BR112014016322B8 - processo para a preparação de 1-[2-(2,4-dimetil-fenilsulfanil)-fenil]-piperazina - Google Patents

processo para a preparação de 1-[2-(2,4-dimetil-fenilsulfanil)-fenil]-piperazina

Info

Publication number
BR112014016322B8
BR112014016322B8 BR112014016322A BR112014016322A BR112014016322B8 BR 112014016322 B8 BR112014016322 B8 BR 112014016322B8 BR 112014016322 A BR112014016322 A BR 112014016322A BR 112014016322 A BR112014016322 A BR 112014016322A BR 112014016322 B8 BR112014016322 B8 BR 112014016322B8
Authority
BR
Brazil
Prior art keywords
piperazine
phenyl
phenylsulfanyl
dimethyl
preparation
Prior art date
Application number
BR112014016322A
Other languages
English (en)
Other versions
BR112014016322B1 (pt
BR112014016322A2 (pt
BR112014016322A8 (pt
Inventor
Lasse Christensen Kim
Original Assignee
H Lundbeck As
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=48744991&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=BR112014016322(B8) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by H Lundbeck As filed Critical H Lundbeck As
Publication of BR112014016322A2 publication Critical patent/BR112014016322A2/pt
Publication of BR112014016322A8 publication Critical patent/BR112014016322A8/pt
Publication of BR112014016322B1 publication Critical patent/BR112014016322B1/pt
Publication of BR112014016322B8 publication Critical patent/BR112014016322B8/pt

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
    • C07D295/096—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

processo para a preparação de 1-[2-(2,4-dimetil fenilsulfanil)-fenil]-piperazina. é revelado um processo para a preparação de 1-[2-(2,4-dimetil-fenilsulfanil)-fenil]-piperazina e sais farmaceuticamente aceitáveis que envolve fazer reagir compostos da fórmula ii, iii, iv, sob catálise com pd e na presença de ligantes fosfina, para dar origem ao composto i.
BR112014016322A 2012-01-03 2012-12-20 processo para a preparação de 1-[2-(2,4-dimetil-fenilsulfanil)-fenil]-piperazina BR112014016322B8 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DKPA201200006 2012-01-03
DKPA201200006 2012-01-03
PCT/EP2012/076377 WO2013102573A1 (en) 2012-01-03 2012-12-20 Process for the manufacture of 1-[2-(2,4-dimethyl-phenylsulfanyl)-phenyl]-piperazine

Publications (4)

Publication Number Publication Date
BR112014016322A2 BR112014016322A2 (pt) 2017-06-13
BR112014016322A8 BR112014016322A8 (pt) 2017-07-04
BR112014016322B1 BR112014016322B1 (pt) 2020-09-15
BR112014016322B8 true BR112014016322B8 (pt) 2020-12-01

Family

ID=48744991

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112014016322A BR112014016322B8 (pt) 2012-01-03 2012-12-20 processo para a preparação de 1-[2-(2,4-dimetil-fenilsulfanil)-fenil]-piperazina

Country Status (24)

Country Link
US (1) US9133144B2 (pt)
EP (1) EP2800746B1 (pt)
JP (1) JP6018644B2 (pt)
KR (1) KR102008039B1 (pt)
CN (1) CN104011034B (pt)
AU (1) AU2012364402B2 (pt)
BR (1) BR112014016322B8 (pt)
CA (1) CA2860103C (pt)
CL (1) CL2014001765A1 (pt)
CO (1) CO7000771A2 (pt)
CY (1) CY1121629T1 (pt)
DK (1) DK2800746T3 (pt)
HK (1) HK1200827A1 (pt)
HR (1) HRP20190769T1 (pt)
IL (1) IL233093A (pt)
LT (1) LT2800746T (pt)
MX (1) MX344144B (pt)
PL (1) PL2800746T3 (pt)
RS (1) RS58683B1 (pt)
RU (1) RU2608307C2 (pt)
SG (1) SG11201403835UA (pt)
SI (1) SI2800746T1 (pt)
WO (1) WO2013102573A1 (pt)
ZA (1) ZA201404881B (pt)

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IN2013MU03121A (pt) 2013-09-30 2015-07-17 Cadila Healthcare Ltd
EP2878596A1 (en) * 2013-11-29 2015-06-03 LEK Pharmaceuticals d.d. Synthesis of vortioxetine via (2-(piperazine-1-yl)phenyl)lithium intermediates
EP2894154A1 (en) 2014-01-14 2015-07-15 LEK Pharmaceuticals d.d. Synthesis of vortioxetine via (2-(piperazine-1-yl)phenyl)aniline intermediates
CN103788020B (zh) * 2014-01-22 2015-11-04 苏州明锐医药科技有限公司 沃替西汀的制备方法
CN103788019B (zh) * 2014-01-22 2015-10-07 苏州明锐医药科技有限公司 沃替西汀的制备方法
CN106103418A (zh) 2014-01-31 2016-11-09 埃吉斯药物私人有限公司 沃替西汀盐的制备方法
EP2930171A1 (en) 2014-04-07 2015-10-14 LEK Pharmaceuticals d.d. Synthesis of vortioxetine via (2,4-dimethylphenyl)(2-iodophenyl)sulfane intermediate
CN104974110A (zh) * 2014-04-10 2015-10-14 江苏豪森药业股份有限公司 1-[2-(2,4-二甲基苯基硫基)苯基]哌嗪氢溴酸盐的新晶型及其制备方法和用途
CN105254590B (zh) * 2014-05-09 2019-09-03 江苏豪森药业集团有限公司 沃替西汀氢溴酸盐晶型及其制备方法和用途
EP3141543B8 (en) * 2014-05-09 2022-06-08 Shanghai Syncores Technologies Inc. Ltd. Vortioxetine intermediate and synthesis process thereof
CN104059030B (zh) * 2014-05-30 2016-05-04 镇江圣安医药有限公司 [(苯硫烷基)-苯基]哌嗪的衍生物及其药物组合物和用途
CN104292183B (zh) * 2014-09-29 2016-01-06 杨献美 一种抗抑郁药物沃替西汀的制备方法
WO2016079751A2 (en) 2014-11-17 2016-05-26 Megafine Pharma (P) Ltd. A process for preparation of vortioxetine and polymorphs thereof
ES2634496T3 (es) 2014-11-21 2017-09-28 Dipharma Francis S.R.L. Proceso para la preparación de un antidepresivo y los intermedios del mismo
CN104356092B (zh) * 2014-11-27 2017-03-22 合肥创新医药技术有限公司 沃替西汀的制备方法
WO2016125191A2 (en) 2015-02-04 2016-08-11 Mylan Laboratories Limited Processes for the preparation of vortioxetine hydrobromide
WO2016135636A1 (en) 2015-02-25 2016-09-01 Lupin Limited Process for the preparation of vortioxetine
CN104650004B (zh) * 2015-03-06 2017-06-06 中山万汉制药有限公司 一种氢溴酸沃替西汀的制备方法
CN105061364A (zh) * 2015-08-17 2015-11-18 河北国龙制药有限公司 氢溴酸沃替西汀的制备方法
EP3337789A1 (en) * 2015-08-19 2018-06-27 Amneal Pharmaceuticals Company GmbH Process for preparation of vortioxetine hydrobromide
CN106556663B (zh) * 2015-09-30 2018-05-29 成都弘达药业有限公司 一种1-[2-(2,4-二甲基苯基硫烷基)苯基]哌嗪或其盐的检测方法
KR20190025556A (ko) 2016-07-01 2019-03-11 하. 룬드벡 아크티에셀스카브 항우울 효과의 신속한 개시를 위한 보티옥세틴 투여 요법
US10519121B2 (en) 2016-12-30 2019-12-31 Apicore Us Llc Process and novel polymorphic form of vortioxetine and its pharmaceutically acceptable salts
CN106831652B (zh) * 2017-01-23 2019-01-11 齐鲁天和惠世制药有限公司 一种沃赛汀的制备方法
CN108017595A (zh) * 2017-12-20 2018-05-11 安徽源久源科技有限公司 一种1-[2-(2,5-二甲基苯硫基)苯基]哌嗪的制备方法
CN112424177B (zh) 2018-06-20 2024-05-03 Vio制药公司 一种用于制备沃替西汀和沃替西汀中间体的一锅式有机假催化c-h活化方法
CN109438390A (zh) * 2018-11-26 2019-03-08 合肥创新医药技术有限公司 一种氢溴酸沃替西汀杂质的合成方法
CN112250642A (zh) * 2020-10-28 2021-01-22 合肥亿帆生物制药有限公司 一种氢溴酸伏硫西汀杂质标准品的制备方法
CN115368318B (zh) * 2022-06-22 2023-11-03 山东辰龙药业有限公司 一种伏硫西汀的合成方法及应用

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JPH07110050A (ja) 1993-10-13 1995-04-25 Daikin Mfg Co Ltd 捩じり振動減衰装置
UA81749C2 (uk) 2001-10-04 2008-02-11 Х. Луннбек А/С Фенілпіперазинові похідні як інгібітори зворотного захоплення серотоніну
CN100457738C (zh) * 2001-12-20 2009-02-04 H·隆德贝克有限公司 芳氧基苯基和芳硫基苯基衍生物
PL2044043T5 (pl) * 2006-06-16 2022-05-02 H. Lundbeck A/S Bromowodorek 1-[2-(2,4-dimetylofenylosulfanylo)fenylo]piperazyny jako związek o połączonym działaniu wychwytu zwrotnego serotoniny i działaniu na 5-ht3 i 5-ht1a do leczenia upośledzenia funckji poznawczych
TW201033181A (en) * 2009-02-17 2010-09-16 Lundbeck & Co As H Purification of 1-[2-(2,4-dimethylphenylsulfanyl)phenyl]piperazine

Also Published As

Publication number Publication date
IL233093A (en) 2017-04-30
EP2800746A1 (en) 2014-11-12
HK1200827A1 (en) 2015-08-14
CA2860103C (en) 2020-07-07
CO7000771A2 (es) 2014-07-21
BR112014016322B1 (pt) 2020-09-15
RU2014131943A (ru) 2016-02-27
CN104011034A (zh) 2014-08-27
WO2013102573A1 (en) 2013-07-11
JP2015504062A (ja) 2015-02-05
DK2800746T3 (da) 2019-05-20
KR20140107357A (ko) 2014-09-04
IL233093A0 (en) 2014-08-03
AU2012364402B2 (en) 2016-10-06
CN104011034B (zh) 2016-08-17
JP6018644B2 (ja) 2016-11-02
KR102008039B1 (ko) 2019-08-06
SG11201403835UA (en) 2014-10-30
RU2608307C2 (ru) 2017-01-17
BR112014016322A2 (pt) 2017-06-13
RS58683B1 (sr) 2019-06-28
CA2860103A1 (en) 2013-07-11
MX2014008052A (es) 2014-09-26
SI2800746T1 (sl) 2019-06-28
US20140343287A1 (en) 2014-11-20
CL2014001765A1 (es) 2014-10-03
HRP20190769T1 (hr) 2019-06-28
CY1121629T1 (el) 2020-07-31
BR112014016322A8 (pt) 2017-07-04
LT2800746T (lt) 2019-06-10
ZA201404881B (en) 2015-12-23
MX344144B (es) 2016-12-07
AU2012364402A1 (en) 2014-07-03
PL2800746T3 (pl) 2019-07-31
US9133144B2 (en) 2015-09-15
EP2800746B1 (en) 2019-04-17

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Legal Events

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B07D Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]

Free format text: DE ACORDO COM O ARTIGO 229-C DA LEI NO 10196/2001, QUE MODIFICOU A LEI NO 9279/96, A CONCESSAO DA PATENTE ESTA CONDICIONADA A ANUENCIA PREVIA DA ANVISA. CONSIDERANDO A APROVACAO DOS TERMOS DO PARECER NO 337/PGF/EA/2010, BEM COMO A PORTARIA INTERMINISTERIAL NO 1065 DE 24/05/2012, ENCAMINHA-SE O PRESENTE PEDIDO PARA AS PROVIDENCIAS CABIVEIS.

B07E Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette]
B06U Preliminary requirement: requests with searches performed by other patent offices: procedure suspended [chapter 6.21 patent gazette]
B09A Decision: intention to grant [chapter 9.1 patent gazette]
B16A Patent or certificate of addition of invention granted [chapter 16.1 patent gazette]

Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 20/12/2012, OBSERVADAS AS CONDICOES LEGAIS.

B16C Correction of notification of the grant [chapter 16.3 patent gazette]

Free format text: REF. RPI 2593 DE 15/09/2020 QUANTO A QUALIFICACAO.