìlico

Legal Events

Date Code Title Description
B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B07A Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
B06A Patent application procedure suspended [chapter 6.1 patent gazette]
B07D Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]
B07E Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette]

Free format text: NOTIFICACAO DE ANUENCIA RELACIONADA COM O ART 229 DA LPI

B09A Decision: intention to grant [chapter 9.1 patent gazette]
B09Y Publication of grant cancelled [chapter 9.1.2 patent gazette]
B09A Decision: intention to grant [chapter 9.1 patent gazette]
B16A Patent or certificate of addition of invention granted [chapter 16.1 patent gazette]

Free format text: PRAZO DE VALIDADE: 10 (DEZ) ANOS CONTADOS A PARTIR DE 13/05/2014, OBSERVADAS AS CONDICOES LEGAIS.

B17A Notification of administrative nullity (patentee has 60 days time to reply to this notification)

Free format text: REQUERENTE DA NULIDADE: LIBBS FARMACEUTICA LTDA. - PETICAO NPWB N.O 860140188642 DE 11/11/2014.

B22O Other matters related to patents and certificates of addition of invention: legal action concerning patent

Free format text: INPI NO 52402.004198/2021-12 ORIGEM: 13O VF DO RIO DE JANEIRO PROCESSO NO: 5084536-83.2020.4.02.5101 AUTOR: LIBBS FARMACEUTICA LTDA. REU(S): H. LUNDBECK A/S E INSTITUTO NACIONAL DA PROPRIEDADE INDUSTRIAL ? INPI

B16C Correction of notification of the grant [chapter 16.3 patent gazette]

Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 02/10/2002 OBSERVADAS AS CONDICOES LEGAIS. PATENTE CONCEDIDA CONFORME ADI 5.529/DF

B22O Other matters related to patents and certificates of addition of invention: legal action concerning patent

Free format text: INPI NO 52402.007731/2021-90 ORIGEM: JUIZO SUBSTITUTO DA 13A VF DO RIO DE JANEIRO (TRF2) PROCESSO NO: 5015034-23.2021.4.02.5101 NULIDADE DA PATENTE DE INVENCAO AUTOR: ALTHAIA S.A. INDUSTRIA FARMACEUTICA REU(S): H. LUNDBECK A/S E INSTITUTO NACIONAL DA PROPRIEDADE INDUSTRIAL ? INPI

B22O Other matters related to patents and certificates of addition of invention: legal action concerning patent

Free format text: INPI NO 52402.009210/2021-77 ORIGEM: JUIZO SUBSTITUTO DA 25A VF DO RIO DE JANEIRO (TRF2) PROCESSO NO: 5005543-89.2021.4.02.5101 NULIDADE DA PATENTE DE INVENCAO AUTOR: ALTHAIA S.A. INDUSTRIA FARMACEUTICA REU(S): H. LUNDBECK A/S E INSTITUTO NACIONAL DA PROPRIEDADE INDUSTRIAL - INPI

B22O Other matters related to patents and certificates of addition of invention: legal action concerning patent

Free format text: INPI NO 52402.004535/2022-44 ORIGEM: 21A VARA FEDERAL CIVEL DA SJDF (TRF1) PROCESSO NO: 1006097-47.2022.4.01.3400 ACAO PELO PROCEDIMENTO COMUM AUTOR: H. LUNDBECK A/S REU(S): AGENCIA NACIONAL DE VIGILANCIA SANITARIA E INSTITUTO NACIONAL DA PROPRIEDADE INDUSTRIAL

B19A Notification of judicial decision: notification of judicial decision

Free format text: PROCESSO INPI NO 52402.004535/2022-44 21A VARA FEDERAL CIVEL DA SJDF PROCESSO JUDICIAL: 1006097-47.2022.4.01.3400 NUP: 00424.125631/2022-73 (REF. 1006097-47.2022.4.01.3400) INTERESSADOS: AGENCIA NACIONAL DE VIGILANCIA SANITARIA - ANVISA E OUTROS DECISAO: PELO EXPOSTO, DEFIRO O PEDIDO DE TUTELA PROVISORIA DE URGENCIA PARA DETERMINAR A SUSPENSAO DOS EFEITOS DO DESPACHO 16.3 (PUBLICADO NA RPI NO 2.629 DE 25/05/21), QUE REDUZIU O PRAZO DE VIGENCIA DAS PATENTES PI0212733-4 E BR 12 2012 023120 7, DE MODO QUE ESTAS PERMANECAM VIGENTES ATE A PROLACAO DE SENTENCA DE MERITO ? LIMITADA A COMPENSACAO DE PRAZO REQUERIDA NO PEDIDO, QUAL SEJA, 663 (SEISCENTOS E SESSENTA E TRES) DIAS PARA A PI02127

B19A Notification of judicial decision: notification of judicial decision

Free format text: PROCESSO INPI NO 52402.001300/2023-81 AUTOR: H.LUDBECK A/S REU: INSTITUTO NACIONAL DA PROPRIEDADE INDUSTRIAL DECISAO: CONSIDERANDO OS TERMOS DA DECISAO EXARADA, O INSTITUTO NACIONAL DA PROPRIEDADE INDUSTRIAL ? INPI, NAO ESTA OBRIGADO A MANTER A EFICACIA DAS PATENTES PI0212733-4 E BR 122012023120-7, MANTENDO-SE INTEGROS OS EFEITOS DO DESPACHO 16.3 (PUBLICADO NA RPI 2629 DE 25/05/2021), QUE REDUZIU O PRAZO DE VIGENCIA DAS PATENTES PI0212733-4 E BR 122012023120-7.

B22O Other matters related to patents and certificates of addition of invention: legal action concerning patent

Free format text: INPI NO 52402.001300/2023-81 ORIGEM: GAB. 13 - DESEMBARGADOR FEDERAL SOUZA PRUDENTE (TRF1) PROCESSO NO: 1039664-84.2022.4.01.0000 ACAO PELO PROCEDIMENTO COMUM AUTOR: H. LUNDBECK A/S REU(S): AGENCIA NACIONAL DE VIGILANCIA SANITARIA E INSTITUTO NACIONAL DA PROPRIEDADE INDUSTRIAL ? INPI