JPS55147236A - Optical resolution of ( )-mandelic acid - Google Patents

Optical resolution of ( )-mandelic acid

Info

Publication number
JPS55147236A
JPS55147236A JP5532479A JP5532479A JPS55147236A JP S55147236 A JPS55147236 A JP S55147236A JP 5532479 A JP5532479 A JP 5532479A JP 5532479 A JP5532479 A JP 5532479A JP S55147236 A JPS55147236 A JP S55147236A
Authority
JP
Japan
Prior art keywords
mandelic acid
optically active
equivalent
soluble salt
reacting
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP5532479A
Inventor
Rieko Fujimura
Tomonori Hoshiko
Hiroyuki Nohira
Original Assignee
Hiroyuki Nohira
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hiroyuki Nohira filed Critical Hiroyuki Nohira
Priority to JP5532479A priority Critical patent/JPS55147236A/en
Publication of JPS55147236A publication Critical patent/JPS55147236A/en
Application status is Pending legal-status Critical

Links

Abstract

PURPOSE: To prepare optically active mandelic acid at low cost in high purity, by reacting (±)-mandelic acid with optically active α-phenyl-ethylamine at an amount about half of the conventionally used amount, thereby improving the optical purity of the scarcely soluble salt of both compounds.
CONSTITUTION: An optically active mandelic acid is prepared by reacting 1 equivalent of (±)-mandelic acid (A) with 0.25W0.75 equivalent of optically active α- phenylethylamine (B). By the use of less than equivalent of (+)- or (-)-B, excess A is retained in the solution in such a form that it has higher solubility than that of the easily soluble salt [(+)-A.(+)-B or (-)-A.(-)-B], whereby the optical purity of the desired hardly soluble salt [(+)-A.(-)-B or (-)-A.(+)-B] is increased. Addition of NaOH, etc. to the reaction system forms soluble mandelic acid salt, and further improves the effect.
COPYRIGHT: (C)1980,JPO&Japio
JP5532479A 1979-05-08 1979-05-08 Optical resolution of ( )-mandelic acid Pending JPS55147236A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP5532479A JPS55147236A (en) 1979-05-08 1979-05-08 Optical resolution of ( )-mandelic acid

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP5532479A JPS55147236A (en) 1979-05-08 1979-05-08 Optical resolution of ( )-mandelic acid

Publications (1)

Publication Number Publication Date
JPS55147236A true JPS55147236A (en) 1980-11-17

Family

ID=12995355

Family Applications (1)

Application Number Title Priority Date Filing Date
JP5532479A Pending JPS55147236A (en) 1979-05-08 1979-05-08 Optical resolution of ( )-mandelic acid

Country Status (1)

Country Link
JP (1) JPS55147236A (en)

Cited By (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0395138A (en) * 1989-09-07 1991-04-19 Nissan Chem Ind Ltd Optical resolution of 3-methylheptanoic acid
JP2002316952A (en) * 2001-04-18 2002-10-31 Daito Kagaku Kk Method for optical purification of optically active 2- phenoxypropionic acid
WO2003051852A1 (en) * 2001-12-19 2003-06-26 Ono Pharmaceutical Co., Ltd. Intermediate and process for producing optically active compound from the intermediate
CN105061190A (en) * 2015-09-02 2015-11-18 彭静 Method for preparing S-five-fluorine amygdalic acid through resolution
CN105085248A (en) * 2015-09-02 2015-11-25 彭静 Resolution preparation method of S-4-methoxymandelic acid
CN105085245A (en) * 2015-08-31 2015-11-25 彭静 Preparing method of (R)-(+)-4-fluoromandelic acid
CN105085234A (en) * 2015-08-31 2015-11-25 彭静 Preparing method of (R)-(-)-4-chloromandelic acid
CN105085236A (en) * 2015-09-02 2015-11-25 彭静 Resolution preparation method of R-pentafluoro DL-mandelic acid
CN105130794A (en) * 2015-09-02 2015-12-09 彭静 Method for preparing S-4-methoxymandelic acid through splitting S-1-phenylethylamine
CN105153108A (en) * 2015-08-31 2015-12-16 彭静 Method of preparing R-3, 4-(methylenedioxy) mandelic acid by resolving
CN105153109A (en) * 2015-09-02 2015-12-16 彭静 Method for split preparation of S-3,4-(methylenedioxy) mandelic acid
CN105175386A (en) * 2015-09-02 2015-12-23 彭静 S-3,4-(methylenedioxy)mandelic acid preparation method

Cited By (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0395138A (en) * 1989-09-07 1991-04-19 Nissan Chem Ind Ltd Optical resolution of 3-methylheptanoic acid
JP2002316952A (en) * 2001-04-18 2002-10-31 Daito Kagaku Kk Method for optical purification of optically active 2- phenoxypropionic acid
WO2003051852A1 (en) * 2001-12-19 2003-06-26 Ono Pharmaceutical Co., Ltd. Intermediate and process for producing optically active compound from the intermediate
CN105153108A (en) * 2015-08-31 2015-12-16 彭静 Method of preparing R-3, 4-(methylenedioxy) mandelic acid by resolving
CN105085245A (en) * 2015-08-31 2015-11-25 彭静 Preparing method of (R)-(+)-4-fluoromandelic acid
CN105085234A (en) * 2015-08-31 2015-11-25 彭静 Preparing method of (R)-(-)-4-chloromandelic acid
CN105085248A (en) * 2015-09-02 2015-11-25 彭静 Resolution preparation method of S-4-methoxymandelic acid
CN105085236A (en) * 2015-09-02 2015-11-25 彭静 Resolution preparation method of R-pentafluoro DL-mandelic acid
CN105130794A (en) * 2015-09-02 2015-12-09 彭静 Method for preparing S-4-methoxymandelic acid through splitting S-1-phenylethylamine
CN105061190A (en) * 2015-09-02 2015-11-18 彭静 Method for preparing S-five-fluorine amygdalic acid through resolution
CN105153109A (en) * 2015-09-02 2015-12-16 彭静 Method for split preparation of S-3,4-(methylenedioxy) mandelic acid
CN105175386A (en) * 2015-09-02 2015-12-23 彭静 S-3,4-(methylenedioxy)mandelic acid preparation method

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