CY1124974T1 - Διαδικασια για την παρασκευη βορτιοξετινης hbr αλφα-μορφης - Google Patents

Διαδικασια για την παρασκευη βορτιοξετινης hbr αλφα-μορφης

Info

Publication number
CY1124974T1
CY1124974T1 CY20221100108T CY221100108T CY1124974T1 CY 1124974 T1 CY1124974 T1 CY 1124974T1 CY 20221100108 T CY20221100108 T CY 20221100108T CY 221100108 T CY221100108 T CY 221100108T CY 1124974 T1 CY1124974 T1 CY 1124974T1
Authority
CY
Cyprus
Prior art keywords
preparation
alpha
procedure
vortioxetine hbr
hbr
Prior art date
Application number
CY20221100108T
Other languages
English (en)
Inventor
Hans Petersen
Original Assignee
H. Lundbeck A/S
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=62111030&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CY1124974(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by H. Lundbeck A/S filed Critical H. Lundbeck A/S
Publication of CY1124974T1 publication Critical patent/CY1124974T1/el

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
    • C07D295/096—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/06—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by halogen atoms or nitro radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Cephalosporin Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Saccharide Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Enzymes And Modification Thereof (AREA)

Abstract

Παρέχεται μία διαδικασία για την παρασκευή βορτιοξετίνης HBr α-μορφής.
CY20221100108T 2017-04-25 2022-02-08 Διαδικασια για την παρασκευη βορτιοξετινης hbr αλφα-μορφης CY1124974T1 (el)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DKPA201700264 2017-04-25
PCT/EP2018/060192 WO2018197360A1 (en) 2017-04-25 2018-04-20 Process for the manufacture of vortioxetine hbr alpha-form

Publications (1)

Publication Number Publication Date
CY1124974T1 true CY1124974T1 (el) 2023-01-05

Family

ID=62111030

Family Applications (1)

Application Number Title Priority Date Filing Date
CY20221100108T CY1124974T1 (el) 2017-04-25 2022-02-08 Διαδικασια για την παρασκευη βορτιοξετινης hbr αλφα-μορφης

Country Status (26)

Country Link
US (1) US11124491B2 (el)
EP (1) EP3615518B1 (el)
JP (1) JP7121751B2 (el)
KR (1) KR102551433B1 (el)
CN (1) CN110520415A (el)
AU (1) AU2018258947C1 (el)
BR (1) BR112018076411A2 (el)
CA (1) CA3059515A1 (el)
CL (1) CL2019003024A1 (el)
CO (1) CO2019011592A2 (el)
CY (1) CY1124974T1 (el)
DK (1) DK3615518T3 (el)
ES (1) ES2905962T3 (el)
HR (1) HRP20220108T1 (el)
HU (1) HUE057993T2 (el)
IL (1) IL270052B2 (el)
LT (1) LT3615518T (el)
MA (1) MA49056A (el)
MX (1) MX2019012765A (el)
PL (1) PL3615518T3 (el)
PT (1) PT3615518T (el)
RS (1) RS62823B1 (el)
SG (1) SG11201909678PA (el)
SI (1) SI3615518T1 (el)
WO (1) WO2018197360A1 (el)
ZA (1) ZA201906829B (el)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2019155352A1 (en) * 2018-02-06 2019-08-15 Piramal Enterprises Limited An improved process for the preparation of vortioxetine and salts thereof
CN112125868B (zh) * 2020-09-25 2021-08-03 中山万远新药研发有限公司 一种氢溴酸伏硫西汀晶型及其制备方法、组合物与用途

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
UA81749C2 (uk) * 2001-10-04 2008-02-11 Х. Луннбек А/С Фенілпіперазинові похідні як інгібітори зворотного захоплення серотоніну
ES2379200T5 (es) * 2006-06-16 2021-10-20 H Lundbeck As Bromhidrato de 1-[2-(2,4-Dimetilfenilsulfanil)fenil]piperazina como compuesto con recaptación de serotonina combinada con actividad 5-HT3 y 5-HT1A para el tratamiento del deterioro cognitivo
TW200848411A (en) * 2007-03-20 2008-12-16 Lundbeck & Co As H Novel therapeutic uses of 1-[2-(2, 4-dimethylphenylsulfanyl)phenyl]-piperazine
TW201033181A (en) * 2009-02-17 2010-09-16 Lundbeck & Co As H Purification of 1-[2-(2,4-dimethylphenylsulfanyl)phenyl]piperazine
BR112015006075B1 (pt) 2012-09-19 2022-10-04 Sandoz Ag Composto cristalino, composição farmacêutica, uso do composto cristalino, hidrato cristalino do bromidrato de vortioxetina, método para a preparação do hidrato cristalino de bromidrato de vortioxetina, método para a preparação do composto cristalino e uso do hidrato cristalino de bromidrato de vortioxetina
US9822086B2 (en) * 2014-01-31 2017-11-21 Egis Gyogyszergyar Zrt. Process for the preparation of vortioxetine salts
US9687484B2 (en) 2014-07-18 2017-06-27 Dipharma Francis S.R.L. Crystalline forms of an antidepressant compound
CN105367515B (zh) * 2015-05-08 2017-10-27 北京北陆药业股份有限公司 一种氢溴酸沃替西汀α晶型的制备方法
CN104910099B (zh) 2015-05-22 2017-03-08 扬子江药业集团有限公司 一种氢溴酸沃替西汀晶体的制备方法
CN106316986B (zh) 2015-07-03 2019-02-05 成都弘达药业有限公司 一种1-[2-(2,4-二甲基苯基硫烷基)苯基]哌嗪氢溴酸盐α型晶体的制备方法

Also Published As

Publication number Publication date
PL3615518T3 (pl) 2022-03-07
ES2905962T3 (es) 2022-04-12
JP7121751B2 (ja) 2022-08-18
WO2018197360A1 (en) 2018-11-01
CO2019011592A2 (es) 2019-10-31
ZA201906829B (en) 2022-03-30
BR112018076411A2 (pt) 2019-04-09
US20200165217A1 (en) 2020-05-28
IL270052B2 (en) 2023-12-01
HUE057993T2 (hu) 2022-06-28
CN110520415A (zh) 2019-11-29
RU2019133770A3 (el) 2021-08-27
IL270052A (el) 2019-12-31
LT3615518T (lt) 2022-03-10
AU2018258947C1 (en) 2021-08-26
EP3615518A1 (en) 2020-03-04
AU2018258947A1 (en) 2019-10-31
MX2019012765A (es) 2019-12-05
DK3615518T3 (da) 2022-02-07
SG11201909678PA (en) 2019-11-28
CA3059515A1 (en) 2018-11-01
MA49056A (fr) 2020-03-04
IL270052B1 (en) 2023-08-01
RS62823B1 (sr) 2022-02-28
HRP20220108T1 (hr) 2022-04-15
JP2020517674A (ja) 2020-06-18
KR102551433B1 (ko) 2023-07-04
RU2019133770A (ru) 2021-05-25
EP3615518B1 (en) 2021-12-15
SI3615518T1 (sl) 2022-02-28
PT3615518T (pt) 2022-02-14
KR20190141155A (ko) 2019-12-23
AU2018258947B2 (en) 2021-02-25
US11124491B2 (en) 2021-09-21
CL2019003024A1 (es) 2020-02-21

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