MX344144B - Proceso para la fabricacion de 1-[2-(2,4-dimetilfenilsulfanil)feni l] piperazina. - Google Patents

Proceso para la fabricacion de 1-[2-(2,4-dimetilfenilsulfanil)feni l] piperazina.

Info

Publication number
MX344144B
MX344144B MX2014008052A MX2014008052A MX344144B MX 344144 B MX344144 B MX 344144B MX 2014008052 A MX2014008052 A MX 2014008052A MX 2014008052 A MX2014008052 A MX 2014008052A MX 344144 B MX344144 B MX 344144B
Authority
MX
Mexico
Prior art keywords
phenylsulfanyl
piperazine
dimethyl
phenyl
manufacture
Prior art date
Application number
MX2014008052A
Other languages
English (en)
Other versions
MX2014008052A (es
Inventor
Lasse Christensen Kim
Original Assignee
H Lundbeck As
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=48744991&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=MX344144(B) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by H Lundbeck As filed Critical H Lundbeck As
Publication of MX2014008052A publication Critical patent/MX2014008052A/es
Publication of MX344144B publication Critical patent/MX344144B/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
    • C07D295/096—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

La presente invención describe un proceso para la fabricación de 1-[2-(2,4-dimetil-fenilsulfanil)-fenil]piperazina y sus sales farmacéuticamente aceptables que involucra hacer reaccionar compuestos de fórmula II, III, IV bajo catálisis de Pd y en presencia de ligandos de fosfina para dar el Compuesto I. (ver Fórmula).
MX2014008052A 2012-01-03 2012-12-20 Proceso para la fabricacion de 1-[2-(2,4-dimetilfenilsulfanil)feni l] piperazina. MX344144B (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201261582527P 2012-01-03 2012-01-03
DKPA201200006 2012-01-03
PCT/EP2012/076377 WO2013102573A1 (en) 2012-01-03 2012-12-20 Process for the manufacture of 1-[2-(2,4-dimethyl-phenylsulfanyl)-phenyl]-piperazine

Publications (2)

Publication Number Publication Date
MX2014008052A MX2014008052A (es) 2014-09-26
MX344144B true MX344144B (es) 2016-12-07

Family

ID=48744991

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2014008052A MX344144B (es) 2012-01-03 2012-12-20 Proceso para la fabricacion de 1-[2-(2,4-dimetilfenilsulfanil)feni l] piperazina.

Country Status (24)

Country Link
US (1) US9133144B2 (es)
EP (1) EP2800746B1 (es)
JP (1) JP6018644B2 (es)
KR (1) KR102008039B1 (es)
CN (1) CN104011034B (es)
AU (1) AU2012364402B2 (es)
BR (1) BR112014016322B8 (es)
CA (1) CA2860103C (es)
CL (1) CL2014001765A1 (es)
CO (1) CO7000771A2 (es)
CY (1) CY1121629T1 (es)
DK (1) DK2800746T3 (es)
HK (1) HK1200827A1 (es)
HR (1) HRP20190769T1 (es)
IL (1) IL233093A (es)
LT (1) LT2800746T (es)
MX (1) MX344144B (es)
PL (1) PL2800746T3 (es)
RS (1) RS58683B1 (es)
RU (1) RU2608307C2 (es)
SG (1) SG11201403835UA (es)
SI (1) SI2800746T1 (es)
WO (1) WO2013102573A1 (es)
ZA (1) ZA201404881B (es)

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IN2013MU03121A (es) 2013-09-30 2015-07-17 Cadila Healthcare Ltd
EP2878596A1 (en) * 2013-11-29 2015-06-03 LEK Pharmaceuticals d.d. Synthesis of vortioxetine via (2-(piperazine-1-yl)phenyl)lithium intermediates
EP2894154A1 (en) 2014-01-14 2015-07-15 LEK Pharmaceuticals d.d. Synthesis of vortioxetine via (2-(piperazine-1-yl)phenyl)aniline intermediates
CN103788020B (zh) * 2014-01-22 2015-11-04 苏州明锐医药科技有限公司 沃替西汀的制备方法
CN103788019B (zh) * 2014-01-22 2015-10-07 苏州明锐医药科技有限公司 沃替西汀的制备方法
CN106103418A (zh) 2014-01-31 2016-11-09 埃吉斯药物私人有限公司 沃替西汀盐的制备方法
EP2930171A1 (en) 2014-04-07 2015-10-14 LEK Pharmaceuticals d.d. Synthesis of vortioxetine via (2,4-dimethylphenyl)(2-iodophenyl)sulfane intermediate
CN104974110A (zh) * 2014-04-10 2015-10-14 江苏豪森药业股份有限公司 1-[2-(2,4-二甲基苯基硫基)苯基]哌嗪氢溴酸盐的新晶型及其制备方法和用途
CN105254590B (zh) * 2014-05-09 2019-09-03 江苏豪森药业集团有限公司 沃替西汀氢溴酸盐晶型及其制备方法和用途
EP3141543B8 (en) * 2014-05-09 2022-06-08 Shanghai Syncores Technologies Inc. Ltd. Vortioxetine intermediate and synthesis process thereof
CN104059030B (zh) * 2014-05-30 2016-05-04 镇江圣安医药有限公司 [(苯硫烷基)-苯基]哌嗪的衍生物及其药物组合物和用途
CN104292183B (zh) * 2014-09-29 2016-01-06 杨献美 一种抗抑郁药物沃替西汀的制备方法
WO2016079751A2 (en) 2014-11-17 2016-05-26 Megafine Pharma (P) Ltd. A process for preparation of vortioxetine and polymorphs thereof
ES2634496T3 (es) 2014-11-21 2017-09-28 Dipharma Francis S.R.L. Proceso para la preparación de un antidepresivo y los intermedios del mismo
CN104356092B (zh) * 2014-11-27 2017-03-22 合肥创新医药技术有限公司 沃替西汀的制备方法
WO2016125191A2 (en) 2015-02-04 2016-08-11 Mylan Laboratories Limited Processes for the preparation of vortioxetine hydrobromide
US10227317B2 (en) 2015-02-25 2019-03-12 Lupin Limited Process for the preparation of vortioxetine
CN104650004B (zh) * 2015-03-06 2017-06-06 中山万汉制药有限公司 一种氢溴酸沃替西汀的制备方法
CN105061364A (zh) * 2015-08-17 2015-11-18 河北国龙制药有限公司 氢溴酸沃替西汀的制备方法
EP3337789A1 (en) * 2015-08-19 2018-06-27 Amneal Pharmaceuticals Company GmbH Process for preparation of vortioxetine hydrobromide
CN106556663B (zh) * 2015-09-30 2018-05-29 成都弘达药业有限公司 一种1-[2-(2,4-二甲基苯基硫烷基)苯基]哌嗪或其盐的检测方法
CN109310691A (zh) 2016-07-01 2019-02-05 H.隆德贝克有限公司 用于快速开始抗抑郁作用的给药方案
US10519121B2 (en) 2016-12-30 2019-12-31 Apicore Us Llc Process and novel polymorphic form of vortioxetine and its pharmaceutically acceptable salts
CN106831652B (zh) * 2017-01-23 2019-01-11 齐鲁天和惠世制药有限公司 一种沃赛汀的制备方法
CN108017595A (zh) * 2017-12-20 2018-05-11 安徽源久源科技有限公司 一种1-[2-(2,5-二甲基苯硫基)苯基]哌嗪的制备方法
PT3810582T (pt) 2018-06-20 2024-04-09 Vio Ag Pharmaceuticals S A Uma abordagem de ativação de c-h organo-pseudocatalítica em um só recipiente para a preparação de vortioxetina e intermediário de vortioxetina
CN109438390A (zh) * 2018-11-26 2019-03-08 合肥创新医药技术有限公司 一种氢溴酸沃替西汀杂质的合成方法
CN112250642A (zh) * 2020-10-28 2021-01-22 合肥亿帆生物制药有限公司 一种氢溴酸伏硫西汀杂质标准品的制备方法
CN115368318B (zh) * 2022-06-22 2023-11-03 山东辰龙药业有限公司 一种伏硫西汀的合成方法及应用

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH07110050A (ja) 1993-10-13 1995-04-25 Daikin Mfg Co Ltd 捩じり振動減衰装置
UA81749C2 (uk) * 2001-10-04 2008-02-11 Х. Луннбек А/С Фенілпіперазинові похідні як інгібітори зворотного захоплення серотоніну
IL161966A0 (en) * 2001-12-20 2005-11-20 Lundbeck & Co As H Aryloxyphenyl and arylsulfanylphenyl
CN102614179B (zh) 2006-06-16 2015-11-25 H.隆德贝克有限公司 作为用于治疗认知损伤的、具有结合的对血清素再吸收、5-ht3和5-ht1a活性的化合物的1-[2-(2，4-二甲基苯基硫烷基)-苯基]哌嗪
TW201033181A (en) * 2009-02-17 2010-09-16 Lundbeck & Co As H Purification of 1-[2-(2,4-dimethylphenylsulfanyl)phenyl]piperazine

Also Published As

Publication number Publication date
DK2800746T3 (da) 2019-05-20
KR20140107357A (ko) 2014-09-04
CN104011034A (zh) 2014-08-27
KR102008039B1 (ko) 2019-08-06
CN104011034B (zh) 2016-08-17
CA2860103A1 (en) 2013-07-11
CA2860103C (en) 2020-07-07
JP6018644B2 (ja) 2016-11-02
US9133144B2 (en) 2015-09-15
BR112014016322B1 (pt) 2020-09-15
WO2013102573A1 (en) 2013-07-11
LT2800746T (lt) 2019-06-10
PL2800746T3 (pl) 2019-07-31
CL2014001765A1 (es) 2014-10-03
CO7000771A2 (es) 2014-07-21
BR112014016322A8 (pt) 2017-07-04
RS58683B1 (sr) 2019-06-28
SG11201403835UA (en) 2014-10-30
US20140343287A1 (en) 2014-11-20
EP2800746B1 (en) 2019-04-17
EP2800746A1 (en) 2014-11-12
MX2014008052A (es) 2014-09-26
ZA201404881B (en) 2015-12-23
BR112014016322A2 (pt) 2017-06-13
CY1121629T1 (el) 2020-07-31
IL233093A (en) 2017-04-30
SI2800746T1 (sl) 2019-06-28
RU2608307C2 (ru) 2017-01-17
HK1200827A1 (en) 2015-08-14
IL233093A0 (en) 2014-08-03
BR112014016322B8 (pt) 2020-12-01
RU2014131943A (ru) 2016-02-27
AU2012364402B2 (en) 2016-10-06
JP2015504062A (ja) 2015-02-05
HRP20190769T1 (hr) 2019-06-28
AU2012364402A1 (en) 2014-07-03

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