JPS55113738A - Optical resolution of mandelic acid - Google Patents

Optical resolution of mandelic acid

Info

Publication number
JPS55113738A
JPS55113738A JP2070279A JP2070279A JPS55113738A JP S55113738 A JPS55113738 A JP S55113738A JP 2070279 A JP2070279 A JP 2070279A JP 2070279 A JP2070279 A JP 2070279A JP S55113738 A JPS55113738 A JP S55113738A
Authority
JP
Japan
Prior art keywords
mandelic acid
salt
diisopropylamine
optical resolution
diisopropylamine salt
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2070279A
Other languages
Japanese (ja)
Inventor
Rieko Fujimura
Noriko Jinbo
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Individual
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Priority to JP2070279A priority Critical patent/JPS55113738A/en
Publication of JPS55113738A publication Critical patent/JPS55113738A/en
Pending legal-status Critical Current

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  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

PURPOSE: To obtain the title compound which is a raw material of antibiotics, in high yield and high purity, by converting (±)-mandelic acid into diisopropylamine salt, and crystallizing the desired compound preferentially in the presence of free mandelic acid or other mandelic acid salt.
CONSTITUTION: The title compound is obtained by adding optically active diisopropylamine salt of mandelic acid to a mixture of (A) mandelic acid diisopropylamine salt obtained by reacting diisopropylamine with (±)-mandelic acid or mandelic acid containing either (+)- or (-)-species in excess, and (B) free (±)-mandelic acid and/or mandelic acid salts other than diisopropylamine salt of (±)-mandelic acid, e.g. 2-hydroxypropylamine salt, and precipitating crystals of the optically active mandelic acid diisopropylamine salt. 2-Propanol is preferable as a solvent.
COPYRIGHT: (C)1980,JPO&Japio
JP2070279A 1979-02-26 1979-02-26 Optical resolution of mandelic acid Pending JPS55113738A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2070279A JPS55113738A (en) 1979-02-26 1979-02-26 Optical resolution of mandelic acid

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP2070279A JPS55113738A (en) 1979-02-26 1979-02-26 Optical resolution of mandelic acid

Publications (1)

Publication Number Publication Date
JPS55113738A true JPS55113738A (en) 1980-09-02

Family

ID=12034474

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2070279A Pending JPS55113738A (en) 1979-02-26 1979-02-26 Optical resolution of mandelic acid

Country Status (1)

Country Link
JP (1) JPS55113738A (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS55115846A (en) * 1979-03-02 1980-09-06 Noyori Gentaro Optical resolution of dl-mandelic acid

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS55115846A (en) * 1979-03-02 1980-09-06 Noyori Gentaro Optical resolution of dl-mandelic acid

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