ES2068624T3 - Procedimiento para la preparacion de l-carnitina a partir de sales d,l-carnitinonitrilo. - Google Patents

Procedimiento para la preparacion de l-carnitina a partir de sales d,l-carnitinonitrilo.

Info

Publication number
ES2068624T3
ES2068624T3 ES92104160T ES92104160T ES2068624T3 ES 2068624 T3 ES2068624 T3 ES 2068624T3 ES 92104160 T ES92104160 T ES 92104160T ES 92104160 T ES92104160 T ES 92104160T ES 2068624 T3 ES2068624 T3 ES 2068624T3
Authority
ES
Spain
Prior art keywords
carnitine
preparation
salts
diastereomer
carnitine nitrile
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES92104160T
Other languages
English (en)
Inventor
Harald Dr Jakob
Klaus Dr Huthmacher
Herbert Dr Klenk
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Evonik Operations GmbH
Original Assignee
Degussa GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Degussa GmbH filed Critical Degussa GmbH
Application granted granted Critical
Publication of ES2068624T3 publication Critical patent/ES2068624T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C227/30—Preparation of optical isomers
    • C07C227/34—Preparation of optical isomers by separation of optical isomers

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Analytical Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

PROCEDIMIENTO PARA LA PRODUCCION DE CARNITINA L A PARTIR DE SALES DE NITRILO DE CARNITINA D, L. LA PRODUCCION DE CARNITINA L POR MEDIO DE DISOCIACION RACEMICA DE SALES DE NITRILO DE CARNITINA D, L, ESPECIALMENTE DE CLORUROS DE NITRILO DE CARNITINA D, L, CON UTILIZACION DE REACTIVOS DE DISOCIACION OPTICAMENTE ACTIVOS, SEPARACION DE LOS DIASTEREOMEROS, TRANSFORMACION DE LOS DIASTEREOMEROS QUE CONTIENEN NITRILO DE CARNITINA L EN UNA SAL DE UN ACIDO OPTICAMENTE NO ACTIVO, Y LA SAPONIFICACION DE LAS SALES DE NITRILO DE CARNITINA L, RESULTAN DE MAS ALTO RENDIMIENTO Y CON MAYOR PUREZA ENANTIOMERICA, AL UTILIZAR COMO AGENTE DE DISOCIACION LA N IL IASTEREOMERO LA HASTA AHORA NECESARIA SEGUNDA ETAPA FRACCIONADA DE CRISTALIZACION.
ES92104160T 1991-04-12 1992-03-11 Procedimiento para la preparacion de l-carnitina a partir de sales d,l-carnitinonitrilo. Expired - Lifetime ES2068624T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE4111913A DE4111913A1 (de) 1991-04-12 1991-04-12 Verfahren zur herstellung von l-carnitin aus d,l-carnitinnitrilsalzen

Publications (1)

Publication Number Publication Date
ES2068624T3 true ES2068624T3 (es) 1995-04-16

Family

ID=6429412

Family Applications (1)

Application Number Title Priority Date Filing Date
ES92104160T Expired - Lifetime ES2068624T3 (es) 1991-04-12 1992-03-11 Procedimiento para la preparacion de l-carnitina a partir de sales d,l-carnitinonitrilo.

Country Status (7)

Country Link
US (1) US5166426A (es)
EP (1) EP0508133B1 (es)
JP (1) JPH05117170A (es)
AT (1) ATE118476T1 (es)
CA (1) CA2065806A1 (es)
DE (2) DE4111913A1 (es)
ES (1) ES2068624T3 (es)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH06116217A (ja) * 1992-10-02 1994-04-26 Kuraray Co Ltd （±）−シス−４−アミノシクロペント−２−エンカルボン酸誘導体の光学分割法
IT1289974B1 (it) * 1997-02-25 1998-10-19 Aldo Fassi Procedimento per la produzione di sali stabili e non igroscopici di l(-)carnitina e di alcanoli l(-)-carnitine
JPH10179183A (ja) * 1996-12-20 1998-07-07 Daicel Chem Ind Ltd カルボン酸の製造方法
KR20080033250A (ko) * 2005-06-10 2008-04-16 플로리다 스테이트 유니버시티 리서치 파운데이션, 인크 β-락탐의 거울상이성질체 혼합물의 분리
JP2008231046A (ja) * 2007-03-22 2008-10-02 Mitsubishi Rayon Co Ltd 光学活性カルニチンアミドハロゲン化物の精製方法
JP5561506B2 (ja) * 2007-10-24 2014-07-30 三菱レイヨン株式会社 Ｌ−カルニチンの単離精製方法
CN102827014B (zh) * 2012-08-10 2014-04-23 杭州海尔希畜牧科技有限公司 一种l（-）-肉碱的制备方法
CN114181101A (zh) * 2021-11-26 2022-03-15 开原亨泰营养科技有限公司 能够控制产品晶型的左旋肉碱酒石酸盐的制备方法

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES332080A1 (es) * 1965-10-15 1967-10-01 Otsuka Pharma Co Ltd Procedimiento para obtencion de complejos de sales opticamente activas de hidroxido de nitrilo,carnitina y acidos glutamicos n-acilos.
US3488729A (en) * 1966-08-22 1970-01-06 Lilly Co Eli Cephalothin ester
FR2536391B1 (fr) * 1982-11-24 1985-05-31 Sanofi Sa Nouveaux sels de carnitinenitrile ainsi que leur procede de preparation
CH658857A5 (de) * 1984-04-04 1986-12-15 Lonza Ag Optisch aktives di-(3-chlor-2-oxy-propyltrimethylammonium)-tartrat.
JPS62286959A (ja) * 1986-06-05 1987-12-12 Seitetsu Kagaku Co Ltd 光学活性シアノカルニチン塩の製造方法
DE3735757A1 (de) * 1987-10-22 1989-05-03 Degussa Optisch aktive salze aus einem substituierten thiazolidin-4-carboxylat und 3-chlor-2-hydroxypropyltrimethylammonium, deren herstellung und verwendung
JPH01131143A (ja) * 1987-11-16 1989-05-24 Earth Chem Corp Ltd ｄ，ｌ−カルニチンニトリルクロライドの光学分割法

Also Published As

Publication number Publication date
EP0508133B1 (de) 1995-02-15
US5166426A (en) 1992-11-24
DE59201373D1 (de) 1995-03-23
DE4111913A1 (de) 1992-10-15
EP0508133A3 (en) 1993-03-03
EP0508133A2 (de) 1992-10-14
ATE118476T1 (de) 1995-03-15
JPH05117170A (ja) 1993-05-14
CA2065806A1 (en) 1992-10-13

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