JPS6452741A - Novel process for producing optically active 1-(p-tolyl) ethylamine - Google Patents
Novel process for producing optically active 1-(p-tolyl) ethylamineInfo
- Publication number
- JPS6452741A JPS6452741A JP20820987A JP20820987A JPS6452741A JP S6452741 A JPS6452741 A JP S6452741A JP 20820987 A JP20820987 A JP 20820987A JP 20820987 A JP20820987 A JP 20820987A JP S6452741 A JPS6452741 A JP S6452741A
- Authority
- JP
- Japan
- Prior art keywords
- ethylamine
- tolyl
- optically active
- solvent
- resolution agent
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Landscapes
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
PURPOSE:To obtain the titled compound useful as an optical resolution agent, in high yield and purity, by reacting (+ or -)-1-(p-tolyl)-ethylamine with an inexpensive resolution agent and separating the produced diastereomer salt taking advantage of the solubility difference. CONSTITUTION:(+ or -)-1-(p-Tolyl)ethylamine is made to react with 0.6-1.2 equivalent of a resolution agent comprising optically active 2-pyrrolidone-5-carboxylic acid or optically active 2-(6-methoxy-2-naphthyl)propionic acid in a solvent (e.g. 2-propanol) preferably at a temperature between about 50 deg.C and the boiling point of the solvent. The reaction product is heated and dissolved to form a supersaturated solution. If necessary, the solution is added with a small amount of a diastereomer salt having lower solubility in said solvent among the two kinds of the diastereomer salts and cooled preferably to 0-50 deg.C. The precipitated hardly soluble salt is separated to obtain the objective compound.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP20820987A JPS6452741A (en) | 1987-08-24 | 1987-08-24 | Novel process for producing optically active 1-(p-tolyl) ethylamine |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP20820987A JPS6452741A (en) | 1987-08-24 | 1987-08-24 | Novel process for producing optically active 1-(p-tolyl) ethylamine |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| JPS6452741A true JPS6452741A (en) | 1989-02-28 |
Family
ID=16552477
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP20820987A Pending JPS6452741A (en) | 1987-08-24 | 1987-08-24 | Novel process for producing optically active 1-(p-tolyl) ethylamine |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPS6452741A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108658784A (en) * | 2018-04-26 | 2018-10-16 | 联化科技股份有限公司 | (R) synthetic method of -1- (4- aminomethyl phenyls) ethamine |
-
1987
- 1987-08-24 JP JP20820987A patent/JPS6452741A/en active Pending
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108658784A (en) * | 2018-04-26 | 2018-10-16 | 联化科技股份有限公司 | (R) synthetic method of -1- (4- aminomethyl phenyls) ethamine |
| CN108658784B (en) * | 2018-04-26 | 2020-12-18 | 联化科技股份有限公司 | Synthesis method of (R) -1- (4-methylphenyl) ethylamine |
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