KR890017223A - 2-아릴프로피온산의 에난티오머를 수득하는 방법 - Google Patents

2-아릴프로피온산의 에난티오머를 수득하는 방법 Download PDF

Info

Publication number
KR890017223A
KR890017223A KR1019890005931A KR890005931A KR890017223A KR 890017223 A KR890017223 A KR 890017223A KR 1019890005931 A KR1019890005931 A KR 1019890005931A KR 890005931 A KR890005931 A KR 890005931A KR 890017223 A KR890017223 A KR 890017223A
Authority
KR
South Korea
Prior art keywords
arylpropionic acid
ibuprofen
salt
enantiomer
acid
Prior art date
Application number
KR1019890005931A
Other languages
English (en)
Inventor
블라쉬케 곳트프리이드
슐테 카알-에른스트
Original Assignee
원본미기재
메디세 켐.-팜. 파브리크 퓌테르 게엠베하 운트 콤파니 카게
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 원본미기재, 메디세 켐.-팜. 파브리크 퓌테르 게엠베하 운트 콤파니 카게 filed Critical 원본미기재
Publication of KR890017223A publication Critical patent/KR890017223A/ko

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C61/00—Compounds having carboxyl groups bound to carbon atoms of rings other than six-membered aromatic rings
    • C07C61/08—Saturated compounds having a carboxyl group bound to a six-membered ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/56—Ring systems containing three or more rings
    • C07D209/80—[b, c]- or [b, d]-condensed
    • C07D209/82—Carbazoles; Hydrogenated carbazoles
    • C07D209/88—Carbazoles; Hydrogenated carbazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the ring system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
    • C07C51/42—Separation; Purification; Stabilisation; Use of additives
    • C07C51/487—Separation; Purification; Stabilisation; Use of additives by treatment giving rise to chemical modification

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

내용 없음

Description

2-아릴프로피온산의 에난티오머를 수득하는 방법
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (8)

  1. 광학적 활성형태의 트레오 - 1 - P - 니트로페닐 - 2 - 아미노프로판 - 1.3 - 디올을 사용하여 2 - 아릴프로피온산의 라세미체를 디아스테레오머염으로 전환시키고, 이들염을 분리한후, 수득된 순수한 디아스테레오머를 에난티오머 형태의 2 - 아릴프로피온산 또는 그의 염의 유리산으로 전환시키는 것을 특징으로하는, 2 - 아릴프로피온산의 라세미 혼합물을 아민 - 에난티오머와 반응시켜 2 - 아릴프로피온산의 에난티오머를 수득하는 방법.
  2. 제 1 항에 있어서, 2 - 아릴프로피온산이 플루트비프로펜, 페노프로펜, 케토프로펜, 나프록센, 베녹사프로펜 및 이부프로펜으로부터 선택된 것임을 특징으로 하는 방법.
  3. 제 2 항에 있어서, 이부프로펜이 2 - 아릴프로피온산으로서 사용되는 것을 특징으로 하는 방법.
  4. 제 1 항 또는 제 2 항에 있어서, 결정화를 이용하여 디아스테레오머염을 절단하는 것을 특징으로 하는 방법.
  5. 전술한 항들중 어느 한 항에 있어서, 2 - 아릴프로피온산을 D(-) - 트레오 - 1 - P - 니트로페닐 - 1 - 아미노프로판 - 1, 3 - 디올과 반응시키는 것을 특징으로 하는 방법.
  6. 전술한 항들중 어느 한 항에 있어서, 광학적 대장체의 염을 침전시킨후 잔류 모액을 농축시키고, 임의로 분리된 대장체의 재결정화 모액을 가하여 수화알칼리와의 슬러리를 형성시킨후, 그로부터 아미노 알코올을 분리하는것을 특징으로 하는 방법.
  7. 전술한 항들중 어느 한 항에 있어서, 침전된 광학 대장체와 아미노 알코올의 염을 분리한 후 수득된 2 - 아릴프로피온산의 에난티오머 용액을 다시 라세미화시키고, 상기 용액을 공정에 재순환시키는 것을 특징으로 하는 방법.
  8. 전술한 항들중 어느 한 항에 있어서, 이부프로펜이 라세미 혼합물로서 사용되고, 그로부터 S(+) - 이부프로펜이 수득되는 것을 특징으로 하는 방법.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019890005931A 1988-05-02 1989-05-02 2-아릴프로피온산의 에난티오머를 수득하는 방법 KR890017223A (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE3814887A DE3814887C1 (ko) 1988-05-02 1988-05-02
DEP3814887.0 1988-05-02

Publications (1)

Publication Number Publication Date
KR890017223A true KR890017223A (ko) 1989-12-15

Family

ID=6353411

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019890005931A KR890017223A (ko) 1988-05-02 1989-05-02 2-아릴프로피온산의 에난티오머를 수득하는 방법

Country Status (13)

Country Link
US (1) US4973745A (ko)
EP (1) EP0340663A3 (ko)
JP (1) JPH02138237A (ko)
KR (1) KR890017223A (ko)
CN (1) CN1037503A (ko)
AU (1) AU607856B2 (ko)
DD (1) DD283802A5 (ko)
DE (1) DE3814887C1 (ko)
FI (1) FI892007A (ko)
HU (1) HU204492B (ko)
IL (1) IL90090A0 (ko)
NO (1) NO171783C (ko)
ZA (1) ZA893107B (ko)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5191112A (en) * 1989-10-17 1993-03-02 Nissan Chemical Industries, Ltd. Process for optical resolution of (±)-2-(3-benzoyl)-phenylpropionic acid
WO1991006295A1 (en) * 1989-11-06 1991-05-16 Sepracor, Inc. Analgesic composition containing optically pure s(+) flurbiprofen
HU219242B (en) 1991-05-13 2001-03-28 Boots Co Plc S(+)-ibuprofen sodium salt dihydrate, pharmaceutical composition comprising this compound and process for production of them
US5756096A (en) * 1991-07-25 1998-05-26 Idec Pharmaceuticals Corporation Recombinant antibodies for human therapy
MX9204374A (es) * 1991-07-25 1993-03-01 Idec Pharma Corp Anticuerpo recombinante y metodo para su produccion.
US6136310A (en) * 1991-07-25 2000-10-24 Idec Pharmaceuticals Corporation Recombinant anti-CD4 antibodies for human therapy
DE4137773A1 (de) * 1991-11-16 1993-05-19 Degussa Herstellung und verwendung von salzen der reinen enantiomere der (alpha)-liponsaeure
US5235101A (en) * 1992-01-24 1993-08-10 Ethyl Corporation Preparation by flotation of optically active aliphatic carboxylic acids
US5235100A (en) * 1992-01-24 1993-08-10 Ethyl Corporation Preparation of optically active aliphatic carboxylic acids
US5220053A (en) * 1992-01-24 1993-06-15 Ethyl Corporation Preparation of optically active aliphatic carboxylic acids
US5235095A (en) * 1992-01-24 1993-08-10 Ethyl Corporation Preparation of optically active aliphatic carboxylic acids
US5331000A (en) * 1992-03-09 1994-07-19 Sepracor Inc. Antipyretic and analgesic methods and compositions containing optically pure R(-) ketoprofen
US5248813A (en) * 1992-10-14 1993-09-28 Ethyl Corporation Enantiomeric resolution
US5260482A (en) * 1992-10-14 1993-11-09 Ethyl Corporation Enantiomeric resolution
US5256816A (en) * 1992-10-14 1993-10-26 Ethyl Corporation Enantiomeric resolution
US5278337A (en) * 1992-10-14 1994-01-11 Ethyl Corporation Enantiomeric resolution of aryl-substituted aliphatic carboxylic acids
US5380867A (en) * 1992-12-02 1995-01-10 Hoechst Celanese Corporation Selective precipitation of α-aryl carboxylic acid salts
US5442117A (en) * 1993-12-13 1995-08-15 Albemarle Corporation Enantiomeric resolution
IT1271800B (it) * 1994-12-27 1997-06-09 Zambon Spa Processo di preparazione degli enantiomeri dell'acido 2- (2-fluoro- 4-bifenil) propionico
US6013808A (en) * 1998-06-16 2000-01-11 Pfizer Inc. Method of purifying carbazole ester precursors of 6-chloro-α-methyl-carbazole-2-acetic acid
ITMI981583A1 (it) * 1998-07-10 2000-01-10 Bracco Spa Processo per la preparazione dell'acido 4 -carbossi-5,8,11-tris (carbossimetil)-1-fenil-2-oxa-5,8,11-triazatridecan-13-oico
US6656730B1 (en) * 1999-06-15 2003-12-02 Isis Pharmaceuticals, Inc. Oligonucleotides conjugated to protein-binding drugs
HU230004B1 (en) 2001-06-21 2015-04-28 Sanofi Aventis Resolution process for (r)-(-)-2-hydroxy-2-(2-chlorophenyl)-acetic acid
TW200628439A (en) * 2004-11-09 2006-08-16 Novartis Ag Organic compounds
GB0811851D0 (en) * 2008-06-30 2008-07-30 Aesica Pharmaceuticals Ltd Process
CN108586413B (zh) * 2018-06-11 2020-04-21 上海应用技术大学 一种光学纯(s)-6-甲氧基苯并二氢吡喃-3-羧酸的制备方法

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ZA70809B (en) * 1969-03-24 1971-09-29 Syntex Corp Amine salts of 2-(6'-methoxy-2'-naphthyl)propionic acids and processes for the preparation thereof
SU408943A1 (ru) * 1971-02-25 1973-11-30 Всесоюзный научно исследовательский институт целлюлозно бумажной промышленности Способ получения l-винной кислоты
DE2362687C3 (de) * 1973-12-17 1982-01-14 Degussa Ag, 6000 Frankfurt Verfahren zur Gewinnung der optischen Isomeren des Penicillamins
US4209638A (en) * 1977-03-08 1980-06-24 The Boots Company Limited Preparation of therapeutic agents
IT1194152B (it) * 1983-03-07 1988-09-14 Secifarma Spa Procedimento di risoluzione enantiomerica di miscele di acidi d- e l-6-metossi-alfa-metil-2-naftalenacetici ed agenti di risoluzione per detto procedimento
JPS61266579A (ja) * 1985-05-22 1986-11-26 Nippon Dakuro Shamrock:Kk 金属表面処理法

Also Published As

Publication number Publication date
JPH02138237A (ja) 1990-05-28
EP0340663A2 (de) 1989-11-08
IL90090A0 (en) 1989-12-15
AU607856B2 (en) 1991-03-14
AU3333989A (en) 1989-11-02
DE3814887C1 (ko) 1989-09-21
US4973745A (en) 1990-11-27
HU204492B (en) 1992-01-28
EP0340663A3 (de) 1991-07-03
CN1037503A (zh) 1989-11-29
ZA893107B (en) 1990-01-31
FI892007A (fi) 1989-11-03
HUT50090A (en) 1989-12-28
NO891793D0 (no) 1989-04-28
DD283802A5 (de) 1990-10-24
NO171783B (no) 1993-01-25
NO171783C (no) 1993-05-05
FI892007A0 (fi) 1989-04-27
NO891793L (no) 1989-11-03

Similar Documents

Publication Publication Date Title
KR890017223A (ko) 2-아릴프로피온산의 에난티오머를 수득하는 방법
DE3750523D1 (de) Verfahren zur Herstellung von L-2-Amino-4-(hydroxymethyl-phosphinyl)-Buttersäure.
GB1268865A (en) THE PREPARATION OF D-THREO-1-p-METHYLSULFONYLPHENYL-2-DICHLOROACETAMIDOPROPANE-1,3-DIOL
DK0828702T3 (da) Fremgangsmåde til opløsning af chirale syrer med 1-aminoindan-2-oler
JP2009108079A (ja) エナンチオマーに富むｎ−アシルアゼチジン−２−カルボン酸の製造方法
ES2068624T3 (es) Procedimiento para la preparacion de l-carnitina a partir de sales d,l-carnitinonitrilo.
KR940002220A (ko) 광학활성 메티오닌아미드를 제조하는 방법
FR2450246B1 (fr) Procede de separation des isomeres optiques du 1-(o-methoxy-phenoxy)-3-isopropyl-amino-propane-2-ol et compositions pharmaceutiques contenant l'antipode levogyre, utile notamment comme agent b-bloquant
JPH07504894A (ja) 光学的に活性な脂肪族カルボン酸の調製
EP0138521B2 (en) Process for preparing d-alpha-(6-methoxy-2-naphthyl)propionic acid
DE69315720D1 (de) Verfahren zur Trennung von 1,2-Isopropylidenglycerinbenzoylester-Enantiomeren
JPS57188563A (en) Preparation of optically active 3-benzoylthio-2-methyl- propionic acid
KR920000694A (ko) 2, 2-디메틸사이클로프로판카본산의 라세미분리에 관한 방법
ATE69804T1 (de) Verfahren zur herstellung von d- oder l-alanin hoher enantiomerenreinheit.
ES8707167A1 (es) Un procedimiento para producir treo-3-(3,4-metilendioxifenil) serina opticamente activa
FR2605314B1 (fr) Procede pour la fabrication de l'acide beta-hydroxybutyrique et de ses sels par hydrolyse d'oligomeres de l'acide beta-hydroxybutyrique en milieu basique.
CA2575912A1 (en) Process for the preparation of optically pure indoline-2-carboxylic acid
GB1587679A (en) Method of racemising n-acyl-amino acid compounds
ATE198189T1 (de) Synthese von optisch aktivem aminoindanol
GB1268867A (en) THE PREPARATION OF D-THREO-beta-p-METHYLSULPHONYLPHENYLSERINE ESTER
Pickard et al. L.—Studies on optically active carbimides. III. The resolution of α-phenyl-α′-4-hydroxyphenylethane by means of l-menthylcarbimide
ATE97127T1 (de) Verfahren zur herstellung von na-salz der diethylmetanilsaeure.
JPH0419215B2 (ko)
JPS55113738A (en) Optical resolution of mandelic acid
JPS6452741A (en) Novel process for producing optically active 1-(p-tolyl) ethylamine

Legal Events

Date Code Title Description
WITN Application deemed withdrawn, e.g. because no request for examination was filed or no examination fee was paid