PL3615518T3 - Sposób wytwarzania postaci alfa wortioksetyny hbr - Google Patents
Sposób wytwarzania postaci alfa wortioksetyny hbrInfo
- Publication number
- PL3615518T3 PL3615518T3 PL18721975T PL18721975T PL3615518T3 PL 3615518 T3 PL3615518 T3 PL 3615518T3 PL 18721975 T PL18721975 T PL 18721975T PL 18721975 T PL18721975 T PL 18721975T PL 3615518 T3 PL3615518 T3 PL 3615518T3
- Authority
- PL
- Poland
- Prior art keywords
- alpha
- manufacture
- vortioxetine hbr
- vortioxetine
- hbr
- Prior art date
Links
- 238000004519 manufacturing process Methods 0.000 title 1
- 238000000034 method Methods 0.000 title 1
- VNGRUFUIHGGOOM-UHFFFAOYSA-N vortioxetine hydrobromide Chemical compound Br.CC1=CC(C)=CC=C1SC1=CC=CC=C1N1CCNCC1 VNGRUFUIHGGOOM-UHFFFAOYSA-N 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
- C07D295/096—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/06—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by halogen atoms or nitro radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/13—Crystalline forms, e.g. polymorphs
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Cephalosporin Compounds (AREA)
- Enzymes And Modification Thereof (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Saccharide Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DKPA201700264 | 2017-04-25 | ||
| PCT/EP2018/060192 WO2018197360A1 (en) | 2017-04-25 | 2018-04-20 | Process for the manufacture of vortioxetine hbr alpha-form |
| EP18721975.3A EP3615518B1 (en) | 2017-04-25 | 2018-04-20 | Process for the manufacture of vortioxetine hbr alpha-form |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PL3615518T3 true PL3615518T3 (pl) | 2022-03-07 |
Family
ID=62111030
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PL18721975T PL3615518T3 (pl) | 2017-04-25 | 2018-04-20 | Sposób wytwarzania postaci alfa wortioksetyny hbr |
Country Status (26)
| Country | Link |
|---|---|
| US (1) | US11124491B2 (pl) |
| EP (1) | EP3615518B1 (pl) |
| JP (1) | JP7121751B2 (pl) |
| KR (1) | KR102551433B1 (pl) |
| CN (1) | CN110520415A (pl) |
| AU (1) | AU2018258947C1 (pl) |
| BR (1) | BR112018076411A2 (pl) |
| CL (1) | CL2019003024A1 (pl) |
| CO (1) | CO2019011592A2 (pl) |
| CY (1) | CY1124974T1 (pl) |
| DK (1) | DK3615518T3 (pl) |
| ES (1) | ES2905962T3 (pl) |
| HR (1) | HRP20220108T1 (pl) |
| HU (1) | HUE057993T2 (pl) |
| IL (1) | IL270052B2 (pl) |
| LT (1) | LT3615518T (pl) |
| MA (1) | MA49056A (pl) |
| MX (1) | MX2019012765A (pl) |
| PL (1) | PL3615518T3 (pl) |
| PT (1) | PT3615518T (pl) |
| RS (1) | RS62823B1 (pl) |
| SG (1) | SG11201909678PA (pl) |
| SI (1) | SI3615518T1 (pl) |
| SM (1) | SMT202200073T1 (pl) |
| WO (1) | WO2018197360A1 (pl) |
| ZA (1) | ZA201906829B (pl) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3762371A1 (en) * | 2018-02-06 | 2021-01-13 | Piramal Enterprises Limited | An improved process for the preparation of vortioxetine and salts thereof |
| CN112125868B (zh) * | 2020-09-25 | 2021-08-03 | 中山万远新药研发有限公司 | 一种氢溴酸伏硫西汀晶型及其制备方法、组合物与用途 |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| UA81749C2 (uk) * | 2001-10-04 | 2008-02-11 | Х. Луннбек А/С | Фенілпіперазинові похідні як інгібітори зворотного захоплення серотоніну |
| KR20090028712A (ko) * | 2006-06-16 | 2009-03-19 | 하. 룬트벡 아크티에 셀스카브 | 인지기능 장애의 치료를 위한, 세로토닌 재흡수, 5-ｈｔ3 및 5-ｈｔ1ａ 활성이 조합된 화합물로서의 1-[2-(2,4-디메틸페닐술파닐)-페닐]피페라진 |
| TW200848411A (en) * | 2007-03-20 | 2008-12-16 | Lundbeck & Co As H | Novel therapeutic uses of 1-[2-(2, 4-dimethylphenylsulfanyl)phenyl]-piperazine |
| TW201033181A (en) * | 2009-02-17 | 2010-09-16 | Lundbeck & Co As H | Purification of 1-[2-(2,4-dimethylphenylsulfanyl)phenyl]piperazine |
| BR112015006075B1 (pt) | 2012-09-19 | 2022-10-04 | Sandoz Ag | Composto cristalino, composição farmacêutica, uso do composto cristalino, hidrato cristalino do bromidrato de vortioxetina, método para a preparação do hidrato cristalino de bromidrato de vortioxetina, método para a preparação do composto cristalino e uso do hidrato cristalino de bromidrato de vortioxetina |
| EA029060B1 (ru) * | 2014-01-31 | 2018-02-28 | Эгиш Дьёдьсердьяр Зрт. | Способ получения солей вортиоксетина |
| US9687484B2 (en) | 2014-07-18 | 2017-06-27 | Dipharma Francis S.R.L. | Crystalline forms of an antidepressant compound |
| CN105367515B (zh) * | 2015-05-08 | 2017-10-27 | 北京北陆药业股份有限公司 | 一种氢溴酸沃替西汀α晶型的制备方法 |
| CN104910099B (zh) | 2015-05-22 | 2017-03-08 | 扬子江药业集团有限公司 | 一种氢溴酸沃替西汀晶体的制备方法 |
| CN106316986B (zh) | 2015-07-03 | 2019-02-05 | 成都弘达药业有限公司 | 一种1-[2-(2,4-二甲基苯基硫烷基)苯基]哌嗪氢溴酸盐α型晶体的制备方法 |
-
2018
- 2018-04-20 JP JP2019557745A patent/JP7121751B2/ja active Active
- 2018-04-20 SG SG11201909678P patent/SG11201909678PA/en unknown
- 2018-04-20 IL IL270052A patent/IL270052B2/en unknown
- 2018-04-20 MX MX2019012765A patent/MX2019012765A/es unknown
- 2018-04-20 LT LTEPPCT/EP2018/060192T patent/LT3615518T/lt unknown
- 2018-04-20 HR HRP20220108TT patent/HRP20220108T1/hr unknown
- 2018-04-20 CN CN201880025179.2A patent/CN110520415A/zh active Pending
- 2018-04-20 EP EP18721975.3A patent/EP3615518B1/en active Active
- 2018-04-20 AU AU2018258947A patent/AU2018258947C1/en active Active
- 2018-04-20 SM SM20220073T patent/SMT202200073T1/it unknown
- 2018-04-20 WO PCT/EP2018/060192 patent/WO2018197360A1/en not_active Ceased
- 2018-04-20 HU HUE18721975A patent/HUE057993T2/hu unknown
- 2018-04-20 KR KR1020197031292A patent/KR102551433B1/ko active Active
- 2018-04-20 PL PL18721975T patent/PL3615518T3/pl unknown
- 2018-04-20 DK DK18721975.3T patent/DK3615518T3/da active
- 2018-04-20 US US16/604,313 patent/US11124491B2/en active Active
- 2018-04-20 SI SI201830537T patent/SI3615518T1/sl unknown
- 2018-04-20 ES ES18721975T patent/ES2905962T3/es active Active
- 2018-04-20 RS RS20220047A patent/RS62823B1/sr unknown
- 2018-04-20 BR BR112018076411-6A patent/BR112018076411A2/pt active Search and Examination
- 2018-04-20 MA MA049056A patent/MA49056A/fr unknown
- 2018-04-20 PT PT187219753T patent/PT3615518T/pt unknown
-
2019
- 2019-10-16 ZA ZA2019/06829A patent/ZA201906829B/en unknown
- 2019-10-18 CO CO2019011592A patent/CO2019011592A2/es unknown
- 2019-10-22 CL CL2019003024A patent/CL2019003024A1/es unknown
-
2022
- 2022-02-08 CY CY20221100108T patent/CY1124974T1/el unknown
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